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Items: 1 to 50 of 63

1.

Non-canonical dimerization of the androgen receptor and other nuclear receptors: implications for human disease.

Jiménez-Panizo A, Pérez P, Rojas AM, Fuentes-Prior P, Estébanez-Perpiñá E.

Endocr Relat Cancer. 2019 Aug;26(8):R479-R497. doi: 10.1530/ERC-19-0132. Review.

PMID:
31252411
2.

TET2 missense variants in human neoplasia. A proposal of structural and functional classification.

Bussaglia E, Antón R, Nomdedéu JF, Fuentes-Prior P.

Mol Genet Genomic Med. 2019 Jul;7(7):e00772. doi: 10.1002/mgg3.772. Epub 2019 Jun 11.

3.

Metazoan evolution of glutamate receptors reveals unreported phylogenetic groups and divergent lineage-specific events.

Ramos-Vicente D, Ji J, Gratacòs-Batlle E, Gou G, Reig-Viader R, Luís J, Burguera D, Navas-Perez E, García-Fernández J, Fuentes-Prior P, Escriva H, Roher N, Soto D, Bayés À.

Elife. 2018 Nov 22;7. pii: e35774. doi: 10.7554/eLife.35774.

4.

A rare STAP1 mutation incompletely associated with familial hypercholesterolemia.

Blanco-Vaca F, Martín-Campos JM, Pérez A, Fuentes-Prior P.

Clin Chim Acta. 2018 Dec;487:270-274. doi: 10.1016/j.cca.2018.10.014. Epub 2018 Oct 9.

PMID:
30308187
5.

Diversity of Quaternary Structures Regulates Nuclear Receptor Activities.

Fuentes-Prior P, Rojas A, Hagler AT, Estébanez-Perpiñá E.

Trends Biochem Sci. 2019 Jan;44(1):2-6. doi: 10.1016/j.tibs.2018.09.005. Epub 2018 Oct 4.

PMID:
30293659
6.

Utility of two SMN1 variants to improve spinal muscular atrophy carrier diagnosis and genetic counselling.

Alías L, Bernal S, Calucho M, Martínez E, March F, Gallano P, Fuentes-Prior P, Abuli A, Serra-Juhe C, Tizzano EF.

Eur J Hum Genet. 2018 Oct;26(10):1554-1557. doi: 10.1038/s41431-018-0193-4. Epub 2018 Jun 14.

7.

C-Reactive Protein as a Therapeutic Target in Age-Related Macular Degeneration.

Molins B, Romero-Vázquez S, Fuentes-Prior P, Adan A, Dick AD.

Front Immunol. 2018 Apr 19;9:808. doi: 10.3389/fimmu.2018.00808. eCollection 2018. Review.

8.

Correlation between SMA type and SMN2 copy number revisited: An analysis of 625 unrelated Spanish patients and a compilation of 2834 reported cases.

Calucho M, Bernal S, Alías L, March F, Venceslá A, Rodríguez-Álvarez FJ, Aller E, Fernández RM, Borrego S, Millán JM, Hernández-Chico C, Cuscó I, Fuentes-Prior P, Tizzano EF.

Neuromuscul Disord. 2018 Mar;28(3):208-215. doi: 10.1016/j.nmd.2018.01.003. Epub 2018 Jan 11.

PMID:
29433793
9.

Structure of the homodimeric androgen receptor ligand-binding domain.

Nadal M, Prekovic S, Gallastegui N, Helsen C, Abella M, Zielinska K, Gay M, Vilaseca M, Taulès M, Houtsmuller AB, van Royen ME, Claessens F, Fuentes-Prior P, Estébanez-Perpiñá E.

Nat Commun. 2017 Feb 6;8:14388. doi: 10.1038/ncomms14388.

10.

Complement factor H binding of monomeric C-reactive protein downregulates proinflammatory activity and is impaired with at risk polymorphic CFH variants.

Molins B, Fuentes-Prior P, Adán A, Antón R, Arostegui JI, Yagüe J, Dick AD.

Sci Rep. 2016 Mar 10;6:22889. doi: 10.1038/srep22889.

11.

A novel gain-of-function STAT1 mutation resulting in basal phosphorylation of STAT1 and increased distal IFN-γ-mediated responses in chronic mucocutaneous candidiasis.

Martinez-Martinez L, Martinez-Saavedra MT, Fuentes-Prior P, Barnadas M, Rubiales MV, Noda J, Badell I, Rodríguez-Gallego C, de la Calle-Martin O.

Mol Immunol. 2015 Dec;68(2 Pt C):597-605. doi: 10.1016/j.molimm.2015.09.014.

PMID:
26514428
12.

K Domain CR9 of Low Density Lipoprotein (LDL) Receptor-related Protein 1 (LRP1) Is Critical for Aggregated LDL-induced Foam Cell Formation from Human Vascular Smooth Muscle Cells.

Costales P, Fuentes-Prior P, Castellano J, Revuelta-Lopez E, Corral-Rodríguez MÁ, Nasarre L, Badimon L, Llorente-Cortes V.

J Biol Chem. 2015 Jun 12;290(24):14852-65. doi: 10.1074/jbc.M115.638361. Epub 2015 Apr 27.

13.

Rare variants in calcium homeostasis modulator 1 (CALHM1) found in early onset Alzheimer's disease patients alter calcium homeostasis.

Rubio-Moscardo F, Setó-Salvia N, Pera M, Bosch-Morató M, Plata C, Belbin O, Gené G, Dols-Icardo O, Ingelsson M, Helisalmi S, Soininen H, Hiltunen M, Giedraitis V, Lannfelt L, Frank A, Bullido MJ, Combarros O, Sánchez-Juan P, Boada M, Tárraga L, Pastor P, Pérez-Tur J, Baquero M, Molinuevo JL, Sánchez-Valle R, Fuentes-Prior P, Fortea J, Blesa R, Muñoz FJ, Lleó A, Valverde MA, Clarimón J.

PLoS One. 2013 Sep 17;8(9):e74203. doi: 10.1371/journal.pone.0074203. eCollection 2013.

14.

Structural and functional analysis of APOA5 mutations identified in patients with severe hypertriglyceridemia.

Mendoza-Barberá E, Julve J, Nilsson SK, Lookene A, Martín-Campos JM, Roig R, Lechuga-Sancho AM, Sloan JH, Fuentes-Prior P, Blanco-Vaca F.

J Lipid Res. 2013 Mar;54(3):649-61. doi: 10.1194/jlr.M031195. Epub 2013 Jan 10.

15.

Unique thrombin inhibition mechanism by anophelin, an anticoagulant from the malaria vector.

Figueiredo AC, de Sanctis D, Gutiérrez-Gallego R, Cereija TB, Macedo-Ribeiro S, Fuentes-Prior P, Pereira PJ.

Proc Natl Acad Sci U S A. 2012 Dec 26;109(52):E3649-58. doi: 10.1073/pnas.1211614109. Epub 2012 Dec 5.

16.

In vivo detection of Staphylococcus aureus endocarditis by targeting pathogen-specific prothrombin activation.

Panizzi P, Nahrendorf M, Figueiredo JL, Panizzi J, Marinelli B, Iwamoto Y, Keliher E, Maddur AA, Waterman P, Kroh HK, Leuschner F, Aikawa E, Swirski FK, Pittet MJ, Hackeng TM, Fuentes-Prior P, Schneewind O, Bock PE, Weissleder R.

Nat Med. 2011 Aug 21;17(9):1142-6. doi: 10.1038/nm.2423.

17.

Structural basis of thrombin-mediated factor V activation: the Glu666-Glu672 sequence is critical for processing at the heavy chain-B domain junction.

Corral-Rodríguez MÁ, Bock PE, Hernández-Carvajal E, Gutiérrez-Gallego R, Fuentes-Prior P.

Blood. 2011 Jun 30;117(26):7164-73. doi: 10.1182/blood-2010-10-315309. Epub 2011 May 9.

18.

Clinical and genetic findings in five female patients with haemophilia A: Identification of a novel missense mutation, p.Phe2127Ser.

Martín-Salces M, Venceslá A, Alvárez-Román MT, Rivas I, Fernandez I, Butta N, Baena M, Fuentes-Prior P, Tizzano EF, Jiménez-Yuste V.

Thromb Haemost. 2010 Oct;104(4):718-23. doi: 10.1160/TH10-02-0085. Epub 2010 Jul 20.

PMID:
20664893
19.

The c.859G>C variant in the SMN2 gene is associated with types II and III SMA and originates from a common ancestor.

Bernal S, Alías L, Barceló MJ, Also-Rallo E, Martínez-Hernández R, Gámez J, Guillén-Navarro E, Rosell J, Hernando I, Rodríguez-Alvarez FJ, Borrego S, Millán JM, Hernández-Chico C, Baiget M, Fuentes-Prior P, Tizzano EF.

J Med Genet. 2010 Sep;47(9):640-2. doi: 10.1136/jmg.2010.079004. Epub 2010 Jun 24.

PMID:
20577007
20.

Leech-derived thrombin inhibitors: from structures to mechanisms to clinical applications.

Corral-Rodríguez MA, Macedo-Ribeiro S, Pereira PJ, Fuentes-Prior P.

J Med Chem. 2010 May 27;53(10):3847-61. doi: 10.1021/jm901743x. Review. No abstract available.

PMID:
20155915
21.

Tick-derived Kunitz-type inhibitors as antihemostatic factors.

Corral-Rodríguez MA, Macedo-Ribeiro S, Barbosa Pereira PJ, Fuentes-Prior P.

Insect Biochem Mol Biol. 2009 Sep;39(9):579-95. doi: 10.1016/j.ibmb.2009.07.003. Epub 2009 Jul 24. Review.

PMID:
19631744
22.

Plasminogen substrate recognition by the streptokinase-plasminogen catalytic complex is facilitated by Arg253, Lys256, and Lys257 in the streptokinase beta-domain and kringle 5 of the substrate.

Tharp AC, Laha M, Panizzi P, Thompson MW, Fuentes-Prior P, Bock PE.

J Biol Chem. 2009 Jul 17;284(29):19511-21. doi: 10.1074/jbc.M109.005512. Epub 2009 May 27.

23.

Potent phagocytic activity with impaired antigen presentation identifying lipopolysaccharide-tolerant human monocytes: demonstration in isolated monocytes from cystic fibrosis patients.

del Fresno C, García-Rio F, Gómez-Piña V, Soares-Schanoski A, Fernández-Ruíz I, Jurado T, Kajiji T, Shu C, Marín E, Gutierrez del Arroyo A, Prados C, Arnalich F, Fuentes-Prior P, Biswas SK, López-Collazo E.

J Immunol. 2009 May 15;182(10):6494-507. doi: 10.4049/jimmunol.0803350. Erratum in: J Immunol. 2009 Aug 1;183(3):2194. Biswas, Subrha K [corrected to Biswas, Subhra K].

24.

Contribution of globular death domains and unstructured linkers to MyD88.IRAK-4 heterodimer formation: an explanation for the antagonistic activity of MyD88s.

Mendoza-Barberá E, Corral-Rodríguez MA, Soares-Schanoski A, Velarde M, Macieira S, Messerschmidt A, López-Collazo E, Fuentes-Prior P.

Biochem Biophys Res Commun. 2009 Feb 27;380(1):183-7. doi: 10.1016/j.bbrc.2009.01.069. Epub 2009 Jan 22.

PMID:
19167362
25.

Mutation update of spinal muscular atrophy in Spain: molecular characterization of 745 unrelated patients and identification of four novel mutations in the SMN1 gene.

Alías L, Bernal S, Fuentes-Prior P, Barceló MJ, Also E, Martínez-Hernández R, Rodríguez-Alvarez FJ, Martín Y, Aller E, Grau E, Peciña A, Antiñolo G, Galán E, Rosa AL, Fernández-Burriel M, Borrego S, Millán JM, Hernández-Chico C, Baiget M, Tizzano EF.

Hum Genet. 2009 Feb;125(1):29-39. doi: 10.1007/s00439-008-0598-1. Epub 2008 Dec 3.

PMID:
19050931
26.

Confirmation of inherited protein S deficiency by PROS1 mutational screening: Identification of three novel PROS1 mutations and haplotype analysis of p.Q279X recurrence.

Hurtado B, Abasolo N, Domènech-Santasusana P, Fuentes-Prior P, García de Frutos P, Sala N.

Thromb Haemost. 2008 Oct;100(4):721-4. No abstract available.

PMID:
18841302
27.

Severe haemophilia A in a female resulting from an inherited gross deletion and a de novo codon deletion in the F8 gene.

Venceslá A, Fuentes-Prior P, Baena M, Quintana M, Baiget M, Tizzano EF.

Haemophilia. 2008 Sep;14(5):1094-8. doi: 10.1111/j.1365-2516.2008.01816.x. Epub 2008 Jul 25. Review.

PMID:
18665854
28.

Monocytes from cystic fibrosis patients are locked in an LPS tolerance state: down-regulation of TREM-1 as putative underlying mechanism.

del Fresno C, Gómez-Piña V, Lores V, Soares-Schanoski A, Fernández-Ruiz I, Rojo B, Alvarez-Sala R, Caballero-Garrido E, García F, Veliz T, Arnalich F, Fuentes-Prior P, García-Río F, López-Collazo E.

PLoS One. 2008 Jul 16;3(7):e2667. doi: 10.1371/journal.pone.0002667.

29.

Isolation, cloning and structural characterisation of boophilin, a multifunctional Kunitz-type proteinase inhibitor from the cattle tick.

Macedo-Ribeiro S, Almeida C, Calisto BM, Friedrich T, Mentele R, Stürzebecher J, Fuentes-Prior P, Pereira PJ.

PLoS One. 2008 Feb 20;3(2):e1624. doi: 10.1371/journal.pone.0001624.

30.

Identification of 31 novel mutations in the F8 gene in Spanish hemophilia A patients: structural analysis of 20 missense mutations suggests new intermolecular binding sites.

Venceslá A, Corral-Rodríguez MA, Baena M, Cornet M, Domènech M, Baiget M, Fuentes-Prior P, Tizzano EF.

Blood. 2008 Apr 1;111(7):3468-78. doi: 10.1182/blood-2007-08-108068. Epub 2008 Jan 9.

31.

Position-dependent expression of GADD45alpha in rat brain tumours.

Brú A, del Fresno C, Soares-Schanoski A, Albertos S, Brú I, Porres A, Rollán-Landeras E, Dopazo A, Casero D, Gómez-Piña V, García L, Arnalich F, Alvarez R, Rodríguez-Rojas A, Fuentes-Prior P, López-Collazo E.

Med Oncol. 2007;24(4):436-44.

PMID:
17917095
32.

Molecular basis of protein S deficiency.

García de Frutos P, Fuentes-Prior P, Hurtado B, Sala N.

Thromb Haemost. 2007 Sep;98(3):543-56. Review.

PMID:
17849042
33.

Metalloproteinases shed TREM-1 ectodomain from lipopolysaccharide-stimulated human monocytes.

Gómez-Piña V, Soares-Schanoski A, Rodríguez-Rojas A, Del Fresno C, García F, Vallejo-Cremades MT, Fernández-Ruiz I, Arnalich F, Fuentes-Prior P, López-Collazo E.

J Immunol. 2007 Sep 15;179(6):4065-73.

34.

Inflammatory responses associated with acute coronary syndrome up-regulate IRAK-M and induce endotoxin tolerance in circulating monocytes.

del Fresno C, Soler-Rangel L, Soares-Schanoski A, Gómez-Piña V, González-León MC, Gómez-García L, Mendoza-Barberá E, Rodríguez-Rojas A, García F, Fuentes-Prior P, Arnalich F, López-Collazo E.

J Endotoxin Res. 2007;13(1):39-52.

PMID:
17621545
35.

6-Methylprednisolone down-regulates IRAK-M in human and murine osteoclasts and boosts bone-resorbing activity: a putative mechanism for corticoid-induced osteoporosis.

Soares-Schanoski A, Gómez-Piña V, del Fresno C, Rodríguez-Rojas A, García F, Glaría A, Sánchez M, Vallejo-Cremades MT, Baos R, Fuentes-Prior P, Arnalich F, López-Collazo E.

J Leukoc Biol. 2007 Sep;82(3):700-9. Epub 2007 Jun 18.

PMID:
17576820
36.

Purification and in vitro refolding of maize chloroplast transglutaminase over-expressed in Escherichia coli.

Carvajal-Vallejos PK, Campos A, Fuentes-Prior P, Villalobos E, Almeida AM, Barberà E, Torné JM, Santos M.

Biotechnol Lett. 2007 Aug;29(8):1255-62. Epub 2007 May 4.

PMID:
17479223
37.

Nitric oxide induces SOCS-1 expression in human monocytes in a TNF-alpha-dependent manner.

González-León MC, Soares-Schanoski A, del Fresno C, Cimadevila A, Goméz-Piña V, Mendoza-Barberá E, García F, Marín E, Arnalich F, Fuentes-Prior P, López-Collazo E.

J Endotoxin Res. 2006;12(5):296-306.

PMID:
17059693
38.

Pathophysiology of interleukin-1 receptor-associated kinase-M: implications in refractory state.

López-Collazo E, Fuentes-Prior P, Arnalich F, del Fresno C.

Curr Opin Infect Dis. 2006 Jun;19(3):237-44. Review.

PMID:
16645484
39.

Novel fluorescent prothrombin analogs as probes of staphylocoagulase-prothrombin interactions.

Panizzi P, Friedrich R, Fuentes-Prior P, Kroh HK, Briggs J, Tans G, Bode W, Bock PE.

J Biol Chem. 2006 Jan 13;281(2):1169-78. Epub 2005 Oct 17.

40.

Fibrinogen substrate recognition by staphylocoagulase.(pro)thrombin complexes.

Panizzi P, Friedrich R, Fuentes-Prior P, Richter K, Bock PE, Bode W.

J Biol Chem. 2006 Jan 13;281(2):1179-87. Epub 2005 Oct 17.

41.

Structural basis for reduced staphylocoagulase-mediated bovine prothrombin activation.

Friedrich R, Panizzi P, Kawabata S, Bode W, Bock PE, Fuentes-Prior P.

J Biol Chem. 2006 Jan 13;281(2):1188-95. Epub 2005 Oct 17.

42.

Tumor cells deactivate human monocytes by up-regulating IL-1 receptor associated kinase-M expression via CD44 and TLR4.

del Fresno C, Otero K, Gómez-García L, González-León MC, Soler-Ranger L, Fuentes-Prior P, Escoll P, Baos R, Caveda L, García F, Arnalich F, López-Collazo E.

J Immunol. 2005 Mar 1;174(5):3032-40.

43.

The staphylocoagulase family of zymogen activator and adhesion proteins.

Panizzi P, Friedrich R, Fuentes-Prior P, Bode W, Bock PE.

Cell Mol Life Sci. 2004 Nov;61(22):2793-8.

44.

The protein structures that shape caspase activity, specificity, activation and inhibition.

Fuentes-Prior P, Salvesen GS.

Biochem J. 2004 Dec 1;384(Pt 2):201-32. Review.

45.

Exploring the collagen-binding site of the DDR1 tyrosine kinase receptor.

Abdulhussein R, McFadden C, Fuentes-Prior P, Vogel WF.

J Biol Chem. 2004 Jul 23;279(30):31462-70. Epub 2004 May 10.

46.

The factor V C1 domain is involved in membrane binding: identification of functionally important amino acid residues within the C1 domain of factor V using alanine scanning mutagenesis.

Saleh M, Peng W, Quinn-Allen MA, Macedo-Ribeiro S, Fuentes-Prior P, Bode W, Kane WH.

Thromb Haemost. 2004 Jan;91(1):16-27.

PMID:
14691564
47.

Staphylocoagulase is a prototype for the mechanism of cofactor-induced zymogen activation.

Friedrich R, Panizzi P, Fuentes-Prior P, Richter K, Verhamme I, Anderson PJ, Kawabata S, Huber R, Bode W, Bock PE.

Nature. 2003 Oct 2;425(6957):535-9.

PMID:
14523451
48.

Subcellular localization and in vivo subunit interactions of ubiquitous mu-calpain.

Gil-Parrado S, Popp O, Knoch TA, Zahler S, Bestvater F, Felgenträger M, Holloschi A, Fernández-Montalván A, Auerswald EA, Fritz H, Fuentes-Prior P, Machleidt W, Spiess E.

J Biol Chem. 2003 May 2;278(18):16336-46. Epub 2003 Feb 18.

49.

The 2.2-A crystal structure of human pro-granzyme K reveals a rigid zymogen with unusual features.

Hink-Schauer C, Estébanez-Perpiñá E, Wilharm E, Fuentes-Prior P, Klinkert W, Bode W, Jenne DE.

J Biol Chem. 2002 Dec 27;277(52):50923-33. Epub 2002 Oct 15.

50.

New insights into binding interfaces of coagulation factors V and VIII and their homologues lessons from high resolution crystal structures.

Fuentes-Prior P, Fujikawa K, Pratt KP.

Curr Protein Pept Sci. 2002 Jun;3(3):313-39. Review.

PMID:
12188899

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