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Items: 35

1.

Structural Basis of Glycerophosphodiester Recognition by the Mycobacterium tuberculosis Substrate-Binding Protein UgpB.

Fenn JS, Nepravishta R, Guy CS, Harrison J, Angulo J, Cameron AD, Fullam E.

ACS Chem Biol. 2019 Sep 20;14(9):1879-1887. doi: 10.1021/acschembio.9b00204. Epub 2019 Aug 21.

PMID:
31433162
2.

Targeting extracellular glycans: tuning multimeric boronic acids for pathogen-selective killing of Mycobacterium tuberculosis.

Guy CS, Gibson MI, Fullam E.

Chem Sci. 2019 May 16;10(23):5935-5942. doi: 10.1039/c9sc00415g. eCollection 2019 Jun 21.

3.

A GFP-strategy for efficient recombinant protein overexpression and purification in Mycobacterium smegmatis.

Radhakrishnan A, Furze CM, Ahangar MS, Fullam E.

RSC Adv. 2018 Sep 27;8(58):33087-33095. doi: 10.1039/c8ra06237d. Epub 2018 Sep 25.

4.

Structural and functional determination of homologs of the Mycobacterium tuberculosis N-acetylglucosamine-6-phosphate deacetylase (NagA).

Ahangar MS, Furze CM, Guy CS, Cooper C, Maskew KS, Graham B, Cameron AD, Fullam E.

J Biol Chem. 2018 Jun 22;293(25):9770-9783. doi: 10.1074/jbc.RA118.002597. Epub 2018 May 4.

5.

Multivalent Antimicrobial Polymer Nanoparticles Target Mycobacteria and Gram-Negative Bacteria by Distinct Mechanisms.

Richards SJ, Isufi K, Wilkins LE, Lipecki J, Fullam E, Gibson MI.

Biomacromolecules. 2018 Jan 8;19(1):256-264. doi: 10.1021/acs.biomac.7b01561. Epub 2017 Dec 15.

6.

Evaluation of the Antimicrobial Activity of Cationic Polymers against Mycobacteria: Toward Antitubercular Macromolecules.

Phillips DJ, Harrison J, Richards SJ, Mitchell DE, Tichauer E, Hubbard ATM, Guy C, Hands-Portman I, Fullam E, Gibson MI.

Biomacromolecules. 2017 May 8;18(5):1592-1599. doi: 10.1021/acs.biomac.7b00210. Epub 2017 Apr 6.

7.

Identification of the anti-mycobacterial functional properties of piperidinol derivatives.

Guy CS, Tichauer E, Kay GL, Phillips DJ, Bailey TL, Harrison J, Furze CM, Millard AD, Gibson MI, Pallen MJ, Fullam E.

Br J Pharmacol. 2017 Jul;174(14):2183-2193. doi: 10.1111/bph.13744. Epub 2017 Mar 23.

8.

Structural and functional analysis of the solute-binding protein UspC from Mycobacterium tuberculosis that is specific for amino sugars.

Fullam E, Prokes I, Fütterer K, Besra GS.

Open Biol. 2016 Jun;6(6). pii: 160105. doi: 10.1098/rsob.160105.

9.

Discrimination between bacterial species by ratiometric analysis of their carbohydrate binding profile.

Otten L, Fullam E, Gibson MI.

Mol Biosyst. 2016 Feb;12(2):341-4. doi: 10.1039/c5mb00720h.

10.

Deuterated carbohydrate probes as 'label-free' substrates for probing nutrient uptake in mycobacteria by nuclear reaction analysis.

Lowery R, Gibson MI, Thompson RL, Fullam E.

Chem Commun (Camb). 2015 Mar 21;51(23):4838-41. doi: 10.1039/c4cc09588j.

11.

Exploration of piperidinols as potential antitubercular agents.

Abuhammad A, Fullam E, Bhakta S, Russell AJ, Morris GM, Finn PW, Sim E.

Molecules. 2014 Oct 10;19(10):16274-90. doi: 10.3390/molecules191016274.

12.

Selective detection of epimeric pentose saccharides at physiological pH using a fluorescent receptor.

Gibson MI, Neres J, Fullam E.

Carbohydr Res. 2014 Jun 4;391:61-5. doi: 10.1016/j.carres.2014.02.007. Epub 2014 Feb 15.

PMID:
24785389
13.

Design, synthesis and structure-activity relationships of 3,5-diaryl-1H-pyrazoles as inhibitors of arylamine N-acetyltransferase.

Fullam E, Talbot J, Abuhammed A, Westwood I, Davies SG, Russell AJ, Sim E.

Bioorg Med Chem Lett. 2013 May 1;23(9):2759-64. doi: 10.1016/j.bmcl.2013.02.052. Epub 2013 Feb 22.

PMID:
23518278
14.

Piperidinols that show anti-tubercular activity as inhibitors of arylamine N-acetyltransferase: an essential enzyme for mycobacterial survival inside macrophages.

Abuhammad A, Fullam E, Lowe ED, Staunton D, Kawamura A, Westwood IM, Bhakta S, Garner AC, Wilson DL, Seden PT, Davies SG, Russell AJ, Garman EF, Sim E.

PLoS One. 2012;7(12):e52790. doi: 10.1371/journal.pone.0052790. Epub 2012 Dec 28.

15.

Structural basis for benzothiazinone-mediated killing of Mycobacterium tuberculosis.

Neres J, Pojer F, Molteni E, Chiarelli LR, Dhar N, Boy-Röttger S, Buroni S, Fullam E, Degiacomi G, Lucarelli AP, Read RJ, Zanoni G, Edmondson DE, De Rossi E, Pasca MR, McKinney JD, Dyson PJ, Riccardi G, Mattevi A, Cole ST, Binda C.

Sci Transl Med. 2012 Sep 5;4(150):150ra121. doi: 10.1126/scitranslmed.3004395.

16.

Structure and function of the transketolase from Mycobacterium tuberculosis and comparison with the human enzyme.

Fullam E, Pojer F, Bergfors T, Jones TA, Cole ST.

Open Biol. 2012 Jan;2(1):110026. doi: 10.1098/rsob.110026.

17.

Analysis of β-amino alcohols as inhibitors of the potential anti-tubercular target N-acetyltransferase.

Fullam E, Abuhammad A, Wilson DL, Anderton MC, Davies SG, Russell AJ, Sim E.

Bioorg Med Chem Lett. 2011 Feb 15;21(4):1185-90. doi: 10.1016/j.bmcl.2010.12.099. Epub 2010 Dec 24.

PMID:
21251821
18.

Identification of arylamine N-acetyltransferase inhibitors as an approach towards novel anti-tuberculars.

Westwood IM, Bhakta S, Russell AJ, Fullam E, Anderton MC, Kawamura A, Mulvaney AW, Vickers RJ, Bhowruth V, Besra GS, Lalvani A, Davies SG, Sim E.

Protein Cell. 2010 Jan;1(1):82-95. doi: 10.1007/s13238-010-0006-1. Epub 2010 Mar 18.

19.

Probing the architecture of the Mycobacterium marinum arylamine N-acetyltransferase active site.

Abuhammad AM, Lowe ED, Fullam E, Noble M, Garman EF, Sim E.

Protein Cell. 2010 Apr;1(4):384-392. doi: 10.1007/s13238-010-0037-7. Epub 2010 May 8.

20.

Comparison of the Arylamine N-acetyltransferase from Mycobacterium marinum and Mycobacterium tuberculosis.

Fullam E, Kawamura A, Wilkinson H, Abuhammad A, Westwood I, Sim E.

Protein J. 2009 Aug;28(6):281-93. doi: 10.1007/s10930-009-9193-0.

PMID:
19636684
21.

Benzothiazinones kill Mycobacterium tuberculosis by blocking arabinan synthesis.

Makarov V, Manina G, Mikusova K, Möllmann U, Ryabova O, Saint-Joanis B, Dhar N, Pasca MR, Buroni S, Lucarelli AP, Milano A, De Rossi E, Belanova M, Bobovska A, Dianiskova P, Kordulakova J, Sala C, Fullam E, Schneider P, McKinney JD, Brodin P, Christophe T, Waddell S, Butcher P, Albrethsen J, Rosenkrands I, Brosch R, Nandi V, Bharath S, Gaonkar S, Shandil RK, Balasubramanian V, Balganesh T, Tyagi S, Grosset J, Riccardi G, Cole ST.

Science. 2009 May 8;324(5928):801-4. doi: 10.1126/science.1171583. Epub 2009 Mar 19.

22.

Temperature stability of proteins essential for the intracellular survival of Mycobacterium tuberculosis.

Lack NA, Kawamura A, Fullam E, Laurieri N, Beard S, Russell AJ, Evangelopoulos D, Westwood I, Sim E.

Biochem J. 2009 Mar 1;418(2):369-78. doi: 10.1042/BJ20082011.

PMID:
19014350
23.

Arylamine N-acetyltransferases: structural and functional implications of polymorphisms.

Sim E, Lack N, Wang CJ, Long H, Westwood I, Fullam E, Kawamura A.

Toxicology. 2008 Dec 30;254(3):170-83. doi: 10.1016/j.tox.2008.08.022. Epub 2008 Sep 12. Review.

PMID:
18852012
24.

Arylamine N-acetyltransferases in mycobacteria.

Sim E, Sandy J, Evangelopoulos D, Fullam E, Bhakta S, Westwood I, Krylova A, Lack N, Noble M.

Curr Drug Metab. 2008 Jul;9(6):510-9. Review.

25.

Divergence of cofactor recognition across evolution: coenzyme A binding in a prokaryotic arylamine N-acetyltransferase.

Fullam E, Westwood IM, Anderton MC, Lowe ED, Sim E, Noble ME.

J Mol Biol. 2008 Jan 4;375(1):178-91. Epub 2007 Oct 13.

PMID:
18005984
26.

Arylamine N-acetyltransferases.

Sim E, Westwood I, Fullam E.

Expert Opin Drug Metab Toxicol. 2007 Apr;3(2):169-84. Review.

PMID:
17428149
27.

Structure and mechanism of arylamine N-acetyltransferases.

Westwood IM, Kawamura A, Fullam E, Russell AJ, Davies SG, Sim E.

Curr Top Med Chem. 2006;6(15):1641-54. Review.

PMID:
16918475
28.
29.

A comparison of light microscope and electron microscope images of identical surface areas.

FULLAM E.

Science. 1950 Oct 20;112(2912):447-8. No abstract available.

PMID:
14781804
30.

The preparation of sections of guinea pig liver for electron microscopy.

CLAUDE A, FULLAM EF.

J Exp Med. 1946 Jun 1;83:499-504. No abstract available.

31.

THE PREPARATION OF SECTIONS OF GUINEA PIG LIVER FOR ELECTRON MICROSCOPY.

Claude A, Fullam EF.

J Exp Med. 1946 May 31;83(6):499-503.

32.

Sectioning for the electron microscope accomplished by the high speed microtome.

GESSLER AE, FULLAM EF.

Am J Anat. 1946 Mar;78:245-83. No abstract available.

PMID:
21024800
33.

A high speed microtome for the electron microscope.

FULLAM EF, GESSLER AE.

Rev Sci Instrum. 1946 Jan;17:23-35. No abstract available.

PMID:
21012214
34.
35.

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