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IL-1R3 blockade broadly attenuates the functions of six members of the IL-1 family, revealing their contribution to models of disease.

Højen JF, Kristensen MLV, McKee AS, Wade MT, Azam T, Lunding LP, de Graaf DM, Swartzwelter BJ, Wegmann M, Tolstrup M, Beckman K, Fujita M, Fischer S, Dinarello CA.

Nat Immunol. 2019 Aug 19. doi: 10.1038/s41590-019-0467-1. [Epub ahead of print]


Beliefs held by breast surgeons that impact the treatment decision process for advanced breast cancer patients: a qualitative study.

Ozeki-Hayashi R, Fujita M, Tsuchiya A, Hatta T, Nakazawa E, Takimoto Y, Akabayashi A.

Breast Cancer (Dove Med Press). 2019 Jul 17;11:221-229. doi: 10.2147/BCTT.S208910. eCollection 2019.


Explicating physiological and biochemical responses of wheat cultivars under acidity stress: insight into the antioxidant defense and glyoxalase systems.

Bhuyan MHMB, Hasanuzzaman M, Mahmud JA, Hossain MS, Alam MU, Fujita M.

Physiol Mol Biol Plants. 2019 Jul;25(4):865-879. doi: 10.1007/s12298-019-00678-0. Epub 2019 May 21.


Structural Elucidation of Tenebrathin: Cytotoxic C-5-Substituted γ-Pyrone with a Nitroaryl Side Chain from Streptoalloteichus tenebrarius.

Hoshino S, Mitsuhashi T, Kikuchi T, Wong CP, Morita H, Awakawa T, Fujita M, Abe I.

Org Lett. 2019 Aug 16;21(16):6519-6522. doi: 10.1021/acs.orglett.9b02443. Epub 2019 Aug 6.


Japan ablation registry: cryoablation in atrioventricular nodal reentrant tachycardia ("JARCANRET study"): results from large multicenter retrospective investigation.

Okishige K, Okumura K, Tsurugi T, Yotsukura A, Nanbu T, Sugiura H, Sanada A, Kondo Y, Takano M, Keida T, Fujita M, Kamiya H, Tsuchiya K, Adachi K, Katoh Y, Hiroshima K, Yamamoto K, Ashikaga K, Hoshiyama T, Sasano T, Hirao K.

J Interv Card Electrophysiol. 2019 Jul 31. doi: 10.1007/s10840-019-00585-0. [Epub ahead of print]


Severe Fever with Thrombocytopenia Syndrome Complicated with Pseudomembranous Aspergillus Tracheobronchitis in a Patient without Apparent Risk Factors for Invasive Aspergillosis: A Case Report.

Sakaguchi K, Koga Y, Yagi T, Nakahara T, Todani M, Fujita M, Tsuruta R.

Intern Med. 2019 Jul 31. doi: 10.2169/internalmedicine.3257-19. [Epub ahead of print]


Neoadjuvant Chemotherapy Increases PD-L1 Expression and CD8+ Tumor-infiltrating Lymphocytes in Esophageal Squamous Cell Carcinoma.

Fukuoka E, Yamashita K, Tanaka T, Sawada R, Sugita Y, Arimoto A, Fujita M, Takiguchi G, Matsuda T, Oshikiri T, Nakamura T, Suzuki S, Kakeji Y.

Anticancer Res. 2019 Aug;39(8):4539-4548. doi: 10.21873/anticanres.13631.


Significance of Elevated HMGB1 Expression in Pituitary Apoplexy.

Okuda T, Fujita M, Kato A.

Anticancer Res. 2019 Aug;39(8):4491-4494. doi: 10.21873/anticanres.13624.


Current and future clinical utilities of Parkinson's disease and dementia biomarkers: can they help us conquer the disease?

Ho G, Takamatsu Y, Waragai M, Wada R, Sugama S, Takenouchi T, Fujita M, Ali A, Hsieh MH, Hashimoto M.

Expert Rev Neurother. 2019 Aug 9:1-13. doi: 10.1080/14737175.2019.1649141. [Epub ahead of print]


Copper ions are novel therapeutic agents for uterine leiomyosarcoma.

Kakuda M, Matsuzaki S, Ueda Y, Shiomi M, Matsuzaki S, Kimura T, Fujita M, Egawa-Takata T, Kobayashi E, Serada S, Yoshino K, Naka T, Kimura T.

Am J Obstet Gynecol. 2019 Jul 24. pii: S0002-9378(19)30935-4. doi: 10.1016/j.ajog.2019.07.030. [Epub ahead of print]


Sepiapterin reductase inhibition selectively reduces inflammatory joint pain and increases urinary sepiapterin.

Fujita M, da Luz Scheffer D, Turnes BL, Cronin SJF, Latrémolière A, Costigan M, Woolf CJ, Latini A, Andrews NA.

Arthritis Rheumatol. 2019 Jul 27. doi: 10.1002/art.41060. [Epub ahead of print]


Melanoma to Vitiligo: The Melanocyte in Biology & Medicine-Joint Montagna Symposium on the Biology of Skin/PanAmerican Society for Pigment Cell Research Annual Meeting.

Leachman SA, Hornyak TJ, Barsh G, Bastian BC, Brash DE, Cleaver JE, Cooper CD, D'Orazio JA, Fujita M, Holmen SL, Indra AK, Kramer KH, Le Poole IC, Lo RS, Lund AW, Manga P, Pavan WJ, Setaluri V, Stemwedel CE, Kulesz-Martin MF.

J Invest Dermatol. 2019 Jul 23. pii: S0022-202X(19)32550-3. doi: 10.1016/j.jid.2019.03.1164. [Epub ahead of print] No abstract available.


Synthesis and Application of Silver Nanoparticles (Ag NPs) for the Prevention of Infection in Healthcare Workers.

Nakamura S, Sato M, Sato Y, Ando N, Takayama T, Fujita M, Ishihara M.

Int J Mol Sci. 2019 Jul 24;20(15). pii: E3620. doi: 10.3390/ijms20153620. Review.


Observation of two types of charge-density-wave orders in superconducting La2-xSrxCuO4.

Wen JJ, Huang H, Lee SJ, Jang H, Knight J, Lee YS, Fujita M, Suzuki KM, Asano S, Kivelson SA, Kao CC, Lee JS.

Nat Commun. 2019 Jul 22;10(1):3269. doi: 10.1038/s41467-019-11167-z.


Association Between Acute Fall in Estimated Glomerular Filtration Rate After Treatment for Primary Aldosteronism and Long-Term Decline in Renal Function.

Kobayashi H, Abe M, Nakamura Y, Takahashi K, Fujita M, Takeda Y, Yoneda T, Kurihara I, Itoh H, Tsuiki M, Wada N, Ichijo T, Katabami T, Ogawa Y, Kawashima J, Yoshimoto T, Sone M, Inagaki N, Watanabe M, Kamemura K, Matsuda Y, Izawa S, Tanabe M, Tanabe A, Suzuki T, Naruse M; JPAS/JRAS Study Group.

Hypertension. 2019 Sep;74(3):630-638. doi: 10.1161/HYPERTENSIONAHA.119.13131. Epub 2019 Jul 22.


Repeated evolution of cytochrome P450-mediated spiroketal steroid biosynthesis in plants.

Christ B, Xu C, Xu M, Li FS, Wada N, Mitchell AJ, Han XL, Wen ML, Fujita M, Weng JK.

Nat Commun. 2019 Jul 19;10(1):3206. doi: 10.1038/s41467-019-11286-7.


Metabolomic Analysis of Skeletal Muscle in Aged Mice.

Uchitomi R, Hatazawa Y, Senoo N, Yoshioka K, Fujita M, Shimizu T, Miura S, Ono Y, Kamei Y.

Sci Rep. 2019 Jul 18;9(1):10425. doi: 10.1038/s41598-019-46929-8.


Renal impairment is closely associated with plasma aldosterone concentration in patients with primary aldosteronism.

Kawashima A, Sone M, Inagaki N, Takeda Y, Itoh H, Kurihara I, Umakoshi H, Ichijo T, Katabami T, Wada N, Ogawa Y, Kawashima J, Fujita M, Miyauchi S, Okamura S, Fukuoka T, Yanase T, Izawa S, Yoshikawa Y, Hashimoto S, Yamada M, Kai T, Suzuki T, Naruse M.

Eur J Endocrinol. 2019 Jul 1. pii: EJE-19-0047.R2. doi: 10.1530/EJE-19-0047. [Epub ahead of print]


Development of a thrombus in the superior mesenteric artery associated with sequential therapy with tyrosine kinase inhibitors for hepatocellular carcinoma.

Nawa T, Katayama K, Kiyota R, Imai T, Abe Y, Hasegawa N, Takada R, Fukutake N, Ikezawa K, Sakakibara M, Fujita M, Ohkawa K.

Clin J Gastroenterol. 2019 Jul 17. doi: 10.1007/s12328-019-01021-6. [Epub ahead of print]


The within- and between-laboratory reproducibility and predictive capacity of the in chemico amino acid derivative reactivity assay: Results of validation study implemented in four participating laboratories.

Fujita M, Yamamoto Y, Watanabe S, Sugawara T, Wakabayashi K, Tahara Y, Horie N, Fujimoto K, Kusakari K, Kurokawa Y, Kawakami T, Kojima K, Sozu T, Nakayama T, Kusao T, Richmond J, Nicole K, Kim BH, Kojima H, Kasahara T, Ono A.

J Appl Toxicol. 2019 Jul 17. doi: 10.1002/jat.3834. [Epub ahead of print]


Optogenetic control of Bacillus subtilis gene expression.

Castillo-Hair SM, Baerman EA, Fujita M, Igoshin OA, Tabor JJ.

Nat Commun. 2019 Jul 15;10(1):3099. doi: 10.1038/s41467-019-10906-6.


Evaluation of Risk Factors for Major Amputation in Patients With Diabetes and Peripheral Artery Disease Receiving Antiplatelet Therapy - Post Hoc Analysis of a Prospective Observational Multicenter Cohort Study (SEASON).

Higashi Y, Miyata T, Shigematsu H, Origasa H, Fujita M, Matsuo H, Naritomi H, Nakajima M, Yuki S, Awano H.

Circ J. 2019 Jul 10. doi: 10.1253/circj.CJ-19-0088. [Epub ahead of print]


Lateralizing Asymmetry of Adrenal Imaging and Adrenal Vein Sampling in Patients With Primary Aldosteronism.

Wada N, Shibayama Y, Yoneda T, Katabami T, Kurihara I, Tsuiki M, Ichijo T, Ogawa Y, Kawashima J, Sone M, Yoshimoto T, Matsuda Y, Fujita M, Kobayashi H, Tamura K, Kamemura K, Otsuki M, Okamura S, Naruse M; JPAS/JRAS Study Group.

J Endocr Soc. 2019 May 16;3(7):1393-1402. doi: 10.1210/js.2019-00131. eCollection 2019 Jul 1.


Squamous cell carcinoma arising in a chronic leg ulcer in Klippel-Trenaunay syndrome after the Charles procedure: A case with 40 years of follow up.

Ishikawa K, Funayama E, Yamamoto Y, Furukawa H, Hayashi T, Murao N, Osawa M, Maeda T, Fujita M, Sasaki S.

J Dermatol. 2019 Jul 8. doi: 10.1111/1346-8138.15001. [Epub ahead of print] No abstract available.


Minimum structural requirements for inhibitors of the zinc finger protein TRAF6.

Radwan MO, Koga R, Hida T, Ejima T, Kanemaru Y, Tateishi H, Okamoto Y, Inoue JI, Fujita M, Otsuka M.

Bioorg Med Chem Lett. 2019 Aug 15;29(16):2162-2167. doi: 10.1016/j.bmcl.2019.06.050. Epub 2019 Jun 27.


Versican is crucial for the initiation of cardiovascular lumen development in medaka (Oryzias latipes).

Mittal N, Yoon SH, Enomoto H, Hiroshi M, Shimizu A, Kawakami A, Fujita M, Watanabe H, Fukuda K, Makino S.

Sci Rep. 2019 Jul 1;9(1):9475. doi: 10.1038/s41598-019-45851-3.


Clinical Characteristics Associated With Lenvatinib-induced Fistula and Tumor-related Bleeding in Patients With Thyroid Cancer.

Staub Y, Nishiyama A, Suga Y, Fujita M, Matsushita R, Yano S.

Anticancer Res. 2019 Jul;39(7):3871-3878. doi: 10.21873/anticanres.13537.


Polyamine Action under Metal/Metalloid Stress: Regulation of Biosynthesis, Metabolism, and Molecular Interactions.

Hasanuzzaman M, Alhaithloul HAS, Parvin K, Bhuyan MHMB, Tanveer M, Mohsin SM, Nahar K, Soliman MH, Mahmud JA, Fujita M.

Int J Mol Sci. 2019 Jun 30;20(13). pii: E3215. doi: 10.3390/ijms20133215. Review.


Oxidative Damage and Antioxidant Defense in Sesamum indicum after Different Waterlogging Durations.

Anee TI, Nahar K, Rahman A, Mahmud JA, Bhuiyan TF, Alam MU, Fujita M, Hasanuzzaman M.

Plants (Basel). 2019 Jun 29;8(7). pii: E196. doi: 10.3390/plants8070196.


Autocrine Production of PDGF Stimulated by the Tenascin-C-Derived Peptide TNIIIA2 Induces Hyper-Proliferation in Glioblastoma Cells.

Fujita M, Yamamoto T, Iyoda T, Fujisawa T, Nagai R, Kudo C, Sasada M, Kodama H, Fukai F.

Int J Mol Sci. 2019 Jun 28;20(13). pii: E3183. doi: 10.3390/ijms20133183.


Spontaneous Regression of Annular Basal Cell Carcinoma: A Case Report.

Go U, Miyata K, Fujita M, Ohide T, Mitsuishi T.

Case Rep Dermatol. 2019 Jun 4;11(2):145-149. doi: 10.1159/000500711. eCollection 2019 May-Aug.


Differential prognostic impact between completion and non-completion of a 5-month cardiac rehabilitation program in outpatients with cardiovascular diseases.

Fujimi K, Imaizumi T, Suematsu Y, Kitajima K, Ueda T, Ishida T, Futami M, Ujifuku Y, Matsuda T, Sakamoto M, Horita T, Teshima R, Kaino K, Fujita M, Arimura T, Shiga Y, Shiota E, Miura SI.

Int J Cardiol. 2019 Oct 1;292:13-18. doi: 10.1016/j.ijcard.2019.06.017. Epub 2019 Jun 12.


Sex Difference in the Association Between Subtype Distribution and Age at Diagnosis in Patients With Primary Aldosteronism.

Akasaka H, Yamamoto K, Rakugi H, Nagasawa M, Nakamaru R, Ichijo T, Takeda Y, Kurihara I, Katabami T, Tsuiki M, Wada N, Ogawa Y, Kawashima J, Sone M, Kamemura K, Yoshimoto T, Matsuda Y, Fujita M, Kobayashi H, Watanabe M, Tamura K, Okamura S, Miyauchi S, Izawa S, Chiba Y, Tanabe A, Naruse M; Japan Primary Aldosteronism Study Group * .

Hypertension. 2019 Aug;74(2):368-374. doi: 10.1161/HYPERTENSIONAHA.119.13006. Epub 2019 Jun 24.


Genomic analysis of pancreatic juice DNA assesses malignant risk of intraductal papillary mucinous neoplasm of pancreas.

Mateos RN, Nakagawa H, Hirono S, Takano S, Fukasawa M, Yanagisawa A, Yasukawa S, Maejima K, Oku-Sasaki A, Nakano K, Dutta M, Tanaka H, Miyano S, Enomoto N, Yamaue H, Nakai K, Fujita M.

Cancer Med. 2019 Jun 21. doi: 10.1002/cam4.2340. [Epub ahead of print]


Comprehensive and quantitative assessment of nitrate dynamics in two contrasting forested basins along the Sea of Japan using dual isotopes of nitrate.

Sugimoto R, Tsuboi T, Fujita MS.

Sci Total Environ. 2019 Oct 15;687:667-678. doi: 10.1016/j.scitotenv.2019.06.090. Epub 2019 Jun 11.


Comparison of Various Disinfectants on Bactericidal Activity Under Organic Matter Contaminated Environments.

Sato Y, Ishihara M, Nakamura S, Fukuda K, Kuwabara M, Takayama T, Hiruma S, Murakami K, Fujita M, Yokoe H.

Biocontrol Sci. 2019;24(2):103-108. doi: 10.4265/bio.24.103.


Nationwide surveillance of bacterial respiratory pathogens conducted by the surveillance committee of Japanese Society of Chemotherapy, the Japanese Association for Infectious Diseases, and the Japanese Society for clinical microbiology in 2014: General view of the pathogens' antibacterial susceptibility.

Yanagihara K, Matsumoto T, Aoki N, Sato J, Wakamura T, Kiyota H, Tateda K, Hanaki H, Ohsaki Y, Fujiuchi S, Takahashi M, Akiba Y, Masunaga S, Takeuchi K, Takeda H, Miki M, Kumagai T, Takahashi H, Utagawa M, Nishiya H, Kawakami S, Ishigaki S, Kobayasi N, Takasaki J, Mezaki K, Iwata S, Katouno Y, Inose R, Niki Y, Kawana A, Fujikura Y, Kudo M, Hirano T, Yamamoto M, Miyazawa N, Tsukada H, Aso S, Yamamoto Y, Iinuma Y, Mikamo H, Yamagishi Y, Nakamura A, Ohashi M, Kawabata A, Sugaki Y, Seki M, Hamaguchi S, Toyokawa M, Kakeya H, Fujikawa Y, Mitsuno N, Ukimura A, Miyara T, Hayasi M, Mikasa K, Kasahara K, Koizumi A, Korohasi N, Matumoto T, Yosimura Y, Katanami Y, Takesue Y, Wada Y, Sugimoto K, Yamamoto T, Kuwabara M, Doi M, Simizu S, Tokuyasu H, Hino S, Negayama K, Mukae H, Kawanami T, Yatera K, Fujita M, Kadota J, Hiramatsu K, Aoki Y, Magarifuchi H, Oho M, Morinaga Y, Suga M, Muranaka H, Fujita J, Higa F, Tateyama M.

J Infect Chemother. 2019 Sep;25(9):657-668. doi: 10.1016/j.jiac.2019.05.006. Epub 2019 Jun 10.


Peptide TNIIIA2 Derived from Tenascin-C Contributes to Malignant Progression in Colitis-Associated Colorectal Cancer via β1-Integrin Activation in Fibroblasts.

Fujita M, Ito-Fujita Y, Iyoda T, Sasada M, Okada Y, Ishibashi K, Osawa T, Kodama H, Fukai F, Suzuki H.

Int J Mol Sci. 2019 Jun 5;20(11). pii: E2752. doi: 10.3390/ijms20112752.


Percutaneous sensitization is limited by in situ inhibition of cutaneous dendritic cell migration through skin-resident regulatory T cells.

Hanakawa S, Kitoh A, Shibuya R, Dainichi T, Nomura T, Honda T, Egawa G, Otsuka A, Nakajima S, Fujita M, Kabashima K.

J Allergy Clin Immunol. 2019 Jun 10. pii: S0091-6749(19)30756-0. doi: 10.1016/j.jaci.2019.05.033. [Epub ahead of print]


Aggressive Progression in Glioblastoma Cells through Potentiated Activation of Integrin α5β1 by the Tenascin-C-Derived Peptide TNIIIA2.

Fujita M, Yamamoto T, Iyoda T, Fujisawa T, Sasada M, Nagai R, Kudo C, Otsuka K, Kamiya S, Kodama H, Fukai F.

Mol Cancer Ther. 2019 Jun 12. doi: 10.1158/1535-7163.MCT-18-1251. [Epub ahead of print]


Handheld flow meter improves COPD detectability regardless of using a conventional questionnaire: A split-sample validation study.

Fujita M, Nagashima K, Takahashi S, Suzuki K, Fujisawa T, Hata A.

Respirology. 2019 Jun 12. doi: 10.1111/resp.13602. [Epub ahead of print]


Successful Treatment with Topical Diphenylcyclopropenone for Three Cases of Anogenital Warts in Children.

Miyata K, Go U, Fujita M, Mitsuishi T.

Case Rep Dermatol. 2019 May 21;11(2):123-129. doi: 10.1159/000500295. eCollection 2019 May-Aug.


An Engineered B. subtilis Inducible Promoter System with over 10 000-Fold Dynamic Range.

Castillo-Hair SM, Fujita M, Igoshin OA, Tabor JJ.

ACS Synth Biol. 2019 Jul 19;8(7):1673-1678. doi: 10.1021/acssynbio.8b00469. Epub 2019 Jun 28.


Extracellular Spermine Triggers a Rapid Intracellular Phosphatidic Acid Response in Arabidopsis, Involving PLDδ Activation and Stimulating Ion Flux.

Zarza X, Shabala L, Fujita M, Shabala S, Haring MA, Tiburcio AF, Munnik T.

Front Plant Sci. 2019 May 21;10:601. doi: 10.3389/fpls.2019.00601. eCollection 2019.


Dynamic pharyngeal collapse in three cats with different pharyngeal pathology.

Fujiwara-Igarashi A, Yu Y, Hamamoto Y, Hasegawa D, Fujita M.

J Vet Med Sci. 2019 Jul 19;81(7):1012-1016. doi: 10.1292/jvms.18-0192. Epub 2019 Jun 6.


Two novel fungal negative-strand RNA viruses related to mymonaviruses and phenuiviruses in the shiitake mushroom (Lentinula edodes).

Lin YH, Fujita M, Chiba S, Hyodo K, Andika IB, Suzuki N, Kondo H.

Virology. 2019 Jul;533:125-136. doi: 10.1016/j.virol.2019.05.008. Epub 2019 May 23.


Clinical and biochemical outcomes after adrenalectomy and medical treatment in patients with unilateral primary aldosteronism.

Katabami T, Fukuda H, Tsukiyama H, Tanaka Y, Takeda Y, Kurihara I, Ito H, Tsuiki M, Ichijo T, Wada N, Shibayama Y, Yoshimoto T, Ogawa Y, Kawashima J, Sone M, Inagaki N, Takahashi K, Fujita M, Watanabe M, Matsuda Y, Kobayashi H, Shibata H, Kamemura K, Otsuki M, Fujii Y, Yamamoto K, Ogo A, Yanase T, Suzuki T, Naruse M; JPAS/JRAS Study Group.

J Hypertens. 2019 Jul;37(7):1513-1520. doi: 10.1097/HJH.0000000000002070.


Genomic and Transcriptomic Profiling of Combined Hepatocellular and Intrahepatic Cholangiocarcinoma Reveals Distinct Molecular Subtypes.

Xue R, Chen L, Zhang C, Fujita M, Li R, Yan SM, Ong CK, Liao X, Gao Q, Sasagawa S, Li Y, Wang J, Guo H, Huang QT, Zhong Q, Tan J, Qi L, Gong W, Hong Z, Li M, Zhao J, Peng T, Lu Y, Lim KHT, Boot A, Ono A, Chayama K, Zhang Z, Rozen SG, Teh BT, Wang XW, Nakagawa H, Zeng MS, Bai F, Zhang N.

Cancer Cell. 2019 Jun 10;35(6):932-947.e8. doi: 10.1016/j.ccell.2019.04.007. Epub 2019 May 23.


Two Cases of Endogenous Endophthalmitis Associated with Pyogenic Liver Abscess Caused by Klebsiella pneumoniae.

Fujita M, Takahashi A, Imaizumi H, Hayashi M, Okai K, Abe K, Ohira H.

Intern Med. 2019 May 22. doi: 10.2169/internalmedicine.2684-19. [Epub ahead of print]


Massively parallel sequencing of tenosynovial giant cell tumors reveals novel CSF1 fusion transcripts and novel somatic CBL mutations.

Tsuda Y, Hirata M, Katayama K, Motoi T, Matsubara D, Oda Y, Fujita M, Kobayashi H, Kawano H, Nishida Y, Sakai T, Okuma T, Goto T, Ogura K, Kawai A, Ae K, Anazawa U, Suehara Y, Iwata S, Miyano S, Imoto S, Shibata T, Nakagawa H, Yamaguchi R, Tanaka S, Matsuda K.

Int J Cancer. 2019 May 20. doi: 10.1002/ijc.32421. [Epub ahead of print]


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