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Items: 1 to 50 of 101

1.

PFKFB3-mediated endothelial glycolysis promotes pulmonary hypertension.

Cao Y, Zhang X, Wang L, Yang Q, Ma Q, Xu J, Wang J, Kovacs L, Ayon RJ, Liu Z, Zhang M, Zhou Y, Zeng X, Xu Y, Wang Y, Fulton DJ, Weintraub NL, Lucas R, Dong Z, Yuan JX, Sullivan JC, Meadows L, Barman SA, Wu C, Quan J, Hong M, Su Y, Huo Y.

Proc Natl Acad Sci U S A. 2019 Jul 2;116(27):13394-13403. doi: 10.1073/pnas.1821401116. Epub 2019 Jun 18.

PMID:
31213542
2.

The Molecular Regulation and Functional Roles of NOX5.

Fulton DJR.

Methods Mol Biol. 2019;1982:353-375. doi: 10.1007/978-1-4939-9424-3_22.

PMID:
31172484
3.

Galectin-3: A Harbinger of Reactive Oxygen Species, Fibrosis, and Inflammation in Pulmonary Arterial Hypertension.

Fulton DJR, Li X, Bordan Z, Wang Y, Mahboubi K, Rudic RD, Haigh S, Chen F, Barman SA.

Antioxid Redox Signal. 2019 Mar 29. doi: 10.1089/ars.2019.7753. [Epub ahead of print]

PMID:
30767565
4.

Galectin-3 is expressed in vascular smooth muscle cells and promotes pulmonary hypertension through changes in proliferation, apoptosis, and fibrosis.

Barman SA, Li X, Haigh S, Kondrikov D, Mahboubi K, Bordan Z, Stepp DW, Zhou J, Wang Y, Weintraub DS, Traber P, Snider W, Jonigk D, Sullivan J, Crislip GR, Butcher JT, Thompson J, Su Y, Chen F, Fulton DJR.

Am J Physiol Lung Cell Mol Physiol. 2019 May 1;316(5):L784-L797. doi: 10.1152/ajplung.00186.2018. Epub 2019 Feb 6.

PMID:
30724100
5.

Modification of Cardiac Progenitor Cell-Derived Exosomes by miR-322 Provides Protection against Myocardial Infarction through Nox2-Dependent Angiogenesis.

Youn SW, Li Y, Kim YM, Sudhahar V, Abdelsaid K, Kim HW, Liu Y, Fulton DJR, Ashraf M, Tang Y, Fukai T, Ushio-Fukai M.

Antioxidants (Basel). 2019 Jan 10;8(1). pii: E18. doi: 10.3390/antiox8010018.

6.

Ablation of Myeloid ADK (Adenosine Kinase) Epigenetically Suppresses Atherosclerosis in ApoE-/- (Apolipoprotein E Deficient) Mice.

Zhang M, Zeng X, Yang Q, Xu J, Liu Z, Zhou Y, Cao Y, Zhang X, An X, Xu Y, Huang L, Han Z, Wang T, Wu C, Fulton DJ, Weintraub NL, Hong M, Huo Y.

Arterioscler Thromb Vasc Biol. 2018 Dec;38(12):2780-2792. doi: 10.1161/ATVBAHA.118.311806.

PMID:
30571174
7.

Hyperglycemia-impaired aortic vasorelaxation mediated through arginase elevation: Role of stress kinase pathways.

Chandra S, Fulton DJR, Caldwell RB, Caldwell RW, Toque HA.

Eur J Pharmacol. 2019 Feb 5;844:26-37. doi: 10.1016/j.ejphar.2018.11.027. Epub 2018 Nov 28.

PMID:
30502342
8.

PRKAA1/AMPKα1-driven glycolysis in endothelial cells exposed to disturbed flow protects against atherosclerosis.

Yang Q, Xu J, Ma Q, Liu Z, Sudhahar V, Cao Y, Wang L, Zeng X, Zhou Y, Zhang M, Xu Y, Wang Y, Weintraub NL, Zhang C, Fukai T, Wu C, Huang L, Han Z, Wang T, Fulton DJ, Hong M, Huo Y.

Nat Commun. 2018 Nov 7;9(1):4667. doi: 10.1038/s41467-018-07132-x.

9.

Increased Muscle Mass Protects Against Hypertension and Renal Injury in Obesity.

Butcher JT, Mintz JD, Larion S, Qiu S, Ruan L, Fulton DJ, Stepp DW.

J Am Heart Assoc. 2018 Aug 21;7(16):e009358. doi: 10.1161/JAHA.118.009358.

10.

Immunohistochemistry of the circadian clock in mouse and human vascular tissues.

Anea CB, Merloiu AM, Fulton DJR, Patel V, Rudic RD.

Vessel Plus. 2018;2. pii: 16. doi: 10.20517/2574-1209.2018.46. Epub 2018 Jul 20.

11.

Hsp70 Suppresses Mitochondrial Reactive Oxygen Species and Preserves Pulmonary Microvascular Barrier Integrity Following Exposure to Bacterial Toxins.

Li X, Yu Y, Gorshkov B, Haigh S, Bordan Z, Weintraub D, Rudic RD, Chakraborty T, Barman SA, Verin AD, Su Y, Lucas R, Stepp DW, Chen F, Fulton DJR.

Front Immunol. 2018 Jun 12;9:1309. doi: 10.3389/fimmu.2018.01309. eCollection 2018.

12.

Neurofibromin Deficiency Induces Endothelial Cell Proliferation and Retinal Neovascularization.

Zhang H, Hudson FZ, Xu Z, Tritz R, Rojas M, Patel C, Haigh SB, Bordán Z, Ingram DA, Fulton DJ, Weintraub NL, Caldwell RB, Stansfield BK.

Invest Ophthalmol Vis Sci. 2018 May 1;59(6):2520-2528. doi: 10.1167/iovs.17-22588.

13.

Neddylation mediates ventricular chamber maturation through repression of Hippo signaling.

Zou J, Ma W, Li J, Littlejohn R, Zhou H, Kim IM, Fulton DJR, Chen W, Weintraub NL, Zhou J, Su H.

Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):E4101-E4110. doi: 10.1073/pnas.1719309115. Epub 2018 Apr 9.

14.

Galectin-3 Promotes Vascular Remodeling and Contributes to Pulmonary Hypertension.

Barman SA, Chen F, Li X, Haigh S, Stepp DW, Kondrikov D, Mahboubi K, Bordan Z, Traber P, Su Y, Fulton DJR.

Am J Respir Crit Care Med. 2018 Jun 1;197(11):1488-1492. doi: 10.1164/rccm.201711-2308LE. No abstract available. Erratum in: Am J Respir Crit Care Med. 2018 Sep 15;198(6):824.

15.

Vasodilator dysfunction and oligodendrocyte dysmaturation in aging white matter.

Bagi Z, Brandner DD, Le P, McNeal DW, Gong X, Dou H, Fulton DJ, Beller A, Ngyuen T, Larson EB, Montine TJ, Keene CD, Back SA.

Ann Neurol. 2018 Jan;83(1):142-152. doi: 10.1002/ana.25129.

16.

Differential mechanisms of adenosine- and ATPγS-induced microvascular endothelial barrier strengthening.

Bátori R, Kumar S, Bordán Z, Cherian-Shaw M, Kovács-Kása A, MacDonald JA, Fulton DJR, Erdődi F, Verin AD.

J Cell Physiol. 2019 May;234(5):5863-5879. doi: 10.1002/jcp.26419. Epub 2018 Dec 17.

PMID:
29271489
17.

Effect of myostatin deletion on cardiac and microvascular function.

Butcher JT, Ali MI, Ma MW, McCarthy CG, Islam BN, Fox LG, Mintz JD, Larion S, Fulton DJ, Stepp DW.

Physiol Rep. 2017 Dec;5(23). doi: 10.14814/phy2.13525.

18.

Extracellular adenosine-induced Rac1 activation in pulmonary endothelium: Molecular mechanisms and barrier-protective role.

Kovacs-Kasa A, Kim KM, Cherian-Shaw M, Black SM, Fulton DJ, Verin AD.

J Cell Physiol. 2018 Aug;233(8):5736-5746. doi: 10.1002/jcp.26281. Epub 2018 Mar 7.

PMID:
29168172
19.

Beyond Impressions: How Altered Shear Stress Connects Hypoxic Signaling to Endothelial Inflammation.

Li X, Weintraub DS, Fulton DJR.

Arterioscler Thromb Vasc Biol. 2017 Nov;37(11):1987-1989. doi: 10.1161/ATVBAHA.117.310149. No abstract available.

20.

Regulation of endothelial intracellular adenosine via adenosine kinase epigenetically modulates vascular inflammation.

Xu Y, Wang Y, Yan S, Yang Q, Zhou Y, Zeng X, Liu Z, An X, Toque HA, Dong Z, Jiang X, Fulton DJ, Weintraub NL, Li Q, Bagi Z, Hong M, Boison D, Wu C, Huo Y.

Nat Commun. 2017 Oct 16;8(1):943. doi: 10.1038/s41467-017-00986-7.

21.

Role of myeloperoxidase in abdominal aortic aneurysm formation: mitigation by taurine.

Kim HW, Blomkalns AL, Ogbi M, Thomas M, Gavrila D, Neltner BS, Cassis LA, Thompson RW, Weiss RM, Lindower PD, Blanco VM, McCormick ML, Daugherty A, Fu X, Hazen SL, Stansfield BK, Huo Y, Fulton DJ, Chatterjee T, Weintraub NL.

Am J Physiol Heart Circ Physiol. 2017 Dec 1;313(6):H1168-H1179. doi: 10.1152/ajpheart.00296.2017. Epub 2017 Sep 29.

22.

Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis.

Liu Z, Yan S, Wang J, Xu Y, Wang Y, Zhang S, Xu X, Yang Q, Zeng X, Zhou Y, Gu X, Lu S, Fu Z, Fulton DJ, Weintraub NL, Caldwell RB, Zhang W, Wu C, Liu XL, Chen JF, Ahmad A, Kaddour-Djebbar I, Al-Shabrawey M, Li Q, Jiang X, Sun Y, Sodhi A, Smith L, Hong M, Huo Y.

Nat Commun. 2017 Sep 19;8(1):584. doi: 10.1038/s41467-017-00551-2.

23.

Intracellular adenosine regulates epigenetic programming in endothelial cells to promote angiogenesis.

Xu Y, Wang Y, Yan S, Zhou Y, Yang Q, Pan Y, Zeng X, An X, Liu Z, Wang L, Xu J, Cao Y, Fulton DJ, Weintraub NL, Bagi Z, Hoda MN, Wang X, Li Q, Hong M, Jiang X, Boison D, Weber C, Wu C, Huo Y.

EMBO Mol Med. 2017 Sep;9(9):1263-1278. doi: 10.15252/emmm.201607066.

24.

Reactive Oxygen and Nitrogen Species in the Development of Pulmonary Hypertension.

Fulton DJR, Li X, Bordan Z, Haigh S, Bentley A, Chen F, Barman SA.

Antioxidants (Basel). 2017 Jul 6;6(3). pii: E54. doi: 10.3390/antiox6030054. Review.

25.

Genetic Deletion of NADPH Oxidase 1 Rescues Microvascular Function in Mice With Metabolic Disease.

Thompson JA, Larion S, Mintz JD, Belin de Chantemèle EJ, Fulton DJ, Stepp DW.

Circ Res. 2017 Aug 18;121(5):502-511. doi: 10.1161/CIRCRESAHA.116.309965. Epub 2017 Jul 6.

26.

Role of Adipose Tissue Endothelial ADAM17 in Age-Related Coronary Microvascular Dysfunction.

Dou H, Feher A, Davila AC, Romero MJ, Patel VS, Kamath VM, Gooz MB, Rudic RD, Lucas R, Fulton DJ, Weintraub NL, Bagi Z.

Arterioscler Thromb Vasc Biol. 2017 Jun;37(6):1180-1193. doi: 10.1161/ATVBAHA.117.309430. Epub 2017 May 4.

27.

A novel role for the Wnt inhibitor APCDD1 in adipocyte differentiation: Implications for diet-induced obesity.

Yiew NKH, Chatterjee TK, Tang YL, Pellenberg R, Stansfield BK, Bagi Z, Fulton DJ, Stepp DW, Chen W, Patel V, Kamath VM, Litwin SE, Hui DY, Rudich SM, Kim HW, Weintraub NL.

J Biol Chem. 2017 Apr 14;292(15):6312-6324. doi: 10.1074/jbc.M116.758078. Epub 2017 Feb 27.

28.

Epigenetic Regulation of Interleukin 6 by Histone Acetylation in Macrophages and Its Role in Paraquat-Induced Pulmonary Fibrosis.

Hu L, Yu Y, Huang H, Fan H, Hu L, Yin C, Li K, Fulton DJ, Chen F.

Front Immunol. 2017 Jan 30;7:696. doi: 10.3389/fimmu.2016.00696. eCollection 2016.

29.

RhoA S-nitrosylation as a regulatory mechanism influencing endothelial barrier function in response to G+-bacterial toxins.

Chen F, Wang Y, Rafikov R, Haigh S, Zhi WB, Kumar S, Doulias PT, Rafikova O, Pillich H, Chakraborty T, Lucas R, Verin AD, Catravas JD, She JX, Black SM, Fulton DJR.

Biochem Pharmacol. 2017 Mar 1;127:34-45. doi: 10.1016/j.bcp.2016.12.014. Epub 2016 Dec 22.

30.

The protective role of MLCP-mediated ERM dephosphorylation in endotoxin-induced lung injury in vitro and in vivo.

Kovacs-Kasa A, Gorshkov BA, Kim KM, Kumar S, Black SM, Fulton DJ, Dimitropoulou C, Catravas JD, Verin AD.

Sci Rep. 2016 Dec 15;6:39018. doi: 10.1038/srep39018.

31.

Differential Regulation of BMAL1, CLOCK, and Endothelial Signaling in the Aortic Arch and Ligated Common Carotid Artery.

Shang X, Pati P, Anea CB, Fulton DJ, Rudic RD.

J Vasc Res. 2016;53(5-6):269-278. doi: 10.1159/000452410. Epub 2016 Dec 7.

32.

Inhibition of histone deacetylase reduces transcription of NADPH oxidases and ROS production and ameliorates pulmonary arterial hypertension.

Chen F, Li X, Aquadro E, Haigh S, Zhou J, Stepp DW, Weintraub NL, Barman SA, Fulton DJR.

Free Radic Biol Med. 2016 Oct;99:167-178. doi: 10.1016/j.freeradbiomed.2016.08.003. Epub 2016 Aug 3.

33.

Cloning, Characteristics, and Functional Analysis of Rabbit NADPH Oxidase 5.

Chen F, Yin C, Dimitropoulou C, Fulton DJ.

Front Physiol. 2016 Jul 19;7:284. doi: 10.3389/fphys.2016.00284. eCollection 2016.

34.

Transcriptional and Posttranslational Regulation of eNOS in the Endothelium.

Fulton DJ.

Adv Pharmacol. 2016;77:29-64. doi: 10.1016/bs.apha.2016.04.001. Epub 2016 May 18.

PMID:
27451094
35.

Pressor recovery after acute stress is impaired in high fructose-fed Lean Zucker rats.

Thompson JA, D'Angelo G, Mintz JD, Fulton DJ, Stepp DW.

Physiol Rep. 2016 Jun;4(12). pii: e12758. doi: 10.14814/phy2.12758.

36.

Neurofibromin is a novel regulator of Ras-induced reactive oxygen species production in mice and humans.

Bessler WK, Hudson FZ, Zhang H, Harris V, Wang Y, Mund JA, Downing B, Ingram DA Jr, Case J, Fulton DJ, Stansfield BK.

Free Radic Biol Med. 2016 Aug;97:212-222. doi: 10.1016/j.freeradbiomed.2016.06.002. Epub 2016 Jun 3.

37.

Endotoxin Disrupts Circadian Rhythms in Macrophages via Reactive Oxygen Species.

Wang Y, Pati P, Xu Y, Chen F, Stepp DW, Huo Y, Rudic RD, Fulton DJ.

PLoS One. 2016 May 11;11(5):e0155075. doi: 10.1371/journal.pone.0155075. eCollection 2016.

38.

Clarity on the Isoform-Specific Roles of NADPH Oxidases and NADPH Oxidase-4 in Atherosclerosis.

Fulton DJ, Barman SA.

Arterioscler Thromb Vasc Biol. 2016 Apr;36(4):579-81. doi: 10.1161/ATVBAHA.116.307096. No abstract available.

39.

Low-Salt Diet and Circadian Dysfunction Synergize to Induce Angiotensin II-Dependent Hypertension in Mice.

Pati P, Fulton DJ, Bagi Z, Chen F, Wang Y, Kitchens J, Cassis LA, Stepp DW, Rudic RD.

Hypertension. 2016 Mar;67(3):661-8. doi: 10.1161/HYPERTENSIONAHA.115.06194. Epub 2016 Jan 18.

40.

Enzymatic regulation and functional relevance of NOX5.

Chen F, Wang Y, Barman S, Fulton DJ.

Curr Pharm Des. 2015;21(41):5999-6008. Review.

41.

Red Blood Cell Dysfunction Induced by High-Fat Diet: Potential Implications for Obesity-Related Atherosclerosis.

Unruh D, Srinivasan R, Benson T, Haigh S, Coyle D, Batra N, Keil R, Sturm R, Blanco V, Palascak M, Franco RS, Tong W, Chatterjee T, Hui DY, Davidson WS, Aronow BJ, Kalfa T, Manka D, Peairs A, Blomkalns A, Fulton DJ, Brittain JE, Weintraub NL, Bogdanov VY.

Circulation. 2015 Nov 17;132(20):1898-908. doi: 10.1161/CIRCULATIONAHA.115.017313. Epub 2015 Oct 14.

42.

Nox5 stability and superoxide production is regulated by C-terminal binding of Hsp90 and CO-chaperones.

Chen F, Haigh S, Yu Y, Benson T, Wang Y, Li X, Dou H, Bagi Z, Verin AD, Stepp DW, Csanyi G, Chadli A, Weintraub NL, Smith SM, Fulton DJ.

Free Radic Biol Med. 2015 Dec;89:793-805. doi: 10.1016/j.freeradbiomed.2015.09.019. Epub 2015 Oct 9.

43.

Obesity alters the peripheral circadian clock in the aorta and microcirculation.

Nernpermpisooth N, Qiu S, Mintz JD, Suvitayavat W, Thirawarapan S, Rudic DR, Fulton DJ, Stepp DW.

Microcirculation. 2015 May;22(4):257-66. doi: 10.1111/micc.12192.

44.

Caveolin-1 prevents sustained angiotensin II-induced resistance artery constriction and obesity-induced high blood pressure.

Czikora I, Feher A, Lucas R, Fulton DJ, Bagi Z.

Am J Physiol Heart Circ Physiol. 2015 Mar 1;308(5):H376-85. doi: 10.1152/ajpheart.00649.2014. Epub 2014 Dec 19.

45.

PKC-dependent phosphorylation of eNOS at T495 regulates eNOS coupling and endothelial barrier function in response to G+ -toxins.

Chen F, Kumar S, Yu Y, Aggarwal S, Gross C, Wang Y, Chakraborty T, Verin AD, Catravas JD, Lucas R, Black SM, Fulton DJ.

PLoS One. 2014 Jul 14;9(7):e99823. doi: 10.1371/journal.pone.0099823. eCollection 2014.

46.

Impact of Nox5 polymorphisms on basal and stimulus-dependent ROS generation.

Wang Y, Chen F, Le B, Stepp DW, Fulton DJ.

PLoS One. 2014 Jul 3;9(7):e100102. doi: 10.1371/journal.pone.0100102. eCollection 2014.

47.

Increasing muscle mass improves vascular function in obese (db/db) mice.

Qiu S, Mintz JD, Salet CD, Han W, Giannis A, Chen F, Yu Y, Su Y, Fulton DJ, Stepp DW.

J Am Heart Assoc. 2014 Jun 25;3(3):e000854. doi: 10.1161/JAHA.114.000854.

48.

NADPH oxidase 4 is expressed in pulmonary artery adventitia and contributes to hypertensive vascular remodeling.

Barman SA, Chen F, Su Y, Dimitropoulou C, Wang Y, Catravas JD, Han W, Orfi L, Szantai-Kis C, Keri G, Szabadkai I, Barabutis N, Rafikova O, Rafikov R, Black SM, Jonigk D, Giannis A, Asmis R, Stepp DW, Ramesh G, Fulton DJ.

Arterioscler Thromb Vasc Biol. 2014 Aug;34(8):1704-15. doi: 10.1161/ATVBAHA.114.303848. Epub 2014 Jun 19.

49.

Caveolin-1 is a negative regulator of NADPH oxidase-derived reactive oxygen species.

Chen F, Barman S, Yu Y, Haigh S, Wang Y, Black SM, Rafikov R, Dou H, Bagi Z, Han W, Su Y, Fulton DJ.

Free Radic Biol Med. 2014 Aug;73:201-13. doi: 10.1016/j.freeradbiomed.2014.04.029. Epub 2014 May 14. Erratum in: Free Radic Biol Med. 2015 Apr;81:184. Black, Stephen M [added]; Rafikov, Ruslan [added].

50.

Endothelial PFKFB3 plays a critical role in angiogenesis.

Xu Y, An X, Guo X, Habtetsion TG, Wang Y, Xu X, Kandala S, Li Q, Li H, Zhang C, Caldwell RB, Fulton DJ, Su Y, Hoda MN, Zhou G, Wu C, Huo Y.

Arterioscler Thromb Vasc Biol. 2014 Jun;34(6):1231-9. doi: 10.1161/ATVBAHA.113.303041. Epub 2014 Apr 3.

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