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Mucosal T Helper 17 and T Regulatory Cell Homeostasis Correlate with Acute Simian Immunodeficiency Virus Viremia and Responsiveness to Antiretroviral Therapy in Macaques.

O'Connor MA, Munson PV, Tunggal HC, Hajari N, Lewis TB, Bratt D, Moats C, Smedley J, Bagley KC, Mullins JI, Fuller DH.

AIDS Res Hum Retroviruses. 2019 Mar;35(3):295-305. doi: 10.1089/AID.2018.0184. Epub 2019 Jan 2.


Correction: Sustained AAV9-mediated expression of a non-self protein in the CNS of non-human primates after immunomodulation.

Ramsingh AI, Gray SJ, Reilly A, Koday M, Bratt D, Koday MT, Munson P, Murnane R, Smedley J, Hu Y, Messer A, Fuller DH.

PLoS One. 2018 Nov 1;13(11):e0207077. doi: 10.1371/journal.pone.0207077. eCollection 2018.


Early cellular innate immune responses drive Zika viral persistence and tissue tropism in pigtail macaques.

O'Connor MA, Tisoncik-Go J, Lewis TB, Miller CJ, Bratt D, Moats CR, Edlefsen PT, Smedley J, Klatt NR, Gale M Jr, Fuller DH.

Nat Commun. 2018 Aug 22;9(1):3371. doi: 10.1038/s41467-018-05826-w.


Sustained AAV9-mediated expression of a non-self protein in the CNS of non-human primates after immunomodulation.

Ramsingh AI, Gray SJ, Reilly A, Koday M, Bratt D, Koday MT, Munson PM, Murnane R, Smedley J, Hu Y, Messer A, Fuller DH.

PLoS One. 2018 Jun 6;13(6):e0198154. doi: 10.1371/journal.pone.0198154. eCollection 2018. Erratum in: PLoS One. 2018 Nov 1;13(11):e0207077.


Therapeutic conserved elements (CE) DNA vaccine induces strong T-cell responses against highly conserved viral sequences during simian-human immunodeficiency virus infection.

Munson P, Liu Y, Bratt D, Fuller JT, Hu X, Pavlakis GN, Felber BK, Mullins JI, Fuller DH.

Hum Vaccin Immunother. 2018 Jul 3;14(7):1820-1831. doi: 10.1080/21645515.2018.1448328. Epub 2018 Apr 12.


Correction: Laparoscopic Technique for Serial Collection of Para-Colonic, Left Colic, and Inferior Mesenteric Lymph Nodes in Macaques.

Smedley J, Macalister R, Wangari S, Gathuka M, Ahrens J, Iwayama N, May D, Bratt D, O'Connor M, Munson P, Koday M, Lifson, Fuller DH.

PLoS One. 2018 Jan 2;13(1):e0190764. doi: 10.1371/journal.pone.0190764. eCollection 2018.


Multigenic DNA vaccine induces protective cross-reactive T cell responses against heterologous influenza virus in nonhuman primates.

Koday MT, Leonard JA, Munson P, Forero A, Koday M, Bratt DL, Fuller JT, Murnane R, Qin S, Reinhart TA, Duus K, Messaoudi I, Hartman AL, Stefano-Cole K, Morrison J, Katze MG, Fuller DH.

PLoS One. 2017 Dec 21;12(12):e0189780. doi: 10.1371/journal.pone.0189780. eCollection 2017.


Massively parallel de novo protein design for targeted therapeutics.

Chevalier A, Silva DA, Rocklin GJ, Hicks DR, Vergara R, Murapa P, Bernard SM, Zhang L, Lam KH, Yao G, Bahl CD, Miyashita SI, Goreshnik I, Fuller JT, Koday MT, Jenkins CM, Colvin T, Carter L, Bohn A, Bryan CM, Fernández-Velasco DA, Stewart L, Dong M, Huang X, Jin R, Wilson IA, Fuller DH, Baker D.

Nature. 2017 Oct 5;550(7674):74-79. doi: 10.1038/nature23912. Epub 2017 Sep 27.


Computational design of trimeric influenza-neutralizing proteins targeting the hemagglutinin receptor binding site.

Strauch EM, Bernard SM, La D, Bohn AJ, Lee PS, Anderson CE, Nieusma T, Holstein CA, Garcia NK, Hooper KA, Ravichandran R, Nelson JW, Sheffler W, Bloom JD, Lee KK, Ward AB, Yager P, Fuller DH, Wilson IA, Baker D.

Nat Biotechnol. 2017 Jul;35(7):667-671. doi: 10.1038/nbt.3907. Epub 2017 Jun 12.


Kinetics of Myeloid-Derived Suppressor Cell Frequency and Function during Simian Immunodeficiency Virus Infection, Combination Antiretroviral Therapy, and Treatment Interruption.

Dross SE, Munson PV, Kim SE, Bratt DL, Tunggal HC, Gervassi AL, Fuller DH, Horton H.

J Immunol. 2017 Jan 15;198(2):757-766. doi: 10.4049/jimmunol.1600759. Epub 2016 Dec 14.


Minor Antigen Vaccine-Sensitized DLI: In Vitro Responses Do Not Predict In Vivo Effects.

Rosinski SL, Stone B, Graves SS, Fuller DH, Fuller JT, Storb R.

Transplant Direct. 2016 Apr 8;2(5):e71. doi: 10.1097/TXD.0000000000000583. eCollection 2016 May.


Laparoscopic Technique for Serial Collection of Para-Colonic, Left Colic, and Inferior Mesenteric Lymph Nodes in Macaques.

Smedley J, Macalister R, Wangari S, Gathuka M, Ahrens J, Iwayama N, May D, Bratt D, O'Connor M, Munson P, Koday M, Lifson J, Fuller DH.

PLoS One. 2016 Jun 16;11(6):e0157535. doi: 10.1371/journal.pone.0157535. eCollection 2016. Erratum in: PLoS One. 2018 Jan 2;13(1):e0190764.


Evaluation of protection induced by a dengue virus serotype 2 envelope domain III protein scaffold/DNA vaccine in non-human primates.

McBurney SP, Sunshine JE, Gabriel S, Huynh JP, Sutton WF, Fuller DH, Haigwood NL, Messer WB.

Vaccine. 2016 Jun 24;34(30):3500-7. doi: 10.1016/j.vaccine.2016.03.108. Epub 2016 Apr 13.


Complex Minigene Library Vaccination for Discovery of Pre-Erythrocytic Plasmodium T Cell Antigens.

Stone BC, Kas A, Billman ZP, Fuller DH, Fuller JT, Shendure J, Murphy SC.

PLoS One. 2016 Apr 12;11(4):e0153449. doi: 10.1371/journal.pone.0153449. eCollection 2016.


Achieving Potent Autologous Neutralizing Antibody Responses against Tier 2 HIV-1 Viruses by Strategic Selection of Envelope Immunogens.

Hessell AJ, Malherbe DC, Pissani F, McBurney S, Krebs SJ, Gomes M, Pandey S, Sutton WF, Burwitz BJ, Gray M, Robins H, Park BS, Sacha JB, LaBranche CC, Fuller DH, Montefiori DC, Stamatatos L, Sather DN, Haigwood NL.

J Immunol. 2016 Apr 1;196(7):3064-78. doi: 10.4049/jimmunol.1500527. Epub 2016 Mar 4.


A Computationally Designed Hemagglutinin Stem-Binding Protein Provides In Vivo Protection from Influenza Independent of a Host Immune Response.

Koday MT, Nelson J, Chevalier A, Koday M, Kalinoski H, Stewart L, Carter L, Nieusma T, Lee PS, Ward AB, Wilson IA, Dagley A, Smee DF, Baker D, Fuller DH.

PLoS Pathog. 2016 Feb 4;12(2):e1005409. doi: 10.1371/journal.ppat.1005409. eCollection 2016 Feb.


Development of a Minor Histocompatibility Antigen Vaccine Regimen in the Canine Model of Hematopoietic Cell Transplantation.

Rosinski SL, Stone B, Graves SS, Fuller DH, De Rosa SC, Spies GA, Mize GJ, Fuller JT, Storb R.

Transplantation. 2015 Oct;99(10):2083-94. doi: 10.1097/TP.0000000000000744.


Isolation, characterization, and functional analysis of ferret lymphatic endothelial cells.

Berendam SJ, Fallert Junecko BA, Murphey-Corb MA, Fuller DH, Reinhart TA.

Vet Immunol Immunopathol. 2015 Feb 15;163(3-4):134-45. doi: 10.1016/j.vetimm.2014.11.013. Epub 2014 Dec 3.


HIV vaccine trial exploits a dual and central role for innate immunity.

Fuller DH, Richert-Spuhler LE, Klatt NR.

J Virol. 2014 Oct;88(20):11640-3. doi: 10.1128/JVI.02140-14. Epub 2014 Aug 13.


A novel tetrameric gp350 1-470 as a potential Epstein-Barr virus vaccine.

Cui X, Cao Z, Sen G, Chattopadhyay G, Fuller DH, Fuller JT, Snapper DM, Snow AL, Mond JJ, Snapper CM.

Vaccine. 2013 Jun 26;31(30):3039-45. doi: 10.1016/j.vaccine.2013.04.071. Epub 2013 May 9.


Functional characterization of ferret CCL20 and CCR6 and identification of chemotactic inhibitors.

Qin S, Klamar CR, Fallert Junecko BA, Craigo J, Fuller DH, Reinhart TA.

Cytokine. 2013 Mar;61(3):924-32. doi: 10.1016/j.cyto.2012.12.015. Epub 2013 Jan 27.


Optimizing particle-mediated epidermal delivery of an influenza DNA vaccine in ferrets.

Yager EJ, Stagnar C, Gopalakrishnan R, Fuller JT, Fuller DH.

Methods Mol Biol. 2013;940:223-37. doi: 10.1007/978-1-62703-110-3_19.


'Omics investigations of HIV and SIV pathogenesis and innate immunity.

Palermo RE, Fuller DH.

Curr Top Microbiol Immunol. 2013;363:87-116. doi: 10.1007/82_2012_255. Review.


Therapeutic DNA vaccine induces broad T cell responses in the gut and sustained protection from viral rebound and AIDS in SIV-infected rhesus macaques.

Fuller DH, Rajakumar P, Che JW, Narendran A, Nyaundi J, Michael H, Yager EJ, Stagnar C, Wahlberg B, Taber R, Haynes JR, Cook FC, Ertl P, Tite J, Amedee AM, Murphey-Corb M.

PLoS One. 2012;7(3):e33715. doi: 10.1371/journal.pone.0033715. Epub 2012 Mar 19.


DNA/Ad5 vaccination with SIV epitopes induced epitope-specific CD4⁺ T cells, but few subdominant epitope-specific CD8⁺ T cells.

Vojnov L, Bean AT, Peterson EJ, Chiuchiolo MJ, Sacha JB, Denes FS, Sandor M, Fuller DH, Fuller JT, Parks CL, McDermott AB, Wilson NA, Watkins DI.

Vaccine. 2011 Oct 6;29(43):7483-90. doi: 10.1016/j.vaccine.2011.07.048. Epub 2011 Aug 10.


Oral immunization with a live coxsackievirus/HIV recombinant induces gag p24-specific T cell responses.

Gu R, Shampang A, Nashar T, Patil M, Fuller DH, Ramsingh AI.

PLoS One. 2010 Sep 2;5(9). pii: e12499. doi: 10.1371/journal.pone.0012499.


GM-CSF increases mucosal and systemic immunogenicity of an H1N1 influenza DNA vaccine administered into the epidermis of non-human primates.

Loudon PT, Yager EJ, Lynch DT, Narendran A, Stagnar C, Franchini AM, Fuller JT, White PA, Nyuandi J, Wiley CA, Murphey-Corb M, Fuller DH.

PLoS One. 2010 Jun 8;5(6):e11021. doi: 10.1371/journal.pone.0011021.


Prospects for developing an effective particle-mediated DNA vaccine against influenza.

Yager EJ, Dean HJ, Fuller DH.

Expert Rev Vaccines. 2009 Sep;8(9):1205-20. doi: 10.1586/erv.09.82. Review.


Immunogenicity of hybrid DNA vaccines expressing hepatitis B core particles carrying human and simian immunodeficiency virus epitopes in mice and rhesus macaques.

Fuller DH, Shipley T, Allen TM, Fuller JT, Wu MS, Horton H, Wilson N, Widera G, Watkins DI.

Virology. 2007 Aug 1;364(2):245-55. Epub 2007 Apr 11.


Preclinical and clinical progress of particle-mediated DNA vaccines for infectious diseases.

Fuller DH, Loudon P, Schmaljohn C.

Methods. 2006 Sep;40(1):86-97. Review.


Effects of monotherapy with (R)-9-(2-phosphonylmethoxypropyl)adenine (PMPA) on the evolution of a primary Simian immunodeficiency virus (SIV) isolate.

Taber R, Rajakumar PA, Fuller DH, Trichel AM, Dowling P, Meleason D, Amedee A, Murphey-Corb M.

Virology. 2006 Oct 10;354(1):116-31. Epub 2006 Aug 1.


DNA immunization in combination with effective antiretroviral drug therapy controls viral rebound and prevents simian AIDS after treatment is discontinued.

Fuller DH, Rajakumar PA, Wu MS, McMahon CW, Shipley T, Fuller JT, Bazmi A, Trichel AM, Allen TM, Mothe B, Haynes JR, Watkins DI, Murphey-Corb M.

Virology. 2006 Apr 25;348(1):200-15. Epub 2006 Jan 24.


Clinical safety and efficacy of a powdered Hepatitis B nucleic acid vaccine delivered to the epidermis by a commercial prototype device.

Roberts LK, Barr LJ, Fuller DH, McMahon CW, Leese PT, Jones S.

Vaccine. 2005 Sep 23;23(40):4867-78.


Multispecific vaccine-induced mucosal cytotoxic T lymphocytes reduce acute-phase viral replication but fail in long-term control of simian immunodeficiency virus SIVmac239.

Vogel TU, Reynolds MR, Fuller DH, Vielhuber K, Shipley T, Fuller JT, Kunstman KJ, Sutter G, Marthas ML, Erfle V, Wolinsky SM, Wang C, Allison DB, Rud EW, Wilson N, Montefiori D, Altman JD, Watkins DI.

J Virol. 2003 Dec;77(24):13348-60.


Particle-mediated DNA vaccination of mice, monkeys and men: looking beyond the dogma.

Payne LG, Fuller DH, Haynes JR.

Curr Opin Mol Ther. 2002 Oct;4(5):459-66. Review.


Differences between T cell epitopes recognized after immunization and after infection.

Vogel TU, Horton H, Fuller DH, Carter DK, Vielhuber K, O'Connor DH, Shipley T, Fuller J, Sutter G, Erfle V, Wilson N, Picker LJ, Watkins DI.

J Immunol. 2002 Oct 15;169(8):4511-21.


Immunization of rhesus macaques with a DNA prime/modified vaccinia virus Ankara boost regimen induces broad simian immunodeficiency virus (SIV)-specific T-cell responses and reduces initial viral replication but does not prevent disease progression following challenge with pathogenic SIVmac239.

Horton H, Vogel TU, Carter DK, Vielhuber K, Fuller DH, Shipley T, Fuller JT, Kunstman KJ, Sutter G, Montefiori DC, Erfle V, Desrosiers RC, Wilson N, Picker LJ, Wolinsky SM, Wang C, Allison DB, Watkins DI.

J Virol. 2002 Jul;76(14):7187-202.


Plasmid vectors encoding cholera toxin or the heat-labile enterotoxin from Escherichia coli are strong adjuvants for DNA vaccines.

Arrington J, Braun RP, Dong L, Fuller DH, Macklin MD, Umlauf SW, Wagner SJ, Wu MS, Payne LG, Haynes JR.

J Virol. 2002 May;76(9):4536-46.


Induction of mucosal protection against primary, heterologous simian immunodeficiency virus by a DNA vaccine.

Fuller DH, Rajakumar PA, Wilson LA, Trichel AM, Fuller JT, Shipley T, Wu MS, Weis K, Rinaldo CR, Haynes JR, Murphey-Corb M.

J Virol. 2002 Apr;76(7):3309-17.


Induction of AIDS virus-specific CTL activity in fresh, unstimulated peripheral blood lymphocytes from rhesus macaques vaccinated with a DNA prime/modified vaccinia virus Ankara boost regimen.

Allen TM, Vogel TU, Fuller DH, Mothé BR, Steffen S, Boyson JE, Shipley T, Fuller J, Hanke T, Sette A, Altman JD, Moss B, McMichael AJ, Watkins DI.

J Immunol. 2000 May 1;164(9):4968-78.


Comparison of immunity generated by nucleic acid-, MF59-, and ISCOM-formulated human immunodeficiency virus type 1 vaccines in Rhesus macaques: evidence for viral clearance.

Verschoor EJ, Mooij P, Oostermeijer H, van der Kolk M, ten Haaft P, Verstrepen B, Sun Y, Morein B, Akerblom L, Fuller DH, Barnett SW, Heeney JL.

J Virol. 1999 Apr;73(4):3292-300.


Gene gun-based nucleic acid immunization alone or in combination with recombinant vaccinia vectors suppresses virus burden in rhesus macaques challenged with a heterologous SIV.

Fuller DH, Simpson L, Cole KS, Clements JE, Panicali DL, Montelaro RC, Murphey-Corb M, Haynes JR.

Immunol Cell Biol. 1997 Aug;75(4):389-96.


Enhancement of immunodeficiency virus-specific immune responses in DNA-immunized rhesus macaques.

Fuller DH, Corb MM, Barnett S, Steimer K, Haynes JR.

Vaccine. 1997 Jun;15(8):924-6.


Vaccination with HIV-1 gp120 DNA induces immune responses that are boosted by a recombinant gp120 protein subunit.

Barnett SW, Rajasekar S, Legg H, Doe B, Fuller DH, Haynes JR, Walker CM, Steimer KS.

Vaccine. 1997 Jun;15(8):869-73.


Induction of immunodeficiency virus-specific immune responses in rhesus monkeys following gene gun-mediated DNA vaccination.

Fuller DH, Murphey-Corb M, Clements J, Barnett S, Haynes JR.

J Med Primatol. 1996 Jun;25(3):236-41.


Immune responses to hepatitis B virus surface and core antigens in mice, monkeys, and pigs after Accell particle-mediated DNA immunization.

Fuller JT, Fuller DH, McCabe D, Haynes JR, Widera G.

Ann N Y Acad Sci. 1995 Nov 27;772:282-4. No abstract available.


Use of DNAs expressing HIV-1 Env and noninfectious HIV-1 particles to raise antibody responses in mice.

Lu S, Santoro JC, Fuller DH, Haynes JR, Robinson HL.

Virology. 1995 May 10;209(1):147-54.


DNA vaccines: a novel approach to immunization.

Fynan EF, Webster RG, Fuller DH, Haynes JR, Santoro JC, Robinson HL.

Int J Immunopharmacol. 1995 Feb;17(2):79-83. Review.


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