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First steps towards combining faecal immunochemical testing with the gut microbiome in colorectal cancer screening.

Grobbee EJ, Lam SY, Fuhler GM, Blakaj B, Konstantinov SR, Bruno MJ, Peppelenbosch MP, Kuipers EJ, Spaander MC.

United European Gastroenterol J. 2019 Dec 19:2050640619890732. doi: 10.1177/2050640619890732. [Epub ahead of print]


Upregulated β-catenin signaling does not affect survival of pancreatic cancer cells during dual inhibition of GSK3B and HDAC.

Nesteruk K, Smits R, Bruno M, Peppelenbosch MP, Fuhler GM.

Pancreatology. 2019 Dec 24. pii: S1424-3903(19)30816-6. doi: 10.1016/j.pan.2019.12.019. [Epub ahead of print] No abstract available.


2019 Gut Microbiota for Health World Summit.

Fuhler GM, Hecht GA; 2019 Gut Microbiota for Health World Summit Meeting Summary Writing Group.

Gastroenterology. 2020 Jan;158(1):28-31. doi: 10.1053/j.gastro.2019.08.044. Epub 2019 Sep 6. No abstract available.


Prediction and Treatment of Radiation Enteropathy: Can Intestinal Bugs Lead the Way?

Lam SY, Peppelenbosch MP, Fuhler GM.

Clin Cancer Res. 2019 Nov 1;25(21):6280-6282. doi: 10.1158/1078-0432.CCR-19-2422. Epub 2019 Sep 6.


Composition of the mucosa-associated microbiota along the entire gastrointestinal tract of human individuals.

Vuik F, Dicksved J, Lam SY, Fuhler GM, van der Laan L, van de Winkel A, Konstantinov SR, Spaander M, Peppelenbosch MP, Engstrand L, Kuipers EJ.

United European Gastroenterol J. 2019 Aug;7(7):897-907. doi: 10.1177/2050640619852255. Epub 2019 May 17.


Targeting Tyrosine Phosphatases by 3-Bromopyruvate Overcomes Hyperactivation of Platelets from Gastrointestinal Cancer Patients.

Faria AVS, Andrade SS, Reijm AN, Spaander MCW, de Maat MPM, Peppelenbosch MP, Ferreira-Halder CV, Fuhler GM.

J Clin Med. 2019 Jun 28;8(7). pii: E936. doi: 10.3390/jcm8070936.


Modulation of cytokine patterns and microbiome during pregnancy in IBD.

van der Giessen J, Binyamin D, Belogolovski A, Frishman S, Tenenbaum-Gavish K, Hadar E, Louzoun Y, Peppelenbosch MP, van der Woude CJ, Koren O, Fuhler GM.

Gut. 2020 Mar;69(3):473-486. doi: 10.1136/gutjnl-2019-318263. Epub 2019 Jun 5.


HOXA9 mediates and marks premalignant compartment size expansion in colonic adenomas.

Janmaat VT, Liu H, da Silva RA, Wisse PHA, Spaander MCW, Ten Hagen TLM, Smits R, Bruno MJ, Fuhler GM, Peppelenbosch MP.

Carcinogenesis. 2019 Dec 31;40(12):1514-1524. doi: 10.1093/carcin/bgz038.


Achalasia and associated esophageal cancer risk: What lessons can we learn from the molecular analysis of Barrett's-associated adenocarcinoma?

Nesteruk K, Spaander MCW, Leeuwenburgh I, Peppelenbosch MP, Fuhler GM.

Biochim Biophys Acta Rev Cancer. 2019 Dec;1872(2). pii: S0304-419X(19)30028-9. doi: 10.1016/j.bbcan.2019.04.007. Epub 2019 May 4. Review.


HOXA cluster gene expression during osteoblast differentiation involves epigenetic control.

da Silva RA, Fuhler GM, Janmaat VT, da C Fernandes CJ, da Silva Feltran G, Oliveira FA, Matos AA, Oliveira RC, Ferreira MR, Zambuzzi WF, Peppelenbosch MP.

Bone. 2019 Aug;125:74-86. doi: 10.1016/j.bone.2019.04.026. Epub 2019 May 1.


Smoothened-dependent and -independent pathways in mammalian noncanonical Hedgehog signaling.

Faria AVS, Akyala AI, Parikh K, Brüggemann LW, Spek CA, Cao W, Bruno MJ, Bijlsma MF, Fuhler GM, Peppelenbosch MP.

J Biol Chem. 2019 Jun 21;294(25):9787-9798. doi: 10.1074/jbc.RA119.007956. Epub 2019 Apr 16.


Modulatory Effects of Pregnancy on Inflammatory Bowel Disease.

van der Giessen J, Huang VW, van der Woude CJ, Fuhler GM.

Clin Transl Gastroenterol. 2019 Mar;10(3):e00009. doi: 10.14309/ctg.0000000000000009.


A Direct Effect of Sex Hormones on Epithelial Barrier Function in Inflammatory Bowel Disease Models.

van der Giessen J, van der Woude CJ, Peppelenbosch MP, Fuhler GM.

Cells. 2019 Mar 19;8(3). pii: E261. doi: 10.3390/cells8030261.


Epithelial endoplasmic reticulum stress orchestrates a protective IgA response.

Grootjans J, Krupka N, Hosomi S, Matute JD, Hanley T, Saveljeva S, Gensollen T, Heijmans J, Li H, Limenitakis JP, Ganal-Vonarburg SC, Suo S, Luoma AM, Shimodaira Y, Duan J, Shih DQ, Conner ME, Glickman JN, Fuhler GM, Palm NW, de Zoete MR, van der Woude CJ, Yuan GC, Wucherpfennig KW, Targan SR, Rosenstiel P, Flavell RA, McCoy KD, Macpherson AJ, Kaser A, Blumberg RS.

Science. 2019 Mar 1;363(6430):993-998. doi: 10.1126/science.aat7186.


Kinase activity is impaired in neutrophils of sepsis patients.

Hoogendijk AJ, van Vught LA, Wiewel MA, Fuhler GM, Belkasim-Bohoudi H, Horn J, Schultz MJ, Scicluna BP, Peppelenbosch MP, van 't Veer C, de Vos AF, van der Poll T.

Haematologica. 2019 Jun;104(6):e233-e235. doi: 10.3324/haematol.2018.201913. Epub 2018 Dec 4. No abstract available.


Human mesenchymal stromal cells in adhesion to cell-derived extracellular matrix and titanium: Comparative kinome profile analysis.

Baroncelli M, Fuhler GM, van de Peppel J, Zambuzzi WF, van Leeuwen JP, van der Eerden BCJ, Peppelenbosch MP.

J Cell Physiol. 2019 Mar;234(3):2984-2996. doi: 10.1002/jcp.27116. Epub 2018 Jul 30.


6-Thioguanine inhibits rotavirus replication through suppression of Rac1 GDP/GTP cycling.

Yin Y, Chen S, Hakim MS, Wang W, Xu L, Dang W, Qu C, Verhaar AP, Su J, Fuhler GM, Peppelenbosch MP, Pan Q.

Antiviral Res. 2018 Aug;156:92-101. doi: 10.1016/j.antiviral.2018.06.011. Epub 2018 Jun 18.


TNF-α exerts potent anti-rotavirus effects via the activation of classical NF-κB pathway.

Hakim MS, Ding S, Chen S, Yin Y, Su J, van der Woude CJ, Fuhler GM, Peppelenbosch MP, Pan Q, Wang W.

Virus Res. 2018 Jul 15;253:28-37. doi: 10.1016/j.virusres.2018.05.022. Epub 2018 May 31.


The gastrointestinal microbiota and its role in oncogenesis.

Lam SY, Yu J, Wong SH, Peppelenbosch MP, Fuhler GM.

Best Pract Res Clin Gastroenterol. 2017 Dec;31(6):607-618. doi: 10.1016/j.bpg.2017.09.010. Epub 2017 Sep 5. Review.


Low dose Naltrexone for induction of remission in inflammatory bowel disease patients.

Lie MRKL, van der Giessen J, Fuhler GM, de Lima A, Peppelenbosch MP, van der Ent C, van der Woude CJ.

J Transl Med. 2018 Mar 9;16(1):55. doi: 10.1186/s12967-018-1427-5.


Correlating Fecal Calprotectin With Hemoglobin Levels Within 1 Sample.

Fuhler GM, van der Giessen J, van der Woude CJ, Peppelenbosch MP.

Inflamm Bowel Dis. 2018 Feb 15;24(3):663. doi: 10.1093/ibd/izx028. No abstract available.


Fecal Matrix Metalloproteinase-9 Measurement for Optimizing Detection of Disease Activity in Inflammatory Bowel Disease.

Kreijne JE, van der Giessen J, Verhaar AP, Peppelenbosch MP, de Vries AC, van der Woude CJ, Fuhler GM.

J Clin Gastroenterol. 2019 May/Jun;53(5):395-397. doi: 10.1097/MCG.0000000000000952. No abstract available.


Genetic polymorphism in ATG16L1 gene is associated with adalimumab use in inflammatory bowel disease.

Nuij VJAA, Peppelenbosch MP, van der Woude CJ, Fuhler GM.

J Transl Med. 2017 Dec 11;15(1):248. doi: 10.1186/s12967-017-1355-9.


Genetic host factors in Helicobacter pylori-induced carcinogenesis: Emerging new paradigms.

Mommersteeg MC, Yu J, Peppelenbosch MP, Fuhler GM.

Biochim Biophys Acta Rev Cancer. 2018 Jan;1869(1):42-52. doi: 10.1016/j.bbcan.2017.11.003. Epub 2017 Nov 24. Review.


Pancreatic cyst fluid harbors a unique microbiome.

Li S, Fuhler GM, Bn N, Jose T, Bruno MJ, Peppelenbosch MP, Konstantinov SR.

Microbiome. 2017 Nov 9;5(1):147. doi: 10.1186/s40168-017-0363-6.


Erratum to: Action and function of Wnt/β-catenin signaling in the progression from chronic hepatitis C to hepatocellular carcinoma.

Wang W, Pan Q, Fuhler GM, Smits R, Peppelenbosch MP.

J Gastroenterol. 2018 Apr;53(4):576-577. doi: 10.1007/s00535-017-1392-4.


Analysis of SHIP1 expression and activity in Crohn's disease patients.

Somasundaram R, Fernandes S, Deuring JJ, de Haar C, Kuipers EJ, Vogelaar L, Middleton FA, van der Woude CJ, Peppelenbosch MP, Kerr WG, Fuhler GM.

PLoS One. 2017 Aug 2;12(8):e0182308. doi: 10.1371/journal.pone.0182308. eCollection 2017.


Prevalence and Phenotype of Concurrent Psoriasis and Inflammatory Bowel Disease.

Eppinga H, Poortinga S, Thio HB, Nijsten TEC, Nuij VJAA, van der Woude CJ, Vodegel RM, Fuhler GM, Peppelenbosch MP.

Inflamm Bowel Dis. 2017 Oct;23(10):1783-1789. doi: 10.1097/MIB.0000000000001169.


Depletion of Saccharomyces cerevisiae in psoriasis patients, restored by Dimethylfumarate therapy (DMF).

Eppinga H, Thio HB, Schreurs MWJ, Blakaj B, Tahitu RI, Konstantinov SR, Peppelenbosch MP, Fuhler GM.

PLoS One. 2017 May 9;12(5):e0176955. doi: 10.1371/journal.pone.0176955. eCollection 2017.


Modulation of Human Peripheral Blood Mononuclear Cell Signaling by Medicinal Cannabinoids.

Utomo WK, de Vries M, Braat H, Bruno MJ, Parikh K, Comalada M, Peppelenbosch MP, van Goor H, Fuhler GM.

Front Mol Neurosci. 2017 Jan 24;10:14. doi: 10.3389/fnmol.2017.00014. eCollection 2017.


A MicroRNA Panel in Pancreatic Cyst Fluid for the Risk Stratification of Pancreatic Cysts in a Prospective Cohort.

Utomo WK, Looijenga LH, Bruno MJ, Hansen BE, Gillis A, Biermann K, Peppelenbosch MP, Fuhler GM, Braat H.

Mol Ther Nucleic Acids. 2016;5:e350. doi: 10.1038/mtna.2016.61.


Defective ATG16L1-mediated removal of IRE1α drives Crohn's disease-like ileitis.

Tschurtschenthaler M, Adolph TE, Ashcroft JW, Niederreiter L, Bharti R, Saveljeva S, Bhattacharyya J, Flak MB, Shih DQ, Fuhler GM, Parkes M, Kohno K, Iwawaki T, Janneke van der Woude C, Harding HP, Smith AM, Peppelenbosch MP, Targan SR, Ron D, Rosenstiel P, Blumberg RS, Kaser A.

J Exp Med. 2017 Feb;214(2):401-422. doi: 10.1084/jem.20160791. Epub 2017 Jan 12.


Action and function of Wnt/β-catenin signaling in the progression from chronic hepatitis C to hepatocellular carcinoma.

Wang W, Pan Q, Fuhler GM, Smits R, Peppelenbosch MP.

J Gastroenterol. 2017 Apr;52(4):419-431. doi: 10.1007/s00535-016-1299-5. Epub 2016 Dec 29. Review. Erratum in: J Gastroenterol. 2017 Oct 11;:.


Action and Function of Vitamin D in Digestive Tract Physiology and Pathology.

Peppelenbosch MP, Fuhler GM, Verhaar AP, van der Laan LJW.

Curr Med Chem. 2017;24(9):928-936. doi: 10.2174/0929867323666161228145137. Review.


Fumarates and Cancer.

Fuhler GM, Eppinga H, Peppelenbosch MP.

Trends Mol Med. 2017 Jan;23(1):3-5. doi: 10.1016/j.molmed.2016.12.001. Epub 2016 Dec 13.


Testing for Anti-PBP Antibody Is Not Useful in Diagnosing Autoimmune Pancreatitis.

Buijs J, Cahen DL, van Heerde MJ, Hansen BE, van Buuren HR, Peppelenbosch MP, Fuhler GM, Bruno MJ.

Am J Gastroenterol. 2016 Nov;111(11):1650-1654. doi: 10.1038/ajg.2016.241. Epub 2016 Jun 21.


Lipid phosphatase SHIP2 functions as oncogene in colorectal cancer by regulating PKB activation.

Hoekstra E, Das AM, Willemsen M, Swets M, Kuppen PJ, van der Woude CJ, Bruno MJ, Shah JP, Ten Hagen TL, Chisholm JD, Kerr WG, Peppelenbosch MP, Fuhler GM.

Oncotarget. 2016 Nov 8;7(45):73525-73540. doi: 10.18632/oncotarget.12321.


DNA integrity as biomarker in pancreatic cyst fluid.

Utomo WK, Janmaat VT, Verhaar AP, Cros J, Lévy P, Ruszniewski P, den Berg MS, Jenster G, Bruno MJ, Braat H, Fuhler GM, Peppelenbosch MP.

Am J Cancer Res. 2016 Aug 1;6(8):1837-41. eCollection 2016.


Gut Microbiota Developments With Emphasis on Inflammatory Bowel Disease: Report From the Gut Microbiota for Health World Summit 2016.

Eppinga H, Fuhler GM, Peppelenbosch MP, Hecht GA.

Gastroenterology. 2016 Aug;151(2):e1-4. doi: 10.1053/j.gastro.2016.06.024. Epub 2016 Jul 1. No abstract available.


Meeting Report Europhosphatase 2015: Phosphatases as Drug Targets in Cancer.

Hoekstra E, Peppelenbosch MP, Fuhler GM.

Cancer Res. 2016 Jan 15;76(2):193-6. doi: 10.1158/0008-5472.CAN-15-2091. Epub 2016 Jan 7.


Improved intra-array and interarray normalization of peptide microarray phosphorylation for phosphorylome and kinome profiling by rational selection of relevant spots.

Scholma J, Fuhler GM, Joore J, Hulsman M, Schivo S, List AF, Reinders MJ, Peppelenbosch MP, Post JN.

Sci Rep. 2016 May 26;6:26695. doi: 10.1038/srep26695.


Convergent Transcription of Interferon-stimulated Genes by TNF-α and IFN-α Augments Antiviral Activity against HCV and HEV.

Wang W, Xu L, Brandsma JH, Wang Y, Hakim MS, Zhou X, Yin Y, Fuhler GM, van der Laan LJ, van der Woude CJ, Sprengers D, Metselaar HJ, Smits R, Poot RA, Peppelenbosch MP, Pan Q.

Sci Rep. 2016 May 6;6:25482. doi: 10.1038/srep25482.


Increased PTP1B expression and phosphatase activity in colorectal cancer results in a more invasive phenotype and worse patient outcome.

Hoekstra E, Das AM, Swets M, Cao W, van der Woude CJ, Bruno MJ, Peppelenbosch MP, Kuppen PJ, Ten Hagen TL, Fuhler GM.

Oncotarget. 2016 Apr 19;7(16):21922-38. doi: 10.18632/oncotarget.7829.


Linkage between genotype and immunological phenotype in Crohn's disease.

Fuhler GM, Parikh K, van der Woude CJ, Peppelenbosch MP.

Ann Transl Med. 2015 Sep;3(16):237. doi: 10.3978/j.issn.2305-5839.2015.09.28.


PAK2 is an effector of TSC1/2 signaling independent of mTOR and a potential therapeutic target for Tuberous Sclerosis Complex.

Alves MM, Fuhler GM, Queiroz KC, Scholma J, Goorden S, Anink J, Spek CA, Hoogeveen-Westerveld M, Bruno MJ, Nellist M, Elgersma Y, Aronica E, Peppelenbosch MP.

Sci Rep. 2015 Sep 28;5:14534. doi: 10.1038/srep14534.


Cannabinoid receptor agonist namisol does not affect cytokine levels in chronic pancreatitis patients.

Utomo WK, de Vries M, van Rijckevorsel DC, Peppelenbosch MP, van Goor H, Fuhler GM.

Am J Gastroenterol. 2015 Aug;110(8):1244-5. doi: 10.1038/ajg.2015.197. No abstract available.


Benefit of Earlier Anti-TNF Treatment on IBD Disease Complications?

Nuij V, Fuhler GM, Edel AJ, Ouwendijk RJ, Rijk MC, Beukers R, Quispel R, van Tilburg AJ, Tang TJ, Smalbraak H, Bruin KF, Lindenburg F, Peyrin-Biroulet L, van der Woude CJ; Dutch Delta IBD Group.

J Crohns Colitis. 2015 Nov;9(11):997-1003. doi: 10.1093/ecco-jcc/jjv130. Epub 2015 Jul 29.


Low-Molecular-Weight Protein Tyrosine Phosphatase Predicts Prostate Cancer Outcome by Increasing the Metastatic Potential.

Ruela-de-Sousa RR, Hoekstra E, Hoogland AM, Souza Queiroz KC, Peppelenbosch MP, Stubbs AP, Pelizzaro-Rocha K, van Leenders GJLH, Jenster G, Aoyama H, Ferreira CV, Fuhler GM.

Eur Urol. 2016 Apr;69(4):710-719. doi: 10.1016/j.eururo.2015.06.040. Epub 2015 Jul 7.


Cytopathological Analysis of Cyst Fluid Enhances Diagnostic Accuracy of Mucinous Pancreatic Cystic Neoplasms.

Utomo WK, Braat H, Bruno MJ, van Eijck CH, Groot Koerkamp B, Krak NC, van de Vreede A, Fuhler GM, Peppelenbosch MP, Biermann K.

Medicine (Baltimore). 2015 Jun;94(24):e988. doi: 10.1097/MD.0000000000000988.


Low molecular weight protein tyrosine phosphatase (LMWPTP) upregulation mediates malignant potential in colorectal cancer.

Hoekstra E, Kodach LL, Das AM, Ruela-de-Sousa RR, Ferreira CV, Hardwick JC, van der Woude CJ, Peppelenbosch MP, Ten Hagen TL, Fuhler GM.

Oncotarget. 2015 Apr 10;6(10):8300-12.

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