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Effect of Vitamin C, Hydrocortisone, and Thiamine vs Hydrocortisone Alone on Time Alive and Free of Vasopressor Support Among Patients With Septic Shock: The VITAMINS Randomized Clinical Trial.

Fujii T, Luethi N, Young PJ, Frei DR, Eastwood GM, French CJ, Deane AM, Shehabi Y, Hajjar LA, Oliveira G, Udy AA, Orford N, Edney SJ, Hunt AL, Judd HL, Bitker L, Cioccari L, Naorungroj T, Yanase F, Bates S, McGain F, Hudson EP, Al-Bassam W, Dwivedi DB, Peppin C, McCracken P, Orosz J, Bailey M, Bellomo R; VITAMINS Trial Investigators.

JAMA. 2020 Jan 17. doi: 10.1001/jama.2019.22176. [Epub ahead of print]


Delayed Complications Due to Polymer Coating Embolism after Endovascular Treatment.

Kitamura T, Oishi H, Fujii T, Teranishi K, Yatomi K, Yamamoto M, Arai H.

NMC Case Rep J. 2019 Dec 18;7(1):5-10. doi: 10.2176/ eCollection 2020 Jan.


Corrigendum to "Human atrial natriuretic peptide for acute kidney injury in adult critically ill patients: A multicenter prospective observational study" [Journal of Critical Care 51(2019) 229-235].

Fujii T, Sato T, Uchino S, Doi K, Iwami T, Kawamura T; JAKID study group.

J Crit Care. 2020 Jan 11. pii: S0883-9441(20)30027-7. doi: 10.1016/j.jcrc.2020.01.005. [Epub ahead of print] No abstract available.


Effect of high-dose strong statin for preventing periprocedural ischemic complications of carotid artery stenting.

Shinozaki N, Murakami T, Ohno Y, Nakano M, Fujii T, Nakazawa G, Yoshimachi F, Ikari Y.

Heart Vessels. 2020 Jan 10. doi: 10.1007/s00380-019-01552-5. [Epub ahead of print]


Targeted transcriptomic study of the implication of central metabolic pathways in mannosylerythritol lipids biosynthesis in Pseudozyma antarctica T-34.

Wada K, Koike H, Fujii T, Morita T.

PLoS One. 2020 Jan 10;15(1):e0227295. doi: 10.1371/journal.pone.0227295. eCollection 2020.


Preclinical validation of the new vitrification device possessing a feature of absorbing excess vitrification solution for the cryopreservation of human embryos.

Takahashi N, Harada M, Oi N, Izumi G, Momozawa K, Matsuzawa A, Tokunaga Y, Hirata T, Fujii T, Osuga Y.

J Obstet Gynaecol Res. 2020 Jan 10. doi: 10.1111/jog.14176. [Epub ahead of print]


Novel Neuropathic Pain Mechanisms Associated With Allergic Inflammation.

Fujii T, Yamasaki R, Kira JI.

Front Neurol. 2019 Dec 17;10:1337. doi: 10.3389/fneur.2019.01337. eCollection 2019. Review.


Cardiac muscle thin filament structures reveal calcium regulatory mechanism.

Yamada Y, Namba K, Fujii T.

Nat Commun. 2020 Jan 9;11(1):153. doi: 10.1038/s41467-019-14008-1.


Sequential Cell-Processing System by Integrating Hydrodynamic Purification and Dielectrophoretic Trapping for Analyses of Suspended Cancer Cells.

Park J, Komori T, Uda T, Miyajima K, Fujii T, Kim SH.

Micromachines (Basel). 2019 Dec 30;11(1). pii: E47. doi: 10.3390/mi11010047.


2019 Diagnostic criteria for mixed connective tissue disease (MCTD): From the Japan research committee of the ministry of health, labor, and welfare for systemic autoimmune diseases.

Tanaka Y, Kuwana M, Fujii T, Kameda H, Muro Y, Fujio K, Itoh Y, Yasuoka H, Fukaya S, Ashihara K, Hirano D, Ohmura K, Tabuchi Y, Hasegawa H, Matsumiya R, Shirai Y, Ogura T, Tsuchida Y, Ogawa-Momohara M, Narazaki H, Inoue Y, Miyagawa I, Nakano K, Hirata S, Mori M.

Mod Rheumatol. 2020 Jan 7:1-5. doi: 10.1080/14397595.2019.1709944. [Epub ahead of print]


Response to tocilizumab and work productivity in patients with rheumatoid arthritis: 2-year follow-up of FIRST ACT-SC study.

Tanaka Y, Kameda H, Saito K, Kaneko Y, Tanaka E, Yasuda S, Tamura N, Fujio K, Fujii T, Kojima T, Anzai T, Hamada C, Fujino Y, Matsuda S, Kohsaka H.

Mod Rheumatol. 2020 Jan 4:1-23. doi: 10.1080/14397595.2019.1709681. [Epub ahead of print]


A new serine protease family with elastase activity is produced by Streptomyces bacteria.

Fujii T, Fukano K, Hirano K, Mimura A, Terauchi M, Etoh SI, Iida A.

Microbiology. 2020 Jan 2. doi: 10.1099/mic.0.000880. [Epub ahead of print]


Boyden chamber-based compartmentalized tumor spheroid culture system to implement localized anticancer drug treatment.

Kaneda S, Kawada J, Shinohara M, Kumemura M, Ueno R, Kawamoto T, Suzuki K, Kim B, Ikeuchi Y, Sakai Y, Collard D, Fujita H, Fujii T.

Biomicrofluidics. 2019 Oct 24;13(5):054111. doi: 10.1063/1.5125650. eCollection 2019 Sep.


[A Patient Surviving More Than Five Years Due to the Effect of Sequential Alternating Chemotherapy Administered to Metachronous Overlapping Cancer of Multiple Myeloma and StageⅣ EGFR Positive Non-Small Cell Lung Cancer].

Fujii T, Ohno N, Matsui T, Kitahara S, Matsunaga T, Sahara N, Doi A, Kurosaki Y, Inoue H, Kobayash S.

Gan To Kagaku Ryoho. 2019 Dec;46(12):1899-1902. Japanese.


SUPREME-HN: a retrospective biomarker study assessing the prognostic value of PD-L1 expression in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck.

Pai SI, Cohen EEW, Lin D, Fountzilas G, Kim ES, Mehlhorn H, Baste N, Clayburgh D, Lipworth L, Resteghini C, Shara N, Fujii T, Zhang J, Stokes M, Wang H, Twumasi-Ankrah P, Wildsmith S, Khaliq A, Melillo G, Shire N.

J Transl Med. 2019 Dec 26;17(1):429. doi: 10.1186/s12967-019-02182-1.


Effect of autophagy induction and cathepsin B inhibition on developmental competence of poor quality bovine oocytes.

Li J, Balboula AZ, Aboelenain M, Fujii T, Moriyasu S, Bai H, Kawahara M, Takahashi M.

J Reprod Dev. 2019 Dec 25. doi: 10.1262/jrd.2019-123. [Epub ahead of print]


Membrane buried-heterostructure DFB laser with an optically coupled III-V/Si waveguide.

Aihara T, Hiraki T, Takeda K, Fujii T, Kakitsuka T, Tsuchizawa T, Matsuo S.

Opt Express. 2019 Dec 9;27(25):36438-36448. doi: 10.1364/OE.27.036438.


Activation of endoplasmic reticulum stress mediates oxidative stress-induced apoptosis of granulosa cells in ovaries affected by endometrioma.

Kunitomi C, Harada M, Takahashi N, Azhary JMK, Kusamoto A, Nose E, Oi N, Takeuchi A, Wada-Hiraike O, Hirata T, Hirota Y, Koga K, Fujii T, Osuga Y.

Mol Hum Reprod. 2019 Dec 23. pii: gaz066. doi: 10.1093/molehr/gaz066. [Epub ahead of print]


Comparing the effects of milrinone and olprinone in patients with congestive heart failure.

Dobashi S, Watanabe I, Nakanishi R, Hisatake S, Kiuchi S, Kabuki T, Oka T, Fujii T, Ikeda T.

Heart Vessels. 2019 Dec 21. doi: 10.1007/s00380-019-01543-6. [Epub ahead of print]


Extremely high levels of multiple cytokines in the cord blood of neonates born to mothers with systemic autoimmune diseases.

Takahashi N, Nagamatsu T, Fujii T, Takahashi K, Tsuchida Y, Fujio K, Fujii T.

Cytokine. 2019 Dec 19;127:154926. doi: 10.1016/j.cyto.2019.154926. [Epub ahead of print]


Unique HLA haplotype associations in IgG4 anti-neurofascin 155 antibody-positive chronic inflammatory demyelinating polyneuropathy.

Ogata H, Isobe N, Zhang X, Yamasaki R, Fujii T, Machida A, Morimoto N, Kaida K, Masuda T, Ando Y, Kuwahara M, Kusunoki S, Nakamura Y, Matsushita T, Kira JI.

J Neuroimmunol. 2020 Feb 15;339:577139. doi: 10.1016/j.jneuroim.2019.577139. Epub 2019 Dec 16.


Aneurysm Sac Thrombus Volume Predicts Aneurysm Expansion with Type II Endoleak after Endovascular Aneurysm Repair.

Fujii T, Banno H, Kodama A, Sugimoto M, Akita N, Tsuruoka T, Sakakibara M, Komori K.

Ann Vasc Surg. 2019 Dec 18. pii: S0890-5096(19)31047-7. doi: 10.1016/j.avsg.2019.11.045. [Epub ahead of print]


Functional Expression of the P2X7 ATP Receptor Requires Eros.

Ryoden Y, Fujii T, Segawa K, Nagata S.

J Immunol. 2019 Dec 20. pii: ji1900448. doi: 10.4049/jimmunol.1900448. [Epub ahead of print]


Ability of Nonswelling Polyethylene Glycol-Based Vitreous Hydrogel to Maintain Transparency in the Presence of Vitreous Hemorrhage.

Hoshi S, Okamoto F, Murakami T, Sakai T, Shinohara Y, Fujii T, Nakatani M, Oshika T.

Transl Vis Sci Technol. 2019 Dec 12;8(6):33. doi: 10.1167/tvst.8.6.33. eCollection 2019 Nov.


Phase II study of Radium-223 dichloride combined with hormonal therapy for hormone receptor-positive, bone-dominant metastatic breast cancer.

Ueno NT, Tahara RK, Fujii T, Reuben JM, Gao H, Saigal B, Lucci A, Iwase T, Ibrahim NK, Damodaran S, Shen Y, Liu DD, Hortobagyi GN, Tripathy D, Lim B, Chasen BA.

Cancer Med. 2019 Dec 18. doi: 10.1002/cam4.2780. [Epub ahead of print]


Validity of the Japanese Core Outcome Measures Index (COMI)-Back for thoracic and lumbar spine surgery: a prospective cohort study.

Nagata K, Oshima Y, Nakamoto H, Sakamoto R, Ohtomo N, Izuka M, Nakajima K, Yoshimoto T, Fujii T, Matsudaira K, Tanaka S, Oka H.

Eur Spine J. 2019 Dec 16. doi: 10.1007/s00586-019-06249-x. [Epub ahead of print]


Complications of femoral versus radial access in neuroendovascular procedures with propensity adjustment.

Catapano JS, Fredrickson VL, Fujii T, Cole TS, Koester SW, Baranoski JF, Cavalcanti DD, Wilkinson DA, Majmundar N, Lang MJ, Lawton MT, Ducruet AF, Albuquerque FC.

J Neurointerv Surg. 2019 Dec 16. pii: neurintsurg-2019-015569. doi: 10.1136/neurintsurg-2019-015569. [Epub ahead of print]


Rikkunshito attenuates induction of epithelial-mesenchymal switch via activation of Sirtuin1 in ovarian cancer cells.

Kanda R, Miyagawa Y, Wada-Hiraike O, Hiraike H, Fukui S, Nagasaka K, Ryo E, Fujii T, Osuga Y, Ayabe T.

Endocr J. 2019 Dec 14. doi: 10.1507/endocrj.EJ19-0368. [Epub ahead of print]


Failure of Flow Diverter Therapy: Predictors and Management Strategies.

Bonney PA, Connor M, Fujii T, Singh P, Koch MJ, Stapleton CJ, Mack WJ, Walcott BP.

Neurosurgery. 2020 Jan 1;86(Supplement_1):S64-S73. doi: 10.1093/neuros/nyz305.


Central nervous system-specific antinuclear antibodies in patients with multiple sclerosis.

Fujii T, Yamasaki R, Miyachi Y, Nagata S, Maimaitijiang G, Nakamura Y, Shinoda K, Matsushita T, Isobe N, Kira JI.

J Neurol Sci. 2019 Dec 6;409:116619. doi: 10.1016/j.jns.2019.116619. [Epub ahead of print]


Redescription of Synactinernus flavus for the First Time after a Century and Description of Synactinernus churaumi sp. nov. (Cnidaria: Anthozoa: Actiniaria).

Izumi T, Fujii T, Yanagi K, Higashiji T, Fujita T.

Zoolog Sci. 2019 Dec 9;36(6):528-538. doi: 10.2108/zs190040.


Double-outlet extension for narrowed retroaortic space.

Tarui S, Miyahara Y, Oyama N, Fujii T, Ishino K, Tomita H.

Asian Cardiovasc Thorac Ann. 2019 Dec 12:218492319896497. doi: 10.1177/0218492319896497. [Epub ahead of print] No abstract available.


High incidence of head and neck cancers after endoscopic resection for esophageal cancer in younger patients.

Maekawa A, Ishihara R, Iwatsubo T, Nakagawa K, Ohmori M, Iwagami H, Matsuno K, Inoue S, Arao M, Nakahira H, Matsuura N, Schichijo S, Kanesaka T, Yamamoto S, Takeuchi Y, Higashino K, Uedo N, Fujii T, Morishima T, Miyashiro I.

J Gastroenterol. 2019 Dec 7. doi: 10.1007/s00535-019-01653-y. [Epub ahead of print]


High-resolution label-free 3D mapping of extracellular pH of single living cells.

Zhang Y, Takahashi Y, Hong SP, Liu F, Bednarska J, Goff PS, Novak P, Shevchuk A, Gopal S, Barozzi I, Magnani L, Sakai H, Suguru Y, Fujii T, Erofeev A, Gorelkin P, Majouga A, Weiss DJ, Edwards C, Ivanov AP, Klenerman D, Sviderskaya EV, Edel JB, Korchev Y.

Nat Commun. 2019 Dec 6;10(1):5610. doi: 10.1038/s41467-019-13535-1.


Average daily ischemic versus bleeding risk in patients with ACS undergoing PCI: Insights from the BleeMACS and RENAMI registries.

D'Ascenzo F, Biolè C, Raposeiras-Roubin S, Gaido F, Abu-Assi E, Kinnaird T, Ariza-Solé A, Liebetrau C, Manzano-Fernández S, Boccuzzi G, Henriques JPS, Templin C, Wilton SB, Omedè P, Velicki L, Xanthopoulou I, Correia L, Cerrato E, Rognoni A, Fabrizio U, Nuñez-Gil I, Montabone A, Taha S, Fujii T, Durante A, Song X, Gili S, Magnani G, Autelli M, Bongiovanni F, Grosso A, Kawaji T, Blanco PF, Garay A, Quadri G, Alexopoulos D, Queija BC, Huczek Z, Paz RC, González-Juanatey JR, Fernández MC, Nie SP, Pousa IM, Kawashiri MA, Rettegno S, Gallo D, Morbiducci U, Conrotto F, Dominguez-Rodriguez A, Valdés M, Cequier A, Iñiguez-Romo A, Biondi-Zoccai G, Stone GW, De Ferrari GM.

Am Heart J. 2019 Nov 11;220:108-115. doi: 10.1016/j.ahj.2019.10.001. [Epub ahead of print]


Anti-Tumor Effect of Inhibition of DNA Damage Response Proteins, ATM and ATR, in Endometrial Cancer Cells.

Takeuchi M, Tanikawa M, Nagasaka K, Oda K, Kawata Y, Oki S, Agapiti C, Sone K, Miyagawa Y, Hiraike H, Wada-Hiraike O, Kuramoto H, Ayabe T, Osuga Y, Fujii T.

Cancers (Basel). 2019 Dec 1;11(12). pii: E1913. doi: 10.3390/cancers11121913.


Usefulness of a deep learning system for diagnosing Sjögren's syndrome using ultrasonography images.

Kise Y, Shimizu M, Ikeda H, Fujii T, Kuwada C, Nishiyama M, Funakoshi T, Ariji Y, Fujita H, Katsumata A, Yoshiura K, Ariji E.

Dentomaxillofac Radiol. 2019 Dec 11:20190348. doi: 10.1259/dmfr.20190348. [Epub ahead of print]


A single paravertebral injection via a needle vs. a catheter for the spreading to multiple intercostal levels: a randomized controlled trial.

Fujii T, Shibata Y, Ban Y, Shitaokoshi A, Takahashi K, Matsui S, Nishiwaki K.

J Anesth. 2019 Dec 4. doi: 10.1007/s00540-019-02713-6. [Epub ahead of print]


Retinopathy progression and the risk of end-stage kidney disease: results from a longitudinal Japanese cohort of 232 patients with type 2 diabetes and biopsy-proven diabetic kidney disease.

Yamanouchi M, Mori M, Hoshino J, Kinowaki K, Fujii T, Ohashi K, Furuichi K, Wada T, Ubara Y.

BMJ Open Diabetes Res Care. 2019 Nov 2;7(1):e000726. doi: 10.1136/bmjdrc-2019-000726. eCollection 2019.


Outcome of Patients With Prior Stroke/Transient Ischemic Attack and Acute Coronary Syndromes.

Zhang D, Song X, Chen Y, Raposeiras-Roubín S, Abu-Assi E, Henriques JPS, D'Ascenzo F, Saucedo J, González-Juanatey JR, Wilton SB, Kikkert WJ, Nuñez-Gil I, Ariza-Sole A, Alexopoulos D, Liebetrau C, Kawaji T, Moretti C, Huczek Z, Nie S, Fujii T, Correia L, Kawashiri MA, García-Acuña JM, Southern D, Alfonso E, Terol B, Garay A, Xanthopoulou I, Osman N, Möllmann H, Shiomi H, Giordana F, Kowara M, Filipiak K, Wang X, Yan Y, Fan J, Ikari Y, Nakahashi T, Sakata K, Yamagishi M, Kalpak O, Kedev S.

Angiology. 2019 Dec 3:3319719889524. doi: 10.1177/0003319719889524. [Epub ahead of print]


Non-contact acquisition of brain function using a time-extracted compact camera.

Ando T, Nakamura T, Fujii T, Shiono T, Nakamura T, Suzuki M, Anzue-Satoi N, Narumi K, Watanabe H, Korenaga T, Okada E, Inoue Y.

Sci Rep. 2019 Nov 28;9(1):17854. doi: 10.1038/s41598-019-54458-7.


Association between high fear-avoidance beliefs about physical activity and chronic disabling low back pain in nurses in Japan.

Fujii T, Oka H, Takano K, Asada F, Nomura T, Kawamata K, Okazaki H, Tanaka S, Matsudaira K.

BMC Musculoskelet Disord. 2019 Nov 28;20(1):572. doi: 10.1186/s12891-019-2965-6.


Pharmacokinetic data support 6-hourly dosing of intravenous vitamin C to critically ill patients with septic shock.

Hudson EP, Collie JT, Fujii T, Luethi N, Udy AA, Doherty S, Eastwood G, Yanase F, Naorungroj T, Bitker L, Abdelhamid YA, Greaves RF, Deane AM, Bellomo R.

Crit Care Resusc. 2019 Dec;21(4):236-42.


The Putative Transcription Factor Gene thaB Regulates Cellulase and Xylanase Production at the Enzymatic and Transcriptional Level in the Fungus Talaromyces cellulolyticus.

Fujii T, Matsushika A.

Appl Biochem Biotechnol. 2019 Nov 26. doi: 10.1007/s12010-019-03190-z. [Epub ahead of print]


IoGAS1, a GPI-Anchored Protein Derived from Issatchenkia orientalis, Confers Tolerance of Saccharomyces cerevisiae to Multiple Acids.

Wada K, Fujii T, Akita H, Matsushika A.

Appl Biochem Biotechnol. 2019 Nov 25. doi: 10.1007/s12010-019-03187-8. [Epub ahead of print]


Wide QRS tachycardia associated with multiple accessory pathways in a patient with Wolff-Parkinson-White syndrome.

Nakamura T, Kanda G, Sasaki Y, Noda R, Hiranuma N, Sumimoto K, Fujii T.

J Cardiol Cases. 2019 Oct 2;20(6):191-196. doi: 10.1016/j.jccase.2019.04.003. eCollection 2019 Dec.


Expression of C-C motif chemokines and their receptors in bovine placentomes at spontaneous and induced parturition.

Hirayama H, Sakumoto R, Koyama K, Yasuhara T, Hasegawa T, Inaba R, Fujii T, Naito A, Moriyasu S, Kageyama S.

J Reprod Dev. 2019 Nov 22. doi: 10.1262/jrd.2019-113. [Epub ahead of print]


RNA-sequence-based microRNA expression signature in breast cancer: tumor-suppressive miR-101-5p regulates molecular pathogenesis.

Toda H, Seki N, Kurozumi S, Shinden Y, Yamada Y, Nohata N, Moriya S, Idichi T, Maemura K, Fujii T, Horiguchi J, Kijima Y, Natsugoe S.

Mol Oncol. 2019 Nov 21. doi: 10.1002/1878-0261.12602. [Epub ahead of print]


Analysis of quality of life after randomized controlled trial of alpha-1 adrenoceptor antagonist alone and in combination with cyclooxygenase-2 inhibitor in patients who underwent low-dose-rate brachytherapy for prostate cancer.

Nakai Y, Tanaka N, Asakawa I, Torimoto K, Miyake M, Anai S, Fujii T, Hasegawa M, Fujimoto K.

J Contemp Brachytherapy. 2019 Oct;11(5):409-416. doi: 10.5114/jcb.2019.88142. Epub 2019 Oct 30.


[A Case of POEMS Syndrome Treated by Ld Prior to HDCTx Followed by aPBSCT].

Fujii T, Ohno N, Sakamoto N, Matsui T, Sahara N, Matsunaga T.

Gan To Kagaku Ryoho. 2019 Nov;46(11):1799-1802. Japanese.


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