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Biomimetic Synthesis of Meroterpenoids by Dearomatization- Driven Polycyclization.

Porco J, Powers Z, Scharf A, Cheng A, Yang F, Himmelbauer M, Mitsuhashi T, Barra L, Taniguchi Y, Kikuchi T, Fujita M, Abe I.

Angew Chem Int Ed Engl. 2019 Sep 13. doi: 10.1002/anie.201910710. [Epub ahead of print]


Antiproliferative S-Trityl-l-Cysteine -Derived Compounds as SIRT2 Inhibitors: Repurposing and Solubility Enhancement.

Radwan MO, Ciftci HI, Ali TFS, Ellakwa DE, Koga R, Tateishi H, Nakata A, Ito A, Yoshida M, Okamoto Y, Fujita M, Otsuka M.

Molecules. 2019 Sep 10;24(18). pii: E3295. doi: 10.3390/molecules24183295.


The Ethics of Cerebral Organoid Research: Being Conscious of Consciousness.

Sawai T, Sakaguchi H, Thomas E, Takahashi J, Fujita M.

Stem Cell Reports. 2019 Sep 10;13(3):440-447. doi: 10.1016/j.stemcr.2019.08.003. Review.


Regulation of Ascorbate-Glutathione Pathway in Mitigating Oxidative Damage in Plants under Abiotic Stress.

Hasanuzzaman M, Bhuyan MHMB, Anee TI, Parvin K, Nahar K, Mahmud JA, Fujita M.

Antioxidants (Basel). 2019 Sep 9;8(9). pii: E384. doi: 10.3390/antiox8090384. Review.


PD-L1 expression on tumor-infiltrating immune cells is highly associated with M2 TAM and aggressive malignant potential in patients with resected non-small cell lung cancer.

Sumitomo R, Hirai T, Fujita M, Murakami H, Otake Y, Huang CL.

Lung Cancer. 2019 Aug 31;136:136-144. doi: 10.1016/j.lungcan.2019.08.023. [Epub ahead of print]


Design, synthesis and biological evaluation of a new series of thiazolyl-pyrazolines as dual EGFR and HER2 inhibitors.

Sever B, Altıntop MD, Radwan MO, Özdemir A, Otsuka M, Fujita M, Ciftci HI.

Eur J Med Chem. 2019 Aug 28;182:111648. doi: 10.1016/j.ejmech.2019.111648. [Epub ahead of print]


Second-look arthroscopic findings of cartilage and meniscus repair after injection of adipose-derived regenerative cells in knee osteoarthrits: Report of two cases.

Onoi Y, Hiranaka T, Nishida R, Takase K, Fujita M, Hida Y, Fujishiro T, Okamoto K.

Regen Ther. 2019 Aug 24;11:212-216. doi: 10.1016/j.reth.2019.07.010. eCollection 2019 Dec.


Cellulose-rich secondary walls in wave-swept red macroalgae fortify flexible tissues.

Martone PT, Janot K, Fujita M, Wasteneys G, Ruel K, Joseleau JP, Estevez JM.

Planta. 2019 Sep 3. doi: 10.1007/s00425-019-03269-1. [Epub ahead of print]


Comparative Physiological and Biochemical Changes in Tomato (Solanum lycopersicum L.) Under Salt Stress and Recovery: Role of Antioxidant Defense and Glyoxalase Systems.

Parvin K, Hasanuzzaman M, Bhuyan MHMB, Nahar K, Mohsin SM, Fujita M.

Antioxidants (Basel). 2019 Sep 1;8(9). pii: E350. doi: 10.3390/antiox8090350.


Applicability of amino acid derivative reactivity assay for prediction of skin sensitization by combining multiple alternative methods to evaluate key events.

Yamamoto Y, Fujita M, Wanibuchi S, Sato A, Akimoto M, Katsuoka Y, Ono A, Kasahara T.

J Toxicol Sci. 2019;44(9):585-600. doi: 10.2131/jts.44.585.


Assessing a polluted river environment by oxidative stress biomarker responses in caddisfly larvae.

Suzuki J, Nakano D, Imamura M, Yamamoto R, Fujita M.

Sci Total Environ. 2019 Aug 21;696:134005. doi: 10.1016/j.scitotenv.2019.134005. [Epub ahead of print]


Historical changes and between-facility differences in adrenal venous sampling for primary aldosteronism in Japan.

Fujii Y, Takeda Y, Kurihara I, Itoh H, Katabami T, Ichijo T, Wada N, Shibayama Y, Yoshimoto T, Ogawa Y, Kawashima J, Sone M, Inagaki N, Takahashi K, Watanabe M, Matsuda Y, Kobayashi H, Shibata H, Kamemura K, Otsuki M, Yamamto K, Ogo A, Yanase T, Okamura S, Miyauchi S, Fujita M, Suzuki T, Umakoshi H, Ogasawara T, Tsuiki M, Naruse M; JPAS Study Group.

J Hum Hypertens. 2019 Aug 28. doi: 10.1038/s41371-019-0229-4. [Epub ahead of print]


Precipitation of test chemicals in reaction solutions used in the amino acid derivative reactivity assay and the direct peptide reactivity assay.

Yamamoto Y, Wanibuchi S, Sato A, Kasahara T, Fujita M.

J Pharmacol Toxicol Methods. 2019 Aug 22:106624. doi: 10.1016/j.vascn.2019.106624. [Epub ahead of print]


Single-drug approach with rivaroxaban: A case of successful anticoagulation against cancer-associated thrombosis.

Shioyama W, Oka T, Yasui T, Fujita M.

J Cardiol Cases. 2019 Jun 28;20(2):39-41. doi: 10.1016/j.jccase.2019.03.005. eCollection 2019 Aug.


IL-1R3 blockade broadly attenuates the functions of six members of the IL-1 family, revealing their contribution to models of disease.

Højen JF, Kristensen MLV, McKee AS, Wade MT, Azam T, Lunding LP, de Graaf DM, Swartzwelter BJ, Wegmann M, Tolstrup M, Beckman K, Fujita M, Fischer S, Dinarello CA.

Nat Immunol. 2019 Sep;20(9):1138-1149. doi: 10.1038/s41590-019-0467-1. Epub 2019 Aug 19.


Beliefs held by breast surgeons that impact the treatment decision process for advanced breast cancer patients: a qualitative study.

Ozeki-Hayashi R, Fujita M, Tsuchiya A, Hatta T, Nakazawa E, Takimoto Y, Akabayashi A.

Breast Cancer (Dove Med Press). 2019 Jul 17;11:221-229. doi: 10.2147/BCTT.S208910. eCollection 2019.


Explicating physiological and biochemical responses of wheat cultivars under acidity stress: insight into the antioxidant defense and glyoxalase systems.

Bhuyan MHMB, Hasanuzzaman M, Mahmud JA, Hossain MS, Alam MU, Fujita M.

Physiol Mol Biol Plants. 2019 Jul;25(4):865-879. doi: 10.1007/s12298-019-00678-0. Epub 2019 May 21.


Structural Elucidation of Tenebrathin: Cytotoxic C-5-Substituted γ-Pyrone with a Nitroaryl Side Chain from Streptoalloteichus tenebrarius.

Hoshino S, Mitsuhashi T, Kikuchi T, Wong CP, Morita H, Awakawa T, Fujita M, Abe I.

Org Lett. 2019 Aug 16;21(16):6519-6522. doi: 10.1021/acs.orglett.9b02443. Epub 2019 Aug 6.


Japan ablation registry: cryoablation in atrioventricular nodal reentrant tachycardia ("JARCANRET study"): results from large multicenter retrospective investigation.

Okishige K, Okumura K, Tsurugi T, Yotsukura A, Nanbu T, Sugiura H, Sanada A, Kondo Y, Takano M, Keida T, Fujita M, Kamiya H, Tsuchiya K, Adachi K, Katoh Y, Hiroshima K, Yamamoto K, Ashikaga K, Hoshiyama T, Sasano T, Hirao K.

J Interv Card Electrophysiol. 2019 Jul 31. doi: 10.1007/s10840-019-00585-0. [Epub ahead of print]


Severe Fever with Thrombocytopenia Syndrome Complicated with Pseudomembranous Aspergillus Tracheobronchitis in a Patient without Apparent Risk Factors for Invasive Aspergillosis: A Case Report.

Sakaguchi K, Koga Y, Yagi T, Nakahara T, Todani M, Fujita M, Tsuruta R.

Intern Med. 2019 Jul 31. doi: 10.2169/internalmedicine.3257-19. [Epub ahead of print]


Neoadjuvant Chemotherapy Increases PD-L1 Expression and CD8+ Tumor-infiltrating Lymphocytes in Esophageal Squamous Cell Carcinoma.

Fukuoka E, Yamashita K, Tanaka T, Sawada R, Sugita Y, Arimoto A, Fujita M, Takiguchi G, Matsuda T, Oshikiri T, Nakamura T, Suzuki S, Kakeji Y.

Anticancer Res. 2019 Aug;39(8):4539-4548. doi: 10.21873/anticanres.13631.


Significance of Elevated HMGB1 Expression in Pituitary Apoplexy.

Okuda T, Fujita M, Kato A.

Anticancer Res. 2019 Aug;39(8):4491-4494. doi: 10.21873/anticanres.13624.


Current and future clinical utilities of Parkinson's disease and dementia biomarkers: can they help us conquer the disease?

Ho G, Takamatsu Y, Waragai M, Wada R, Sugama S, Takenouchi T, Fujita M, Ali A, Hsieh MH, Hashimoto M.

Expert Rev Neurother. 2019 Aug 9:1-13. doi: 10.1080/14737175.2019.1649141. [Epub ahead of print]


Copper ions are novel therapeutic agents for uterine leiomyosarcoma.

Kakuda M, Matsuzaki S, Ueda Y, Shiomi M, Matsuzaki S, Kimura T, Fujita M, Egawa-Takata T, Kobayashi E, Serada S, Yoshino K, Naka T, Kimura T.

Am J Obstet Gynecol. 2019 Jul 24. pii: S0002-9378(19)30935-4. doi: 10.1016/j.ajog.2019.07.030. [Epub ahead of print]


Sepiapterin reductase inhibition selectively reduces inflammatory joint pain and increases urinary sepiapterin.

Fujita M, da Luz Scheffer D, Lenfers Turnes B, Cronin SJF, Latrémolière A, Costigan M, Woolf CJ, Latini A, Andrews NA.

Arthritis Rheumatol. 2019 Jul 27. doi: 10.1002/art.41060. [Epub ahead of print]


Melanoma to Vitiligo: The Melanocyte in Biology & Medicine-Joint Montagna Symposium on the Biology of Skin/PanAmerican Society for Pigment Cell Research Annual Meeting.

Leachman SA, Hornyak TJ, Barsh G, Bastian BC, Brash DE, Cleaver JE, Cooper CD, D'Orazio JA, Fujita M, Holmen SL, Indra AK, Kramer KH, Le Poole IC, Lo RS, Lund AW, Manga P, Pavan WJ, Setaluri V, Stemwedel CE, Kulesz-Martin MF.

J Invest Dermatol. 2019 Jul 23. pii: S0022-202X(19)32550-3. doi: 10.1016/j.jid.2019.03.1164. [Epub ahead of print] No abstract available.


Synthesis and Application of Silver Nanoparticles (Ag NPs) for the Prevention of Infection in Healthcare Workers.

Nakamura S, Sato M, Sato Y, Ando N, Takayama T, Fujita M, Ishihara M.

Int J Mol Sci. 2019 Jul 24;20(15). pii: E3620. doi: 10.3390/ijms20153620. Review.


Observation of two types of charge-density-wave orders in superconducting La2-xSrxCuO4.

Wen JJ, Huang H, Lee SJ, Jang H, Knight J, Lee YS, Fujita M, Suzuki KM, Asano S, Kivelson SA, Kao CC, Lee JS.

Nat Commun. 2019 Jul 22;10(1):3269. doi: 10.1038/s41467-019-11167-z.


Association Between Acute Fall in Estimated Glomerular Filtration Rate After Treatment for Primary Aldosteronism and Long-Term Decline in Renal Function.

Kobayashi H, Abe M, Nakamura Y, Takahashi K, Fujita M, Takeda Y, Yoneda T, Kurihara I, Itoh H, Tsuiki M, Wada N, Ichijo T, Katabami T, Ogawa Y, Kawashima J, Yoshimoto T, Sone M, Inagaki N, Watanabe M, Kamemura K, Matsuda Y, Izawa S, Tanabe M, Tanabe A, Suzuki T, Naruse M; JPAS/JRAS Study Group.

Hypertension. 2019 Sep;74(3):630-638. doi: 10.1161/HYPERTENSIONAHA.119.13131. Epub 2019 Jul 22.


Repeated evolution of cytochrome P450-mediated spiroketal steroid biosynthesis in plants.

Christ B, Xu C, Xu M, Li FS, Wada N, Mitchell AJ, Han XL, Wen ML, Fujita M, Weng JK.

Nat Commun. 2019 Jul 19;10(1):3206. doi: 10.1038/s41467-019-11286-7.


Metabolomic Analysis of Skeletal Muscle in Aged Mice.

Uchitomi R, Hatazawa Y, Senoo N, Yoshioka K, Fujita M, Shimizu T, Miura S, Ono Y, Kamei Y.

Sci Rep. 2019 Jul 18;9(1):10425. doi: 10.1038/s41598-019-46929-8.


Renal impairment is closely associated with plasma aldosterone concentration in patients with primary aldosteronism.

Kawashima A, Sone M, Inagaki N, Takeda Y, Itoh H, Kurihara I, Umakoshi H, Ichijo T, Katabami T, Wada N, Ogawa Y, Kawashima J, Fujita M, Miyauchi S, Okamura S, Fukuoka T, Yanase T, Izawa S, Yoshikawa Y, Hashimoto S, Yamada M, Kai T, Suzuki T, Naruse M.

Eur J Endocrinol. 2019 Jul 1. pii: EJE-19-0047.R2. doi: 10.1530/EJE-19-0047. [Epub ahead of print]


Development of a thrombus in the superior mesenteric artery associated with sequential therapy with tyrosine kinase inhibitors for hepatocellular carcinoma.

Nawa T, Katayama K, Kiyota R, Imai T, Abe Y, Hasegawa N, Takada R, Fukutake N, Ikezawa K, Sakakibara M, Fujita M, Ohkawa K.

Clin J Gastroenterol. 2019 Jul 17. doi: 10.1007/s12328-019-01021-6. [Epub ahead of print]


The within- and between-laboratory reproducibility and predictive capacity of the in chemico amino acid derivative reactivity assay: Results of validation study implemented in four participating laboratories.

Fujita M, Yamamoto Y, Watanabe S, Sugawara T, Wakabayashi K, Tahara Y, Horie N, Fujimoto K, Kusakari K, Kurokawa Y, Kawakami T, Kojima K, Sozu T, Nakayama T, Kusao T, Richmond J, Nicole K, Kim BH, Kojima H, Kasahara T, Ono A.

J Appl Toxicol. 2019 Jul 17. doi: 10.1002/jat.3834. [Epub ahead of print]


Optogenetic control of Bacillus subtilis gene expression.

Castillo-Hair SM, Baerman EA, Fujita M, Igoshin OA, Tabor JJ.

Nat Commun. 2019 Jul 15;10(1):3099. doi: 10.1038/s41467-019-10906-6.


Evaluation of Risk Factors for Major Amputation in Patients With Diabetes and Peripheral Artery Disease Receiving Antiplatelet Therapy - Post Hoc Analysis of a Prospective Observational Multicenter Cohort Study (SEASON).

Higashi Y, Miyata T, Shigematsu H, Origasa H, Fujita M, Matsuo H, Naritomi H, Nakajima M, Yuki S, Awano H.

Circ J. 2019 Aug 23;83(9):1929-1936. doi: 10.1253/circj.CJ-19-0088. Epub 2019 Jul 10.


Lateralizing Asymmetry of Adrenal Imaging and Adrenal Vein Sampling in Patients With Primary Aldosteronism.

Wada N, Shibayama Y, Yoneda T, Katabami T, Kurihara I, Tsuiki M, Ichijo T, Ogawa Y, Kawashima J, Sone M, Yoshimoto T, Matsuda Y, Fujita M, Kobayashi H, Tamura K, Kamemura K, Otsuki M, Okamura S, Naruse M; JPAS/JRAS Study Group.

J Endocr Soc. 2019 May 16;3(7):1393-1402. doi: 10.1210/js.2019-00131. eCollection 2019 Jul 1.


Squamous cell carcinoma arising in a chronic leg ulcer in Klippel-Trenaunay syndrome after the Charles procedure: A case with 40 years of follow up.

Ishikawa K, Funayama E, Yamamoto Y, Furukawa H, Hayashi T, Murao N, Osawa M, Maeda T, Fujita M, Sasaki S.

J Dermatol. 2019 Jul 8. doi: 10.1111/1346-8138.15001. [Epub ahead of print] No abstract available.


Minimum structural requirements for inhibitors of the zinc finger protein TRAF6.

Radwan MO, Koga R, Hida T, Ejima T, Kanemaru Y, Tateishi H, Okamoto Y, Inoue JI, Fujita M, Otsuka M.

Bioorg Med Chem Lett. 2019 Aug 15;29(16):2162-2167. doi: 10.1016/j.bmcl.2019.06.050. Epub 2019 Jun 27.


Versican is crucial for the initiation of cardiovascular lumen development in medaka (Oryzias latipes).

Mittal N, Yoon SH, Enomoto H, Hiroshi M, Shimizu A, Kawakami A, Fujita M, Watanabe H, Fukuda K, Makino S.

Sci Rep. 2019 Jul 1;9(1):9475. doi: 10.1038/s41598-019-45851-3.


Clinical Characteristics Associated With Lenvatinib-induced Fistula and Tumor-related Bleeding in Patients With Thyroid Cancer.

Staub Y, Nishiyama A, Suga Y, Fujita M, Matsushita R, Yano S.

Anticancer Res. 2019 Jul;39(7):3871-3878. doi: 10.21873/anticanres.13537.


Polyamine Action under Metal/Metalloid Stress: Regulation of Biosynthesis, Metabolism, and Molecular Interactions.

Hasanuzzaman M, Alhaithloul HAS, Parvin K, Bhuyan MHMB, Tanveer M, Mohsin SM, Nahar K, Soliman MH, Mahmud JA, Fujita M.

Int J Mol Sci. 2019 Jun 30;20(13). pii: E3215. doi: 10.3390/ijms20133215. Review.


Oxidative Damage and Antioxidant Defense in Sesamum indicum after Different Waterlogging Durations.

Anee TI, Nahar K, Rahman A, Mahmud JA, Bhuiyan TF, Alam MU, Fujita M, Hasanuzzaman M.

Plants (Basel). 2019 Jun 29;8(7). pii: E196. doi: 10.3390/plants8070196.


Autocrine Production of PDGF Stimulated by the Tenascin-C-Derived Peptide TNIIIA2 Induces Hyper-Proliferation in Glioblastoma Cells.

Fujita M, Yamamoto T, Iyoda T, Fujisawa T, Nagai R, Kudo C, Sasada M, Kodama H, Fukai F.

Int J Mol Sci. 2019 Jun 28;20(13). pii: E3183. doi: 10.3390/ijms20133183.


Spontaneous Regression of Annular Basal Cell Carcinoma: A Case Report.

Go U, Miyata K, Fujita M, Ohide T, Mitsuishi T.

Case Rep Dermatol. 2019 Jun 4;11(2):145-149. doi: 10.1159/000500711. eCollection 2019 May-Aug.


Differential prognostic impact between completion and non-completion of a 5-month cardiac rehabilitation program in outpatients with cardiovascular diseases.

Fujimi K, Imaizumi T, Suematsu Y, Kitajima K, Ueda T, Ishida T, Futami M, Ujifuku Y, Matsuda T, Sakamoto M, Horita T, Teshima R, Kaino K, Fujita M, Arimura T, Shiga Y, Shiota E, Miura SI.

Int J Cardiol. 2019 Oct 1;292:13-18. doi: 10.1016/j.ijcard.2019.06.017. Epub 2019 Jun 12.


Sex Difference in the Association Between Subtype Distribution and Age at Diagnosis in Patients With Primary Aldosteronism.

Akasaka H, Yamamoto K, Rakugi H, Nagasawa M, Nakamaru R, Ichijo T, Takeda Y, Kurihara I, Katabami T, Tsuiki M, Wada N, Ogawa Y, Kawashima J, Sone M, Kamemura K, Yoshimoto T, Matsuda Y, Fujita M, Kobayashi H, Watanabe M, Tamura K, Okamura S, Miyauchi S, Izawa S, Chiba Y, Tanabe A, Naruse M; Japan Primary Aldosteronism Study Group * .

Hypertension. 2019 Aug;74(2):368-374. doi: 10.1161/HYPERTENSIONAHA.119.13006. Epub 2019 Jun 24.


Genomic analysis of pancreatic juice DNA assesses malignant risk of intraductal papillary mucinous neoplasm of pancreas.

Mateos RN, Nakagawa H, Hirono S, Takano S, Fukasawa M, Yanagisawa A, Yasukawa S, Maejima K, Oku-Sasaki A, Nakano K, Dutta M, Tanaka H, Miyano S, Enomoto N, Yamaue H, Nakai K, Fujita M.

Cancer Med. 2019 Aug;8(10):4565-4573. doi: 10.1002/cam4.2340. Epub 2019 Jun 21.


Comprehensive and quantitative assessment of nitrate dynamics in two contrasting forested basins along the Sea of Japan using dual isotopes of nitrate.

Sugimoto R, Tsuboi T, Fujita MS.

Sci Total Environ. 2019 Oct 15;687:667-678. doi: 10.1016/j.scitotenv.2019.06.090. Epub 2019 Jun 11.


Comparison of Various Disinfectants on Bactericidal Activity Under Organic Matter Contaminated Environments.

Sato Y, Ishihara M, Nakamura S, Fukuda K, Kuwabara M, Takayama T, Hiruma S, Murakami K, Fujita M, Yokoe H.

Biocontrol Sci. 2019;24(2):103-108. doi: 10.4265/bio.24.103.

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