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Site-Selective Supramolecular Complexation Activates Catalytic Ethane-Oxidation of μ-Nitrido-Bridged Iron Porphyrinoid Dimer.

Yamada Y, Mihara N, Takaya H, Kitagawa Y, Igawa K, Tomooka K, Fujii H, Tanaka K.

Chemistry. 2018 Dec 13. doi: 10.1002/chem.201805580. [Epub ahead of print]


Differences in the actions of adrenaline and noradrenaline with regard to glucose intolerance in patients with pheochromocytoma.

Abe I, Fujii H, Ohishi H, Sugimoto K, Minezaki M, Nakagawa M, Takahara S, Kudo T, Abe M, Ohe K, Yanase T, Kobayashi K.

Endocr J. 2018 Dec 13. doi: 10.1507/endocrj.EJ18-0407. [Epub ahead of print]


Changes in serum and intracardiac fibroblast growth factor 23 during the progression of left ventricular hypertrophy in hypertensive model rats.

Fujii H, Watanabe K, Kono K, Goto S, Watanabe S, Nishi S.

Clin Exp Nephrol. 2018 Dec 11. doi: 10.1007/s10157-018-1680-1. [Epub ahead of print]


Effect of Oral Alfacalcidol on Clinical Outcomes in Patients Without Secondary Hyperparathyroidism Receiving Maintenance Hemodialysis: The J-DAVID Randomized Clinical Trial.

J-DAVID Investigators, Shoji T, Inaba M, Fukagawa M, Ando R, Emoto M, Fujii H, Fujimori A, Fukui M, Hase H, Hashimoto T, Hirakata H, Honda H, Hosoya T, Ikari Y, Inaguma D, Inoue T, Isaka Y, Iseki K, Ishimura E, Itami N, Ito C, Kakuta T, Kawai T, Kawanishi H, Kobayashi S, Kumagai J, Maekawa K, Masakane I, Minakuchi J, Mitsuiki K, Mizuguchi T, Morimoto S, Murohara T, Nakatani T, Negi S, Nishi S, Nishikawa M, Ogawa T, Ohta K, Ohtake T, Okamura M, Okuno S, Shigematsu T, Sugimoto T, Suzuki M, Tahara H, Takemoto Y, Tanaka K, Tominaga Y, Tsubakihara Y, Tsujimoto Y, Tsuruya K, Ueda S, Watanabe Y, Yamagata K, Yamakawa T, Yano S, Yokoyama K, Yorioka N, Yoshiyama M, Nishizawa Y.

JAMA. 2018 Dec 11;320(22):2325-2334. doi: 10.1001/jama.2018.17749.


A subanalysis of Japanese patients in a randomized, double-blind, placebo-controlled, phase 3 trial of nivolumab for patients with advanced gastric or gastro-esophageal junction cancer refractory to, or intolerant of, at least two previous chemotherapy regimens (ONO-4538-12, ATTRACTION-2).

Kato K, Satoh T, Muro K, Yoshikawa T, Tamura T, Hamamoto Y, Chin K, Minashi K, Tsuda M, Yamaguchi K, Machida N, Esaki T, Goto M, Komatsu Y, Nakajima TE, Sugimoto N, Yoshida K, Oki E, Nishina T, Tsuji A, Fujii H, Kunieda K, Saitoh S, Omuro Y, Azuma M, Iwamoto Y, Taku K, Fushida S, Chen LT, Kang YK, Boku N.

Gastric Cancer. 2018 Dec 1. doi: 10.1007/s10120-018-0899-6. [Epub ahead of print]


Anorectal Cancer in Crohn's Disease Has a Poor Prognosis Due to its Advanced Stage and Aggressive Histological Features: a Systematic Literature Review of Japanese Patients.

Ueda T, Inoue T, Nakamoto T, Nishigori N, Kuge H, Sasaki Y, Fujii H, Koyama F.

J Gastrointest Cancer. 2018 Nov 26. doi: 10.1007/s12029-018-0180-6. [Epub ahead of print]


A refined two-step oligoribonucleotide interference-PCR method for precise discrimination of nucleotide differences.

Fujita T, Yuno M, Kitaura F, Fujii H.

Sci Rep. 2018 Nov 21;8(1):17195. doi: 10.1038/s41598-018-35479-0.


Amyloid β1-42-Induced Rapid Zn2+ Influx into Dentate Granule Cells Attenuates Maintained LTP Followed by Retrograde Amnesia.

Tamano H, Suzuki H, Murakami T, Fujii H, Adlard PA, Bush AI, Takeda A.

Mol Neurobiol. 2018 Nov 20. doi: 10.1007/s12035-018-1429-6. [Epub ahead of print]


Severe Neutropenia is Associated with Better Clinical Outcomes in Patients with Advanced Pancreatic Cancer Who Receive Modified FOLFIRINOX Therapy.

Yamada Y, Fujii H, Watanabe D, Kato-Hayashi H, Ohata K, Kobayashi R, Ishihara T, Uemura S, Iwashita T, Shimizu M, Suzuki A.

Cancers (Basel). 2018 Nov 16;10(11). pii: E454. doi: 10.3390/cancers10110454.


Evidence for the involvement of FXR signaling in ovarian granulosa cell function.

Takae K, Nakata M, Watanabe T, Sasada H, Fujii H, Tomioka I.

J Reprod Dev. 2018 Nov 16. doi: 10.1262/jrd.2018-054. [Epub ahead of print]


Impact of UGT1A1 genetic polymorphism on toxicity in unresectable pancreatic cancer patients undergoing FOLFIRINOX.

Shirasu H, Todaka A, Omae K, Fujii H, Mizuno N, Ozaka M, Ueno H, Kobayashi S, Uesugi K, Kobayashi N, Hayashi H, Sudo K, Okano N, Horita Y, Kamei K, Yukisawa S, Kobayashi M, Fukutomi A.

Cancer Sci. 2018 Nov 17. doi: 10.1111/cas.13883. [Epub ahead of print]


Core fucose is essential glycosylation for CD14-dependent Toll-like receptor 4 and Toll-like receptor 2 signaling in macrophages.

Nakayama K, Wakamatsu K, Fujii H, Shinzaki S, Takamatsu S, Kitazume S, Kamada Y, Takehara T, Taniguchi N, Miyoshi E.

J Biochem. 2018 Nov 15. doi: 10.1093/jb/mvy098. [Epub ahead of print]


Demand for home medical care will continue to increase in the next decades: An analysis from the Yokohama Original Medical Database (YoMDB).

Suzuki Y, Dohmae S, Ohyama K, Nishino H, Fujii H, Shuri J.

Geriatr Gerontol Int. 2018 Nov;18(11):1578-1579. doi: 10.1111/ggi.13533. No abstract available.


Feasibility of Combination Therapy with Nab-paclitaxel Plus Gemcitabine in Patients with Recurrent Pancreatic Cancer.

Kawaida H, Kono H, Amemiya H, Saitou R, Yamamoto A, Hosomura N, Watanabe M, Kimura A, Furuya S, Shimizu H, Akaike H, Kawaguchi Y, Sudo M, Itakura J, Hayakawa H, Shindo H, Takahashi EI, Takano S, Fukasawa M, Ichikawa S, Fujii H, Ichikawa D.

Anticancer Res. 2018 Nov;38(11):6537-6542. doi: 10.21873/anticanres.13019.


Improvement of Dysgeusia by Polaprezinc, a Zinc-L-carnosine, in Outpatients Receiving Cancer Chemotherapy.

Fujii H, Hirose C, Ishihara M, Iihara H, Imai H, Tanaka Y, Matsuhashi N, Takahashi T, Yamaguchi K, Yoshida K, Suzuki A.

Anticancer Res. 2018 Nov;38(11):6367-6373. doi: 10.21873/anticanres.12995.


The serum creatinine to cystatin C ratio predicts bone fracture in patients with type 2 diabetes: The Fukuoka Diabetes Registry.

Komorita Y, Iwase M, Fujii H, Ide H, Ohkuma T, Jodai-Kitamura T, Sumi A, Yoshinari M, Nakamura U, Kitazono T.

Diabetes Res Clin Pract. 2018 Dec;146:202-210. doi: 10.1016/j.diabres.2018.10.021. Epub 2018 Nov 1.


Short-term histological evaluations after achieving a sustained virologic response to direct-acting antiviral treatment for chronic hepatitis C.

Enomoto M, Ikura Y, Tamori A, Kozuka R, Motoyama H, Kawamura E, Hagihara A, Fujii H, Uchida-Kobayashi S, Morikawa H, Murakami Y, Kawada N.

United European Gastroenterol J. 2018 Nov;6(9):1391-1400. doi: 10.1177/2050640618791053. Epub 2018 Jul 19.


[Examination of Fever Risk Factors after Prophylaxis with G-CSF].

Okuda Y, Mori M, Shinada M, Fujii H, Sudoh T.

Gan To Kagaku Ryoho. 2018 Oct;45(10):1431-1434. Japanese.


Dose adjustment of irinotecan based on UGT1A1 polymorphisms in patients with colorectal cancer.

Fujii H, Yamada Y, Watanabe D, Matsuhashi N, Takahashi T, Yoshida K, Suzuki A.

Cancer Chemother Pharmacol. 2018 Oct 30. doi: 10.1007/s00280-018-3711-8. [Epub ahead of print]


Externalized transapical guidewire technique for complex aortic disease: a single-centre experience.

Murakami T, Morisaki A, Nishimura S, Takahashi Y, Sakon Y, Nakano M, Sohgawa E, Fujii H, Shibata T.

Eur J Cardiothorac Surg. 2018 Oct 22. doi: 10.1093/ejcts/ezy349. [Epub ahead of print]


PR deviation as a risk marker for cardiac events in patients with Takotsubo syndrome.

Shimizu M, Fujii H, Suzuki M, Yamawake N, Nishizaki M.

Pacing Clin Electrophysiol. 2018 Dec;41(12):1652-1659. doi: 10.1111/pace.13530. Epub 2018 Nov 8.


Abundant a proliferation-inducing ligand (APRIL)-producing macrophages contribute to plasma cell accumulation in immunoglobulin G4-related disease.

Kawakami T, Mizushima I, Yamada K, Fujii H, Ito K, Yasuno T, Izui S, Yamagishi M, Huard B, Kawano M.

Nephrol Dial Transplant. 2018 Oct 15. doi: 10.1093/ndt/gfy296. [Epub ahead of print]


Sasa veitchii extract protects against carbon tetrachloride-induced hepatic fibrosis in mice.

Yoshioka H, Nonogaki T, Fukaya S, Ichimaru Y, Nagatsu A, Yoshikawa M, Fujii H, Nakao M.

Environ Health Prev Med. 2018 Oct 15;23(1):49. doi: 10.1186/s12199-018-0739-7.


Non-invasive mapping of glutathione levels in mouse brains by in vivo electron paramagnetic resonance (EPR) imaging: Applied to a kindling mouse model.

Emoto MC, Sato-Akaba H, Matsuoka Y, Yamada KI, Fujii HG.

Neurosci Lett. 2018 Oct 2;690:6-10. doi: 10.1016/j.neulet.2018.10.001. [Epub ahead of print]


[Right Atrial Approach for the Surgical Repair of Delayed Ventricular Septal Rupture].

Ikuta T, Kishimoto N, Fujii H, Kimura E, Shimizu Y.

Kyobu Geka. 2018 Sep;71(9):669-673. Japanese.


Changes in plasma interleukin-8 and tumor necrosis factor-α levels during the early treatment period as a predictor of the response to sorafenib in patients with unresectable hepatocellular carcinoma.

Iida-Ueno A, Enomoto M, Uchida-Kobayashi S, Hagihara A, Teranishi Y, Fujii H, Morikawa H, Murakami Y, Tamori A, Thuy LTT, Kawada N.

Cancer Chemother Pharmacol. 2018 Nov;82(5):857-864. doi: 10.1007/s00280-018-3681-x. Epub 2018 Sep 3.


Synthesis and Evaluation as a Blood-Brain Barrier-Permeable Probe of 7-N-(PROXYL-3-yl-methyl)theophylline.

Emoto MC, Sasaki K, Maeda K, Fujii HG, Sato S.

Chem Pharm Bull (Tokyo). 2018;66(9):887-891. doi: 10.1248/cpb.c18-00333.


Relationship Between Thymidine Kinase 1 Expression and Trifluridine/Tipiracil Therapy in Refractory Metastatic Colorectal Cancer: A Pooled Analysis of 2 Randomized Clinical Trials.

Yoshino T, Yamazaki K, Shinozaki E, Komatsu Y, Nishina T, Baba H, Tsuji A, Tsuji Y, Yamaguchi K, Sugimoto N, Denda T, Muro K, Takayama T, Esaki T, Hamamoto Y, Moriwaki T, Shimada Y, Goto M, Nakayama N, Fujii H, Tanase T, Ohtsu A.

Clin Colorectal Cancer. 2018 Dec;17(4):e719-e732. doi: 10.1016/j.clcc.2018.07.009. Epub 2018 Jul 26.


A novel fatty acid-binding protein 5-estrogen-related receptor α signaling pathway promotes cell growth and energy metabolism in prostate cancer cells.

Senga S, Kawaguchi K, Kobayashi N, Ando A, Fujii H.

Oncotarget. 2018 Aug 3;9(60):31753-31770. doi: 10.18632/oncotarget.25878. eCollection 2018 Aug 3.


Association between HLA-DQA1/DRB1 polymorphism and development of hepatocellular carcinoma during entecavir treatment.

Kozuka R, Enomoto M, Sato-Matsubara M, Yoshida K, Motoyama H, Hagihara A, Fujii H, Uchida-Kobayashi S, Morikawa H, Tamori A, Kawada N, Murakami Y.

J Gastroenterol Hepatol. 2018 Aug 30. doi: 10.1111/jgh.14454. [Epub ahead of print]


MITE insertion-dependent expression of CitRKD1 with a RWP-RK domain regulates somatic embryogenesis in citrus nucellar tissues.

Shimada T, Endo T, Fujii H, Nakano M, Sugiyama A, Daido G, Ohta S, Yoshioka T, Omura M.

BMC Plant Biol. 2018 Aug 13;18(1):166. doi: 10.1186/s12870-018-1369-3.


Ventricular Fibrillation Induced by Coronary Vasospasm in a Patient with Early Repolarization and Hyperthyroidism.

Iiya M, Yamawake N, Nishizaki M, Shimizu M, Fujii H, Suzuki M, Sakurada H, Hiraoka M.

Intern Med. 2018 Dec 1;57(23):3389-3392. doi: 10.2169/internalmedicine.1104-18. Epub 2018 Aug 10.


Coexpression of 5-Aminolevulinic Acid Synthase Gene Facilitates Heterologous Production of Thermostable Cytochrome P450, CYP119, in Holo Form in Escherichia coli.

Honda Y, Nanasawa K, Fujii H.

Chembiochem. 2018 Oct 18;19(20):2156-2159. doi: 10.1002/cbic.201800331. Epub 2018 Sep 26.


Combination of hemoglobin and low-flow duration can predict neurological outcome in the initial phase of out-of-hospital cardiac arrest.

Iiya M, Shimizu M, Takahashi K, Fujii H, Suzuki M, Yamawake N, Nishizaki M.

J Crit Care. 2018 Oct;47:269-273. doi: 10.1016/j.jcrc.2018.07.013. Epub 2018 Aug 7.


A case of anti-MOG antibody-positive unilaterally dominant meningoencephalitis followed by longitudinally extensive transverse myelitis.

Sugimoto T, Ishibashi H, Hayashi M, Tachiyama K, Fujii H, Kaneko K, Takahashi T, Kurokawa K, Yamawaki T.

Mult Scler Relat Disord. 2018 Oct;25:128-130. doi: 10.1016/j.msard.2018.07.028. Epub 2018 Jul 26.


A case of IgG4-related kidney disease with predominantly unilateral renal atrophy.

Takeji A, Yamada K, Inoue D, Mizushima I, Hara S, Ito K, Fujii H, Nakajima K, Mizutomi K, Yamagishi M, Kawano M.

CEN Case Rep. 2018 Jul 30. doi: 10.1007/s13730-018-0355-9. [Epub ahead of print]


Clinical Impact of Histological Heterogeneity in the Metastatic Lymph Nodes of Patients with Colorectal Cancer.

Hirayama K, Sudoh M, Shimizu H, Furuya S, Akazawa Y, Iino H, Shiraishi K, Akaike H, Hosomura N, Kawaguchi Y, Amemiya H, Kawaida H, Inoue S, Kono H, Fujii H, Ichikawa D.

Anticancer Res. 2018 Aug;38(8):4797-4803. doi: 10.21873/anticanres.12789.


Mesenchymal stem cells up-regulate the invasive potential of prostate cancer cells via the eotaxin-3/CCR3 axis.

Ishida Y, Kido A, Akahane M, Kishi S, Tsukamoto S, Fujii H, Honoki K, Tanaka Y.

Pathol Res Pract. 2018 Sep;214(9):1297-1302. doi: 10.1016/j.prp.2018.06.012. Epub 2018 Jun 25.


Mandibular Osteitis Leading to the Diagnosis of SAPHO Syndrome.

Kikuchi T, Fujii H, Fujita A, Sugiyama T, Sugimoto H.

Case Rep Radiol. 2018 Jun 13;2018:9142362. doi: 10.1155/2018/9142362. eCollection 2018.


A Data Mining-based Prognostic Algorithm for NAFLD-related Hepatoma Patients: A Nationwide Study by the Japan Study Group of NAFLD.

Kawaguchi T, Tokushige K, Hyogo H, Aikata H, Nakajima T, Ono M, Kawanaka M, Sawada K, Imajo K, Honda K, Takahashi H, Mori K, Tanaka S, Seko Y, Nozaki Y, Kamada Y, Fujii H, Kawaguchi A, Takehara T, Yanase M, Sumida Y, Eguchi Y, Seike M, Yoneda M, Suzuki Y, Saibara T, Karino Y, Chayama K, Hashimoto E, George J, Torimura T.

Sci Rep. 2018 Jul 11;8(1):10434. doi: 10.1038/s41598-018-28650-0.


Soybean-Derived Glycine-Arginine Dipeptide Administration Promotes Neurotrophic Factor Expression in the Mouse Brain.

Shimizu A, Mitani T, Tanaka S, Fujii H, Maebuchi M, Amiya Y, Tanaka M, Matsui T, Nakamura S, Katayama S.

J Agric Food Chem. 2018 Aug 1;66(30):7935-7941. doi: 10.1021/acs.jafc.8b01581. Epub 2018 Jul 20.


Spontaneous intracranial hypotension complicated by cerebral venous thrombosis.

Fujii N, Fujii H, Fujita A, Kim Y, Sugimoto H.

Radiol Case Rep. 2018 Jun 20;13(4):834-838. doi: 10.1016/j.radcr.2018.05.014. eCollection 2018 Aug.


Early tumor shrinkage and depth of response in patients with advanced gastric cancer: a retrospective analysis of a randomized phase III study of first-line S-1 plus oxaliplatin vs. S-1 plus cisplatin.

Nishina T, Azuma M, Nishikawa K, Gotoh M, Bando H, Sugimoto N, Amagai K, Chin K, Niwa Y, Tsuji A, Imamura H, Tsuda M, Yasui H, Fujii H, Yamaguchi K, Yasui H, Hironaka S, Shimada K, Miwa H, Mitome T, Kageyama H, Hyodo I.

Gastric Cancer. 2018 Jun 9. doi: 10.1007/s10120-018-0845-7. [Epub ahead of print]


DNA damage response induced by Etoposide promotes steroidogenesis via GADD45A in cultured adrenal cells.

Tamamori-Adachi M, Koga A, Susa T, Fujii H, Tsuchiya M, Okinaga H, Hisaki H, Iizuka M, Kitajima S, Okazaki T.

Sci Rep. 2018 Jun 25;8(1):9636. doi: 10.1038/s41598-018-27938-5.


Severe acyclovir-resistant herpes simplex virus 1 infection following cord blood transplantation.

Shigemura T, Nakazawa Y, Yoshikawa T, Fujii H, Yamada S, Saijo M, Okuyama R.

Int J Hematol. 2018 Jun 19. doi: 10.1007/s12185-018-2480-9. [Epub ahead of print] No abstract available.


Fatty acid-binding protein 5 (FABP5) promotes lipolysis of lipid droplets, de novo fatty acid (FA) synthesis and activation of nuclear factor-kappa B (NF-κB) signaling in cancer cells.

Senga S, Kobayashi N, Kawaguchi K, Ando A, Fujii H.

Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Sep;1863(9):1057-1067. doi: 10.1016/j.bbalip.2018.06.010. Epub 2018 Jun 12.


An enChIP system for the analysis of bacterial genome functions.

Fujita T, Yuno M, Fujii H.

BMC Res Notes. 2018 Jun 14;11(1):387. doi: 10.1186/s13104-018-3486-3.


Peritoneal metastasis as a predictive factor for nab-paclitaxel in patients with pretreated advanced gastric cancer: an exploratory analysis of the phase III ABSOLUTE trial.

Takashima A, Shitara K, Fujitani K, Koeda K, Hara H, Nakayama N, Hironaka S, Nishikawa K, Kimura Y, Amagai K, Fujii H, Muro K, Esaki T, Choda Y, Takano T, Chin K, Sato A, Goto M, Fukushima N, Hara T, Machida N, Ohta M, Boku N, Shimura M, Morita S, Koizumi W.

Gastric Cancer. 2018 May 31. doi: 10.1007/s10120-018-0838-6. [Epub ahead of print]


Acyclovir Sensitivity and Neurovirulence of Herpes Simplex Virus Type 1 with Amino Acid Substitutions in the Viral Thymidine Kinase Gene, Which Were Detected in the Patients with Intractable Herpes Simplex Encephalitis Previously Reported.

Inagaki T, Satoh M, Fujii H, Yamada S, Shibamura M, Yoshikawa T, Harada S, Takeyama H, Saijo M.

Jpn J Infect Dis. 2018 Sep 21;71(5):343-349. doi: 10.7883/yoken.JJID.2018.176. Epub 2018 May 31.


Correction to: The novel cutoff points for the FIB4 index categorized by age increase the diagnostic accuracy in NAFLD: a multi-center study.

Ishiba H, Sumida Y, Tanaka S, Yoneda M, Hyogo H, Ono M, Fujii H, Eguchi Y, Suzuki Y, Yoneda M, Takahashi H, Nakahara T, Seko Y, Mori K, Kanemasa K, Shimada K, Imai S, Imajo K, Kawaguchi T, Nakajima A, Chayama K, Saibara T, Shima T, Fujimoto K, Okanoue T, Itoh Y; Japan Study Group of Non-Alcoholic Fatty Liver Disease (JSG-NAFLD).

J Gastroenterol. 2018 Nov;53(11):1225. doi: 10.1007/s00535-018-1478-7.


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