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Items: 1 to 50 of 243

1.

Progesterone induced mesenchymal differentiation and rescued cystic dilation of renal tubules of Pkd1(-/-) mice.

Wachi T, Yoshida N, Funae Y, Ueno M, Germino GG, Hirotsune S, Deguchi N.

Biochem Biophys Res Commun. 2012 Aug 24;425(2):212-8. doi: 10.1016/j.bbrc.2012.07.070. Epub 2012 Jul 23.

2.

Pravastatin-induced proangiogenic effects depend upon extracellular FGF-2.

Shiota M, Hikita Y, Kawamoto Y, Kusakabe H, Tanaka M, Izumi Y, Nakao T, Miura K, Funae Y, Iwao H.

J Cell Mol Med. 2012 Sep;16(9):2001-9. doi: 10.1111/j.1582-4934.2011.01494.x.

3.

Overexpression of CYP3A4, but not of CYP2D6, promotes hypoxic response and cell growth of Hep3B cells.

Oguro A, Sakamoto K, Funae Y, Imaoka S.

Drug Metab Pharmacokinet. 2011;26(4):407-15. Epub 2011 May 12.

4.

Coadministration of carvedilol attenuates nitrate tolerance by preventing cytochrome p450 depletion.

Nakahira A, Minamiyama Y, Takemura S, Hirai H, Sasaki Y, Okada S, Funae Y, Suehiro S.

Circ J. 2010 Aug;74(8):1711-7. Epub 2010 Jun 22.

5.

LKM-1 sera from autoimmune hepatitis patients that recognize ERp57, carboxylesterase 1 and CYP2D6.

Komurasaki R, Imaoka S, Tada N, Okada K, Nishiguchi S, Funae Y.

Drug Metab Pharmacokinet. 2010;25(1):84-92.

6.

Heat shock cognate protein 70 is essential for Akt signaling in endothelial function.

Shiota M, Kusakabe H, Izumi Y, Hikita Y, Nakao T, Funae Y, Miura K, Iwao H.

Arterioscler Thromb Vasc Biol. 2010 Mar;30(3):491-7. doi: 10.1161/ATVBAHA.109.193631. Epub 2009 Dec 17.

7.

Hydroxylated polychlorinated biphenyls (PCBs) interact with protein disulfide isomerase and inhibit its activity.

Okada K, Hashimoto S, Funae Y, Imaoka S.

Chem Res Toxicol. 2009 May;22(5):899-904. doi: 10.1021/tx800476j.

PMID:
19374345
8.

The mechanism causing the difference in kinetic properties between rat CYP2D4 and human CYP2D6 in the oxidation of dextromethorphan and bufuralol.

Narimatsu S, Kazamori D, Masuda K, Katsu T, Funae Y, Naito S, Nakura H, Yamano S, Hanioka N.

Biochem Pharmacol. 2009 Mar 1;77(5):920-31. doi: 10.1016/j.bcp.2008.11.006. Epub 2008 Nov 17.

PMID:
19059219
9.

Analysis of gene and protein expression of cytochrome P450 and stress-associated molecules in rat liver after spaceflight.

Baba T, Nishimura M, Kuwahara Y, Ueda N, Naitoh S, Kume M, Yamamoto Y, Fujita J, Funae Y, Fukumoto M.

Pathol Int. 2008 Sep;58(9):589-95. doi: 10.1111/j.1440-1827.2008.02275.x.

PMID:
18801074
10.

Epoxyeicosatrienoic acids and/or their metabolites promote hypoxic response of cells.

Suzuki S, Oguro A, Osada-Oka M, Funae Y, Imaoka S.

J Pharmacol Sci. 2008 Sep;108(1):79-88. Epub 2008 Sep 6.

11.
12.

The roles of amino acid residues at positions 216 and 219 in the structural stability and metabolic functions of rat cytochrome P450 2D1 and 2D2.

Narimatsu S, Kiryu K, Yonemoto R, Yoshino M, Kobatake M, Kazamori D, Hagino S, Masuda K, Katsu T, Asanuma M, Kumamoto T, Ishikawa T, Funae Y, Yamano S, Hanioka N, Naito S.

Chem Biol Interact. 2008 Mar 10;172(1):11-21. doi: 10.1016/j.cbi.2007.11.010. Epub 2007 Nov 28.

PMID:
18191824
13.

Over-expression of protein disulfide isomerase reduces the release of growth hormone induced by bisphenol A and/or T3.

Okada K, Imaoka S, Hashimoto S, Hiroi T, Funae Y.

Mol Cell Endocrinol. 2007 Nov 15;278(1-2):44-51. Epub 2007 Aug 23.

PMID:
17928132
14.

Overexpression of CYP3A aggravates endotoxin-induced liver injury in hypophysectomized female rats.

Takemura S, Minamiyama Y, Toyokuni S, Imaoka S, Hai S, Kubo S, Hirohashi K, Funae Y, Okada S.

Hepatol Res. 2008 Jan;38(1):70-8. Epub 2007 Jul 20.

PMID:
17645516
15.

Cytochrome P450 is responsible for nitric oxide generation from NO-aspirin and other organic nitrates.

Minamiyama Y, Takemura S, Imaoka S, Funae Y, Okada S.

Drug Metab Pharmacokinet. 2007 Feb 25;22(1):15-9.

16.

Different mechanisms for inhibition of human cytochromes P450 1A1, 1A2, and 1B1 by polycyclic aromatic inhibitors.

Shimada T, Murayama N, Okada K, Funae Y, Yamazaki H, Guengerich FP.

Chem Res Toxicol. 2007 Mar;20(3):489-96. Epub 2007 Feb 10.

PMID:
17291012
17.

Nicorandil elevates tissue cGMP levels in a nitric-oxide-independent manner.

Minamiyama Y, Takemura S, Hai S, Suehiro S, Okada S, Funae Y.

J Pharmacol Sci. 2007 Jan;103(1):33-9. Epub 2007 Jan 1.

18.

CYP2A13 expressed in human bladder metabolically activates 4-aminobiphenyl.

Nakajima M, Itoh M, Sakai H, Fukami T, Katoh M, Yamazaki H, Kadlubar FF, Imaoka S, Funae Y, Yokoi T.

Int J Cancer. 2006 Dec 1;119(11):2520-6.

19.

Inhibitory effects of environmental chemicals on protein disulfide isomerase in vitro.

Okada K, Hiroi T, Imaoka S, Funae Y.

Osaka City Med J. 2005 Dec;51(2):51-63.

PMID:
16617682
20.

Recovery of hepatic function determined by cytochrome P450-dependent drug metabolism lags after compensatory hepatic volume changes after portal vein ligation in rats.

Takemura S, Minamiyama Y, Hirohashi K, Kubo S, Funae Y, Kinoshita H.

J Surg Res. 2006 Aug;134(2):285-91. Epub 2006 Mar 29.

PMID:
16564546
21.

Bisphenol A binds to protein disulfide isomerase and inhibits its enzymatic and hormone-binding activities.

Hiroi T, Okada K, Imaoka S, Osada M, Funae Y.

Endocrinology. 2006 Jun;147(6):2773-80. Epub 2006 Mar 16.

PMID:
16543366
22.
23.

A new epitope of CYP2D6 recognized by liver kidney microsomal autoantibody from japanese patients with autoimmune hepatitis.

Imaoka S, Obata N, Hiroi T, Osada-Oka M, Hara R, Nishiguchi S, Funae Y.

Biol Pharm Bull. 2005 Dec;28(12):2240-3.

24.

Dose-dependence of promotion of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline-induced rat hepatocarcinogenesis by ethanol: evidence for a threshold.

Kushida M, Wanibuchi H, Morimura K, Kinoshita A, Kang JS, Puatanachokchai R, Wei M, Funae Y, Fukushima S.

Cancer Sci. 2005 Nov;96(11):747-57.

25.

Alpha-benzene hexachloride exerts hormesis in preneoplastic lesion formation of rat hepatocarcinogenesis with the possible role for hepatic detoxifying enzymes.

Puatanachokchai R, Morimura K, Wanibuchi H, Oka M, Kinoshita A, Mitsuru F, Yamaguchi S, Funae Y, Fukushima S.

Cancer Lett. 2006 Aug 18;240(1):102-13. Epub 2005 Oct 24.

PMID:
16246485
26.

Cytochrome P450 2E polymorphism in feline liver.

Tanaka N, Shinkyo R, Sakaki T, Kasamastu M, Imaoka S, Funae Y, Yokota H.

Biochim Biophys Acta. 2005 Nov 15;1726(2):194-205. Epub 2005 Aug 18.

PMID:
16168565
27.

Importance of CYP2D3 in polymorphism of diazepam p-hydroxylation in rats.

Sakai N, Saito K, Kim HS, Kazusaka A, Ishizuka M, Funae Y, Fujita S.

Drug Metab Dispos. 2005 Nov;33(11):1657-60. Epub 2005 Aug 4.

28.

Mechanisms of chemopreventive effects of 8-methoxypsoralen against 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced mouse lung adenomas.

Miyazaki M, Yamazaki H, Takeuchi H, Saoo K, Yokohira M, Masumura K, Nohmi T, Funae Y, Imaida K, Kamataki T.

Carcinogenesis. 2005 Nov;26(11):1947-55. Epub 2005 Jun 15. Erratum in: Carcinogenesis. 2005 Dec;26(12):2214.

PMID:
15958517
29.

Different effects of desipramine on bufuralol 1''-hydroxylation by rat and human CYP2D enzymes.

Isobe T, Hichiya H, Hanioka N, Yamamoto S, Shinoda S, Funae Y, Satoh T, Yamano S, Narimatsu S.

Biol Pharm Bull. 2005 Apr;28(4):634-40.

30.

CYP2D in the brain.

Funae Y, Kishimoto W, Cho T, Niwa T, Hiroi T.

Drug Metab Pharmacokinet. 2003;18(6):337-49.

31.

Production of inhibitory polyclonal antibodies against cytochrome P450s.

Ng PS, Imaoka S, Hiroi T, Osada M, Niwa T, Kamataki T, Funae Y.

Drug Metab Pharmacokinet. 2003;18(3):163-72.

32.

Major cytochrome P450 enzymes responsible for microsomal aldehyde oxygenation of 11-oxo-Delta8-tetrahydrocannabinol and 9-anthraldehyde in human liver.

Watanabe K, Matsunaga T, Kimura T, Funahashi T, Funae Y, Ohshima T, Yamamoto I.

Drug Metab Pharmacokinet. 2002;17(6):516-21.

33.

Metabolism of selegiline hydrochloride, a selective monoamine b-type inhibitor, in human liver microsomes.

Kamada T, Chow T, Hiroi T, Imaoka S, Morimoto K, Ohde H, Funae Y.

Drug Metab Pharmacokinet. 2002;17(3):199-206.

34.

Contribution of CYP4A8 to the formation of 20-hydroxyeicosatetraenoic acid from arachidonic acid in rat kidney.

Yamaguchi Y, Kirita S, Hasegawa H, Aoyama J, Imaoka S, Minamiyama S, Funae Y, Baba T, Matsubara T.

Drug Metab Pharmacokinet. 2002;17(2):109-16.

35.

The roles of amino acid residues at positions 43 and 45 in microsomal contents and enzymatic functions of rat CYP2D1 and CYP2D2.

Narimatsu S, Imoto K, Isobe T, Kiryu K, Naito S, Hichiya H, Funae Y, Hanioka N, Yamamoto S.

Biochem Biophys Res Commun. 2004 Nov 12;324(2):627-33.

PMID:
15474473
36.

Effect of genetic polymorphism on the metabolism of endogenous neuroactive substances, progesterone and p-tyramine, catalyzed by CYP2D6.

Niwa T, Hiroi T, Tsuzuki D, Yamamoto S, Narimatsu S, Fukuda T, Azuma J, Funae Y.

Brain Res Mol Brain Res. 2004 Oct 22;129(1-2):117-23.

PMID:
15469888
38.

CYP3A induction aggravates endotoxemic liver injury via reactive oxygen species in male rats.

Minamiyama Y, Takemura S, Toyokuni S, Imaoka S, Funae Y, Hirohashi K, Yoshikawa T, Okada S.

Free Radic Biol Med. 2004 Sep 1;37(5):703-12.

PMID:
15288127
39.

Cytochrome p450 gene expression levels in peripheral blood mononuclear cells in comparison with the liver.

Furukawa M, Nishimura M, Ogino D, Chiba R, Ikai I, Ueda N, Naito S, Kuribayashi S, Moustafa MA, Uchida T, Sawada H, Kamataki T, Funae Y, Fukumoto M.

Cancer Sci. 2004 Jun;95(6):520-9.

41.

Blood glucose lowering and toxicological effects of zinc (II) complexes with maltol, threonine, and picolinic acid.

Kojima Y, Yoshikawa Y, Ueda E, Kondo M, Takahashi S, Matsukura T, Sakurai H, Hiroi T, Imaoka S, Funae Y.

Res Commun Mol Pathol Pharmacol. 2002;112(1-4):91-104.

PMID:
15080500
42.

Role of phenobarbital-inducible cytochrome P450s as a source of active oxygen species in DNA-oxidation.

Imaoka S, Osada M, Minamiyama Y, Yukimura T, Toyokuni S, Takemura S, Hiroi T, Funae Y.

Cancer Lett. 2004 Jan 20;203(2):117-25.

PMID:
14732219
43.

Non-genomic modulation of dopamine release by bisphenol-A in PC12 cells.

Yoneda T, Hiroi T, Osada M, Asada A, Funae Y.

J Neurochem. 2003 Dec;87(6):1499-508.

44.

Regulation of CYP2D expression in rat brain by toluene.

Mizuno D, Hiroi T, Ng P, Kishimoto W, Imaoka S, Funae Y.

Osaka City Med J. 2003 Jun;49(1):49-56.

PMID:
14703099
45.

Continuous administration of organic nitrate decreases hepatic cytochrome P450.

Minamiyama Y, Takemura S, Yamasaki K, Hai S, Hirohashi K, Funae Y, Okada S.

J Pharmacol Exp Ther. 2004 Feb;308(2):729-35. Epub 2003 Oct 30.

46.

Cytochrome P450 2D catalyze steroid 21-hydroxylation in the brain.

Kishimoto W, Hiroi T, Shiraishi M, Osada M, Imaoka S, Kominami S, Igarashi T, Funae Y.

Endocrinology. 2004 Feb;145(2):699-705. Epub 2003 Oct 16.

PMID:
14563706
47.

A novel transcriptional element which regulates expression of the CYP2D4 gene by Oct-1 and YY-1 binding.

Mizuno D, Takahashi Y, Hiroi T, Imaoka S, Kamataki T, Funae Y.

Biochim Biophys Acta. 2003 Jun 19;1627(2-3):121-8.

PMID:
12818430
48.

Phenobarbital at low dose exerts hormesis in rat hepatocarcinogenesis by reducing oxidative DNA damage, altering cell proliferation, apoptosis and gene expression.

Kinoshita A, Wanibuchi H, Morimura K, Wei M, Shen J, Imaoka S, Funae Y, Fukushima S.

Carcinogenesis. 2003 Aug;24(8):1389-99. Epub 2003 Jun 5.

PMID:
12807726
49.

No major difference in inhibitory susceptibility between CYP2C9.1 and CYP2C9.3.

Hanatani T, Fukuda T, Onishi S, Funae Y, Azuma J.

Eur J Clin Pharmacol. 2003 Jul;59(3):233-5. Epub 2003 May 17.

PMID:
12756514
50.

Mediation of arachidonic acid metabolite(s) produced by endothelial cytochrome P-450 3A4 in monkey arterial relaxation.

Ayajiki K, Fujioka H, Toda N, Okada S, Minamiyama Y, Imaoka S, Funae Y, Watanabe S, Nakamura A, Okamura T.

Hypertens Res. 2003 Mar;26(3):237-43.

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