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Items: 1 to 50 of 309

1.

Blood Free-Circulating DNA Testing of Methylated RUNX3 Is Useful for Diagnosing Early Gastric Cancer.

Hideura E, Suehiro Y, Nishikawa J, Shuto T, Fujimura H, Ito S, Goto A, Hamabe K, Saeki I, Okamoto T, Higaki S, Fujii I, Suzuki C, Hoshida T, Matsumoto T, Takami T, Sakaida I, Yamasaki T.

Cancers (Basel). 2020 Mar 26;12(4). pii: E789. doi: 10.3390/cancers12040789.

PMID:
32224873
2.

Novel Liquid Biopsy Test Based on a Sensitive Methylated SEPT9 Assay for Diagnosing Hepatocellular Carcinoma.

Kotoh Y, Suehiro Y, Saeki I, Hoshida T, Maeda M, Iwamoto T, Matsumoto T, Hidaka I, Ishikawa T, Takami T, Higaki S, Fujii I, Suzuki C, Shindo Y, Tokumitsu Y, Nagano H, Sakaida I, Yamasaki T.

Hepatol Commun. 2020 Jan 2;4(3):461-470. doi: 10.1002/hep4.1469. eCollection 2020 Mar.

3.

Shimalactone Biosynthesis Involves Spontaneous Double Bicyclo-Ring Formation with 8π-6π Electrocyclization.

Fujii I, Hashimoto M, Konishi K, Unezawa A, Sakuraba H, Suzuki K, Tsushima H, Iwasaki M, Yoshida S, Kudo A, Fujita R, Hichiwa A, Saito K, Asano T, Ishikawa J, Wakana D, Goda Y, Watanabe A, Watanabe M, Masumoto Y, Kanazawa J, Sato H, Uchiyama M.

Angew Chem Int Ed Engl. 2020 Mar 4. doi: 10.1002/anie.202001024. [Epub ahead of print]

PMID:
32129542
4.

Producing the sulfur-containing metabolite asparaptine in Asparagus calluses and a suspension cell line.

Nakabayashi R, Nishizawa T, Mori T, Sudo H, Fujii I, Asano T, Saito K.

Plant Biotechnol (Tokyo). 2019 Dec 25;36(4):265-267. doi: 10.5511/plantbiotechnology.19.1002a.

5.

An Immune-Stimulatory Helix-Loop-Helix Peptide: Selective Inhibition of CTLA-4-B7 Interaction.

Ramanayake Mudiyanselage TMR, Michigami M, Ye Z, Uyeda A, Inoue N, Sugiura K, Fujii I, Fujiwara D.

ACS Chem Biol. 2020 Feb 21;15(2):360-368. doi: 10.1021/acschembio.9b00743. Epub 2020 Jan 8.

PMID:
31841301
6.

Functional expression of a highly-reducing polyketide synthase of Emericella variecolor IFM42010, an asteltoxin-producing strain, resulted in production of two polyenoic β-ketolactones with opposite stereochemistry.

Hashimoto M, Ichijo H, Fujiwara K, Sugasawa H, Abo S, Matsudo K, Uchiyama N, Goda Y, Fujii I.

Bioorg Med Chem Lett. 2019 Dec 15;29(24):126686. doi: 10.1016/j.bmcl.2019.126686. Epub 2019 Oct 14.

PMID:
31678008
7.

Author Correction: BiFC-based visualisation system reveals cell fusion morphology and heterokaryon incompatibility in the filamentous fungus Aspergillus oryzae.

Okabe T, Katayama T, Mo T, Mori N, Jin FJ, Fujii I, Iwashita K, Kitamoto K, Maruyama JI.

Sci Rep. 2019 Oct 31;9(1):16078. doi: 10.1038/s41598-019-52663-y.

8.

Intracellular target delivery of cell-penetrating peptide-conjugated dodecaborate for boron neutron capture therapy (BNCT).

Nakase I, Katayama M, Hattori Y, Ishimura M, Inaura S, Fujiwara D, Takatani-Nakase T, Fujii I, Futaki S, Kirihata M.

Chem Commun (Camb). 2019 Nov 19;55(93):13955-13958. doi: 10.1039/c9cc03924d.

PMID:
31617510
9.

Effects of gefitinib treatment on cellular uptake of extracellular vesicles in EGFR-mutant non-small cell lung cancer cells.

Takenaka T, Nakai S, Katayama M, Hirano M, Ueno N, Noguchi K, Takatani-Nakase T, Fujii I, Kobayashi SS, Nakase I.

Int J Pharm. 2019 Dec 15;572:118762. doi: 10.1016/j.ijpharm.2019.118762. Epub 2019 Oct 11.

PMID:
31610280
10.

Field Survey of Glycyrrhiza Plants in Central Asia (5). Chemical Characterization of G. bucharica Collected in Tajikistan.

Hayashi H, Yokoshima K, Chiba R, Fujii I, Fattokhov I, Saidov M.

Chem Pharm Bull (Tokyo). 2019;67(6):534-539. doi: 10.1248/cpb.c18-00881.

11.

Field Survey of Ephedra Plants in Central Asia (1). Characterization of Ephedra equisetina, Ephedra intermedia, and Their Putative Hybrids Collected in the Zaravshan Mountains of Tajikistan.

Hayashi H, Shukurova M, Oikawa S, Ohta M, Fujii I, Nasyrova F, Aliev K, Hisoriev H, Fattokhov I, Saidov M.

Biol Pharm Bull. 2019;42(4):552-560. doi: 10.1248/bpb.b18-00289.

12.

Crystal structures of racemic and enantiopure synephrine correlated with physicochemical properties from IR spectroscopy and thermal analysis.

Fujii I.

Acta Crystallogr C Struct Chem. 2018 Nov 1;74(Pt 11):1531-1539. doi: 10.1107/S2053229618014419. Epub 2018 Oct 24.

PMID:
30398210
13.

Generation of Novel Anti-MUC1 Monoclonal Antibodies with Designed Carbohydrate Specificities Using MUC1 Glycopeptide Library.

Naito S, Takahashi T, Onoda J, Uemura S, Ohyabu N, Takemoto H, Yamane S, Fujii I, Nishimura SI, Numata Y.

ACS Omega. 2017 Nov 30;2(11):7493-7505. doi: 10.1021/acsomega.7b00708. Epub 2017 Nov 1.

14.

Highly Sensitive and Practical Fluorescent Sandwich ELISA for Ciguatoxins.

Tsumuraya T, Sato T, Hirama M, Fujii I.

Anal Chem. 2018 Jun 19;90(12):7318-7324. doi: 10.1021/acs.analchem.8b00519. Epub 2018 May 29.

PMID:
29770692
15.

Blood free-circulating DNA testing by highly sensitive methylation assay to diagnose colorectal neoplasias.

Suehiro Y, Hashimoto S, Higaki S, Fujii I, Suzuki C, Hoshida T, Matsumoto T, Yamaoka Y, Takami T, Sakaida I, Yamasaki T.

Oncotarget. 2018 Mar 30;9(24):16974-16987. doi: 10.18632/oncotarget.24768. eCollection 2018 Mar 30.

16.

A novel polysaccharide derived from algae extract inhibits cancer progression via JNK, not via the p38 MAPK signaling pathway.

Xie P, Horio F, Fujii I, Zhao J, Shinohara M, Matsukura M.

Int J Oncol. 2018 May;52(5):1380-1390. doi: 10.3892/ijo.2018.4297. Epub 2018 Mar 2.

17.

Structural basis of the broad substrate tolerance of the antibody 7B9-catalyzed hydrolysis of p-nitrobenzyl esters.

Miyamoto N, Yoshimura M, Okubo Y, Suzuki-Nagata K, Tsumuraya T, Ito N, Fujii I.

Bioorg Med Chem. 2018 May 1;26(8):1412-1417. doi: 10.1016/j.bmc.2017.07.050. Epub 2017 Aug 19.

PMID:
29496413
18.

pH-dependent production of himeic acid A and its non-enzymatic conversions to himeic acids B and C.

Katsuki A, Kato H, Tahara Y, Hashimoto M, Fujii I, Tsukamoto S.

Bioorg Med Chem. 2018 May 1;26(8):1869-1874. doi: 10.1016/j.bmc.2018.02.034. Epub 2018 Feb 20.

PMID:
29486950
19.

Discovery of a Fungal Multicopper Oxidase That Catalyzes the Regioselective Coupling of a Tricyclic Naphthopyranone To Produce Atropisomers.

Kawaguchi M, Ohshiro T, Toyoda M, Ohte S, Inokoshi J, Fujii I, Tomoda H.

Angew Chem Int Ed Engl. 2018 Apr 23;57(18):5115-5119. doi: 10.1002/anie.201800415. Epub 2018 Mar 22.

PMID:
29468784
20.

BiFC-based visualisation system reveals cell fusion morphology and heterokaryon incompatibility in the filamentous fungus Aspergillus oryzae.

Okabe T, Katayama T, Mo T, Mori N, Jin FJ, Fujii I, Iwashita K, Kitamoto K, Maruyama JI.

Sci Rep. 2018 Feb 13;8(1):2922. doi: 10.1038/s41598-018-21323-y. Erratum in: Sci Rep. 2019 Oct 31;9(1):16078.

21.

Identification of the Biosynthetic Gene Cluster for Himeic Acid A: A Ubiquitin-Activating Enzyme (E1) Inhibitor in Aspergillus japonicus MF275.

Hashimoto M, Kato H, Katsuki A, Tsukamoto S, Fujii I.

Chembiochem. 2018 Mar 16;19(6):535-539. doi: 10.1002/cbic.201700584. Epub 2018 Feb 6.

PMID:
29314577
22.

Functional validation and expression analysis of myotubes converted from skin fibroblasts using a simple direct reprogramming strategy.

Horio F, Sakurai H, Ohsawa Y, Nakano S, Matsukura M, Fujii I.

eNeurologicalSci. 2016 Nov 3;6:9-15. doi: 10.1016/j.ensci.2016.11.002. eCollection 2017 Mar.

23.

Crystal structure of (1S,2R)-2-hy-droxy-1,2-di-phenyl-ethan-1-aminium (S)-2-aza-niumyl-butane-dioate monohydrate.

Fujii I.

Acta Crystallogr E Crystallogr Commun. 2017 Nov 3;73(Pt 12):1827-1830. doi: 10.1107/S2056989017015729. eCollection 2017 Dec 1.

24.

Gefitinib Enhances Mitochondrial Biological Functions in NSCLCs with EGFR Mutations at a High Cell Density.

Takenaka T, Katayama M, Sugiyama A, Hagiwara M, Fujii I, Takatani-Nakase T, Kobayashi SS, Nakase I.

Anticancer Res. 2017 Sep;37(9):4779-4788.

PMID:
28870896
25.

Arginine-rich cell-penetrating peptide-modified extracellular vesicles for active macropinocytosis induction and efficient intracellular delivery.

Nakase I, Noguchi K, Aoki A, Takatani-Nakase T, Fujii I, Futaki S.

Sci Rep. 2017 May 16;7(1):1991. doi: 10.1038/s41598-017-02014-6.

26.

Successful removal of an impacted stone in the common bile duct by electric lithotripsy using a needle-knife and a forward-viewing endoscope.

Fujita K, Hasegawa K, Akamatsu T, Kasuga T, Miyake K, Fujii I, Morita S.

Endoscopy. 2017 Feb;49(S 01):E129-E131. doi: 10.1055/s-0043-103404. Epub 2017 Mar 22. No abstract available.

PMID:
28329880
27.

Effects of substrate conformational strain on binding kinetics of catalytic antibodies.

Oda M, Tsumuraya T, Fujii I.

Biophys Physicobiol. 2016 Jul 14;13:135-138. eCollection 2016.

28.

Receptor clustering and activation by multivalent interaction through recognition peptides presented on exosomes.

Nakase I, Ueno N, Katayama M, Noguchi K, Takatani-Nakase T, Kobayashi NB, Yoshida T, Fujii I, Futaki S.

Chem Commun (Camb). 2016 Dec 22;53(2):317-320. doi: 10.1039/c6cc06719k.

PMID:
27853769
29.

Field Survey of Glycyrrhiza Plants in Central Asia (4). Characterization of G. glabra and G. bucharica Collected in Tajikistan.

Hayashi H, Tamura S, Chiba R, Fujii I, Yoshikawa N, Fattokhov I, Saidov M.

Biol Pharm Bull. 2016;39(11):1781-1786.

30.

Site-Directed Chemical Mutations on Abzymes: Large Rate Accelerations in the Catalysis by Exchanging the Functionalized Small Nonprotein Components.

Ishikawa F, Shirahashi M, Hayakawa H, Yamaguchi A, Hirokawa T, Tsumuraya T, Fujii I.

ACS Chem Biol. 2016 Oct 21;11(10):2803-2811. Epub 2016 Aug 29.

PMID:
27552288
31.
32.

A novel polysaccharide derived from algae extract induces apoptosis and cell cycle arrest in human gastric carcinoma MKN45 cells via ROS/JNK signaling pathway.

Xie P, Fujii I, Zhao J, Shinohara M, Matsukura M.

Int J Oncol. 2016 Oct;49(4):1561-1568. doi: 10.3892/ijo.2016.3658. Epub 2016 Aug 18.

PMID:
27633119
33.

A Cyclized Helix-Loop-Helix Peptide as a Molecular Scaffold for the Design of Inhibitors of Intracellular Protein-Protein Interactions by Epitope and Arginine Grafting.

Fujiwara D, Kitada H, Oguri M, Nishihara T, Michigami M, Shiraishi K, Yuba E, Nakase I, Im H, Cho S, Joung JY, Kodama S, Kono K, Ham S, Fujii I.

Angew Chem Int Ed Engl. 2016 Aug 26;55(36):10612-5. doi: 10.1002/anie.201603230. Epub 2016 Jul 28.

PMID:
27467415
34.

Identification and Heterologous Expression of the Topopyrone Nonaketide Synthase Gene from Phoma sp.

Kashiwa N, Ebizuka Y, Fujii I.

Chem Pharm Bull (Tokyo). 2016;64(7):947-51. doi: 10.1248/cpb.c16-00172.

35.

Multiple Oxidative Modifications in the Ophiobolin Biosynthesis: P450 Oxidations Found in Genome Mining.

Narita K, Chiba R, Minami A, Kodama M, Fujii I, Gomi K, Oikawa H.

Org Lett. 2016 May 6;18(9):1980-3. doi: 10.1021/acs.orglett.6b00552. Epub 2016 Apr 26.

PMID:
27116000
36.

Macrocyclization and labeling of helix-loop-helix peptide with intramolecular bis-thioether linkage.

Nishihara T, Kitada H, Fujiwara D, Fujii I.

Biopolymers. 2016 Nov 4;106(4):415-21. doi: 10.1002/bip.22826.

PMID:
26917088
37.

Crystal structure of racemic cis-2-amino-1,2-di-phenyl-ethanol (ADE).

Fujii I.

Acta Crystallogr E Crystallogr Commun. 2015 Nov 28;71(Pt 12):1539-41. doi: 10.1107/S2056989015022318. eCollection 2015 Dec 1.

38.

Crystal structure of (S)-2-amino-2-methyl-succinic acid.

Fujii I.

Acta Crystallogr E Crystallogr Commun. 2015 Sep 12;71(Pt 10):o731-2. doi: 10.1107/S2056989015016709. eCollection 2015 Oct 1.

39.

[Novel type III polyketide synthase CsyB from Aspergillus oryzae].

Hashimoto M, Fujii I.

Seikagaku. 2015 Aug;87(4):471-4. Review. Japanese. No abstract available.

PMID:
26571621
40.

Reconstitution of biosynthetic machinery of fungal polyketides: unexpected oxidations of biosynthetic intermediates by expression host.

Fujii R, Ugai T, Ichinose H, Hatakeyama M, Kosaki T, Gomi K, Fujii I, Minami A, Oikawa H.

Biosci Biotechnol Biochem. 2016;80(3):426-31. doi: 10.1080/09168451.2015.1104234. Epub 2015 Nov 5.

41.

Use of a biosynthetic intermediate to explore the chemical diversity of pseudo-natural fungal polyketides.

Asai T, Tsukada K, Ise S, Shirata N, Hashimoto M, Fujii I, Gomi K, Nakagawara K, Kodama EN, Oshima Y.

Nat Chem. 2015 Sep;7(9):737-43. doi: 10.1038/nchem.2308. Epub 2015 Aug 3.

PMID:
26291946
42.

Development of a novel immunoassay specific for mouse intact proinsulin.

Imai S, Takahashi T, Naito S, Yamauchi A, Okada C, Notsu Y, Sakikawa I, Hatanaka M, Iwasaki T, Morita A, Fujii I, Yamane S.

Anal Biochem. 2015 Sep 1;484:91-8. doi: 10.1016/j.ab.2015.05.012. Epub 2015 May 28.

43.

'Turn On/Off' fluorescence probe for the screening of unactivated Bruton's tyrosine kinase.

Kawahata W, Asami T, Fujii I, Sawa M.

Bioorg Med Chem Lett. 2015;25(10):2141-5. doi: 10.1016/j.bmcl.2015.03.063. Epub 2015 Mar 30.

PMID:
25843639
44.

Product identification of non-reducing polyketide synthases with C-terminus methyltransferase domain from Talaromyces stipitatus using Aspergillus oryzae heterologous expression.

Hashimoto M, Wakana D, Ueda M, Kobayashi D, Goda Y, Fujii I.

Bioorg Med Chem Lett. 2015 Apr 1;25(7):1381-4. doi: 10.1016/j.bmcl.2015.02.057. Epub 2015 Feb 28.

PMID:
25770780
45.

Structural basis for the formation of acylalkylpyrones from two β-ketoacyl units by the fungal type III polyketide synthase CsyB.

Mori T, Yang D, Matsui T, Hashimoto M, Morita H, Fujii I, Abe I.

J Biol Chem. 2015 Feb 20;290(8):5214-25. doi: 10.1074/jbc.M114.626416. Epub 2015 Jan 6.

46.

Development of an ultrasensitive immunoassay using affinity maturated antibodies for the measurement of rodent insulin.

Imai S, Naito S, Takahashi T, Yamauchi A, Nakamura E, Sato M, Mitsuda Y, Takagi H, Numata Y, Fujii I, Yamane S.

Anal Biochem. 2015 Mar 15;473:72-9. doi: 10.1016/j.ab.2014.12.003. Epub 2014 Dec 15.

PMID:
25524616
47.

Isoliquiritigenin is a potent inhibitor of NLRP3 inflammasome activation and diet-induced adipose tissue inflammation.

Honda H, Nagai Y, Matsunaga T, Okamoto N, Watanabe Y, Tsuneyama K, Hayashi H, Fujii I, Ikutani M, Hirai Y, Muraguchi A, Takatsu K.

J Leukoc Biol. 2014 Dec;96(6):1087-100. doi: 10.1189/jlb.3A0114-005RR. Epub 2014 Sep 10.

PMID:
25210146
48.

Fungal type III polyketide synthases.

Hashimoto M, Nonaka T, Fujii I.

Nat Prod Rep. 2014 Oct;31(10):1306-17. doi: 10.1039/c4np00096j. Review.

PMID:
25182423
49.

Expression, purification and crystallization of a fungal type III polyketide synthase that produces the csypyrones.

Yang D, Mori T, Matsui T, Hashimoto M, Morita H, Fujii I, Abe I.

Acta Crystallogr F Struct Biol Commun. 2014 Jun;70(Pt 6):730-3. doi: 10.1107/S2053230X14008516. Epub 2014 May 10.

50.

Aspergillus oryzae CsyB catalyzes the condensation of two β-ketoacyl-CoAs to form 3-acetyl-4-hydroxy-6-alkyl-α-pyrone.

Hashimoto M, Koen T, Takahashi H, Suda C, Kitamoto K, Fujii I.

J Biol Chem. 2014 Jul 18;289(29):19976-84. doi: 10.1074/jbc.M114.569095. Epub 2014 Jun 3.

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