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Items: 1 to 50 of 407

1.

Single-dose radiotherapy disables tumor cell homologous recombination via ischemia/reperfusion injury.

Bodo S, Campagne C, Thin TH, Higginson DS, Vargas HA, Hua G, Fuller JD, Ackerstaff E, Russell J, Zhang Z, Klingler S, Cho H, Kaag MG, Mazaheri Y, Rimner A, Manova-Todorova K, Epel B, Zatcky J, Cleary CR, Rao SS, Yamada Y, Zelefsky MJ, Halpern HJ, Koutcher JA, Cordon-Cardo C, Greco C, Haimovitz-Friedman A, Sala E, Powell SN, Kolesnick R, Fuks Z.

J Clin Invest. 2018 Nov 27. pii: 97631. doi: 10.1172/JCI97631. [Epub ahead of print]

2.

Logarithmic expansion of LGR5+ cells in human colorectal cancer.

Martin ML, Zeng Z, Adileh M, Jacobo A, Li C, Vakiani E, Hua G, Zhang L, Haimovitz-Friedman A, Fuks Z, Kolesnick R, Paty PB.

Cell Signal. 2018 Jan;42:97-105. doi: 10.1016/j.cellsig.2017.09.018. Epub 2017 Sep 25.

PMID:
28958617
3.

Gemcitabine kills proliferating endothelial cells exclusively via acid sphingomyelinase activation.

van Hell AJ, Haimovitz-Friedman A, Fuks Z, Tap WD, Kolesnick R.

Cell Signal. 2017 Jun;34:86-91. doi: 10.1016/j.cellsig.2017.02.021. Epub 2017 Feb 24.

4.

Distinct Levels of Radioresistance in Lgr5+ Colonic Epithelial Stem Cells versus Lgr5+ Small Intestinal Stem Cells.

Hua G, Wang C, Pan Y, Zeng Z, Lee SG, Martin ML, Haimovitz-Friedman A, Fuks Z, Paty PB, Kolesnick R.

Cancer Res. 2017 Apr 15;77(8):2124-2133. doi: 10.1158/0008-5472.CAN-15-2870. Epub 2017 Feb 15.

5.

Targeting acid sphingomyelinase with anti-angiogenic chemotherapy.

Jacobi J, García-Barros M, Rao S, Rotolo JA, Thompson C, Mizrachi A, Feldman R, Manova K, Bielawska A, Bielawska J, Fuks Z, Kolesnick R, Haimovitz-Friedman A.

Cell Signal. 2017 Jan;29:52-61. doi: 10.1016/j.cellsig.2016.09.010. Epub 2016 Oct 1.

6.

Correction: Targeting Homologous Recombination in Notch-Driven C. elegans Stem Cell and Human Tumors.

Deng X, Michaelson D, Tchieu J, Cheng J, Rothenstein D, Feldman R, Lee SG, Fuller J, Haimovitz-Friedman A, Studer L, Powell S, Fuks Z, Albert Hubbard EJ, Kolesnick R.

PLoS One. 2016 Jan 22;11(1):e0141673. doi: 10.1371/journal.pone.0141673. eCollection 2016. No abstract available.

7.

Correction: Mitochondrial Ceramide-Rich Macrodomains Functionalize Bax upon Irradiation.

Lee H, Rotolo JA, Mesicek J, Penate-Medina T, Rimner A, Liao WC, Yin X, Ragupathi G, Ehleiter D, Gulbins E, Zhai D, Reed JC, Haimovitz-Friedman A, Fuks Z, Kolesnick R.

PLoS One. 2015 Dec 30;10(12):e0146210. doi: 10.1371/journal.pone.0146210. eCollection 2015. No abstract available.

8.

Spinal metastases: From conventional fractionated radiotherapy to single-dose SBRT.

Greco C, Pares O, Pimentel N, Moser E, Louro V, Morales X, Salas B, Fuks Z.

Rep Pract Oncol Radiother. 2015 Nov-Dec;20(6):454-63. doi: 10.1016/j.rpor.2015.03.004. Epub 2015 Apr 18. Review.

9.

Targeting Homologous Recombination in Notch-Driven C. elegans Stem Cell and Human Tumors.

Deng X, Michaelson D, Tchieu J, Cheng J, Rothenstein D, Feldman R, Lee SG, Fuller J, Haimovitz-Friedman A, Studer L, Powell S, Fuks Z, Hubbard EJ, Kolesnick R.

PLoS One. 2015 Jun 29;10(6):e0127862. doi: 10.1371/journal.pone.0127862. eCollection 2015. Erratum in: PLoS One. 2016;11(1):e0141673.

10.

Axitinib sensitization of high Single Dose Radiotherapy.

Rao SS, Thompson C, Cheng J, Haimovitz-Friedman A, Powell SN, Fuks Z, Kolesnick RN.

Radiother Oncol. 2014 Apr;111(1):88-93. doi: 10.1016/j.radonc.2014.02.010. Epub 2014 Apr 29.

11.

Adenoviral transduction of human acid sphingomyelinase into neo-angiogenic endothelium radiosensitizes tumor cure.

Stancevic B, Varda-Bloom N, Cheng J, Fuller JD, Rotolo JA, García-Barros M, Feldman R, Rao S, Weichselbaum RR, Harats D, Haimovitz-Friedman A, Fuks Z, Sadelain M, Kolesnick R.

PLoS One. 2013 Aug 2;8(8):e69025. doi: 10.1371/journal.pone.0069025. Print 2013.

12.

Crypt base columnar stem cells in small intestines of mice are radioresistant.

Hua G, Thin TH, Feldman R, Haimovitz-Friedman A, Clevers H, Fuks Z, Kolesnick R.

Gastroenterology. 2012 Nov;143(5):1266-1276. doi: 10.1053/j.gastro.2012.07.106. Epub 2012 Jul 27.

13.

Anti-ceramide antibody prevents the radiation gastrointestinal syndrome in mice.

Rotolo J, Stancevic B, Zhang J, Hua G, Fuller J, Yin X, Haimovitz-Friedman A, Kim K, Qian M, Cardó-Vila M, Fuks Z, Pasqualini R, Arap W, Kolesnick R.

J Clin Invest. 2012 May;122(5):1786-90. doi: 10.1172/JCI59920. Epub 2012 Apr 2.

14.

Mitochondrial ceramide-rich macrodomains functionalize Bax upon irradiation.

Lee H, Rotolo JA, Mesicek J, Penate-Medina T, Rimner A, Liao WC, Yin X, Ragupathi G, Ehleiter D, Gulbins E, Zhai D, Reed JC, Haimovitz-Friedman A, Fuks Z, Kolesnick R.

PLoS One. 2011;6(6):e19783. doi: 10.1371/journal.pone.0019783. Epub 2011 Jun 13. Erratum in: PLoS One. 2015;10(12):e0146210.

15.

Tumor control outcomes after hypofractionated and single-dose stereotactic image-guided intensity-modulated radiotherapy for extracranial metastases from renal cell carcinoma.

Zelefsky MJ, Greco C, Motzer R, Magsanoc JM, Pei X, Lovelock M, Mechalakos J, Zatcky J, Fuks Z, Yamada Y.

Int J Radiat Oncol Biol Phys. 2012 Apr 1;82(5):1744-8. doi: 10.1016/j.ijrobp.2011.02.040. Epub 2011 May 17.

16.

Sphingosine-1-phosphate activates the AKT pathway to protect small intestines from radiation-induced endothelial apoptosis.

Bonnaud S, Niaudet C, Legoux F, Corre I, Delpon G, Saulquin X, Fuks Z, Gaugler MH, Kolesnick R, Paris F.

Cancer Res. 2010 Dec 1;70(23):9905-15. doi: 10.1158/0008-5472.CAN-10-2043. Epub 2010 Nov 30.

17.

Endothelial membrane remodeling is obligate for anti-angiogenic radiosensitization during tumor radiosurgery.

Truman JP, García-Barros M, Kaag M, Hambardzumyan D, Stancevic B, Chan M, Fuks Z, Kolesnick R, Haimovitz-Friedman A.

PLoS One. 2010 Sep 30;5(9). doi: 10.1371/annotation/6e222ad5-b175-4a00-9d04-4d120568a897.

18.

Impact of stromal sensitivity on radiation response of tumors implanted in SCID hosts revisited.

García-Barros M, Thin TH, Maj J, Cordon-Cardo C, Haimovitz-Friedman A, Fuks Z, Kolesnick R.

Cancer Res. 2010 Oct 15;70(20):8179-86. doi: 10.1158/0008-5472.CAN-10-1871. Epub 2010 Oct 5.

19.

Endothelial membrane remodeling is obligate for anti-angiogenic radiosensitization during tumor radiosurgery.

Truman JP, García-Barros M, Kaag M, Hambardzumyan D, Stancevic B, Chan M, Fuks Z, Kolesnick R, Haimovitz-Friedman A.

PLoS One. 2010 Aug 19;5(8):e12310. doi: 10.1371/journal.pone.0012310. Corrected and republished in: PLoS One. 2010;5(9). doi: 10.1371/annotation/6e222ad5-b175-4a00-9d04-4d120568a897.

20.

Predictors of local control after single-dose stereotactic image-guided intensity-modulated radiotherapy for extracranial metastases.

Greco C, Zelefsky MJ, Lovelock M, Fuks Z, Hunt M, Rosenzweig K, Zatcky J, Kim B, Yamada Y.

Int J Radiat Oncol Biol Phys. 2011 Mar 15;79(4):1151-7. doi: 10.1016/j.ijrobp.2009.12.038. Epub 2010 May 25.

PMID:
20510537
21.

Ceramide synthases 2, 5, and 6 confer distinct roles in radiation-induced apoptosis in HeLa cells.

Mesicek J, Lee H, Feldman T, Jiang X, Skobeleva A, Berdyshev EV, Haimovitz-Friedman A, Fuks Z, Kolesnick R.

Cell Signal. 2010 Sep;22(9):1300-7. doi: 10.1016/j.cellsig.2010.04.006. Epub 2010 Apr 18.

22.

Metastasis after radical prostatectomy or external beam radiotherapy for patients with clinically localized prostate cancer: a comparison of clinical cohorts adjusted for case mix.

Zelefsky MJ, Eastham JA, Cronin AM, Fuks Z, Zhang Z, Yamada Y, Vickers A, Scardino PT.

J Clin Oncol. 2010 Mar 20;28(9):1508-13. doi: 10.1200/JCO.2009.22.2265. Epub 2010 Feb 16.

23.

Regulation of ceramide synthase-mediated crypt epithelium apoptosis by DNA damage repair enzymes.

Rotolo JA, Mesicek J, Maj J, Truman JP, Haimovitz-Friedman A, Kolesnick R, Fuks Z.

Cancer Res. 2010 Feb 1;70(3):957-67. doi: 10.1158/0008-5472.CAN-09-1562. Epub 2010 Jan 19.

24.

Kinase suppressor of Ras transphosphorylates c-Raf-1.

Zafrullah M, Yin X, Haimovitz-Friedman A, Fuks Z, Kolesnick R.

Biochem Biophys Res Commun. 2009 Dec 18;390(3):434-40. doi: 10.1016/j.bbrc.2009.09.048. Epub 2009 Sep 17.

25.

A ceramide-binding C1 domain mediates kinase suppressor of ras membrane translocation.

Yin X, Zafrullah M, Lee H, Haimovitz-Friedman A, Fuks Z, Kolesnick R.

Cell Physiol Biochem. 2009;24(3-4):219-30. doi: 10.1159/000233248. Epub 2009 Aug 3.

26.

Cytolytic T cells induce ceramide-rich platforms in target cell membranes to initiate graft-versus-host disease.

Rotolo JA, Stancevic B, Lu SX, Zhang J, Suh D, King CG, Kappel LW, Murphy GF, Liu C, Fuks Z, van den Brink MR, Kolesnick R.

Blood. 2009 Oct 22;114(17):3693-706. doi: 10.1182/blood-2008-11-191148. Epub 2009 Aug 7.

27.

Timing of lethality from gastrointestinal syndrome in mice revisited.

Rotolo JA, Kolesnick R, Fuks Z.

Int J Radiat Oncol Biol Phys. 2009 Jan 1;73(1):6-8. doi: 10.1016/j.ijrobp.2008.09.009. No abstract available.

PMID:
19100919
28.

PKCalpha activation downregulates ATM and radio-sensitizes androgen-sensitive human prostate cancer cells in vitro and in vivo.

Truman JP, Rotenberg SA, Kang JH, Lerman G, Fuks Z, Kolesnick R, Marquez VE, Haimovitz-Friedman A.

Cancer Biol Ther. 2009 Jan;8(1):54-63. Epub 2009 Jan 4.

29.

Ceramide biogenesis is required for radiation-induced apoptosis in the germ line of C. elegans.

Deng X, Yin X, Allan R, Lu DD, Maurer CW, Haimovitz-Friedman A, Fuks Z, Shaham S, Kolesnick R.

Science. 2008 Oct 3;322(5898):110-5. doi: 10.1126/science.1158111.

30.

Downregulation of KSR1 in pancreatic cancer xenografts by antisense oligonucleotide correlates with tumor drug uptake.

Zhang J, Zafrullah M, Yang X, Yin X, Zhang Z, Fuks Z, Kolesnick R.

Cancer Biol Ther. 2008 Sep;7(9):1490-5. Epub 2008 Sep 15.

31.

Comparison of kilovoltage cone-beam computed tomography with megavoltage projection pairs for paraspinal radiosurgery patient alignment and position verification.

Kriminski SA, Lovelock DM, Seshan VE, Ali I, Munro P, Amols HI, Fuks Z, Bilsky M, Yamada Y.

Int J Radiat Oncol Biol Phys. 2008 Aug 1;71(5):1572-80. doi: 10.1016/j.ijrobp.2008.04.029. Epub 2008 Jun 6.

PMID:
18539405
32.

Influence of local tumor control on distant metastases and cancer related mortality after external beam radiotherapy for prostate cancer.

Zelefsky MJ, Reuter VE, Fuks Z, Scardino P, Shippy A.

J Urol. 2008 Apr;179(4):1368-73; discussion 1373. doi: 10.1016/j.juro.2007.11.063. Epub 2008 Mar 4.

33.

Long-term results of conformal radiotherapy for prostate cancer: impact of dose escalation on biochemical tumor control and distant metastases-free survival outcomes.

Zelefsky MJ, Yamada Y, Fuks Z, Zhang Z, Hunt M, Cahlon O, Park J, Shippy A.

Int J Radiat Oncol Biol Phys. 2008 Jul 15;71(4):1028-33. doi: 10.1016/j.ijrobp.2007.11.066. Epub 2008 Feb 14.

PMID:
18280056
34.

High-dose, single-fraction image-guided intensity-modulated radiotherapy for metastatic spinal lesions.

Yamada Y, Bilsky MH, Lovelock DM, Venkatraman ES, Toner S, Johnson J, Zatcky J, Zelefsky MJ, Fuks Z.

Int J Radiat Oncol Biol Phys. 2008 Jun 1;71(2):484-90. doi: 10.1016/j.ijrobp.2007.11.046. Epub 2008 Jan 30.

PMID:
18234445
35.

Bax and Bak do not exhibit functional redundancy in mediating radiation-induced endothelial apoptosis in the intestinal mucosa.

Rotolo JA, Maj JG, Feldman R, Ren D, Haimovitz-Friedman A, Cordon-Cardo C, Cheng EH, Kolesnick R, Fuks Z.

Int J Radiat Oncol Biol Phys. 2008 Mar 1;70(3):804-15. doi: 10.1016/j.ijrobp.2007.11.043. Epub 2008 Jan 11.

PMID:
18191336
36.

Ultra-high dose (86.4 Gy) IMRT for localized prostate cancer: toxicity and biochemical outcomes.

Cahlon O, Zelefsky MJ, Shippy A, Chan H, Fuks Z, Yamada Y, Hunt M, Greenstein S, Amols H.

Int J Radiat Oncol Biol Phys. 2008 Jun 1;71(2):330-7. doi: 10.1016/j.ijrobp.2007.10.004. Epub 2007 Dec 31.

PMID:
18164858
37.

Kinetic characterization of mammalian ceramide synthases: determination of K(m) values towards sphinganine.

Lahiri S, Lee H, Mesicek J, Fuks Z, Haimovitz-Friedman A, Kolesnick RN, Futerman AH.

FEBS Lett. 2007 Nov 13;581(27):5289-94. Epub 2007 Oct 23.

38.

A CERTain role for ceramide in taxane-induced cell death.

Kolesnick R, Altieri D, Fuks Z.

Cancer Cell. 2007 Jun;11(6):473-5.

39.

Image-fusion of MR spectroscopic images for treatment planning of gliomas.

Chang J, Thakur S, Perera G, Kowalski A, Huang W, Karimi S, Hunt M, Koutcher J, Fuks Z, Amols H, Narayana A.

Med Phys. 2006 Jan;33(1):32-40.

PMID:
16485406
40.

From IMRT to IGRT: frontierland or neverland?

Ling CC, Yorke E, Fuks Z.

Radiother Oncol. 2006 Feb;78(2):119-22. Epub 2006 Jan 18.

PMID:
16413622
41.

Accurate setup of paraspinal patients using a noninvasive patient immobilization cradle and portal imaging.

Lovelock DM, Hua C, Wang P, Hunt M, Fournier-Bidoz N, Yenice K, Toner S, Lutz W, Amols H, Bilsky M, Fuks Z, Yamada Y.

Med Phys. 2005 Aug;32(8):2606-14.

PMID:
16193791
42.

Engaging the vascular component of the tumor response.

Fuks Z, Kolesnick R.

Cancer Cell. 2005 Aug;8(2):89-91.

43.

Whole pelvic radiotherapy for prostate cancer using 3D conformal and intensity-modulated radiotherapy.

Ashman JB, Zelefsky MJ, Hunt MS, Leibel SA, Fuks Z.

Int J Radiat Oncol Biol Phys. 2005 Nov 1;63(3):765-71.

PMID:
15913914
44.

ATM regulates target switching to escalating doses of radiation in the intestines.

Ch'ang HJ, Maj JG, Paris F, Xing HR, Zhang J, Truman JP, Cardon-Cardo C, Haimovitz-Friedman A, Kolesnick R, Fuks Z.

Nat Med. 2005 May;11(5):484-90. Epub 2005 May 1. Erratum in: Nat Med. 2006 Feb;12(2):253.

PMID:
15864314
45.

Caspase-dependent and -independent activation of acid sphingomyelinase signaling.

Rotolo JA, Zhang J, Donepudi M, Lee H, Fuks Z, Kolesnick R.

J Biol Chem. 2005 Jul 15;280(28):26425-34. Epub 2005 Apr 22.

46.

Down-regulation of ATM protein sensitizes human prostate cancer cells to radiation-induced apoptosis.

Truman JP, Gueven N, Lavin M, Leibel S, Kolesnick R, Fuks Z, Haimovitz-Friedman A.

J Biol Chem. 2005 Jun 17;280(24):23262-72. Epub 2005 Apr 18.

47.

Outcome predictors for the increasing PSA state after definitive external-beam radiotherapy for prostate cancer.

Zelefsky MJ, Ben-Porat L, Scher HI, Chan HM, Fearn PA, Fuks ZY, Leibel SA, Venkatraman ES.

J Clin Oncol. 2005 Feb 1;23(4):826-31.

PMID:
15681527
48.

Host acid sphingomyelinase regulates microvascular function not tumor immunity.

Garcia-Barros M, Lacorazza D, Petrie H, Haimovitz-Friedman A, Cardon-Cardo C, Nimer S, Fuks Z, Kolesnick R.

Cancer Res. 2004 Nov 15;64(22):8285-91.

49.

Caenorhabditis elegans ABL-1 antagonizes p53-mediated germline apoptosis after ionizing irradiation.

Deng X, Hofmann ER, Villanueva A, Hobert O, Capodieci P, Veach DR, Yin X, Campodonico L, Glekas A, Cordon-Cardo C, Clarkson B, Bornmann WG, Fuks Z, Hengartner MO, Kolesnick R.

Nat Genet. 2004 Aug;36(8):906-12. Epub 2004 Jul 25.

PMID:
15273685
50.

Advances in translational radiation oncology: from molecular signaling to cancer cure.

Bernier J, Fuks Z.

Int J Radiat Oncol Biol Phys. 2004 Feb 1;58(2):305-6. No abstract available.

PMID:
14751497

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