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Items: 43

1.

MicroRNAs Regulate Multiple Aspects of Locomotor Behavior in Drosophila.

Donelson NC, Dixit R, Pichardo-Casas I, Chiu EY, Ohman RT, Slawson JB, Klein M, Fulga TA, Van Vactor D, Griffith LC.

G3 (Bethesda). 2019 Nov 6. pii: g3.400793.2019. doi: 10.1534/g3.119.400793. [Epub ahead of print]

2.

Addendum: Precise tuning of gene expression levels in mammalian cells.

Michaels YS, Barnkob MB, Barbosa H, Baeumler TA, Thompson MK, Andre V, Colin-York H, Fritzsche M, Gileadi U, Sheppard HM, Knapp DJHF, Milne TA, Cerundolo V, Fulga TA.

Nat Commun. 2019 Jun 10;10(1):2622. doi: 10.1038/s41467-019-10615-0.

3.

Decoupling tRNA promoter and processing activities enables specific Pol-II Cas9 guide RNA expression.

Knapp DJHF, Michaels YS, Jamilly M, Ferry QRV, Barbosa H, Milne TA, Fulga TA.

Nat Commun. 2019 Apr 2;10(1):1490. doi: 10.1038/s41467-019-09148-3.

4.

Precise tuning of gene expression levels in mammalian cells.

Michaels YS, Barnkob MB, Barbosa H, Baeumler TA, Thompson MK, Andre V, Colin-York H, Fritzsche M, Gileadi U, Sheppard HM, Knapp DJHF, Milne TA, Cerundolo V, Fulga TA.

Nat Commun. 2019 Feb 18;10(1):818. doi: 10.1038/s41467-019-08777-y.

5.

CRISPR-Cas9 targeting of MMP13 in human chondrocytes leads to significantly reduced levels of the metalloproteinase and enhanced type II collagen accumulation.

Seidl CI, Fulga TA, Murphy CL.

Osteoarthritis Cartilage. 2019 Jan;27(1):140-147. doi: 10.1016/j.joca.2018.09.001. Epub 2018 Sep 15.

PMID:
30223022
6.

MicroRNAs Regulate Sleep and Sleep Homeostasis in Drosophila.

Goodwin PR, Meng A, Moore J, Hobin M, Fulga TA, Van Vactor D, Griffith LC.

Cell Rep. 2018 Jun 26;23(13):3776-3786. doi: 10.1016/j.celrep.2018.05.078.

7.

The Drosophila homologue of MEGF8 is essential for early development.

Lloyd DL, Toegel M, Fulga TA, Wilkie AOM.

Sci Rep. 2018 Jun 8;8(1):8790. doi: 10.1038/s41598-018-27076-y.

8.

Regulation of Circadian Behavior by Astroglial MicroRNAs in Drosophila.

You S, Fulga TA, Van Vactor D, Jackson FR.

Genetics. 2018 Mar;208(3):1195-1207. doi: 10.1534/genetics.117.300342.

9.

In situ functional dissection of RNA cis-regulatory elements by multiplex CRISPR-Cas9 genome engineering.

Wu Q, Ferry QRV, Baeumler TA, Michaels YS, Vitsios DM, Habib O, Arnold R, Jiang X, Maio S, Steinkraus BR, Tapia M, Piazza P, Xu N, Holländer GA, Milne TA, Kim JS, Enright AJ, Bassett AR, Fulga TA.

Nat Commun. 2017 Dec 13;8(1):2109. doi: 10.1038/s41467-017-00686-2.

10.

A multiplexable TALE-based binary expression system for in vivo cellular interaction studies.

Toegel M, Azzam G, Lee EY, Knapp DJHF, Tan Y, Fa M, Fulga TA.

Nat Commun. 2017 Nov 21;8(1):1663. doi: 10.1038/s41467-017-01592-3.

11.

Engineering Synthetic Signaling Pathways with Programmable dCas9-Based Chimeric Receptors.

Baeumler TA, Ahmed AA, Fulga TA.

Cell Rep. 2017 Sep 12;20(11):2639-2653. doi: 10.1016/j.celrep.2017.08.044.

12.

Treating the placenta to prevent adverse effects of gestational hypoxia on fetal brain development.

Phillips TJ, Scott H, Menassa DA, Bignell AL, Sood A, Morton JS, Akagi T, Azuma K, Rogers MF, Gilmore CE, Inman GJ, Grant S, Chung Y, Aljunaidy MM, Cooke CL, Steinkraus BR, Pocklington A, Logan A, Collett GP, Kemp H, Holmans PA, Murphy MP, Fulga TA, Coney AM, Akashi M, Davidge ST, Case CP.

Sci Rep. 2017 Aug 22;7(1):9079. doi: 10.1038/s41598-017-06300-1.

13.

Interrogation of Functional miRNA-Target Interactions by CRISPR/Cas9 Genome Engineering.

Michaels YS, Wu Q, Fulga TA.

Methods Mol Biol. 2017;1580:79-97. doi: 10.1007/978-1-4939-6866-4_7.

PMID:
28439828
14.

Rational design of inducible CRISPR guide RNAs for de novo assembly of transcriptional programs.

Ferry QR, Lyutova R, Fulga TA.

Nat Commun. 2017 Mar 3;8:14633. doi: 10.1038/ncomms14633.

15.

Deubiquitinase Usp8 regulates α-synuclein clearance and modifies its toxicity in Lewy body disease.

Alexopoulou Z, Lang J, Perrett RM, Elschami M, Hurry ME, Kim HT, Mazaraki D, Szabo A, Kessler BM, Goldberg AL, Ansorge O, Fulga TA, Tofaris GK.

Proc Natl Acad Sci U S A. 2016 Aug 9;113(32):E4688-97. doi: 10.1073/pnas.1523597113. Epub 2016 Jul 21.

16.

Up-regulation of miR-31 in human atrial fibrillation begets the arrhythmia by depleting dystrophin and neuronal nitric oxide synthase.

Reilly SN, Liu X, Carnicer R, Recalde A, Muszkiewicz A, Jayaram R, Carena MC, Wijesurendra R, Stefanini M, Surdo NC, Lomas O, Ratnatunga C, Sayeed R, Krasopoulos G, Rajakumar T, Bueno-Orovio A, Verheule S, Fulga TA, Rodriguez B, Schotten U, Casadei B.

Sci Transl Med. 2016 May 25;8(340):340ra74. doi: 10.1126/scitranslmed.aac4296.

17.

Tiny giants of gene regulation: experimental strategies for microRNA functional studies.

Steinkraus BR, Toegel M, Fulga TA.

Wiley Interdiscip Rev Dev Biol. 2016 May-Jun;5(3):311-62. doi: 10.1002/wdev.223. Epub 2016 Mar 7. Review.

18.

The Drosophila tricellular junction protein Gliotactin regulates its own mRNA levels through BMP-mediated induction of miR-184.

Sharifkhodaei Z, Padash-Barmchi M, Gilbert MM, Samarasekera G, Fulga TA, Van Vactor D, Auld VJ.

J Cell Sci. 2016 Apr 1;129(7):1477-89. doi: 10.1242/jcs.178608. Epub 2016 Feb 16.

19.

ASXL1 mutation correction by CRISPR/Cas9 restores gene function in leukemia cells and increases survival in mouse xenografts.

Valletta S, Dolatshad H, Bartenstein M, Yip BH, Bello E, Gordon S, Yu Y, Shaw J, Roy S, Scifo L, Schuh A, Pellagatti A, Fulga TA, Verma A, Boultwood J.

Oncotarget. 2015 Dec 29;6(42):44061-71. doi: 10.18632/oncotarget.6392.

20.

microRNAs That Promote or Inhibit Memory Formation in Drosophila melanogaster.

Busto GU, Guven-Ozkan T, Fulga TA, Van Vactor D, Davis RL.

Genetics. 2015 Jun;200(2):569-80. doi: 10.1534/genetics.114.169623.

21.

A transgenic resource for conditional competitive inhibition of conserved Drosophila microRNAs.

Fulga TA, McNeill EM, Binari R, Yelick J, Blanche A, Booker M, Steinkraus BR, Schnall-Levin M, Zhao Y, DeLuca T, Bejarano F, Han Z, Lai EC, Wall DP, Perrimon N, Van Vactor D.

Nat Commun. 2015 Jun 17;6:7279. doi: 10.1038/ncomms8279.

22.

MicroRNA-Dependent Transcriptional Silencing of Transposable Elements in Drosophila Follicle Cells.

Mugat B, Akkouche A, Serrano V, Armenise C, Li B, Brun C, Fulga TA, Van Vactor D, Pélisson A, Chambeyron S.

PLoS Genet. 2015 May 19;11(5):e1005194. doi: 10.1371/journal.pgen.1005194. eCollection 2015 May.

23.

Corrigendum: Cross-talking noncoding RNAs contribute to cell-specific neurodegeneration in SCA7.

Tan JY, Vance KW, Varela MA, Sirey T, Watson LM, Curtis HJ, Marinello M, Alves S, Steinkraus BR, Cooper S, Nesterova T, Brockdorff N, Fulga TA, Brice A, Sittler A, Oliver PL, Wood MJ, Ponting CP, Marques AC.

Nat Struct Mol Biol. 2015 Mar;22(3):272. doi: 10.1038/nsmb0315-272b. No abstract available.

PMID:
25736092
24.

Dysregulation of microRNA-219 promotes neurodegeneration through post-transcriptional regulation of tau.

Santa-Maria I, Alaniz ME, Renwick N, Cela C, Fulga TA, Van Vactor D, Tuschl T, Clark LN, Shelanski ML, McCabe BD, Crary JF.

J Clin Invest. 2015 Feb;125(2):681-6. doi: 10.1172/JCI78421. Epub 2015 Jan 9.

25.

Understanding functional miRNA-target interactions in vivo by site-specific genome engineering.

Bassett AR, Azzam G, Wheatley L, Tibbit C, Rajakumar T, McGowan S, Stanger N, Ewels PA, Taylor S, Ponting CP, Liu JL, Sauka-Spengler T, Fulga TA.

Nat Commun. 2014 Aug 19;5:4640. doi: 10.1038/ncomms5640.

26.

A genome-wide transgenic resource for conditional expression of Drosophila microRNAs.

Bejarano F, Bortolamiol-Becet D, Dai Q, Sun K, Saj A, Chou YT, Raleigh DR, Kim K, Ni JQ, Duan H, Yang JS, Fulga TA, Van Vactor D, Perrimon N, Lai EC.

Development. 2012 Aug;139(15):2821-31. doi: 10.1242/dev.079939. Epub 2012 Jun 28.

27.

miR-132 enhances dendritic morphogenesis, spine density, synaptic integration, and survival of newborn olfactory bulb neurons.

Pathania M, Torres-Reveron J, Yan L, Kimura T, Lin TV, Gordon V, Teng ZQ, Zhao X, Fulga TA, Van Vactor D, Bordey A.

PLoS One. 2012;7(5):e38174. doi: 10.1371/journal.pone.0038174. Epub 2012 May 31.

28.

A neuroprotective role for the DNA damage checkpoint in tauopathy.

Khurana V, Merlo P, DuBoff B, Fulga TA, Sharp KA, Campbell SD, Götz J, Feany MB.

Aging Cell. 2012 Apr;11(2):360-2. doi: 10.1111/j.1474-9726.2011.00778.x. Epub 2012 Feb 1.

29.

Lysosomal dysfunction promotes cleavage and neurotoxicity of tau in vivo.

Khurana V, Elson-Schwab I, Fulga TA, Sharp KA, Loewen CA, Mulkearns E, Tyynelä J, Scherzer CR, Feany MB.

PLoS Genet. 2010 Jul 15;6(7):e1001026. doi: 10.1371/journal.pgen.1001026.

30.

Understanding neuronal connectivity through the post-transcriptional toolkit.

Loya CM, Van Vactor D, Fulga TA.

Genes Dev. 2010 Apr 1;24(7):625-35. doi: 10.1101/gad.1907710. Review.

31.

Transgenic microRNA inhibition with spatiotemporal specificity in intact organisms.

Loya CM, Lu CS, Van Vactor D, Fulga TA.

Nat Methods. 2009 Dec;6(12):897-903. doi: 10.1038/nmeth.1402. Epub 2009 Nov 15.

32.

Modeling spinal muscular atrophy in Drosophila.

Chang HC, Dimlich DN, Yokokura T, Mukherjee A, Kankel MW, Sen A, Sridhar V, Fulga TA, Hart AC, Van Vactor D, Artavanis-Tsakonas S.

PLoS One. 2008 Sep 15;3(9):e3209. doi: 10.1371/journal.pone.0003209.

33.

Synapses and growth cones on two sides of a highwire.

Fulga TA, Van Vactor D.

Neuron. 2008 Feb 7;57(3):339-44. doi: 10.1016/j.neuron.2008.01.016. Review.

34.

Tau phosphorylation sites work in concert to promote neurotoxicity in vivo.

Steinhilb ML, Dias-Santagata D, Fulga TA, Felch DL, Feany MB.

Mol Biol Cell. 2007 Dec;18(12):5060-8. Epub 2007 Oct 10.

35.

Two distinct modes of guidance signalling during collective migration of border cells.

Bianco A, Poukkula M, Cliffe A, Mathieu J, Luque CM, Fulga TA, Rørth P.

Nature. 2007 Jul 19;448(7151):362-5.

PMID:
17637670
36.

Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo.

Fulga TA, Elson-Schwab I, Khurana V, Steinhilb ML, Spires TL, Hyman BT, Feany MB.

Nat Cell Biol. 2007 Feb;9(2):139-48. Epub 2006 Dec 24.

PMID:
17187063
37.

Oxidative stress mediates tau-induced neurodegeneration in Drosophila.

Dias-Santagata D, Fulga TA, Duttaroy A, Feany MB.

J Clin Invest. 2007 Jan;117(1):236-45. Epub 2006 Dec 14.

38.

Senseless makes sense for spinocerebellar ataxia-1.

Khurana V, Fulga TA, Feany MB.

Nat Neurosci. 2005 Nov;8(11):1422-4. No abstract available.

PMID:
16251977
39.

Invasive cell migration is initiated by guided growth of long cellular extensions.

Fulga TA, Rørth P.

Nat Cell Biol. 2002 Sep;4(9):715-9.

PMID:
12198500
40.

Distinct modes of signal recognition particle interaction with the ribosome.

Pool MR, Stumm J, Fulga TA, Sinning I, Dobberstein B.

Science. 2002 Aug 23;297(5585):1345-8.

41.

Crystal structure of PTP-SL/PTPBR7 catalytic domain: implications for MAP kinase regulation.

Szedlacsek SE, Aricescu AR, Fulga TA, Renault L, Scheidig AJ.

J Mol Biol. 2001 Aug 17;311(3):557-68.

PMID:
11493009
42.

SRbeta coordinates signal sequence release from SRP with ribosome binding to the translocon.

Fulga TA, Sinning I, Dobberstein B, Pool MR.

EMBO J. 2001 May 1;20(9):2338-47.

43.

Intramolecular interactions in protein tyrosine phosphatase RPTPmu: kinetic evidence.

Aricescu AR, Fulga TA, Cismasiu V, Goody RS, Szedlacsek SE.

Biochem Biophys Res Commun. 2001 Jan 12;280(1):319-27.

PMID:
11162517

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