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Cannabidiol reduces seizures following CNS infection with Theiler's murine encephalomyelitis virus.

Patel DC, Wallis G, Fujinami RS, Wilcox KS, Smith MD.

Epilepsia Open. 2019 Jul 19;4(3):431-442. doi: 10.1002/epi4.12351. eCollection 2019 Sep.


Differential transcriptional profiles identify microglial- and macrophage-specific gene markers expressed during virus-induced neuroinflammation.

DePaula-Silva AB, Gorbea C, Doty DJ, Libbey JE, Sanchez JMS, Hanak TJ, Cazalla D, Fujinami RS.

J Neuroinflammation. 2019 Jul 20;16(1):152. doi: 10.1186/s12974-019-1545-x.


The microbiota protects from viral-induced neurologic damage through microglia-intrinsic TLR signaling.

Brown DG, Soto R, Yandamuri S, Stone C, Dickey L, Gomes-Neto JC, Pastuzyn ED, Bell R, Petersen C, Buhrke K, Fujinami RS, O'Connell RM, Stephens WZ, Shepherd JD, Lane TE, Round JL.

Elife. 2019 Jul 16;8. pii: e47117. doi: 10.7554/eLife.47117.


Depletion of PD-1-positive cells ameliorates autoimmune disease.

Zhao P, Wang P, Dong S, Zhou Z, Cao Y, Yagita H, He X, Zheng SG, Fisher SJ, Fujinami RS, Chen M.

Nat Biomed Eng. 2019 Apr;3(4):292-305. doi: 10.1038/s41551-019-0360-0. Epub 2019 Mar 4.


Microglial cell depletion is fatal with low level picornavirus infection of the central nervous system.

Sanchez JMS, DePaula-Silva AB, Doty DJ, Truong A, Libbey JE, Fujinami RS.

J Neurovirol. 2019 Jun;25(3):415-421. doi: 10.1007/s13365-019-00740-3. Epub 2019 Mar 11.


Positive modulation of mGluR5 attenuates seizures and reduces TNF-α+ macrophages and microglia in the brain in a murine model of virus-induced temporal lobe epilepsy.

Hanak TJ, Libbey JE, Doty DJ, Sim JT, DePaula-Silva AB, Fujinami RS.

Exp Neurol. 2019 Jan;311:194-204. doi: 10.1016/j.expneurol.2018.10.006. Epub 2018 Oct 11.


Viral Triggers and Inflammatory Mechanisms in Pediatric Epilepsy.

Bartolini L, Libbey JE, Ravizza T, Fujinami RS, Jacobson S, Gaillard WD.

Mol Neurobiol. 2019 Mar;56(3):1897-1907. doi: 10.1007/s12035-018-1215-5. Epub 2018 Jul 5. Review.


Induced CNS expression of CXCL1 augments neurologic disease in a murine model of multiple sclerosis via enhanced neutrophil recruitment.

Grist JJ, Marro BS, Skinner DD, Syage AR, Worne C, Doty DJ, Fujinami RS, Lane TE.

Eur J Immunol. 2018 Jul;48(7):1199-1210. doi: 10.1002/eji.201747442. Epub 2018 May 16.


The immune response to picornavirus infection and the effect of immune manipulation on acute seizures.

DePaula-Silva AB, Sonderegger FL, Libbey JE, Doty DJ, Fujinami RS.

J Neurovirol. 2018 Aug;24(4):464-477. doi: 10.1007/s13365-018-0636-2. Epub 2018 Apr 23.


Diffusion Basis Spectrum and Diffusion Tensor Imaging Detect Hippocampal Inflammation and Dendritic Injury in a Virus-Induced Mouse Model of Epilepsy.

Zhan J, Lin TH, Libbey JE, Sun P, Ye Z, Song C, Wallendorf M, Gong H, Fujinami RS, Song SK.

Front Neurosci. 2018 Feb 15;12:77. doi: 10.3389/fnins.2018.00077. eCollection 2018.


Variations in diet cause alterations in microbiota and metabolites that follow changes in disease severity in a multiple sclerosis model.

Libbey JE, Sanchez JM, Doty DJ, Sim JT, Cusick MF, Cox JE, Fischer KF, Round JL, Fujinami RS.

Benef Microbes. 2018 Apr 25;9(3):495-513. doi: 10.3920/BM2017.0116. Epub 2018 Jan 30.


The role of peripheral interleukin-6 in the development of acute seizures following virus encephalitis.

Cusick MF, Libbey JE, Doty DJ, DePaula-Silva AB, Fujinami RS.

J Neurovirol. 2017 Oct;23(5):696-703. doi: 10.1007/s13365-017-0554-8. Epub 2017 Jul 24.


Hippocampal TNFα Signaling Contributes to Seizure Generation in an Infection-Induced Mouse Model of Limbic Epilepsy.

Patel DC, Wallis G, Dahle EJ, McElroy PB, Thomson KE, Tesi RJ, Szymkowski DE, West PJ, Smeal RM, Patel M, Fujinami RS, White HS, Wilcox KS.

eNeuro. 2017 May 9;4(2). pii: ENEURO.0105-17.2017. doi: 10.1523/ENEURO.0105-17.2017. eCollection 2017 Mar-Apr.


Microbiota promotes systemic T-cell survival through suppression of an apoptotic factor.

Soto R, Petersen C, Novis CL, Kubinak JL, Bell R, Stephens WZ, Lane TE, Fujinami RS, Bosque A, O'Connell RM, Round JL.

Proc Natl Acad Sci U S A. 2017 May 23;114(21):5497-5502. doi: 10.1073/pnas.1619336114. Epub 2017 May 9.


Complement Components Are Expressed by Infiltrating Macrophages/Activated Microglia Early Following Viral Infection.

Libbey JE, Cusick MF, Doty DJ, Fujinami RS.

Viral Immunol. 2017 Jun;30(5):304-314. doi: 10.1089/vim.2016.0175. Epub 2017 Apr 12.


Theiler's murine encephalomyelitis virus infection of SJL/J and C57BL/6J mice: Models for multiple sclerosis and epilepsy.

DePaula-Silva AB, Hanak TJ, Libbey JE, Fujinami RS.

J Neuroimmunol. 2017 Jul 15;308:30-42. doi: 10.1016/j.jneuroim.2017.02.012. Epub 2017 Feb 12. Review.


Complete Genome Sequence of Murine Pneumotropic Virus (Polyomaviridae) Clone pKV(37-1).

Libbey JE, Fujinami RS.

Genome Announc. 2016 May 19;4(3). pii: e00404-16. doi: 10.1128/genomeA.00404-16.


The effects of diet on the severity of central nervous system disease: One part of lab-to-lab variability.

Libbey JE, Doty DJ, Sim JT, Cusick MF, Round JL, Fujinami RS.

Nutrition. 2016 Jul-Aug;32(7-8):877-83. doi: 10.1016/j.nut.2016.01.009. Epub 2016 Jan 21.


NBQX, a highly selective competitive antagonist of AMPA and KA ionotropic glutamate receptors, increases seizures and mortality following picornavirus infection.

Libbey JE, Hanak TJ, Doty DJ, Wilcox KS, Fujinami RS.

Exp Neurol. 2016 Jun;280:89-96. doi: 10.1016/j.expneurol.2016.04.010. Epub 2016 Apr 9.


Infections, inflammation and epilepsy.

Vezzani A, Fujinami RS, White HS, Preux PM, Blümcke I, Sander JW, Löscher W.

Acta Neuropathol. 2016 Feb;131(2):211-234. doi: 10.1007/s00401-015-1481-5. Epub 2015 Sep 30. Review.


DA virus mutant H101 has altered CNS pathogenesis and causes immunosuppression.

Cusick MF, Libbey JE, Doty DJ, Fujinami RS.

J Neuroimmunol. 2014 Dec 15;277(1-2):118-26. doi: 10.1016/j.jneuroim.2014.10.012. Epub 2014 Nov 6.


Acthar gel treatment suppresses acute exacerbations in a murine model of relapsing-remitting multiple sclerosis.

Cusick MF, Libbey JE, Oh L, Jordan S, Fujinami RS.

Autoimmunity. 2015 Jun;48(4):222-30. doi: 10.3109/08916934.2014.984836. Epub 2014 Nov 20.


Picornavirus infection leading to immunosuppression.

Cusick MF, Libbey JE, Fujinami RS.

Future Virol. 2014 May 1;9(5):475-482.


Axonal pathology and demyelination in viral models of multiple sclerosis.

Libbey JE, Lane TE, Fujinami RS.

Discov Med. 2014 Jul-Aug;18(97):79-89. Review.


Adaptive immune response to viral infections in the central nervous system.

Libbey JE, Fujinami RS.

Handb Clin Neurol. 2014;123:225-47. doi: 10.1016/B978-0-444-53488-0.00010-9. No abstract available.


Diffusion basis spectrum imaging detects and distinguishes coexisting subclinical inflammation, demyelination and axonal injury in experimental autoimmune encephalomyelitis mice.

Wang X, Cusick MF, Wang Y, Sun P, Libbey JE, Trinkaus K, Fujinami RS, Song SK.

NMR Biomed. 2014 Jul;27(7):843-52. doi: 10.1002/nbm.3129. Epub 2014 May 12.


Targeting insulin-like growth factor 1 leads to amelioration of inflammatory demyelinating disease.

Cusick MF, Libbey JE, Trede NS, Fujinami RS.

PLoS One. 2014 Apr 9;9(4):e94486. doi: 10.1371/journal.pone.0094486. eCollection 2014.


Reviews in neuroimmunology.

Fujinami RS.

J Neurovirol. 2014 Apr;20(2):105-6. doi: 10.1007/s13365-013-0230-6. Epub 2014 Feb 19. No abstract available.


CD4+ T-cell engagement by both wild-type and variant HCV peptides modulates the conversion of viral clearing helper T cells to Tregs.

Cusick MF, Libbey JE, Cox Gill J, Fujinami RS, Eckels DD.

Future Virol. 2013 Jul;8(7). doi: 10.2217/fvl.13.49.


Role of pathogens in multiple sclerosis.

Libbey JE, Cusick MF, Fujinami RS.

Int Rev Immunol. 2014 Jul-Aug;33(4):266-83. doi: 10.3109/08830185.2013.823422. Epub 2013 Nov 22. Review.


Multiple sclerosis: autoimmunity and viruses.

Cusick MF, Libbey JE, Fujinami RS.

Curr Opin Rheumatol. 2013 Jul;25(4):496-501. doi: 10.1097/BOR.0b013e328362004d. Review.


Discovery of biologically active oncologic and immunologic small molecule therapies using zebrafish: overview and example of modulation of T cell activation.

Trede NS, Heaton W, Ridges S, Sofla H, Cusick M, Bearss D, Jones D, Fujinami RS.

Curr Protoc Pharmacol. 2013 Mar;Chapter 14:Unit14.24. doi: 10.1002/0471141755.ph1424s60.


Infiltrating macrophages are key to the development of seizures following virus infection.

Cusick MF, Libbey JE, Patel DC, Doty DJ, Fujinami RS.

J Virol. 2013 Feb;87(3):1849-60. doi: 10.1128/JVI.02747-12. Epub 2012 Dec 12.


In vitro antigen-specific induction of IL-22 in human subjects that resolved HCV infection.

Cusick MF, Libbey JE, Fujinami RS, Eckels DD.

Future Virol. 2012 Jul 1;7(7):719-728.


Theiler's murine encephalomyelitis virus contrasts with encephalomyocarditis and foot-and-mouth disease viruses in its functional utilization of the StopGo non-standard translation mechanism.

Loughran G, Libbey JE, Uddowla S, Scallan MF, Ryan MD, Fujinami RS, Rieder E, Atkins JF.

J Gen Virol. 2013 Feb;94(Pt 2):348-53. doi: 10.1099/vir.0.047571-0. Epub 2012 Oct 24.


Possible role of interleukin-17 in a prime/challenge model of multiple sclerosis.

Libbey JE, Tsunoda I, Fujinami RS.

J Neurovirol. 2012 Dec;18(6):471-8. doi: 10.1007/s13365-012-0125-y. Epub 2012 Sep 19.


Immunization with structural and non-structural proteins of Theiler's murine encephalomyelitis virus alters demyelinating disease.

Tsunoda I, Libbey JE, Fujinami RS.

J Neurovirol. 2012 Apr;18(2):127-37. doi: 10.1007/s13365-012-0087-0. Epub 2012 Mar 9.


The activity within the CA3 excitatory network during Theiler's virus encephalitis is distinct from that observed during chronic epilepsy.

Smeal RM, Stewart KA, Iacob E, Fujinami RS, White HS, Wilcox KS.

J Neurovirol. 2012 Feb;18(1):30-44. doi: 10.1007/s13365-012-0082-5. Epub 2012 Feb 11.


Antiviral CD8⁺ T cells cause an experimental autoimmune encephalomyelitis-like disease in naive mice.

Libbey JE, Cusick MF, Tsunoda I, Fujinami RS.

J Neurovirol. 2012 Feb;18(1):45-54. doi: 10.1007/s13365-012-0077-2. Epub 2012 Jan 27.


Human T cell expansion and experimental autoimmune encephalomyelitis inhibited by Lenaldekar, a small molecule discovered in a zebrafish screen.

Cusick MF, Libbey JE, Trede NS, Eckels DD, Fujinami RS.

J Neuroimmunol. 2012 Mar;244(1-2):35-44. doi: 10.1016/j.jneuroim.2011.12.024. Epub 2012 Jan 14.


Molecular mimicry as a mechanism of autoimmune disease.

Cusick MF, Libbey JE, Fujinami RS.

Clin Rev Allergy Immunol. 2012 Feb;42(1):102-11. doi: 10.1007/s12016-011-8293-8. Review.


Once initiated, viral encephalitis-induced seizures are consistent no matter the treatment or lack of interleukin-6.

Libbey JE, Kennett NJ, Wilcox KS, White HS, Fujinami RS.

J Neurovirol. 2011 Oct;17(5):496-9. doi: 10.1007/s13365-011-0050-5. Epub 2011 Aug 11.


Lack of correlation of central nervous system inflammation and neuropathology with the development of seizures following acute virus infection.

Libbey JE, Kennett NJ, Wilcox KS, White HS, Fujinami RS.

J Virol. 2011 Aug;85(16):8149-57. doi: 10.1128/JVI.00730-11. Epub 2011 Jun 15.


Interleukin-6, produced by resident cells of the central nervous system and infiltrating cells, contributes to the development of seizures following viral infection.

Libbey JE, Kennett NJ, Wilcox KS, White HS, Fujinami RS.

J Virol. 2011 Jul;85(14):6913-22. doi: 10.1128/JVI.00458-11. Epub 2011 May 4.


Development of postinfection epilepsy after Theiler's virus infection of C57BL/6 mice.

Stewart KA, Wilcox KS, Fujinami RS, White HS.

J Neuropathol Exp Neurol. 2010 Dec;69(12):1210-9. doi: 10.1097/NEN.0b013e3181ffc420.


Experimental autoimmune encephalomyelitis as a testing paradigm for adjuvants and vaccines.

Libbey JE, Fujinami RS.

Vaccine. 2011 Apr 12;29(17):3356-62. doi: 10.1016/j.vaccine.2010.08.103. Epub 2010 Sep 16. Review.


Role for antibodies in altering behavior and movement.

Libbey JE, Fujinami RS.

Autism Res. 2010 Aug;3(4):147-52. doi: 10.1002/aur.144. Review.


Role for complement in the development of seizures following acute viral infection.

Libbey JE, Kirkman NJ, Wilcox KS, White HS, Fujinami RS.

J Virol. 2010 Jul;84(13):6452-60. doi: 10.1128/JVI.00422-10. Epub 2010 Apr 28.

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