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Principles and Practice to Facilitate a Complete Photodocumentation of the Upper GI Tract: World Endoscopy Organization (WEO) Position Statement.

Emura F, Sharma P, Arantes V, Cerisoli C, Parra-Blanco A, Sumiyama K, Araya R, Sobrino S, Chiu P, Matsuda K, Gonzalez R, Fujishiro M, Tajiri H.

Dig Endosc. 2019 Sep 16. doi: 10.1111/den.13530. [Epub ahead of print] Review.


Rapid increase of platelet counts during antiviral therapy in patients with hepatitis C virus infection.

Ishizu Y, Ishigami M, Hayashi K, Honda T, Kuzuya T, Ito T, Fujishiro M.

Hepatol Res. 2019 Sep 8. doi: 10.1111/hepr.13426. [Epub ahead of print]


Narrow-band imaging for scar classification: from conception to multicenter validation.

Cheng Tao Pu LZ, Chiam KH, Yamamura T, Nakamura M, Berzin TM, Mir FF, Hourneaux de Moura EG, Madruga Neto AC, Ching Koay DS, Loong CK, Ovenden A, Edwards S, Burt AD, Hirooka Y, Fujishiro M, Singh R.

Gastrointest Endosc. 2019 Sep 5. pii: S0016-5107(19)32206-0. doi: 10.1016/j.gie.2019.08.036. [Epub ahead of print]


Prognostic impact of PD-L1 expression in primary gastric and intestinal diffuse large B-cell lymphoma.

Ishikawa E, Nakamura M, Shimada K, Tanaka T, Satou A, Kohno K, Sakakibara A, Furukawa K, Yamamura T, Miyahara R, Nakamura S, Kato S, Fujishiro M.

J Gastroenterol. 2019 Sep 6. doi: 10.1007/s00535-019-01616-3. [Epub ahead of print]


Clinical usefulness of a deep learning-based system as the first screening on small-bowel capsule endoscopy reading.

Aoki T, Yamada A, Aoyama K, Saito H, Fujisawa G, Odawara N, Kondo R, Tsuboi A, Ishibashi R, Nakada A, Niikura R, Fujishiro M, Oka S, Ishihara S, Matsuda T, Nakahori M, Tanaka S, Koike K, Tada T.

Dig Endosc. 2019 Aug 23. doi: 10.1111/den.13517. [Epub ahead of print]


Meflin-positive cancer-associated fibroblasts inhibit pancreatic carcinogenesis.

Mizutani Y, Kobayashi H, Iida T, Asai N, Masamune A, Hara A, Esaki N, Ushida K, Mii S, Shiraki Y, Ando K, Weng L, Ishihara S, Ponik SM, Conklin MW, Haga H, Nagasaka A, Miyata T, Matsuyama M, Kobayashi T, Fujii T, Yamada S, Yamaguchi J, Wang T, Woods SL, Worthley D, Shimamura T, Fujishiro M, Hirooka Y, Takahashi M, Enomoto A.

Cancer Res. 2019 Aug 22. pii: canres.0454.2019. doi: 10.1158/0008-5472.CAN-19-0454. [Epub ahead of print]


Serum Nutritional Markers as Prognostic Factors for Hepatic and Extrahepatic Carcinogenesis in Japanese Patients with Nonalcoholic Fatty Liver Disease.

Ito T, Ishigami M, Ishizu Y, Kuzuya T, Honda T, Ishikawa T, Toyoda H, Kumada T, Fujishiro M.

Nutr Cancer. 2019 Aug 21:1-8. doi: 10.1080/01635581.2019.1653474. [Epub ahead of print]


Artificial intelligence using a convolutional neural network for automatic detection of small-bowel angioectasia in capsule endoscopy images.

Tsuboi A, Oka S, Aoyama K, Saito H, Aoki T, Yamada A, Matsuda T, Fujishiro M, Ishihara S, Nakahori M, Koike K, Tanaka S, Tada T.

Dig Endosc. 2019 Aug 7. doi: 10.1111/den.13507. [Epub ahead of print]


Oxyntic gland neoplasm of the stomach: expanding the spectrum and proposal of terminology.

Ushiku T, Kunita A, Kuroda R, Shinozaki-Ushiku A, Yamazawa S, Tsuji Y, Fujishiro M, Fukayama M.

Mod Pathol. 2019 Aug 2. doi: 10.1038/s41379-019-0338-1. [Epub ahead of print]


A Case Where Administration of Ustekinumab Maintained the Intestinal Patency After Balloon Dilation for Small Intestinal Stenosis Caused by Crohn's Disease.

Murate K, Nakamura M, Fujishiro M.

Inflamm Bowel Dis. 2019 Aug 2. pii: izz166. doi: 10.1093/ibd/izz166. [Epub ahead of print] No abstract available.


CF290 for pancolonic chromoendoscopy improved sessile serrated polyp detection and procedure time: a propensity score-matching study.

Toyoshima O, Yoshida S, Nishizawa T, Yamakawa T, Sakitani K, Hata K, Takahashi Y, Fujishiro M, Watanabe H, Koike K.

Endosc Int Open. 2019 Aug;7(8):E987-E993. doi: 10.1055/a-0953-1909. Epub 2019 Jul 24.


Possible involvement of normalized Pin1 expression level and AMPK activation in the molecular mechanisms underlying renal protective effects of SGLT2 inhibitors in mice.

Inoue MK, Matsunaga Y, Nakatsu Y, Yamamotoya T, Ueda K, Kushiyama A, Sakoda H, Fujishiro M, Ono H, Iwashita M, Sano T, Nishimura F, Morii K, Sasaki K, Masaki T, Asano T.

Diabetol Metab Syndr. 2019 Jul 22;11:57. doi: 10.1186/s13098-019-0454-6. eCollection 2019.


A multicenter database registry for endoscopic retrograde cholangiopancreatography: the Japan Endoscopic Database Project.

Kato M, Tanaka K, Kida M, Ryozawa S, Matsuda K, Fujishiro M, Saito Y, Ohtsuka K, Oda I, Katada C, Kobayashi K, Hoteya S, Horimatsu T, Kodashima S, Matsuda T, Muto M, Yamamoto H, Iwakiri R, Kutsumi H, Miyata H, Kato M, Haruma K, Fujimoto K, Uemura N, Kaminishi M, Tajiri H.

Dig Endosc. 2019 Jul 30. doi: 10.1111/den.13495. [Epub ahead of print] Review.


Two Adult Siblings With Myotonic Dystrophy Type 1 With Different Phenotypes Presenting With Chronic Respiratory Insufficiency and Sleep Apnea Syndrome.

Kohno G, Ogawa K, Kushimoto M, Tanaka S, Ikeda J, Nishizawa T, Mitsuke K, Nakayama T, Suzuki Y, Ishihara H, Fujishiro M.

Front Neurol. 2019 Jul 4;10:681. doi: 10.3389/fneur.2019.00681. eCollection 2019.


High-throughput method to analyze tegafur and 5-fluorouracil in human tears and plasma using hydrophilic interaction liquid chromatography-tandem mass spectrometry.

Shiokawa R, Lee XP, Yamada M, Fujishiro M, Sakamaki H, Hasegawa C, Ishida H, Ikeda K, Fujita KI, Iwabuchi S, Onda H, Kumazawa T, Sasaki Y, Sato K, Matsuyama T.

Rapid Commun Mass Spectrom. 2019 Jul 19. doi: 10.1002/rcm.8531. [Epub ahead of print]


Successful Treatment of Hepatocellular Carcinoma with Regorafenib after Sorafenib-induced Hypersensitivity.

Yoshioka N, Kuzuya T, Ito T, Ishizu Y, Honda T, Ishikawa T, Ishigami M, Fujishiro M.

Intern Med. 2019 Jun 27. doi: 10.2169/internalmedicine.2812-19. [Epub ahead of print]


Color information from linked color imaging is associated with invasion depth and vascular diameter in superficial esophageal squamous cell carcinoma.

Kobayashi K, Miyahara R, Funasaka K, Furukawa K, Sawada T, Maeda K, Yamamura T, Ishikawa T, Ohno E, Nakamura M, Kawashima H, Nakaguro M, Okumura Y, Hirooka Y, Fujishiro M.

Dig Endosc. 2019 Jun 20. doi: 10.1111/den.13469. [Epub ahead of print]


Acute esophageal necrosis after cellulitis in an obese patient with diabetes mellitus.

Tanaka S, Fujishiro M, Ichijima R, Kohno G, Abe M, Ishihara H.

J Diabetes Investig. 2019 Jun 20. doi: 10.1111/jdi.13104. [Epub ahead of print]


Sarcopenia impairs health-related quality of life in cirrhotic patients.

Ando Y, Ishigami M, Ito T, Ishizu Y, Kuzuya T, Honda T, Ishikawa T, Fujishiro M.

Eur J Gastroenterol Hepatol. 2019 Jun 14. doi: 10.1097/MEG.0000000000001472. [Epub ahead of print]


Spleen stiffness by 2-D shear wave elastography is the most accurate predictor of high-risk esophagogastric varices in children with biliary atresia.

Yokoyama S, Ishigami M, Honda T, Kuzuya T, Ishizu Y, Ito T, Hirooka Y, Tanaka Y, Tainaka T, Shirota C, Chiba K, Uchida H, Fujishiro M.

Hepatol Res. 2019 May 27. doi: 10.1111/hepr.13381. [Epub ahead of print]


Clinical characteristics and outcomes of candidates for second-line therapy, including regorafenib and ramucirumab, for advanced hepatocellular carcinoma after sorafenib treatment.

Kuzuya T, Ishigami M, Ito T, Ishizu Y, Honda T, Ishikawa T, Hirooka Y, Fujishiro M.

Hepatol Res. 2019 Apr 29. doi: 10.1111/hepr.13358. [Epub ahead of print]


The Reduction in Gastric Atrophy after Helicobacter pylori Eradication Is Reduced by Treatment with Inhibitors of Gastric Acid Secretion.

Niikura R, Hayakawa Y, Hirata Y, Ogura K, Fujishiro M, Yamada A, Ushiku T, Konishi M, Fukayama M, Koike K.

Int J Mol Sci. 2019 Apr 18;20(8). pii: E1913. doi: 10.3390/ijms20081913.


Mucinous cystic neoplasm of the pancreas assessed with a real-time three-dimensional imaging using a transesophageal echocardiography probe.

Ishikawa T, Hirooka Y, Kawashima H, Ohno E, Fujishiro M.

Clin J Gastroenterol. 2019 Apr 2. doi: 10.1007/s12328-019-00975-x. [Epub ahead of print]


Red Fluorescence Probe Targeted to Dipeptidylpeptidase-IV for Highly Sensitive Detection of Esophageal Cancer.

Ogasawara A, Kamiya M, Sakamoto K, Kuriki Y, Fujita K, Komatsu T, Ueno T, Hanaoka K, Onoyama H, Abe H, Tsuji Y, Fujishiro M, Koike K, Fukayama M, Seto Y, Urano Y.

Bioconjug Chem. 2019 Apr 17;30(4):1055-1060. doi: 10.1021/acs.bioconjchem.9b00198. Epub 2019 Apr 3.


Prolyl isomerase Pin1 binds to and stabilizes acetyl CoA carboxylase 1 protein, thereby supporting cancer cell proliferation.

Ueda K, Nakatsu Y, Yamamotoya T, Ono H, Inoue Y, Inoue MK, Mizuno Y, Matsunaga Y, Kushiyama A, Sakoda H, Fujishiro M, Takahashi SI, Matsubara A, Asano T.

Oncotarget. 2019 Feb 26;10(17):1637-1648. doi: 10.18632/oncotarget.26691. eCollection 2019 Feb 26.


Prolyl Isomerase Pin1 Suppresses Thermogenic Programs in Adipocytes by Promoting Degradation of Transcriptional Co-activator PRDM16.

Nakatsu Y, Matsunaga Y, Yamamotoya T, Ueda K, Inoue MK, Mizuno Y, Nakanishi M, Sano T, Yamawaki Y, Kushiyama A, Sakoda H, Fujishiro M, Ryo A, Ono H, Minamino T, Takahashi SI, Ohno H, Yoneda M, Takahashi K, Ishihara H, Katagiri H, Nishimura F, Kanematsu T, Yamada T, Asano T.

Cell Rep. 2019 Mar 19;26(12):3221-3230.e3. doi: 10.1016/j.celrep.2019.02.066.


Retention of aberrant cortisol secretion in a patient with bilateral macronodular adrenal hyperplasia after unilateral adrenalectomy.

Tanaka S, Fujishiro M, Nakamura Y, Hatanaka Y, Abe M.

Ther Clin Risk Manag. 2019 Feb 27;15:337-342. doi: 10.2147/TCRM.S196171. eCollection 2019.


Application of convolutional neural networks for evaluating Helicobacter pylori infection status on the basis of endoscopic images.

Shichijo S, Endo Y, Aoyama K, Takeuchi Y, Ozawa T, Takiyama H, Matsuo K, Fujishiro M, Ishihara S, Ishihara R, Tada T.

Scand J Gastroenterol. 2019 Feb;54(2):158-163. doi: 10.1080/00365521.2019.1577486. Epub 2019 Mar 17.


Endoscopic tissue shielding to prevent bleeding after endoscopic submucosal dissection: a prospective multicenter randomized controlled trial.

Kataoka Y, Tsuji Y, Hirasawa K, Takimoto K, Wada T, Mochizuki S, Ohata K, Sakaguchi Y, Niimi K, Ono S, Kodashima S, Yamamichi N, Fujishiro M, Koike K.

Endoscopy. 2019 Jul;51(7):619-627. doi: 10.1055/a-0860-5280. Epub 2019 Mar 12.


Analysis of predictive factors for R0 resection and immediate bleeding of cold snare polypectomy in colonoscopy.

Aoki T, Yoshida S, Abe H, Ono S, Nakada A, Ota Y, Narita A, Yoshikawa T, Kinoshita H, Tsuji Y, Yamada A, Fujishiro M, Hirata Y, Fukayama M, Koike K.

PLoS One. 2019 Mar 1;14(3):e0213281. doi: 10.1371/journal.pone.0213281. eCollection 2019.


MicroRNA-766-3p Contributes to Anti-Inflammatory Responses through the Indirect Inhibition of NF-κB Signaling.

Hayakawa K, Kawasaki M, Hirai T, Yoshida Y, Tsushima H, Fujishiro M, Ikeda K, Morimoto S, Takamori K, Sekigawa I.

Int J Mol Sci. 2019 Feb 14;20(4). pii: E809. doi: 10.3390/ijms20040809.


Plasma Dynorphin A Concentration Reflects the Degree of Pruritus in Chronic Liver Disease: A Preliminary Report.

Moniaga CS, Iwamoto S, Kitamura T, Fujishiro M, Takahashi N, Kina K, Ogawa H, Tominaga M, Takamori K.

Acta Derm Venereol. 2019 Apr 1;99(4):442-443. doi: 10.2340/00015555-3139. No abstract available.


Automatic detection of erosions and ulcerations in wireless capsule endoscopy images based on a deep convolutional neural network.

Aoki T, Yamada A, Aoyama K, Saito H, Tsuboi A, Nakada A, Niikura R, Fujishiro M, Oka S, Ishihara S, Matsuda T, Tanaka S, Koike K, Tada T.

Gastrointest Endosc. 2019 Feb;89(2):357-363.e2. doi: 10.1016/j.gie.2018.10.027. Epub 2018 Oct 25.


Diagnosis using deep-learning artificial intelligence based on the endocytoscopic observation of the esophagus.

Kumagai Y, Takubo K, Kawada K, Aoyama K, Endo Y, Ozawa T, Hirasawa T, Yoshio T, Ishihara S, Fujishiro M, Tamaru JI, Mochiki E, Ishida H, Tada T.

Esophagus. 2019 Apr;16(2):180-187. doi: 10.1007/s10388-018-0651-7. Epub 2018 Dec 13.


The Xanthine Oxidase Inhibitor Febuxostat Suppresses the Progression of IgA Nephropathy, Possibly via Its Anti-Inflammatory and Anti-Fibrotic Effects in the gddY Mouse Model.

Inoue MK, Yamamotoya T, Nakatsu Y, Ueda K, Inoue Y, Matsunaga Y, Sakoda H, Fujishiro M, Ono H, Morii K, Sasaki K, Masaki T, Suzuki Y, Asano T, Kushiyama A.

Int J Mol Sci. 2018 Dec 10;19(12). pii: E3967. doi: 10.3390/ijms19123967.


Current status of esophageal endoscopy including the evaluation of smoking and alcohol consumption in Japan: an analysis based on the Japan endoscopy database.

Katada C, Horimatsu T, Muto M, Tanaka K, Matsuda K, Fujishiro M, Saito Y, Ohtsuka K, Oda I, Kato M, Kida M, Kobayashi K, Hoteya S, Kodashima S, Matsuda T, Yamamoto H, Ryozawa S, Iwakiri R, Kutsumi H, Miyata H, Kato M, Haruma K, Fujimoto K, Uemura N, Kaminishi M, Tajiri H.

Esophagus. 2019 Apr;16(2):174-179. doi: 10.1007/s10388-018-0650-8. Epub 2018 Dec 5.


Comparative assessment of 24-hr primary skin irritation test and human patch test data with in vitro skin irritation tests according to OECD Test Guideline 439 (for quasi-drugs in Japan).

Sugiyama M, Akita M, Alépée N, Fujishiro M, Hagino S, Handa Y, Ikeda H, Imai N, Jitsukawa S, Katoh M, Kurihara K, Kyotani D, Nomura S, Okamoto Y, Okumura H, Omori T, Sugibayashi K, Todo H, Toyoda A, Ohno Y.

J Toxicol Sci. 2018;43(12):751-768. doi: 10.2131/jts.43.751.


Initial and crucial genetic events in intestinal-type gastric intramucosal neoplasia.

Rokutan H, Abe H, Nakamura H, Ushiku T, Arakawa E, Hosoda F, Yachida S, Tsuji Y, Fujishiro M, Koike K, Totoki Y, Fukayama M, Shibata T.

J Pathol. 2019 Apr;247(4):494-504. doi: 10.1002/path.5208. Epub 2019 Jan 16.


The Effects of Direct Oral Anticoagulants, Warfarin, Aspirin and Thienopyridine on the Performance of Immunochemical, Faecal, Occult Blood Tests.

Niikura R, Yamada A, Fujishiro M, Tanaka K, Matsuda K, Saito Y, Ohtsuka K, Oda I, Katada C, Kato M, Kida M, Kobayashi K, Hoteya S, Horimatsu T, Kodashima S, Matsuda T, Muto M, Yamamoto H, Ryozawa S, Iwakiri R, Kutsumi H, Miyata H, Kato M, Haruma K, Fujimoto K, Uemura N, Kaminishi M, Shinozaki T, Tajiri H, Koike K.

Digestion. 2019;100(2):117-126. doi: 10.1159/000494251. Epub 2018 Nov 8.


Development of Pin1 inhibitors and their potential as therapeutic agents.

Nakatsu Y, Matsunaga Y, Ueda K, Yamamotoya T, Inoue Y, Inoue MK, Mizuno Y, Kushiyama A, Ono H, Fujishiro M, Ito H, Okabe T, Asano T.

Curr Med Chem. 2018 Nov 5. doi: 10.2174/0929867325666181105120911. [Epub ahead of print]


Novel computer-assisted diagnosis system for endoscopic disease activity in patients with ulcerative colitis.

Ozawa T, Ishihara S, Fujishiro M, Saito H, Kumagai Y, Shichijo S, Aoyama K, Tada T.

Gastrointest Endosc. 2019 Feb;89(2):416-421.e1. doi: 10.1016/j.gie.2018.10.020. Epub 2018 Oct 24.


Elsberg syndrome related to varicella zoster virus infection with painless skin lesions in an elderly woman with poorly controlled type 2 diabetes mellitus.

Saito H, Ebashi M, Kushimoto M, Ikeda J, Egashira F, Yamaguchi S, Watanabe K, Ogawa K, Suzuki Y, Ishihara H, Fujishiro M.

Ther Clin Risk Manag. 2018 Oct 9;14:1951-1954. doi: 10.2147/TCRM.S178782. eCollection 2018.


Status of Helicobacter pylori infection and gastric mucosal atrophy in patients with gastric cancer: Analysis based on the Japan Endoscopy Database.

Oda I, Hoteya S, Fujishiro M.

Dig Endosc. 2019 Jan;31(1):103. doi: 10.1111/den.13287. Epub 2018 Nov 9. No abstract available.


Roles of Gut-Derived Secretory Factors in the Pathogenesis of Non-Alcoholic Fatty Liver Disease and Their Possible Clinical Applications.

Okubo H, Kushiyama A, Nakatsu Y, Yamamotoya T, Matsunaga Y, Fujishiro M, Sakoda H, Ohno H, Yoneda M, Asano T.

Int J Mol Sci. 2018 Oct 8;19(10). pii: E3064. doi: 10.3390/ijms19103064. Review.


Transduced caudal-type homeobox (CDX) 2/CDX1 can induce growth inhibition on CDX-deficient gastric cancer by rapid intestinal differentiation.

Nakayama C, Yamamichi N, Tomida S, Takahashi Y, Kageyama-Yahara N, Sakurai K, Takeuchi C, Inada KI, Shiogama K, Nagae G, Ono S, Tsuji Y, Niimi K, Fujishiro M, Aburatani H, Tsutsumi Y, Koike K.

Cancer Sci. 2018 Dec;109(12):3853-3864. doi: 10.1111/cas.13821. Epub 2018 Oct 26.


Rationale and Design of the STOP-OB Study for Evaluating the Effects of Tofogliflozin and Glimepiride on Fat Deposition in Type 2 Diabetes Patients Treated with Metformin/DPP-4 Inhibitor Dual Therapy.

Ishihara H, Anai M, Seino H, Kitazawa T, Ohashi H, Ai M, Inoue M, Fujishiro M, Inazawa T, Kuroda H, Yamada M.

Diabetes Ther. 2018 Oct;9(5):2117-2125. doi: 10.1007/s13300-018-0491-4. Epub 2018 Aug 25.


Diagnostic outcomes of esophageal cancer by artificial intelligence using convolutional neural networks.

Horie Y, Yoshio T, Aoyama K, Yoshimizu S, Horiuchi Y, Ishiyama A, Hirasawa T, Tsuchida T, Ozawa T, Ishihara S, Kumagai Y, Fujishiro M, Maetani I, Fujisaki J, Tada T.

Gastrointest Endosc. 2019 Jan;89(1):25-32. doi: 10.1016/j.gie.2018.07.037. Epub 2018 Aug 16.


Role of warfarin as a predictor of recurrent bleeding after negative small-bowel capsule endoscopy.

Niikura R, Yamada A, Hirata Y, Hayakawa Y, Suzuki H, Yamamoto S, Fujishiro M, Koike K.

Gastrointest Endosc. 2018 Sep;88(3):574-574.e2. doi: 10.1016/j.gie.2018.04.2344. No abstract available.


Short-term outcomes of multicenter prospective cohort study of gastric endoscopic resection: 'Real-world evidence' in Japan.

Suzuki H, Takizawa K, Hirasawa T, Takeuchi Y, Ishido K, Hoteya S, Yano T, Tanaka S, Endo M, Nakagawa M, Toyonaga T, Doyama H, Hirasawa K, Matsuda M, Yamamoto H, Fujishiro M, Hashimoto S, Maeda Y, Oyama T, Takenaka R, Yamamoto Y, Naito Y, Michida T, Kobayashi N, Kawahara Y, Hirano M, Jin M, Hori S, Niwa Y, Hikichi T, Shimazu T, Ono H, Tanabe S, Kondo H, Iishi H, Ninomiya M; Ichiro Oda for J-WEB/EGC group.

Dig Endosc. 2019 Jan;31(1):30-39. doi: 10.1111/den.13246. Epub 2018 Sep 25.


Protective Effect of Sex Hormone-Binding Globulin against Metabolic Syndrome: In Vitro Evidence Showing Anti-Inflammatory and Lipolytic Effects on Adipocytes and Macrophages.

Yamazaki H, Kushiyama A, Sakoda H, Fujishiro M, Yamamotoya T, Nakatsu Y, Kikuchi T, Kaneko S, Tanaka H, Asano T.

Mediators Inflamm. 2018 Jun 25;2018:3062319. doi: 10.1155/2018/3062319. eCollection 2018.

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