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Combined Casein Kinase II inhibition and epigenetic modulation in acute B-lymphoblastic leukemia.

Richter A, Roolf C, Hamed M, Gladbach YS, Sender S, Konkolefski C, Knübel G, Sekora A, Fuellen G, Vollmar B, Murua Escobar H, Junghanss C.

BMC Cancer. 2019 Mar 6;19(1):202. doi: 10.1186/s12885-019-5411-0.


Mitochondrial complex IV mutation increases reactive oxygen species production and reduces lifespan in aged mice.

Reichart G, Mayer J, Zehm C, Kirschstein T, Tokay T, Lange F, Baltrusch S, Tiedge M, Fuellen G, Ibrahim S, Köhling R.

Acta Physiol (Oxf). 2019 Apr;225(4):e13214. doi: 10.1111/apha.13214. Epub 2018 Nov 20.


A workflow for the integrative transcriptomic description of molecular pathology and the suggestion of normalizing compounds, exemplified by Parkinson's disease.

Hamed M, Gladbach Y, Möller S, Fischer S, Ernst M, Struckmann S, Storch A, Fuellen G.

Sci Rep. 2018 May 21;8(1):7937. doi: 10.1038/s41598-018-25754-5.


Comparative High-Resolution Transcriptome Sequencing of Lymphoma Cell Lines and de novo Lymphomas Reveals Cell-Line-Specific Pathway Dysregulation.

Taher L, Beck J, Liu W, Roolf C, Soller JT, Rütgen BC, Hammer SE, Chodisetti M, Sender S, Sterenczak KA, Fuellen G, Junghanss C, Brenig B, Nolte I, Schütz E, Murua Escobar H.

Sci Rep. 2018 Apr 19;8(1):6279. doi: 10.1038/s41598-018-23207-7.


Low-level mitochondrial heteroplasmy modulates DNA replication, glucose metabolism and lifespan in mice.

Hirose M, Schilf P, Gupta Y, Zarse K, Künstner A, Fähnrich A, Busch H, Yin J, Wright MN, Ziegler A, Vallier M, Belheouane M, Baines JF, Tautz D, Johann K, Oelkrug R, Mittag J, Lehnert H, Othman A, Jöhren O, Schwaninger M, Prehn C, Adamski J, Shima K, Rupp J, Häsler R, Fuellen G, Köhling R, Ristow M, Ibrahim SM.

Sci Rep. 2018 Apr 12;8(1):5872. doi: 10.1038/s41598-018-24290-6.


The informative error: A framework for the construction of individualized phenotypes.

Hertel J, Frenzel S, König J, Wittfeld K, Fuellen G, Holtfreter B, Pietzner M, Friedrich N, Nauck M, Völzke H, Kocher T, Grabe HJ.

Stat Methods Med Res. 2018 Jan 1:962280218759138. doi: 10.1177/0962280218759138. [Epub ahead of print]


Cellular vaccination of MLH1-/- mice - an immunotherapeutic proof of concept study.

Maletzki C, Gladbach YS, Hamed M, Fuellen G, Semmler ML, Stenzel J, Linnebacher M.

Oncoimmunology. 2017 Dec 14;7(3):e1408748. doi: 10.1080/2162402X.2017.1408748. eCollection 2018.


ADAM23 promotes neuronal differentiation of human neural progenitor cells.

Markus-Koch A, Schmitt O, Seemann S, Lukas J, Koczan D, Ernst M, Fuellen G, Wree A, Rolfs A, Luo J.

Cell Mol Biol Lett. 2017 Aug 18;22:16. doi: 10.1186/s11658-017-0045-1. eCollection 2017.


The risks of biomarker-based epidemiology: Associations of circulating calcium levels with age, mortality, and frailty vary substantially across populations.

Cohen AA, Legault V, Fuellen G, Fülöp T, Fried LP, Ferrucci L.

Exp Gerontol. 2018 Jul 1;107:11-17. doi: 10.1016/j.exger.2017.07.011. Epub 2017 Jul 16. Review.


Mortality is associated with inflammation, anemia, specific diseases and treatments, and molecular markers.

Moeller M, Pink C, Endlich N, Endlich K, Grabe HJ, Völzke H, Dörr M, Nauck M, Lerch MM, Köhling R, Holtfreter B, Kocher T, Fuellen G.

PLoS One. 2017 Apr 19;12(4):e0175909. doi: 10.1371/journal.pone.0175909. eCollection 2017.


FocusHeuristics - expression-data-driven network optimization and disease gene prediction.

Ernst M, Du Y, Warsow G, Hamed M, Endlich N, Endlich K, Murua Escobar H, Sklarz LM, Sender S, Junghanß C, Möller S, Fuellen G, Struckmann S.

Sci Rep. 2017 Feb 16;7:42638. doi: 10.1038/srep42638.


Linking Hematopoietic Differentiation to Co-Expressed Sets of Pluripotency-Associated and Imprinted Genes and to Regulatory microRNA-Transcription Factor Motifs.

Hamed M, Trumm J, Spaniol C, Sethi R, Irhimeh MR, Fuellen G, Paulsen M, Helms V.

PLoS One. 2017 Jan 4;12(1):e0166852. doi: 10.1371/journal.pone.0166852. eCollection 2017.


A novel assay to assess the effect of pharmaceutical compounds on the differentiation of podocytes.

Kindt F, Hammer E, Kemnitz S, Blumenthal A, Klemm P, Schlüter R, Quaggin SE, van den Brandt J, Fuellen G, Völker U, Endlich K, Endlich N.

Br J Pharmacol. 2017 Jan;174(2):163-176. doi: 10.1111/bph.13667. Epub 2016 Dec 20.


Polymorphism in Murine mtATP8 Gene Correlates with Decreased Reactive Oxygen Species in Aging Hematopoietic Cells.

Roolf C, Kretzschmar C, Timmer K, Sekora A, Knübel G, Murua Escobar H, Fuellen G, Ibrahim SM, Tiedge M, Baltrusch S, Müller S, Köhling R, Junghanss C.

In Vivo. 2016 Nov 12;30(6):751-760.


Uncoupling protein 2 deficiency results in higher neutrophil counts and lower B-cell counts during aging in mice.

Kretzschmar C, Roolf C, Timmer K, Sekora A, Knübel G, Murua Escobar H, Jaster R, Müller S, Fuellen G, Köhling R, Junghanss C.

Exp Hematol. 2016 Nov;44(11):1085-1091.e2. doi: 10.1016/j.exphem.2016.08.003. Epub 2016 Aug 17.


Analysis of microRNA and Gene Expression Profiles in Multiple Sclerosis: Integrating Interaction Data to Uncover Regulatory Mechanisms.

Freiesleben S, Hecker M, Zettl UK, Fuellen G, Taher L.

Sci Rep. 2016 Oct 3;6:34512. doi: 10.1038/srep34512.


Polymorphisms of the murine mitochondrial ND4, CYTB and COX3 genes impact hematopoiesis during aging.

Kretzschmar C, Roolf C, Timmer K, Sekora A, Knübel G, Murua Escobar H, Fuellen G, Ibrahim SM, Tiedge M, Baltrusch S, Jaster R, Köhling R, Junghanss C.

Oncotarget. 2016 Nov 15;7(46):74460-74472. doi: 10.18632/oncotarget.11952.


Revealing complex function, process and pathway interactions with high-throughput expression and biological annotation data.

Singh NK, Ernst M, Liebscher V, Fuellen G, Taher L.

Mol Biosyst. 2016 Oct 20;12(10):3196-208. doi: 10.1039/c6mb00280c. Epub 2016 Aug 10.


Proteomic Analysis of Mouse Oocytes Identifies PRMT7 as a Reprogramming Factor that Replaces SOX2 in the Induction of Pluripotent Stem Cells.

Wang B, Pfeiffer MJ, Drexler HC, Fuellen G, Boiani M.

J Proteome Res. 2016 Aug 5;15(8):2407-21. doi: 10.1021/acs.jproteome.5b01083. Epub 2016 Jul 12.


Ageing with elegans: a research proposal to map healthspan pathways.

Luyten W, Antal P, Braeckman BP, Bundy J, Cirulli F, Fang-Yen C, Fuellen G, Leroi A, Liu Q, Martorell P, Metspalu A, Perola M, Ristow M, Saul N, Schoofs L, Siems K, Temmerman L, Smets T, Wolk A, Rattan SI.

Biogerontology. 2016 Aug;17(4):771-82. doi: 10.1007/s10522-016-9644-x. Epub 2016 Apr 4.


Advanced Running Performance by Genetic Predisposition in Male Dummerstorf Marathon Mice (DUhTP) Reveals Higher Sterol Regulatory Element-Binding Protein (SREBP) Related mRNA Expression in the Liver and Higher Serum Levels of Progesterone.

Ohde D, Moeller M, Brenmoehl J, Walz C, Ponsuksili S, Schwerin M, Fuellen G, Hoeflich A.

PLoS One. 2016 Jan 22;11(1):e0146748. doi: 10.1371/journal.pone.0146748. eCollection 2016.


Living Long and Well: Prospects for a Personalized Approach to the Medicine of Ageing.

Fuellen G, Schofield P, Flatt T, Schulz RJ, Boege F, Kraft K, Rimbach G, Ibrahim S, Tietz A, Schmidt C, Köhling R, Simm A.

Gerontology. 2016;62(4):409-16. doi: 10.1159/000442746. Epub 2015 Dec 17. Review.


TRIM32 modulates pluripotency entry and exit by directly regulating Oct4 stability.

Bahnassawy L, Perumal TM, Gonzalez-Cano L, Hillje AL, Taher L, Makalowski W, Suzuki Y, Fuellen G, del Sol A, Schwamborn JC.

Sci Rep. 2015 Aug 26;5:13456. doi: 10.1038/srep13456.


Reduced adolescent-age spatial learning ability associated with elevated juvenile-age superoxide levels in complex I mouse mutants.

Mayer J, Reichart G, Tokay T, Lange F, Baltrusch S, Junghanss C, Wolkenhauer O, Jaster R, Kunz M, Tiedge M, Ibrahim S, Fuellen G, Köhling R.

PLoS One. 2015 Apr 8;10(4):e0123863. doi: 10.1371/journal.pone.0123863. eCollection 2015.


A mutation in the NADH-dehydrogenase subunit 2 suppresses fibroblast aging.

Schauer M, Kottek T, Schönherr M, Bhattacharya A, Ibrahim SM, Hirose M, Köhling R, Fuellen G, Schmitz U, Kunz M.

Oncotarget. 2015 Apr 20;6(11):8552-66.


Comparative computational analysis of pluripotency in human and mouse stem cells.

Ernst M, Abu Dawud R, Kurtz A, Schotta G, Taher L, Fuellen G.

Sci Rep. 2015 Jan 21;5:7927. doi: 10.1038/srep07927.


Differences in embryo quality are associated with differences in oocyte composition: a proteomic study in inbred mice.

Pfeiffer MJ, Taher L, Drexler H, Suzuki Y, Makałowski W, Schwarzer C, Wang B, Fuellen G, Boiani M.

Proteomics. 2015 Feb;15(4):675-87. doi: 10.1002/pmic.201400334. Epub 2015 Jan 3.


Systems biology approaches in aging research.

Chauhan A, Liebal UW, Vera J, Baltrusch S, Junghanß C, Tiedge M, Fuellen G, Wolkenhauer O, Köhling R.

Interdiscip Top Gerontol. 2015;40:155-76. doi: 10.1159/000364981. Epub 2014 Oct 14. Review.


Bioinformatics approaches to single-blastomere transcriptomics.

Taher L, Pfeiffer MJ, Fuellen G.

Mol Hum Reprod. 2015 Feb;21(2):115-25. doi: 10.1093/molehr/gau083. Epub 2014 Sep 19.


Adenoviral overexpression of Lhx2 attenuates cell viability but does not preserve the stem cell like phenotype of hepatic stellate cells.

Genz B, Thomas M, Pützer BM, Siatkowski M, Fuellen G, Vollmar B, Abshagen K.

Exp Cell Res. 2014 Nov 1;328(2):429-43. doi: 10.1016/j.yexcr.2014.06.019. Epub 2014 Jul 1.


Inbred mouse strains reveal biomarkers that are pro-longevity, antilongevity or role switching.

Moeller M, Hirose M, Mueller S, Roolf C, Baltrusch S, Ibrahim S, Junghanss C, Wolkenhauer O, Jaster R, Köhling R, Kunz M, Tiedge M, Schofield PN, Fuellen G.

Aging Cell. 2014 Aug;13(4):729-38. doi: 10.1111/acel.12226. Epub 2014 May 23.


Age-dependent effects of UCP2 deficiency on experimental acute pancreatitis in mice.

Müller S, Kaiser H, Krüger B, Fitzner B, Lange F, Bock CN, Nizze H, Ibrahim SM, Fuellen G, Wolkenhauer O, Jaster R.

PLoS One. 2014 Apr 10;9(4):e94494. doi: 10.1371/journal.pone.0094494. eCollection 2014.


Maternal age effect on mouse oocytes: new biological insight from proteomic analysis.

Schwarzer C, Siatkowski M, Pfeiffer MJ, Baeumer N, Drexler HC, Wang B, Fuellen G, Boiani M.

Reproduction. 2014 Jul;148(1):55-72. doi: 10.1530/REP-14-0126. Epub 2014 Mar 31.


Aberrant expressions of delta-protocadherins in the brain of Npc1 mutant mice.

Yan X, Lukas J, Lin J, Ernst M, Koczan D, Witt M, Fuellen G, Wree A, Rolfs A, Luo J.

Histol Histopathol. 2014 Sep;29(9):1185-99. doi: 10.14670/HH-29.1185. Epub 2014 Mar 26.


Differential network analysis applied to preoperative breast cancer chemotherapy response.

Warsow G, Struckmann S, Kerkhoff C, Reimer T, Engel N, Fuellen G.

PLoS One. 2013 Dec 9;8(12):e81784. doi: 10.1371/journal.pone.0081784. eCollection 2013.


Epitope predictions indicate the presence of two distinct types of epitope-antibody-reactivities determined by epitope profiling of intravenous immunoglobulins.

Luštrek M, Lorenz P, Kreutzer M, Qian Z, Steinbeck F, Wu D, Born N, Ziems B, Hecker M, Blank M, Shoenfeld Y, Cao Z, Glocker MO, Li Y, Fuellen G, Thiesen HJ.

PLoS One. 2013 Nov 11;8(11):e78605. doi: 10.1371/journal.pone.0078605. eCollection 2013.


CellFateScout - a bioinformatics tool for elucidating small molecule signaling pathways that drive cells in a specific direction.

Siatkowski M, Liebscher V, Fuellen G.

Cell Commun Signal. 2013 Nov 8;11:85. doi: 10.1186/1478-811X-11-85.


In silico approaches and the role of ontologies in aging research.

Fuellen G, Boerries M, Busch H, de Grey A, Hahn U, Hiller T, Hoeflich A, Jansen L, Janssens GE, Kaleta C, Meinema AC, Schäuble S, Simm A, Schofield PN, Smith B, Sühnel J, Vera J, Wagner W, Wönne EC, Wuttke D.

Rejuvenation Res. 2013 Dec;16(6):540-6. doi: 10.1089/rej.2013.1517.


Identifying genes relevant to specific biological conditions in time course microarray experiments.

Singh NK, Repsilber D, Liebscher V, Taher L, Fuellen G.

PLoS One. 2013 Oct 11;8(10):e76561. doi: 10.1371/journal.pone.0076561. eCollection 2013.


Using ontologies to study cell transitions.

Fuellen G, Jansen L, Leser U, Kurtz A.

J Biomed Semantics. 2013 Oct 8;4(1):25. doi: 10.1186/2041-1480-4-25.


Ocular fibroblast types differ in their mRNA profiles--implications for fibrosis prevention after aqueous shunt implantation.

Löbler M, Buß D, Kastner C, Mostertz J, Homuth G, Ernst M, Guthoff R, Wree A, Stahnke T, Fuellen G, Voelker U, Schmitz KP.

Mol Vis. 2013 Jun 12;19:1321-31. Print 2013.


PodNet, a protein-protein interaction network of the podocyte.

Warsow G, Endlich N, Schordan E, Schordan S, Chilukoti RK, Homuth G, Moeller MJ, Fuellen G, Endlich K.

Kidney Int. 2013 Jul;84(1):104-15. doi: 10.1038/ki.2013.64. Epub 2013 Apr 3.


The intrinsic connectome of the rat amygdala.

Schmitt O, Eipert P, Philipp K, Kettlitz R, Fuellen G, Wree A.

Front Neural Circuits. 2012 Dec 11;6:81. doi: 10.3389/fncir.2012.00081. eCollection 2012.


Tissue-based Alzheimer gene expression markers-comparison of multiple machine learning approaches and investigation of redundancy in small biomarker sets.

Scheubert L, Luštrek M, Schmidt R, Repsilber D, Fuellen G.

BMC Bioinformatics. 2012 Oct 15;13:266. doi: 10.1186/1471-2105-13-266.


Systems biology and bioinformatics in aging research: a workshop report.

Fuellen G, Dengjel J, Hoeflich A, Hoeijemakers J, Kestler HA, Kowald A, Priebe S, Rebholz-Schuhmann D, Schmeck B, Schmitz U, Stolzing A, Sühnel J, Wuttke D, Vera J.

Rejuvenation Res. 2012 Dec;15(6):631-41. doi: 10.1089/rej.2012.1360. Epub 2012 Nov 19.


Pluripotent stem cells in mice.

Schmidt R, Scheubert L, Lustrek M, Repsilber D, Fuellen G.

Stud Health Technol Inform. 2012;180:1159-61.


Mitochondrial physiology and gene expression analyses reveal metabolic and translational dysregulation in oocyte-induced somatic nuclear reprogramming.

Esteves TC, Psathaki OE, Pfeiffer MJ, Balbach ST, Zeuschner D, Shitara H, Yonekawa H, Siatkowski M, Fuellen G, Boiani M.

PLoS One. 2012;7(6):e36850. doi: 10.1371/journal.pone.0036850. Epub 2012 Jun 5.


Derivation of an interaction/regulation network describing pluripotency in human.

Som A, Luštrek M, Singh NK, Fuellen G.

Gene. 2012 Jul 10;502(2):99-107. doi: 10.1016/j.gene.2012.04.025. Epub 2012 Apr 20.


Nuclear reprogramming: kinetics of cell cycle and metabolic progression as determinants of success.

Balbach ST, Esteves TC, Houghton FD, Siatkowski M, Pfeiffer MJ, Tsurumi C, Kanzler B, Fuellen G, Boiani M.

PLoS One. 2012;7(4):e35322. doi: 10.1371/journal.pone.0035322. Epub 2012 Apr 18.


Primary cultures of glomerular parietal epithelial cells or podocytes with proven origin.

Kabgani N, Grigoleit T, Schulte K, Sechi A, Sauer-Lehnen S, Tag C, Boor P, Kuppe C, Warsow G, Schordan S, Mostertz J, Chilukoti RK, Homuth G, Endlich N, Tacke F, Weiskirchen R, Fuellen G, Endlich K, Floege J, Smeets B, Moeller MJ.

PLoS One. 2012;7(4):e34907. doi: 10.1371/journal.pone.0034907. Epub 2012 Apr 18.

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