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Items: 21


Synthesis, biological characterization and molecular modeling insights of spirochromanes as potent HDAC inhibitors.

Thaler F, Moretti L, Amici R, Abate A, Colombo A, Carenzi G, Fulco MC, Boggio R, Dondio G, Gagliardi S, Minucci S, Sartori L, Varasi M, Mercurio C.

Eur J Med Chem. 2016 Jan 27;108:53-67. doi: 10.1016/j.ejmech.2015.11.010. Epub 2015 Nov 11.


The NAD(+)-dependent SIRT1 deacetylase translates a metabolic switch into regulatory epigenetics in skeletal muscle stem cells.

Ryall JG, Dell'Orso S, Derfoul A, Juan A, Zare H, Feng X, Clermont D, Koulnis M, Gutierrez-Cruz G, Fulco M, Sartorelli V.

Cell Stem Cell. 2015 Feb 5;16(2):171-83. doi: 10.1016/j.stem.2014.12.004. Epub 2015 Jan 15.


Discovery, synthesis, and pharmacological evaluation of spiropiperidine hydroxamic acid based derivatives as structurally novel histone deacetylase (HDAC) inhibitors.

Varasi M, Thaler F, Abate A, Bigogno C, Boggio R, Carenzi G, Cataudella T, Dal Zuffo R, Fulco MC, Rozio MG, Mai A, Dondio G, Minucci S, Mercurio C.

J Med Chem. 2011 Apr 28;54(8):3051-64. doi: 10.1021/jm200146u. Epub 2011 Apr 1.


SirT1 in muscle physiology and disease: lessons from mouse models.

Vinciguerra M, Fulco M, Ladurner A, Sartorelli V, Rosenthal N.

Dis Model Mech. 2010 May-Jun;3(5-6):298-303. doi: 10.1242/dmm.004655. Epub 2010 Mar 30. Review.


Comparing and contrasting the roles of AMPK and SIRT1 in metabolic tissues.

Fulco M, Sartorelli V.

Cell Cycle. 2008 Dec;7(23):3669-79. Epub 2008 Dec 9. Review.


Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt.

Fulco M, Cen Y, Zhao P, Hoffman EP, McBurney MW, Sauve AA, Sartorelli V.

Dev Cell. 2008 May;14(5):661-73. doi: 10.1016/j.devcel.2008.02.004.


Synthesis, molecular modeling studies, and preliminary pharmacological characterization of all possible 2-(2'-sulfonocyclopropyl)glycine stereoisomers as conformationally constrained L-homocysteic acid analogs.

Pellicciari R, Marinozzi M, Macchiarulo A, Fulco MC, Gafarova J, Serpi M, Giorgi G, Nielsen S, Thomsen C.

J Med Chem. 2007 Sep 20;50(19):4630-41. Epub 2007 Aug 29.


Synthesis and preliminary biological evaluation of 2'-substituted 2-(3'-carboxybicyclo[1.1.1]pentyl)glycine derivatives as group I selective metabotropic glutamate receptor ligands.

Pellicciari R, Filosa R, Fulco MC, Marinozzi M, Macchiarulo A, Novak C, Natalini B, Hermit MB, Nielsen S, Sager TN, Stensbøl TB, Thomsen C.

ChemMedChem. 2006 Mar;1(3):358-65.


A role of p73 in mitotic exit.

Merlo P, Fulco M, Costanzo A, Mangiacasale R, Strano S, Blandino G, Taya Y, Lavia P, Levrero M.

J Biol Chem. 2005 Aug 26;280(34):30354-60. Epub 2005 Jun 28.


Molecular and cellular determinants of skeletal muscle atrophy and hypertrophy.

Sartorelli V, Fulco M.

Sci STKE. 2004 Jul 27;2004(244):re11. Review.


Regulation of the p300 HAT domain via a novel activation loop.

Thompson PR, Wang D, Wang L, Fulco M, Pediconi N, Zhang D, An W, Ge Q, Roeder RG, Wong J, Levrero M, Sartorelli V, Cotter RJ, Cole PA.

Nat Struct Mol Biol. 2004 Apr;11(4):308-15. Epub 2004 Mar 7.


p73 is regulated by phosphorylation at the G2/M transition.

Fulco M, Costanzo A, Merlo P, Mangiacasale R, Strano S, Blandino G, Balsano C, Lavia P, Levrero M.

J Biol Chem. 2003 Dec 5;278(49):49196-202. Epub 2003 Aug 13.


Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state.

Fulco M, Schiltz RL, Iezzi S, King MT, Zhao P, Kashiwaya Y, Hoffman E, Veech RL, Sartorelli V.

Mol Cell. 2003 Jul;12(1):51-62. Erratum in: Mol Cell. 2005 Nov 11;20(3):491.


Prevalence and genomic variability of transfusion transmitted virus in Italian cryptogenic chronic liver disease and healthy blood donors.

Artini M, Cariani E, Almerighi C, Fulco M, Rossini A, Pietropaolo L, Stivali G, Montalto G, Caratozzolo M, Girelli G, Grimali E, Costanzo A, Levrero M, Balsano C.

Dig Liver Dis. 2002 Aug;34(8):570-6.


DNA damage-dependent acetylation of p73 dictates the selective activation of apoptotic target genes.

Costanzo A, Merlo P, Pediconi N, Fulco M, Sartorelli V, Cole PA, Fontemaggi G, Fanciulli M, Schiltz L, Blandino G, Balsano C, Levrero M.

Mol Cell. 2002 Jan;9(1):175-86.


Evaluation by ultrasound of abdominal lymphadenopathy in chronic hepatitis C.

Soresi M, Carroccio A, Agate V, Bonfissuto GD, Magliarisi C, Fulco M, Aragona F, Montalto G.

Am J Gastroenterol. 1999 Feb;94(2):497-501.


Comparative responses to three different types of interferon-alpha in patients with chronic hepatitis C.

Montalto G, Soresi M, Carroccio A, Anastasi G, Campagna P, Vasile F, Di Prima L, Cartabellotta A, Giannitrapani L, Fulco M.

Curr Med Res Opin. 1998;14(4):235-41.


The hepatitis B virus HBx protein inhibits caspase 3 activity.

Gottlob K, Fulco M, Levrero M, Graessmann A.

J Biol Chem. 1998 Dec 11;273(50):33347-53. Erratum in: J Biol Chem. 2013 Nov 1;288(44):31915.


Intravenous natural beta-interferon in white patients with chronic hepatitis C who are nonresponders to alpha-interferon.

Montalto G, Tripi S, Cartabellotta A, Fulco M, Soresi M, Di Gaetano G, Carroccio A, Levrero M.

Am J Gastroenterol. 1998 Jun;93(6):950-3.


Regulation of E2F4 mitogenic activity during terminal differentiation by its heterodimerization partners for nuclear translocation.

Puri PL, Cimino L, Fulco M, Zimmerman C, La Thangue NB, Giordano A, Graessmann A, Levrero M.

Cancer Res. 1998 Apr 1;58(7):1325-31.

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