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Items: 1 to 50 of 71

1.

A new mouse model of GLUT1 deficiency syndrome exhibits abnormal sleep-wake patterns and alterations of glucose kinetics in the brain.

Furuse T, Mizuma H, Hirose Y, Kushida T, Yamada I, Miura I, Masuya H, Funato H, Yanagisawa M, Onoe H, Wakana S.

Dis Model Mech. 2019 Sep 12;12(9). pii: dmm038828. doi: 10.1242/dmm.038828.

2.

Methodology and theoretical basis of forward genetic screening for sleep/wakefulness in mice.

Miyoshi C, Kim SJ, Ezaki T, Ikkyu A, Hotta-Hirashima N, Kanno S, Kakizaki M, Yamada M, Wakana S, Yanagisawa M, Funato H.

Proc Natl Acad Sci U S A. 2019 Aug 6;116(32):16062-16067. doi: 10.1073/pnas.1906774116. Epub 2019 Jul 23.

PMID:
31337678
3.

A single phosphorylation site of SIK3 regulates daily sleep amounts and sleep need in mice.

Honda T, Fujiyama T, Miyoshi C, Ikkyu A, Hotta-Hirashima N, Kanno S, Mizuno S, Sugiyama F, Takahashi S, Funato H, Yanagisawa M.

Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):10458-10463. doi: 10.1073/pnas.1810823115. Epub 2018 Sep 25.

4.

Ablation of Central Serotonergic Neurons Decreased REM Sleep and Attenuated Arousal Response.

Iwasaki K, Komiya H, Kakizaki M, Miyoshi C, Abe M, Sakimura K, Funato H, Yanagisawa M.

Front Neurosci. 2018 Aug 7;12:535. doi: 10.3389/fnins.2018.00535. eCollection 2018.

5.

Corticotropin-Releasing Factor Receptor 1 in the Anterior Cingulate Cortex Mediates Maternal Absence-Induced Attenuation of Transport Response in Mouse Pups.

Yoshida S, Ohnishi R, Tsuneoka Y, Yamamoto-Mimura Y, Muramatsu R, Kato T, Funato H, Kuroda KO.

Front Cell Neurosci. 2018 Jul 13;12:204. doi: 10.3389/fncel.2018.00204. eCollection 2018.

6.

Mechanisms of sleep deprivation-induced hepatic steatosis and insulin resistance in mice.

Shigiyama F, Kumashiro N, Tsuneoka Y, Igarashi H, Yoshikawa F, Kakehi S, Funato H, Hirose T.

Am J Physiol Endocrinol Metab. 2018 Nov 1;315(5):E848-E858. doi: 10.1152/ajpendo.00072.2018. Epub 2018 Jul 10.

PMID:
29989853
7.

Forebrain Ptf1a Is Required for Sexual Differentiation of the Brain.

Fujiyama T, Miyashita S, Tsuneoka Y, Kanemaru K, Kakizaki M, Kanno S, Ishikawa Y, Yamashita M, Owa T, Nagaoka M, Kawaguchi Y, Yanagawa Y, Magnuson MA, Muratani M, Shibuya A, Nabeshima YI, Yanagisawa M, Funato H, Hoshino M.

Cell Rep. 2018 Jul 3;24(1):79-94. doi: 10.1016/j.celrep.2018.06.010.

8.

Quantitative phosphoproteomic analysis of the molecular substrates of sleep need.

Wang Z, Ma J, Miyoshi C, Li Y, Sato M, Ogawa Y, Lou T, Ma C, Gao X, Lee C, Fujiyama T, Yang X, Zhou S, Hotta-Hirashima N, Klewe-Nebenius D, Ikkyu A, Kakizaki M, Kanno S, Cao L, Takahashi S, Peng J, Yu Y, Funato H, Yanagisawa M, Liu Q.

Nature. 2018 Jun;558(7710):435-439. doi: 10.1038/s41586-018-0218-8. Epub 2018 Jun 13.

9.

Large-scale forward genetics screening identifies Trpa1 as a chemosensor for predator odor-evoked innate fear behaviors.

Wang Y, Cao L, Lee CY, Matsuo T, Wu K, Asher G, Tang L, Saitoh T, Russell J, Klewe-Nebenius D, Wang L, Soya S, Hasegawa E, Chérasse Y, Zhou J, Li Y, Wang T, Zhan X, Miyoshi C, Irukayama Y, Cao J, Meeks JP, Gautron L, Wang Z, Sakurai K, Funato H, Sakurai T, Yanagisawa M, Nagase H, Kobayakawa R, Kobayakawa K, Beutler B, Liu Q.

Nat Commun. 2018 May 23;9(1):2041. doi: 10.1038/s41467-018-04324-3.

10.

Immunolocalization of muscarinic M1 receptor in the rat medial prefrontal cortex.

Oda S, Tsuneoka Y, Yoshida S, Adachi-Akahane S, Ito M, Kuroda M, Funato H.

J Comp Neurol. 2018 Jun 1;526(8):1329-1350. doi: 10.1002/cne.24409. Epub 2018 Feb 28.

11.

Sleep/Wake Behaviors in Mice During Pregnancy and Pregnancy-Associated Hypertensive Mice.

Komiya H, Miyoshi C, Iwasaki K, Hotta-Hirashima N, Ikkyu A, Kanno S, Honda T, Gosho M, Hamada H, Satoh T, Fukamizu A, Funato H, Yanagisawa M.

Sleep. 2018 Mar 1;41(3). doi: 10.1093/sleep/zsx209.

PMID:
29309677
12.

Effect of Minerals on Intestinal IgA Production Using Deep Sea Water Drinks.

Shiraishi H, Fujino M, Shirakawa N, Ishida N, Funato H, Hirata A, Abe N, Iizuka M, Jobu K, Yokota J, Miyamura M.

Biol Pharm Bull. 2017;40(10):1700-1705. doi: 10.1248/bpb.b17-00258.

13.

Neurotransmitters and neuropeptides in gonadal steroid receptor-expressing cells in medial preoptic area subregions of the male mouse.

Tsuneoka Y, Yoshida S, Takase K, Oda S, Kuroda M, Funato H.

Sci Rep. 2017 Aug 29;7(1):9809. doi: 10.1038/s41598-017-10213-4.

14.

Moxd1 Is a Marker for Sexual Dimorphism in the Medial Preoptic Area, Bed Nucleus of the Stria Terminalis and Medial Amygdala.

Tsuneoka Y, Tsukahara S, Yoshida S, Takase K, Oda S, Kuroda M, Funato H.

Front Neuroanat. 2017 Mar 27;11:26. doi: 10.3389/fnana.2017.00026. eCollection 2017.

15.

Forward-genetics analysis of sleep in randomly mutagenized mice.

Funato H, Miyoshi C, Fujiyama T, Kanda T, Sato M, Wang Z, Ma J, Nakane S, Tomita J, Ikkyu A, Kakizaki M, Hotta-Hirashima N, Kanno S, Komiya H, Asano F, Honda T, Kim SJ, Harano K, Muramoto H, Yonezawa T, Mizuno S, Miyazaki S, Connor L, Kumar V, Miura I, Suzuki T, Watanabe A, Abe M, Sugiyama F, Takahashi S, Sakimura K, Hayashi Y, Liu Q, Kume K, Wakana S, Takahashi JS, Yanagisawa M.

Nature. 2016 Nov 17;539(7629):378-383. doi: 10.1038/nature20142. Epub 2016 Nov 2.

16.

Identification of mutations through dominant screening for obesity using C57BL/6 substrains.

Hossain MS, Asano F, Fujiyama T, Miyoshi C, Sato M, Ikkyu A, Kanno S, Hotta N, Kakizaki M, Honda T, Kim SJ, Komiya H, Miura I, Suzuki T, Kobayashi K, Kaneda H, Kumar V, Takahashi JS, Wakana S, Funato H, Yanagisawa M.

Sci Rep. 2016 Sep 2;6:32453. doi: 10.1038/srep32453.

17.

Ginger Orally Disintegrating Tablets to Improve Swallowing in Older People.

Hirata A, Funato H, Nakai M, Iizuka M, Abe N, Yagi Y, Shiraishi H, Jobu K, Yokota J, Hirose K, Hyodo M, Miyamura M.

Biol Pharm Bull. 2016;39(7):1107-11. doi: 10.1248/bpb.b15-01045.

18.

[Evaluation of Gastric Mucosal Injury Model Animals of Rebamipide Formulation--Study of Therapeutic Equivalence].

Abe N, Funato H, Hirata A, Nakai M, Iizuka M, Shiraishi H, Jobu K, Yagi Y, Kadota A, Ogi K, Yokota J, Miyamura M.

Yakugaku Zasshi. 2016;136(4):677-84. doi: 10.1248/yakushi.15-00014. Japanese.

19.

High-fat diet feeding alters olfactory-, social-, and reward-related behaviors of mice independent of obesity.

Takase K, Tsuneoka Y, Oda S, Kuroda M, Funato H.

Obesity (Silver Spring). 2016 Apr;24(4):886-94. doi: 10.1002/oby.21441. Epub 2016 Feb 18.

20.

Sleep as a biological problem: an overview of frontiers in sleep research.

Kanda T, Tsujino N, Kuramoto E, Koyama Y, Susaki EA, Chikahisa S, Funato H.

J Physiol Sci. 2016 Jan;66(1):1-13. doi: 10.1007/s12576-015-0414-3. Epub 2015 Nov 5. Review.

21.

Orexin/hypocretin activates mTOR complex 1 (mTORC1) via an Erk/Akt-independent and calcium-stimulated lysosome v-ATPase pathway.

Wang Z, Liu S, Kakizaki M, Hirose Y, Ishikawa Y, Funato H, Yanagisawa M, Yu Y, Liu Q.

J Biol Chem. 2014 Nov 14;289(46):31950-9. doi: 10.1074/jbc.M114.600015. Epub 2014 Oct 2.

22.

Meta-analysis of melanin-concentrating hormone signaling-deficient mice on behavioral and metabolic phenotypes.

Takase K, Kikuchi K, Tsuneoka Y, Oda S, Kuroda M, Funato H.

PLoS One. 2014 Jun 12;9(6):e99961. doi: 10.1371/journal.pone.0099961. eCollection 2014.

23.

A subset of thalamocortical projections to the retrosplenial cortex possesses two vesicular glutamate transporter isoforms, VGluT1 and VGluT2, in axon terminals and somata.

Oda S, Funato H, Sato F, Adachi-Akahane S, Ito M, Takase K, Kuroda M.

J Comp Neurol. 2014 Jun 15;522(9):2089-106. doi: 10.1002/cne.23519.

PMID:
24639017
24.

Monoaminergic and neuropeptidergic neurons have distinct expression profiles of histone deacetylases.

Takase K, Oda S, Kuroda M, Funato H.

PLoS One. 2013;8(3):e58473. doi: 10.1371/journal.pone.0058473. Epub 2013 Mar 4.

25.

Fasting and high-fat diet alter histone deacetylase expression in the medial hypothalamus.

Funato H, Oda S, Yokofujita J, Igarashi H, Kuroda M.

PLoS One. 2011 Apr 15;6(4):e18950. doi: 10.1371/journal.pone.0018950.

26.

Early life stress enhances behavioral vulnerability to stress through the activation of REST4-mediated gene transcription in the medial prefrontal cortex of rodents.

Uchida S, Hara K, Kobayashi A, Funato H, Hobara T, Otsuki K, Yamagata H, McEwen BS, Watanabe Y.

J Neurosci. 2010 Nov 10;30(45):15007-18. doi: 10.1523/JNEUROSCI.1436-10.2010.

27.

Loss of Goosecoid-like and DiGeorge syndrome critical region 14 in interpeduncular nucleus results in altered regulation of rapid eye movement sleep.

Funato H, Sato M, Sinton CM, Gautron L, Williams SC, Skach A, Elmquist JK, Skoultchi AI, Yanagisawa M.

Proc Natl Acad Sci U S A. 2010 Oct 19;107(42):18155-60. doi: 10.1073/pnas.1012764107. Epub 2010 Oct 4.

28.

Dopamine D5 receptor immunoreactivity is differentially distributed in GABAergic interneurons and pyramidal cells in the rat medial prefrontal cortex.

Oda S, Funato H, Adachi-Akahane S, Ito M, Okada A, Igarashi H, Yokofujita J, Kuroda M.

Brain Res. 2010 May 6;1329:89-102. doi: 10.1016/j.brainres.2010.03.011. Epub 2010 Mar 11.

PMID:
20226768
29.

Aberrant REST-mediated transcriptional regulation in major depressive disorder.

Otsuki K, Uchida S, Wakabayashi Y, Matsubara T, Hobara T, Funato H, Watanabe Y.

J Psychiatr Res. 2010 Apr;44(6):378-84. doi: 10.1016/j.jpsychires.2009.09.009. Epub 2009 Oct 20.

PMID:
19846118
30.

Altered gene expression of histone deacetylases in mood disorder patients.

Hobara T, Uchida S, Otsuki K, Matsubara T, Funato H, Matsuo K, Suetsugi M, Watanabe Y.

J Psychiatr Res. 2010 Apr;44(5):263-70. doi: 10.1016/j.jpsychires.2009.08.015. Epub 2009 Sep 19.

PMID:
19767015
31.

Hand2 controls osteoblast differentiation in the branchial arch by inhibiting DNA binding of Runx2.

Funato N, Chapman SL, McKee MD, Funato H, Morris JA, Shelton JM, Richardson JA, Yanagisawa H.

Development. 2009 Feb;136(4):615-25. doi: 10.1242/dev.029355. Epub 2009 Jan 14.

32.

Enhanced orexin receptor-2 signaling prevents diet-induced obesity and improves leptin sensitivity.

Funato H, Tsai AL, Willie JT, Kisanuki Y, Williams SC, Sakurai T, Yanagisawa M.

Cell Metab. 2009 Jan 7;9(1):64-76. doi: 10.1016/j.cmet.2008.10.010.

33.

Reduced expression of glyoxalase-1 mRNA in mood disorder patients.

Fujimoto M, Uchida S, Watanuki T, Wakabayashi Y, Otsuki K, Matsubara T, Suetsugi M, Funato H, Watanabe Y.

Neurosci Lett. 2008 Jun 20;438(2):196-9. doi: 10.1016/j.neulet.2008.04.024. Epub 2008 Apr 12.

PMID:
18455873
34.

State-dependent changes in the expression levels of NCAM-140 and L1 in the peripheral blood cells of bipolar disorders, but not in the major depressive disorders.

Wakabayashi Y, Uchida S, Funato H, Matsubara T, Watanuki T, Otsuki K, Fujimoto M, Nishida A, Watanabe Y.

Prog Neuropsychopharmacol Biol Psychiatry. 2008 Jul 1;32(5):1199-205. doi: 10.1016/j.pnpbp.2008.03.005. Epub 2008 Mar 15.

PMID:
18430502
35.

Altered expression of neurotrophic factors in patients with major depression.

Otsuki K, Uchida S, Watanuki T, Wakabayashi Y, Fujimoto M, Matsubara T, Funato H, Watanabe Y.

J Psychiatr Res. 2008 Oct;42(14):1145-53. doi: 10.1016/j.jpsychires.2008.01.010. Epub 2008 Feb 29.

PMID:
18313696
36.

Increased expression of splicing factor SRp20 mRNA in bipolar disorder patients.

Watanuki T, Funato H, Uchida S, Matsubara T, Kobayashi A, Wakabayashi Y, Otsuki K, Nishida A, Watanabe Y.

J Affect Disord. 2008 Sep;110(1-2):62-9. doi: 10.1016/j.jad.2008.01.003. Epub 2008 Feb 20.

PMID:
18281098
37.

An essential role for orexins in emergence from general anesthesia.

Kelz MB, Sun Y, Chen J, Cheng Meng Q, Moore JT, Veasey SC, Dixon S, Thornton M, Funato H, Yanagisawa M.

Proc Natl Acad Sci U S A. 2008 Jan 29;105(4):1309-14. doi: 10.1073/pnas.0707146105. Epub 2008 Jan 14.

38.

Differential effects of antidepressants on dexamethasone-induced nuclear translocation and expression of glucocorticoid receptor.

Funato H, Kobayashi A, Watanabe Y.

Brain Res. 2006 Oct 30;1117(1):125-34. Epub 2006 Sep 7.

PMID:
16956592
39.

Reduced Glucocorticoid Receptor alpha Expression in Mood Disorder Patients and First-Degree Relatives.

Matsubara T, Funato H, Kobayashi A, Nobumoto M, Watanabe Y.

Biol Psychiatry. 2006 Apr 15;59(8):689-95. Epub 2006 Feb 3.

PMID:
16458268
40.
41.
42.
43.

Treatment of a vertical root fracture.

Funato A, Funato H, Matsumoto K.

Endod Dent Traumatol. 1999 Feb;15(1):46-7.

PMID:
10219155
44.

Neuroprotective action of a novel compound--M50463--in primary cultured neurons.

Shimojo M, Takasugi K, Yamamoto I, Funato H, Mochizuki H, Kohsaka S.

Brain Res. 1999 Jan 2;815(1):131-9.

PMID:
9974133
45.

Mandibular central incisor with two root canals.

Funato A, Funato H, Matsumoto K.

Endod Dent Traumatol. 1998 Dec;14(6):285-6.

PMID:
9972162
46.

[Benefits and problems of "home care score"--discussion of deviation from home care].

Shibuya R, Matsuoka Y, Usui Y, Niwa Y, Kato A, Funato T, Funato H.

Gan To Kagaku Ryoho. 1998 Dec;25 Suppl 4:640-5. Japanese.

PMID:
9884656
47.

[Terminal home care "Ikigai no Yoake--The real aim of our life"--case report].

Funato T, Funato H, Kato A, Matsuoka Y, Shibuya R, Usui Y, Niwa Y.

Gan To Kagaku Ryoho. 1998 Dec;25 Suppl 4:579-84. Japanese.

PMID:
9884644
48.

Quantitation of amyloid beta-protein (A beta) in the cortex during aging and in Alzheimer's disease.

Funato H, Yoshimura M, Kusui K, Tamaoka A, Ishikawa K, Ohkoshi N, Namekata K, Okeda R, Ihara Y.

Am J Pathol. 1998 Jun;152(6):1633-40.

49.

Amyloid beta-protein (A beta) accumulation in the putamen and mammillary body during aging and in Alzheimer disease.

Nakabayashi J, Yoshimura M, Morishima-Kawashima M, Funato H, Miyakawa T, Yamazaki T, Ihara Y.

J Neuropathol Exp Neurol. 1998 Apr;57(4):343-52.

PMID:
9600228
50.

Acute glucosuria after continuous glucocorticoid loading in the rat in vivo.

Yamanouchi T, Sekino N, Yoshimura T, Kawasaki T, Koshibu E, Inoue T, Funato H, Ogata N, Miyashita H.

Eur J Pharmacol. 1998 Jan 12;341(2-3):257-63.

PMID:
9543247

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