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Items: 1 to 50 of 80

1.

CD45+CD326+ Cells are Predictive of Poor Prognosis in Non-Small Cell Lung Cancer Patients.

Ishizawa K, Yamanaka M, Saiki Y, Miyauchi E, Fukushige S, Akaishi T, Asao A, Mimori T, Saito R, Tojo Y, Yamashita R, Abe M, Sakurada A, Pham NA, Li M, Okada Y, Ishii T, Ishii N, Kobayashi S, Nagasaki M, Ichinose M, Tsao MS, Horii A.

Clin Cancer Res. 2019 Nov 15;25(22):6756-6763. doi: 10.1158/1078-0432.CCR-19-0545. Epub 2019 Aug 5.

PMID:
31383733
2.

Expression of SNAIL in accompanying PanIN is a key prognostic indicator in pancreatic ductal adenocarcinomas.

Fujiwara S, Saiki Y, Ishizawa K, Fukushige S, Yamanaka M, Sato M, Ishida M, Motoi F, Unno M, Horii A.

Cancer Med. 2019 Apr;8(4):1671-1678. doi: 10.1002/cam4.2016. Epub 2019 Feb 21.

3.

S100A10 upregulation associates with poor prognosis in lung squamous cell carcinoma.

Sato K, Saiki Y, Arai K, Ishizawa K, Fukushige S, Aoki K, Abe J, Takahashi S, Sato I, Sakurada A, Okada Y, Horii A.

Biochem Biophys Res Commun. 2018 Oct 28;505(2):466-470. doi: 10.1016/j.bbrc.2018.09.118. Epub 2018 Sep 27.

PMID:
30268496
4.

NDRG2, suppressed expression associates with poor prognosis in pancreatic cancer, is hypermethylated in the second promoter in human gastrointestinal cancers.

Yamamura A, Miura K, Karasawa H, Motoi F, Mizuguchi Y, Saiki Y, Fukushige S, Sunamura M, Shibata C, Unno M, Horii A.

Biochem Biophys Res Commun. 2017 Feb 26;484(1):138-143. doi: 10.1016/j.bbrc.2017.01.055. Epub 2017 Jan 16.

PMID:
28093228
5.

Atrial natriuretic peptide induces peroxisome proliferator activated receptor γ during cardiac ischemia-reperfusion in swine heart.

Suzuki T, Saiki Y, Horii A, Fukushige S, Kawamoto S, Adachi O, Akiyama M, Ito K, Masaki N, Saiki Y.

Gen Thorac Cardiovasc Surg. 2017 Feb;65(2):85-95. doi: 10.1007/s11748-016-0704-6. Epub 2016 Aug 10.

PMID:
27510704
6.

Targeted TET oxidase activity through methyl-CpG-binding domain extensively suppresses cancer cell proliferation.

Mizuguchi Y, Saiki Y, Horii A, Fukushige S.

Cancer Med. 2016 Sep;5(9):2522-33. doi: 10.1002/cam4.830. Epub 2016 Jul 25.

7.

Technological advances in epigenomics lead to a better understanding of inflammatory diseases, decitabine and H3K27me3.

Fukushige S, Horii A.

Epigenomics. 2015;7(2):133-6. doi: 10.2217/epi.14.90. No abstract available.

PMID:
25942529
8.

Single-dose rosuvastatin ameliorates lung ischemia-reperfusion injury via upregulation of endothelial nitric oxide synthase and inhibition of macrophage infiltration in rats with pulmonary hypertension.

Matsuo S, Saiki Y, Adachi O, Kawamoto S, Fukushige S, Horii A, Saiki Y.

J Thorac Cardiovasc Surg. 2015 Mar;149(3):902-9. doi: 10.1016/j.jtcvs.2014.10.030. Epub 2014 Oct 15.

9.

Highlights from the latest articles in epigenomics.

Fukushige S, Horii A.

Epigenomics. 2014 Apr;6(2):171-3. doi: 10.2217/epi.14.2. No abstract available.

PMID:
24811785
10.

S100A4 is frequently overexpressed in lung cancer cells and promotes cell growth and cell motility.

Chen N, Sato D, Saiki Y, Sunamura M, Fukushige S, Horii A.

Biochem Biophys Res Commun. 2014 May 9;447(3):459-64. doi: 10.1016/j.bbrc.2014.04.025. Epub 2014 Apr 13.

PMID:
24732359
11.

Suppressed expression of NDRG2 correlates with poor prognosis in pancreatic cancer.

Yamamura A, Miura K, Karasawa H, Morishita K, Abe K, Mizuguchi Y, Saiki Y, Fukushige S, Kaneko N, Sase T, Nagase H, Sunamura M, Motoi F, Egawa S, Shibata C, Unno M, Sasaki I, Horii A.

Biochem Biophys Res Commun. 2013 Nov 8;441(1):102-7. doi: 10.1016/j.bbrc.2013.10.010. Epub 2013 Oct 14.

PMID:
24134849
12.

DNA methylation in cancer: a gene silencing mechanism and the clinical potential of its biomarkers.

Fukushige S, Horii A.

Tohoku J Exp Med. 2013 Mar;229(3):173-85. Review.

13.

S100A4, frequently overexpressed in various human cancers, accelerates cell motility in pancreatic cancer cells.

Sekine H, Chen N, Sato K, Saiki Y, Yoshino Y, Umetsu Y, Jin G, Nagase H, Gu Z, Fukushige S, Sunamura M, Horii A.

Biochem Biophys Res Commun. 2012 Dec 14;429(3-4):214-9. doi: 10.1016/j.bbrc.2012.10.048. Epub 2012 Oct 19.

PMID:
23085231
14.

miR-34a is downregulated in cis-diamminedichloroplatinum treated sinonasal squamous cell carcinoma patients with poor prognosis.

Ogawa T, Saiki Y, Shiga K, Chen N, Fukushige S, Sunamura M, Nagase H, Hashimoto S, Matsuura K, Saijo S, Kobayashi T, Horii A.

Cancer Sci. 2012 Sep;103(9):1737-43. doi: 10.1111/j.1349-7006.2012.02338.x. Epub 2012 Jul 6.

15.

DCK is frequently inactivated in acquired gemcitabine-resistant human cancer cells.

Saiki Y, Yoshino Y, Fujimura H, Manabe T, Kudo Y, Shimada M, Mano N, Nakano T, Lee Y, Shimizu S, Oba S, Fujiwara S, Shimizu H, Chen N, Nezhad ZK, Jin G, Fukushige S, Sunamura M, Ishida M, Motoi F, Egawa S, Unno M, Horii A.

Biochem Biophys Res Commun. 2012 Apr 27;421(1):98-104. doi: 10.1016/j.bbrc.2012.03.122. Epub 2012 Apr 3.

PMID:
22490663
16.

Road to early detection of pancreatic cancer: Attempts to utilize epigenetic biomarkers.

Fukushige S, Horii A.

Cancer Lett. 2014 Jan 28;342(2):231-7. doi: 10.1016/j.canlet.2012.03.022. Epub 2012 Mar 23. Review.

PMID:
22450751
17.

Identification of epigenetically silenced genes in human pancreatic cancer by a novel method "microarray coupled with methyl-CpG targeted transcriptional activation" (MeTA-array).

Shimizu H, Horii A, Sunamura M, Motoi F, Egawa S, Unno M, Fukushige S.

Biochem Biophys Res Commun. 2011 Jul 22;411(1):162-7. doi: 10.1016/j.bbrc.2011.06.121. Epub 2011 Jun 23.

PMID:
21723258
19.

CaMKII phosphorylates serine 10 of p27 and confers apoptosis resistance to HeLa cells.

Kajihara R, Fukushige S, Shioda N, Tanabe K, Fukunaga K, Inui S.

Biochem Biophys Res Commun. 2010 Oct 22;401(3):350-5. doi: 10.1016/j.bbrc.2010.09.051. Epub 2010 Sep 17.

PMID:
20851109
20.

Methyl-CpG targeted recruitment of p300 reactivates tumor suppressor genes in human cancer cells.

Fukushige S, Kondo E, Horii A.

Biochem Biophys Res Commun. 2009 Feb 20;379(4):1021-6. doi: 10.1016/j.bbrc.2009.01.010. Epub 2009 Jan 13.

PMID:
19146826
21.

Methyl-CpG targeted transcriptional activation allows re-expression of tumor suppressor genes in human cancer cells.

Fukushige S, Kondo E, Horii A.

Biochem Biophys Res Commun. 2008 Dec 12;377(2):600-605. doi: 10.1016/j.bbrc.2008.10.016. Epub 2008 Oct 16.

PMID:
18929535
22.

Involvement of CREM in CYP1A1 induction through ligand-independent activation pathway of aryl hydrocarbon receptor in HepG2 cells.

Sasamori E, Shimoyama S, Fukushige S, Kikuchi H.

Arch Biochem Biophys. 2008 Oct 1;478(1):26-35. doi: 10.1016/j.abb.2008.07.021. Epub 2008 Jul 31.

PMID:
18700132
23.

The interplay between hMLH1 and hMRE11: role in MMR and the effect of hMLH1 mutations.

Zhao N, Zhu F, Yuan F, Haick AK, Fukushige S, Gu L, Her C.

Biochem Biophys Res Commun. 2008 May 30;370(2):338-43. doi: 10.1016/j.bbrc.2008.03.082. Epub 2008 Mar 26.

24.

RET finger protein enhances MBD2- and MBD4-dependent transcriptional repression.

Fukushige S, Kondo E, Gu Z, Suzuki H, Horii A.

Biochem Biophys Res Commun. 2006 Dec 8;351(1):85-92. Epub 2006 Oct 10.

PMID:
17049487
25.

Comparative genomic hybridization and mutation analyses of sporadic schwannomas.

Ikeda T, Hashimoto S, Fukushige S, Ohmori H, Horii A.

J Neurooncol. 2005 May;72(3):225-30.

PMID:
15937644
26.
27.

The ability of Sgs1 to interact with DNA topoisomerase III is essential for damage-induced recombination.

Ui A, Seki M, Ogiwara H, Onodera R, Fukushige S, Onoda F, Enomoto T.

DNA Repair (Amst). 2005 Feb 3;4(2):191-201.

PMID:
15590327
28.

The role of chromosome 18 abnormalities in the progression of pancreatic adenocarcinoma.

Sunamura M, Lefter LP, Duda DG, Morita R, Inoue H, Yokoyama T, Yatsuoka T, Abe T, Egawa S, Furukawa T, Fukushige S, Oshimura M, Horii A, Matsuno S.

Pancreas. 2004 Apr;28(3):311-6.

PMID:
15084978
29.

DSCP1, a novel TP53-inducible gene, is upregulated by strong genotoxic stresses and its overexpression inhibits tumor cell growth in vitro.

Hata T, Ogawa T, Yokoyama TA, Fukushige S, Horii A, Furukawa T.

Int J Oncol. 2004 Mar;24(3):513-20.

PMID:
14767535
30.

A yeast two-hybrid assay provides a simple way to evaluate the vast majority of hMLH1 germ-line mutations.

Kondo E, Suzuki H, Horii A, Fukushige S.

Cancer Res. 2003 Jun 15;63(12):3302-8.

31.

Presence on human chromosome 10 of omeprazole-sensitivity gene whose product mediates CYP1A1 induction.

Kikuchi H, Fukushige S, Shibazaki M, Shiratori Y.

Cytogenet Genome Res. 2002;97(1-2):51-7.

PMID:
12438738
32.

Isolation and characterization of the human gene homologous to the Drosophila headcase (hdc) gene in chromosome bands 6q23-q24, a region of common deletion in human pancreatic cancer.

Makino N, Yamato T, Inoue H, Furukawa T, Abe T, Yokoyama T, Yatsuoka T, Fukushige S, Orikasa S, Takahashi T, Horii A.

DNA Seq. 2001;11(6):547-53.

PMID:
11696983
34.

Association of poor prognosis with loss of 12q, 17p, and 18q, and concordant loss of 6q/17p and 12q/18q in human pancreatic ductal adenocarcinoma.

Yatsuoka T, Sunamura M, Furukawa T, Fukushige S, Yokoyama T, Inoue H, Shibuya K, Takeda K, Matsuno S, Horii A.

Am J Gastroenterol. 2000 Aug;95(8):2080-5.

PMID:
10950061
35.

Not hMSH2 but hMLH1 is frequently silenced by hypermethylation in endometrial cancer but rarely silenced in pancreatic cancer with microsatellite instability.

Kondo E, Furukawa T, Yoshinaga K, Kijima H, Semba S, Yatsuoka T, Yokoyama T, Fukushige S, Horii A.

Int J Oncol. 2000 Sep;17(3):535-41.

PMID:
10938395
36.

Frequent loss of copy number on the long arm of chromosome 21 in human esophageal squamous cell carcinoma.

Mayama T, Fukushige S, Shineha R, Nishihira T, Satomi S, Horii A.

Int J Oncol. 2000 Aug;17(2):245-52.

PMID:
10891531
37.

p24/ING1-ALT1 and p47/ING1-ALT2, distinct alternative transcripts of p33/ING1.

Saito A, Furukawa T, Fukushige S, Koyama S, Hoshi M, Hayashi Y, Horii A.

J Hum Genet. 2000;45(3):177-81.

PMID:
10807544
38.

Isolation and characterization of the novel gene, TU3A, in a commonly deleted region on 3p14.3-->p14.2 in renal cell carcinoma.

Yamato T, Orikasa K, Fukushige S, Orikasa S, Horii A.

Cytogenet Cell Genet. 1999;87(3-4):291-5.

PMID:
10702698
39.

Cloning and characterization of the human UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IV-homologue (hGnT-IV-H) gene.

Furukawa T, Youssef EM, Yatsuoka T, Yokoyama T, Makino N, Inoue H, Fukushige S, Hoshi M, Hayashi Y, Sunamura M, Horii A.

J Hum Genet. 1999;44(6):397-401.

PMID:
10570912
40.

Adenovirus-mediated delivery of the PTEN gene inhibits cell growth by induction of apoptosis in endometrial cancer.

Sakurada A, Hamada H, Fukushige S, Yokoyama T, Yoshinaga K, Furukawa T, Sato S, Yajima A, Sato M, Fujimura S, Horii A.

Int J Oncol. 1999 Dec;15(6):1069-74.

PMID:
10568810
41.

Identification of a 5-cM region of common allelic loss on 8p12-p21 in human breast cancer and genomic analysis of the hEXT1L/EXTR1/EXTL3 gene in this locus.

Suzuki A, Shao X, Song XQ, Hanaoka T, Irie S, Kashiwada M, Samara G, Close LG, Aoki T, Fujimori M, Ishikawa Y, Hatori M, Hosaka M, Sakurada A, Sato M, Ohuchi N, Satomi S, Fukushige S, Horii A, Sato T.

Int J Oncol. 1999 Sep;15(3):443-51.

PMID:
10427123
42.

Chromosome band 16q24 is frequently deleted in human gastric cancer.

Mori Y, Matsunaga M, Abe T, Fukushige S, Miura K, Sunamura M, Shiiba K, Sato M, Nukiwa T, Horii A.

Br J Cancer. 1999 May;80(3-4):556-62.

43.

Identification of three commonly deleted regions on chromosome arm 6q in human pancreatic cancer.

Abe T, Makino N, Furukawa T, Ouyang H, Kimura M, Yatsuoka T, Yokoyama T, Inoue H, Fukushige S, Hoshi M, Hayashi Y, Sunamura M, Kobari M, Matsuno S, Horii A.

Genes Chromosomes Cancer. 1999 May;25(1):60-4. Erratum in: Genes Chromosomes Cancer 2000 Sep;29(1):88.

PMID:
10221341
44.

Infrequent somatic mutations of the p73 gene in various human cancers.

Han S, Semba S, Abe T, Makino N, Furukawa T, Fukushige S, Takahashi H, Sakurada A, Sato M, Shiiba K, Matsuno S, Nimura Y, Nakagawara A, Horii A.

Eur J Surg Oncol. 1999 Apr;25(2):194-8.

PMID:
10218465
45.

The human PMS2L proteins do not interact with hMLH1, a major DNA mismatch repair protein.

Kondo E, Horii A, Fukushige S.

J Biochem. 1999 Apr;125(4):818-25.

46.

Genomic analysis of DUSP6, a dual specificity MAP kinase phosphatase, in pancreatic cancer.

Furukawa T, Yatsuoka T, Youssef EM, Abe T, Yokoyama T, Fukushige S, Soeda E, Hoshi M, Hayashi Y, Sunamura M, Kobari M, Horii A.

Cytogenet Cell Genet. 1998;82(3-4):156-9.

PMID:
9858808
47.

Infrequent genetic alterations of the PTEN gene in Japanese patients with sporadic prostate cancer.

Orikasa K, Fukushige S, Hoshi S, Orikasa S, Kondo K, Miyoshi Y, Kubota Y, Horii A.

J Hum Genet. 1998;43(4):228-30.

PMID:
9852672
48.

Loss of chromosome 18q is an early event in pancreatic ductal tumorigenesis.

Fukushige S, Furukawa T, Satoh K, Sunamura M, Kobari M, Koizumi M, Horii A.

Cancer Res. 1998 Oct 1;58(19):4222-6.

49.

Identification of a 910-kb region of common allelic loss in chromosome bands 16q24.1-q24.2 in human lung cancer.

Sato M, Mori Y, Sakurada A, Fukushige S, Ishikawa Y, Tsuchiya E, Saito Y, Nukiwa T, Fujimura S, Horii A.

Genes Chromosomes Cancer. 1998 May;22(1):1-8.

PMID:
9591628
50.

Alternative splicing of GTBP in normal human tissues.

Shiwaku HO, Wakatsuki S, Mori Y, Fukushige S, Horii A.

DNA Res. 1997 Oct 31;4(5):359-62.

PMID:
9455487

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