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Interaction of Quinone-Related Electron Acceptors with Hydropersulfide Na2S2: Evidence for One-Electron Reduction Reaction.

Abiko Y, Nakai Y, Luong NC, Bianco CL, Fukuto JM, Kumagai Y.

Chem Res Toxicol. 2019 Apr 15;32(4):551-556. doi: 10.1021/acs.chemrestox.8b00158. Epub 2019 Feb 15.


The Uptake and Release of Polysulfur Cysteine Species by Cells: Physiological and Toxicological Implications.

Lin J, Akiyama M, Bica I, Long FT, Henderson CF, Goddu RN, Suarez V, Baker B, Ida T, Shinkai Y, Nagy P, Akaike T, Fukuto JM, Kumagai Y.

Chem Res Toxicol. 2019 Mar 18;32(3):447-455. doi: 10.1021/acs.chemrestox.8b00340. Epub 2019 Feb 7.


Polysulfide stabilization by tyrosine and hydroxyphenyl-containing derivatives that is important for a reactive sulfur metabolomics analysis.

Hamid HA, Tanaka A, Ida T, Nishimura A, Matsunaga T, Fujii S, Morita M, Sawa T, Fukuto JM, Nagy P, Tsutsumi R, Motohashi H, Ihara H, Akaike T.

Redox Biol. 2019 Feb;21:101096. doi: 10.1016/j.redox.2019.101096. Epub 2019 Jan 2.


The reaction of alkyl hydropersulfides (RSSH, R = CH3 and tBu) with H2S in the gas phase and in aqueous solution.

Zhang L, Zhang X, Wu YD, Xie Y, Fukuto JM, Schaefer HF.

Phys Chem Chem Phys. 2019 Jan 2;21(2):537-545. doi: 10.1039/c8cp05503c.


Chronic exposure of the RAW246.7 macrophage cell line to H2O2 leads to increased catalase expression.

Goddu RN, Henderson CF, Young AK, Muradian BE, Calderon L, Bleeg LH, Fukuto JM, Lin J.

Free Radic Biol Med. 2018 Oct;126:67-72. doi: 10.1016/j.freeradbiomed.2018.07.021. Epub 2018 Jul 29.


Speciation of reactive sulfur species and their reactions with alkylating agents: do we have any clue about what is present inside the cell?

Bogdándi V, Ida T, Sutton TR, Bianco C, Ditrói T, Koster G, Henthorn HA, Minnion M, Toscano JP, van der Vliet A, Pluth MD, Feelisch M, Fukuto JM, Akaike T, Nagy P.

Br J Pharmacol. 2019 Feb;176(4):646-670. doi: 10.1111/bph.14394. Epub 2018 Aug 23.


A recent history of nitroxyl chemistry, pharmacology and therapeutic potential.

Fukuto JM.

Br J Pharmacol. 2019 Jan;176(2):135-146. doi: 10.1111/bph.14384. Epub 2018 Jul 1. Review.


The reaction of hydrogen sulfide with disulfides: formation of a stable trisulfide and implications for biological systems.

Bianco CL, Akaike T, Ida T, Nagy P, Bogdandi V, Toscano JP, Kumagai Y, Henderson CF, Goddu RN, Lin J, Fukuto JM.

Br J Pharmacol. 2019 Feb;176(4):671-683. doi: 10.1111/bph.14372. Epub 2018 Jun 28.


Biological hydropersulfides and related polysulfides - a new concept and perspective in redox biology.

Fukuto JM, Ignarro LJ, Nagy P, Wink DA, Kevil CG, Feelisch M, Cortese-Krott MM, Bianco CL, Kumagai Y, Hobbs AJ, Lin J, Ida T, Akaike T.

FEBS Lett. 2018 Jun;592(12):2140-2152. doi: 10.1002/1873-3468.13090. Epub 2018 May 24. Review.


Mechanisms of myeloperoxidase catalyzed oxidation of H2S by H2O2 or O2 to produce potent protein Cys-polysulfide-inducing species.

Garai D, Ríos-González BB, Furtmüller PG, Fukuto JM, Xian M, López-Garriga J, Obinger C, Nagy P.

Free Radic Biol Med. 2017 Dec;113:551-563. doi: 10.1016/j.freeradbiomed.2017.10.384. Epub 2017 Oct 31.


Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics.

Akaike T, Ida T, Wei FY, Nishida M, Kumagai Y, Alam MM, Ihara H, Sawa T, Matsunaga T, Kasamatsu S, Nishimura A, Morita M, Tomizawa K, Nishimura A, Watanabe S, Inaba K, Shima H, Tanuma N, Jung M, Fujii S, Watanabe Y, Ohmuraya M, Nagy P, Feelisch M, Fukuto JM, Motohashi H.

Nat Commun. 2017 Oct 27;8(1):1177. doi: 10.1038/s41467-017-01311-y.


Cysteine perthiosulfenic acid (Cys-SSOH): A novel intermediate in thiol-based redox signaling?

Heppner DE, Hristova M, Ida T, Mijuskovic A, Dustin CM, Bogdándi V, Fukuto JM, Dick TP, Nagy P, Li J, Akaike T, van der Vliet A.

Redox Biol. 2018 Apr;14:379-385. doi: 10.1016/j.redox.2017.10.006. Epub 2017 Oct 9.


Chemical Biology of Hydropersulfides and Related Species: Possible Roles in Cellular Protection and Redox Signaling.

Álvarez L, Bianco CL, Toscano JP, Lin J, Akaike T, Fukuto JM.

Antioxid Redox Signal. 2017 Oct 1;27(10):622-633. doi: 10.1089/ars.2017.7081. Epub 2017 Jun 13. Review.


The Reactive Species Interactome: Evolutionary Emergence, Biological Significance, and Opportunities for Redox Metabolomics and Personalized Medicine.

Cortese-Krott MM, Koning A, Kuhnle GGC, Nagy P, Bianco CL, Pasch A, Wink DA, Fukuto JM, Jackson AA, van Goor H, Olson KR, Feelisch M.

Antioxid Redox Signal. 2017 Oct 1;27(10):684-712. doi: 10.1089/ars.2017.7083. Epub 2017 Jun 6. Review.


The chemical biology of the persulfide (RSSH)/perthiyl (RSS·) redox couple and possible role in biological redox signaling.

Bianco CL, Chavez TA, Sosa V, Saund SS, Nguyen QNN, Tantillo DJ, Ichimura AS, Toscano JP, Fukuto JM.

Free Radic Biol Med. 2016 Dec;101:20-31. doi: 10.1016/j.freeradbiomed.2016.09.020. Epub 2016 Sep 25.


Selenols are resistant to irreversible modification by HNO.

Bianco CL, Moore CD, Fukuto JM, Toscano JP.

Free Radic Biol Med. 2016 Oct;99:71-78. doi: 10.1016/j.freeradbiomed.2016.07.008. Epub 2016 Jul 14.


Carbon disulfide. Just toxic or also bioregulatory and/or therapeutic?

DeMartino AW, Zigler DF, Fukuto JM, Ford PC.

Chem Soc Rev. 2017 Jan 3;46(1):21-39. doi: 10.1039/c6cs00585c. Review.


The chemical biology of HNO signaling.

Bianco CL, Toscano JP, Bartberger MD, Fukuto JM.

Arch Biochem Biophys. 2017 Mar 1;617:129-136. doi: 10.1016/ Epub 2016 Aug 20. Review.


The chemical biology of protein hydropersulfides: Studies of a possible protective function of biological hydropersulfide generation.

Millikin R, Bianco CL, White C, Saund SS, Henriquez S, Sosa V, Akaike T, Kumagai Y, Soeda S, Toscano JP, Lin J, Fukuto JM.

Free Radic Biol Med. 2016 Aug;97:136-147. doi: 10.1016/j.freeradbiomed.2016.05.013. Epub 2016 May 27.


The chemical biology of hydropersulfides (RSSH): Chemical stability, reactivity and redox roles.

Saund SS, Sosa V, Henriquez S, Nguyen QN, Bianco CL, Soeda S, Millikin R, White C, Le H, Ono K, Tantillo DJ, Kumagai Y, Akaike T, Lin J, Fukuto JM.

Arch Biochem Biophys. 2015 Dec 15;588:15-24. doi: 10.1016/ Epub 2015 Nov 5.


Examining the reaction of NO and H2S and the possible cross-talk between the two signaling pathways.

Bianco CL, Fukuto JM.

Proc Natl Acad Sci U S A. 2015 Aug 25;112(34):10573-4. doi: 10.1073/pnas.1513510112. Epub 2015 Aug 12. No abstract available.


Signaling and stress: The redox landscape in NOS2 biology.

Thomas DD, Heinecke JL, Ridnour LA, Cheng RY, Kesarwala AH, Switzer CH, McVicar DW, Roberts DD, Glynn S, Fukuto JM, Wink DA, Miranda KM.

Free Radic Biol Med. 2015 Oct;87:204-25. doi: 10.1016/j.freeradbiomed.2015.06.002. Epub 2015 Jun 24. Review.


Persulfides: current knowledge and challenges in chemistry and chemical biology.

Park CM, Weerasinghe L, Day JJ, Fukuto JM, Xian M.

Mol Biosyst. 2015 Jul;11(7):1775-85. doi: 10.1039/c5mb00216h. Review.


Involvement of reactive persulfides in biological bismethylmercury sulfide formation.

Abiko Y, Yoshida E, Ishii I, Fukuto JM, Akaike T, Kumagai Y.

Chem Res Toxicol. 2015 Jun 15;28(6):1301-6. doi: 10.1021/acs.chemrestox.5b00101. Epub 2015 Apr 29.


Redox chemistry and chemical biology of H2S, hydropersulfides, and derived species: implications of their possible biological activity and utility.

Ono K, Akaike T, Sawa T, Kumagai Y, Wink DA, Tantillo DJ, Hobbs AJ, Nagy P, Xian M, Lin J, Fukuto JM.

Free Radic Biol Med. 2014 Dec;77:82-94. doi: 10.1016/j.freeradbiomed.2014.09.007. Epub 2014 Sep 16. Review.


Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling.

Ida T, Sawa T, Ihara H, Tsuchiya Y, Watanabe Y, Kumagai Y, Suematsu M, Motohashi H, Fujii S, Matsunaga T, Yamamoto M, Ono K, Devarie-Baez NO, Xian M, Fukuto JM, Akaike T.

Proc Natl Acad Sci U S A. 2014 May 27;111(21):7606-11. doi: 10.1073/pnas.1321232111. Epub 2014 Apr 14.


Controlled free radical attack in the apoplast: a hypothesis for roles of O, N and S species in regulatory and polysaccharide cleavage events during rapid abscission by Azolla.

Cohen MF, Gurung S, Fukuto JM, Yamasaki H.

Plant Sci. 2014 Mar;217-218:120-6. doi: 10.1016/j.plantsci.2013.12.008. Epub 2013 Dec 16. Review.


Production of reactive oxygen and nitrogen species by light irradiation of a nitrosyl phthalocyanine ruthenium complex as a strategy for cancer treatment.

Heinrich TA, Tedesco AC, Fukuto JM, da Silva RS.

Dalton Trans. 2014 Mar 14;43(10):4021-5. doi: 10.1039/c3dt52217b.


The effects of nitroxyl (HNO) on H₂O₂ metabolism and possible mechanisms of HNO signaling.

Jackson MI, Fields HF, Lujan TS, Cantrell MM, Lin J, Fukuto JM.

Arch Biochem Biophys. 2013 Oct 15;538(2):120-9. doi: 10.1016/ Epub 2013 Aug 26.


Biological nitric oxide signalling: chemistry and terminology.

Heinrich TA, da Silva RS, Miranda KM, Switzer CH, Wink DA, Fukuto JM.

Br J Pharmacol. 2013 Aug;169(7):1417-29. doi: 10.1111/bph.12217. Review.


Synthesis and characterization of lithium oxonitrate (LiNO).

Switzer CH, Miller TW, Farmer PJ, Fukuto JM.

J Inorg Biochem. 2013 Jan;118:128-33. doi: 10.1016/j.jinorgbio.2012.09.022. Epub 2012 Oct 6.


A comparison of the chemistry associated with the biological signaling and actions of nitroxyl (HNO) and nitric oxide (NO).

Fukuto JM, Cisneros CJ, Kinkade RL.

J Inorg Biochem. 2013 Jan;118:201-8. doi: 10.1016/j.jinorgbio.2012.08.027. Epub 2012 Oct 5. Review.


Small molecule signaling agents: the integrated chemistry and biochemistry of nitrogen oxides, oxides of carbon, dioxygen, hydrogen sulfide, and their derived species.

Fukuto JM, Carrington SJ, Tantillo DJ, Harrison JG, Ignarro LJ, Freeman BA, Chen A, Wink DA.

Chem Res Toxicol. 2012 Apr 16;25(4):769-93. doi: 10.1021/tx2005234. Epub 2012 Feb 9. Review.


The diversity of microbial responses to nitric oxide and agents of nitrosative stress close cousins but not identical twins.

Bowman LA, McLean S, Poole RK, Fukuto JM.

Adv Microb Physiol. 2011;59:135-219. doi: 10.1016/B978-0-12-387661-4.00006-9. Review.


The reaction of H(2)S with oxidized thiols: generation of persulfides and implications to H(2)S biology.

Francoleon NE, Carrington SJ, Fukuto JM.

Arch Biochem Biophys. 2011 Dec 15;516(2):146-53. doi: 10.1016/ Epub 2011 Oct 6.


HNO signaling mechanisms.

Fukuto JM, Carrington SJ.

Antioxid Redox Signal. 2011 May 1;14(9):1649-57. doi: 10.1089/ars.2010.3855. Epub 2011 Mar 2. Review.


The specificity of nitroxyl chemistry is unique among nitrogen oxides in biological systems.

Flores-Santana W, Salmon DJ, Donzelli S, Switzer CH, Basudhar D, Ridnour L, Cheng R, Glynn SA, Paolocci N, Fukuto JM, Miranda KM, Wink DA.

Antioxid Redox Signal. 2011 May 1;14(9):1659-74. doi: 10.1089/ars.2010.3841. Epub 2011 Mar 16. Review.


Reactions of HNO with heme proteins: new routes to HNO-heme complexes and insight into physiological effects.

Kumar MR, Fukuto JM, Miranda KM, Farmer PJ.

Inorg Chem. 2010 Jul 19;49(14):6283-92. doi: 10.1021/ic902319d.


Nitric oxide photogeneration from trans-Cr(cyclam)(ONO)(2)(+) in a reducing environment. activation of soluble guanylyl cyclase and arterial vasorelaxation.

Ostrowski AD, Deakin SJ, Azhar B, Miller TW, Franco N, Cherney MM, Lee AJ, Burstyn JN, Fukuto JM, Megson IL, Ford PC.

J Med Chem. 2010 Jan 28;53(2):715-22. doi: 10.1021/jm9013357.


Comparing the chemical biology of NO and HNO.

Flores-Santana W, Switzer C, Ridnour LA, Basudhar D, Mancardi D, Donzelli S, Thomas DD, Miranda KM, Fukuto JM, Wink DA.

Arch Pharm Res. 2009 Aug;32(8):1139-53. doi: 10.1007/s12272-009-1805-x. Epub 2009 Aug 29.


Kinetic feasibility of nitroxyl reduction by physiological reductants and biological implications.

Jackson MI, Han TH, Serbulea L, Dutton A, Ford E, Miranda KM, Houk KN, Wink DA, Fukuto JM.

Free Radic Biol Med. 2009 Oct 15;47(8):1130-9. doi: 10.1016/j.freeradbiomed.2009.06.034. Epub 2009 Jul 2.


Nitroxyl (HNO) signaling.

Fukuto JM, Bianco CL, Chavez TA.

Free Radic Biol Med. 2009 Nov 1;47(9):1318-24. doi: 10.1016/j.freeradbiomed.2009.06.014. Epub 2009 Jun 17. Review.


The effects of nitroxyl (HNO) on soluble guanylate cyclase activity: interactions at ferrous heme and cysteine thiols.

Miller TW, Cherney MM, Lee AJ, Francoleon NE, Farmer PJ, King SB, Hobbs AJ, Miranda KM, Burstyn JN, Fukuto JM.

J Biol Chem. 2009 Aug 14;284(33):21788-96. doi: 10.1074/jbc.M109.014282. Epub 2009 Jun 15.


The emergence of nitroxyl (HNO) as a pharmacological agent.

Switzer CH, Flores-Santana W, Mancardi D, Donzelli S, Basudhar D, Ridnour LA, Miranda KM, Fukuto JM, Paolocci N, Wink DA.

Biochim Biophys Acta. 2009 Jul;1787(7):835-40. doi: 10.1016/j.bbabio.2009.04.015. Epub 2009 May 6. Review.


The chemistry of cell signaling by reactive oxygen and nitrogen species and 4-hydroxynonenal.

Forman HJ, Fukuto JM, Miller T, Zhang H, Rinna A, Levy S.

Arch Biochem Biophys. 2008 Sep 15;477(2):183-95. doi: 10.1016/ Epub 2008 Jun 24. Review.


Increased susceptibility of breast cancer cells to stress mediated inhibition of protein synthesis.

Pervin S, Tran AH, Zekavati S, Fukuto JM, Singh R, Chaudhuri G.

Cancer Res. 2008 Jun 15;68(12):4862-74. doi: 10.1158/0008-5472.CAN-08-0074.


Thiol chemistry in peroxidase catalysis and redox signaling.

Bindoli A, Fukuto JM, Forman HJ.

Antioxid Redox Signal. 2008 Sep;10(9):1549-64. doi: 10.1089/ars.2008.2063. Review.


Examining nitroxyl in biological systems.

Fukuto JM, Jackson MI, Kaludercic N, Paolocci N.

Methods Enzymol. 2008;440:411-31. doi: 10.1016/S0076-6879(07)00826-9. Review.


Nitroxyl inhibits breast tumor growth and angiogenesis.

Norris AJ, Sartippour MR, Lu M, Park T, Rao JY, Jackson MI, Fukuto JM, Brooks MN.

Int J Cancer. 2008 Apr 15;122(8):1905-10.


Interactive endogenous small molecule (gaseous) signaling: implications for teratogenesis.

Fukuto JM, Collins MD.

Curr Pharm Des. 2007;13(29):2952-78. Review.


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