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Cellular interactions between L-arginine and asymmetric dimethylarginine: Transport and metabolism.

Shin S, Thapa SK, Fung HL.

PLoS One. 2017 May 31;12(5):e0178710. doi: 10.1371/journal.pone.0178710. eCollection 2017.


Identification of methylation haplotype blocks aids in deconvolution of heterogeneous tissue samples and tumor tissue-of-origin mapping from plasma DNA.

Guo S, Diep D, Plongthongkum N, Fung HL, Zhang K, Zhang K.

Nat Genet. 2017 Apr;49(4):635-642. doi: 10.1038/ng.3805. Epub 2017 Mar 6.


Neuronal subtypes and diversity revealed by single-nucleus RNA sequencing of the human brain.

Lake BB, Ai R, Kaeser GE, Salathia NS, Yung YC, Liu R, Wildberg A, Gao D, Fung HL, Chen S, Vijayaraghavan R, Wong J, Chen A, Sheng X, Kaper F, Shen R, Ronaghi M, Fan JB, Wang W, Chun J, Zhang K.

Science. 2016 Jun 24;352(6293):1586-90. doi: 10.1126/science.aaf1204.


Characterization of chromatin accessibility with a transposome hypersensitive sites sequencing (THS-seq) assay.

Sos BC, Fung HL, Gao DR, Osothprarop TF, Kia A, He MM, Zhang K.

Genome Biol. 2016 Feb 4;17:20. doi: 10.1186/s13059-016-0882-7.


Perspectives on the history and scientific contributions of Gerhard Levy.

Fung HL, Jusko WJ.

J Pharmacokinet Pharmacodyn. 2015 Oct;42(5):429-46. doi: 10.1007/s10928-015-9442-0. Epub 2015 Sep 24. No abstract available.


Preface to the special issue to honor Gerhard Levy and 50 years of PK/PD.

Jusko WJ, Fung HL.

J Pharmacokinet Pharmacodyn. 2015 Oct;42(5):427. doi: 10.1007/s10928-015-9443-z. No abstract available.


Estimation of nitric oxide synthase activity via liquid chromatography/tandem mass spectrometric assay determination of 15N3 -citrulline in biological samples.

Shin BS, Fung HL, Upadhyay M, Shin S.

Rapid Commun Mass Spectrom. 2015 Mar 15;29(5):447-55. doi: 10.1002/rcm.7124.


Characterization of genome-methylome interactions in 22 nuclear pedigrees.

Plongthongkum N, van Eijk KR, de Jong S, Wang T, Sul JH, Boks MP, Kahn RS, Fung HL, Ophoff RA, Zhang K.

PLoS One. 2014 Jul 14;9(7):e99313. doi: 10.1371/journal.pone.0099313. eCollection 2014.


Domestic dog health worsens with socio-economic deprivation of their home communities.

Fung HL, Calzada J, Saldaña A, Santamaria AM, Pineda V, Gonzalez K, Chaves LF, Garner B, Gottdenker N.

Acta Trop. 2014 Jul;135:67-74. doi: 10.1016/j.actatropica.2014.03.010. Epub 2014 Mar 26.


Environmental variabilities and the distribution of octocorals and black corals in Hong Kong.

Yeung CW, Cheang CC, Lee MW, Fung HL, Chow WK, Ang P Jr.

Mar Pollut Bull. 2014 Aug 30;85(2):774-82. doi: 10.1016/j.marpolbul.2013.12.043. Epub 2014 Jan 13.


Chromatin signature of widespread monoallelic expression.

Nag A, Savova V, Fung HL, Miron A, Yuan GC, Zhang K, Gimelbrant AA.

Elife. 2013 Dec 31;2:e01256. doi: 10.7554/eLife.01256.


Massively parallel polymerase cloning and genome sequencing of single cells using nanoliter microwells.

Gole J, Gore A, Richards A, Chiu YJ, Fung HL, Bushman D, Chiang HI, Chun J, Lo YH, Zhang K.

Nat Biotechnol. 2013 Dec;31(12):1126-32. doi: 10.1038/nbt.2720. Epub 2013 Nov 10.


In vitro organic nitrate bioactivation to nitric oxide by recombinant aldehyde dehydrogenase 3A1.

Lin S, Page NA, Fung SM, Fung HL.

Nitric Oxide. 2013 Nov 30;35:137-43. doi: 10.1016/j.niox.2013.09.005. Epub 2013 Oct 11.


Organic nitrate metabolism and action: toward a unifying hypothesis and the future-a dedication to Professor Leslie Z. Benet.

Page NA, Fung HL.

J Pharm Sci. 2013 Sep;102(9):3070-81. doi: 10.1002/jps.23550. Epub 2013 May 13. Review.


Genome-wide analysis reveals TET- and TDG-dependent 5-methylcytosine oxidation dynamics.

Shen L, Wu H, Diep D, Yamaguchi S, D'Alessio AC, Fung HL, Zhang K, Zhang Y.

Cell. 2013 Apr 25;153(3):692-706. doi: 10.1016/j.cell.2013.04.002. Epub 2013 Apr 18.


Analysis of protein-coding mutations in hiPSCs and their possible role during somatic cell reprogramming.

Ruiz S, Gore A, Li Z, Panopoulos AD, Montserrat N, Fung HL, Giorgetti A, Bilic J, Batchelder EM, Zaehres H, Schöler HR, Zhang K, Izpisua Belmonte JC.

Nat Commun. 2013;4:1382. doi: 10.1038/ncomms2381.


Identification of a specific reprogramming-associated epigenetic signature in human induced pluripotent stem cells.

Ruiz S, Diep D, Gore A, Panopoulos AD, Montserrat N, Plongthongkum N, Kumar S, Fung HL, Giorgetti A, Bilic J, Batchelder EM, Zaehres H, Kan NG, Schöler HR, Mercola M, Zhang K, Izpisua Belmonte JC.

Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16196-201. doi: 10.1073/pnas.1202352109. Epub 2012 Sep 18.


Mechanism of cellular oxidation stress induced by asymmetric dimethylarginine.

Mohan S, Fung HL.

Int J Mol Sci. 2012;13(6):7521-31. doi: 10.3390/ijms13067521. Epub 2012 Jun 18.


Library-free methylation sequencing with bisulfite padlock probes.

Diep D, Plongthongkum N, Gore A, Fung HL, Shoemaker R, Zhang K.

Nat Methods. 2012 Feb 5;9(3):270-2. doi: 10.1038/nmeth.1871.


Continuous exposure to L-arginine induces oxidative stress and physiological tolerance in cultured human endothelial cells.

Mohan S, Wu CC, Shin S, Fung HL.

Amino Acids. 2012 Sep;43(3):1179-88. doi: 10.1007/s00726-011-1173-y. Epub 2011 Dec 1.


Intracellular L-arginine concentration does not determine NO production in endothelial cells: implications on the "L-arginine paradox".

Shin S, Mohan S, Fung HL.

Biochem Biophys Res Commun. 2011 Nov 4;414(4):660-3. doi: 10.1016/j.bbrc.2011.09.112. Epub 2011 Oct 1.


Human oocytes reprogram somatic cells to a pluripotent state.

Noggle S, Fung HL, Gore A, Martinez H, Satriani KC, Prosser R, Oum K, Paull D, Druckenmiller S, Freeby M, Greenberg E, Zhang K, Goland R, Sauer MV, Leibel RL, Egli D.

Nature. 2011 Oct 5;478(7367):70-5. doi: 10.1038/nature10397.


Evaluation of an LC-MS/MS assay for 15N-nitrite for cellular studies of L-arginine action.

Shin S, Fung HL.

J Pharm Biomed Anal. 2011 Dec 15;56(5):1127-31. doi: 10.1016/j.jpba.2011.08.017. Epub 2011 Aug 12.


Differential metabolism of organic nitrates by aldehyde dehydrogenase 1a1 and 2: substrate selectivity, enzyme inactivation, and active cysteine sites.

Tsou PS, Page NA, Lee SG, Fung SM, Keung WM, Fung HL.

AAPS J. 2011 Dec;13(4):548-55. doi: 10.1208/s12248-011-9295-4. Epub 2011 Aug 5.


Identification of nitroglycerin-induced cysteine modifications of pro-matrix metalloproteinase-9.

Krishnatry AS, Kamei T, Wang H, Qu J, Fung HL.

Rapid Commun Mass Spectrom. 2011 Aug 30;25(16):2291-8. doi: 10.1002/rcm.5118.


Editorial: a new series of commentaries entitled "Landmark publications in the pharmaceutical sciences: the backstory".

Fung HL.

AAPS J. 2011 Sep;13(3):319. doi: 10.1208/s12248-011-9278-5. Epub 2011 May 21. No abstract available.


Targeted gene correction of laminopathy-associated LMNA mutations in patient-specific iPSCs.

Liu GH, Suzuki K, Qu J, Sancho-Martinez I, Yi F, Li M, Kumar S, Nivet E, Kim J, Soligalla RD, Dubova I, Goebl A, Plongthongkum N, Fung HL, Zhang K, Loring JF, Laurent LC, Izpisua Belmonte JC.

Cell Stem Cell. 2011 Jun 3;8(6):688-94. doi: 10.1016/j.stem.2011.04.019. Epub 2011 May 19.


Genetic correction and analysis of induced pluripotent stem cells from a patient with gyrate atrophy.

Howden SE, Gore A, Li Z, Fung HL, Nisler BS, Nie J, Chen G, McIntosh BE, Gulbranson DR, Diol NR, Taapken SM, Vereide DT, Montgomery KD, Zhang K, Gamm DM, Thomson JA.

Proc Natl Acad Sci U S A. 2011 Apr 19;108(16):6537-42. doi: 10.1073/pnas.1103388108. Epub 2011 Apr 4.


Somatic coding mutations in human induced pluripotent stem cells.

Gore A, Li Z, Fung HL, Young JE, Agarwal S, Antosiewicz-Bourget J, Canto I, Giorgetti A, Israel MA, Kiskinis E, Lee JH, Loh YH, Manos PD, Montserrat N, Panopoulos AD, Ruiz S, Wilbert ML, Yu J, Kirkness EF, Izpisua Belmonte JC, Rossi DJ, Thomson JA, Eggan K, Daley GQ, Goldstein LS, Zhang K.

Nature. 2011 Mar 3;471(7336):63-7. doi: 10.1038/nature09805.


Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndrome.

Liu GH, Barkho BZ, Ruiz S, Diep D, Qu J, Yang SL, Panopoulos AD, Suzuki K, Kurian L, Walsh C, Thompson J, Boue S, Fung HL, Sancho-Martinez I, Zhang K, Yates J 3rd, Izpisua Belmonte JC.

Nature. 2011 Apr 14;472(7342):221-5. doi: 10.1038/nature09879. Epub 2011 Feb 23.


Simultaneous bioanalysis of L-arginine, L-citrulline, and dimethylarginines by LC-MS/MS.

Shin S, Fung SM, Mohan S, Fung HL.

J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Mar 1;879(7-8):467-74. doi: 10.1016/j.jchromb.2011.01.006. Epub 2011 Jan 14.


Nitroglycerin alters matrix remodeling proteins in THP-1 human macrophages and plasma metalloproteinase activity in rats.

Krishnatry AS, Fung SM, Brazeau DA, Soda D, Fung HL.

Nitric Oxide. 2011 Mar 15;24(2):66-76. doi: 10.1016/j.niox.2010.12.002. Epub 2010 Dec 13.


Broad regulation of matrix and adhesion molecules in THP-1 human macrophages by nitroglycerin.

Krishnatry AS, Brazeau DA, Fung HL.

Nitric Oxide. 2010 Jan 1;22(1):11-7. doi: 10.1016/j.niox.2009.10.004. Epub 2009 Oct 15.


Role of glutaredoxin-mediated protein S-glutathionylation in cellular nitroglycerin tolerance.

Tsou PS, Addanki V, Haas JA, Page NA, Fung HL.

J Pharmacol Exp Ther. 2009 May;329(2):649-56. doi: 10.1124/jpet.108.149997. Epub 2009 Feb 17.


Dissociation between superoxide accumulation and nitroglycerin-induced tolerance.

Tsou PS, Addanki V, Fung HL.

J Pharmacol Exp Ther. 2008 Oct;327(1):97-104. doi: 10.1124/jpet.108.138784. Epub 2008 Jul 24.


Pharmacokinetics of 1,4-butanediol in rats: bioactivation to gamma-hydroxybutyric acid, interaction with ethanol, and oral bioavailability.

Fung HL, Tsou PS, Bulitta JB, Tran DC, Page NA, Soda D, Mi Fung S.

AAPS J. 2008;10(1):56-69. doi: 10.1208/s12248-007-9006-3. Epub 2008 Feb 8.


Effects of inhalant nitrites on VEGF expression: a feasible link to Kaposi's sarcoma?

Fung HL, Tran DC.

J Neuroimmune Pharmacol. 2006 Sep;1(3):317-22. Review.


Inactivation of hepatic enzymes by inhalant nitrite--in vivo and in vitro studies.

Turowski SG, Jank KE, Fung HL.

AAPS J. 2007 Jul 27;9(3):E298-305.


Simultaneous determination of nitroglycerin and dinitrate metabolites in metabolism studies using liquid chromatography-mass spectrometry with electrospray ionization.

Miyayama T, Tsou PS, Fung SM, Fung HL.

J Chromatogr B Analyt Technol Biomed Life Sci. 2006 May 1;835(1-2):21-6. Epub 2006 Mar 30.


Effects of repeated in vivo inhalant nitrite exposure on gene expression in mouse liver and lungs.

Tran DC, Brazeau DA, Nickerson PA, Fung HL.

Nitric Oxide. 2006 Jun;14(4):279-89. Epub 2005 Nov 8.


Liquid chromatographic-mass spectrometric determination of endogenous gamma-hydroxybutyrate concentrations in rat brain regions and plasma.

Fung HL, Haas E, Raybon J, Xu J, Fung SM.

J Chromatogr B Analyt Technol Biomed Life Sci. 2004 Aug 5;807(2):287-91.


Biochemical mechanism of nitroglycerin action and tolerance: is this old mystery solved?

Fung HL.

Annu Rev Pharmacol Toxicol. 2004;44:67-85. Review.


Inhalant nitrite exposure alters mouse hepatic angiogenic gene expression.

Tran DC, Yeh KC, Brazeau DA, Fung HL.

Biochem Biophys Res Commun. 2003 Oct 17;310(2):439-45.


Beneficial effects of intraluminal nitroglycerin in intestinal ischemia-reperfusion injury in rats.

Khanna A, Rossman J, Caty MG, Fung HL.

J Surg Res. 2003 Sep;114(1):15-24.


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