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Items: 49

1.

Conjugation is essential for the anticholestatic effect of NorUrsodeoxycholic acid in taurolithocholic acid-induced cholestasis in rat liver.

Denk GU, Maitz S, Wimmer R, Rust C, Invernizzi P, Ferdinandusse S, Kulik W, Fuchsbichler A, Fickert P, Trauner M, Hofmann AF, Beuers U.

Hepatology. 2010 Nov;52(5):1758-68. doi: 10.1002/hep.23911.

PMID:
21038414
2.

Signal transducer and activator of transcription 3 protects from liver injury and fibrosis in a mouse model of sclerosing cholangitis.

Mair M, Zollner G, Schneller D, Musteanu M, Fickert P, Gumhold J, Schuster C, Fuchsbichler A, Bilban M, Tauber S, Esterbauer H, Kenner L, Poli V, Blaas L, Kornfeld JW, Casanova E, Mikulits W, Trauner M, Eferl R.

Gastroenterology. 2010 Jun;138(7):2499-508. doi: 10.1053/j.gastro.2010.02.049. Epub 2010 Feb 26.

PMID:
20193684
3.

Farnesoid X receptor critically determines the fibrotic response in mice but is expressed to a low extent in human hepatic stellate cells and periductal myofibroblasts.

Fickert P, Fuchsbichler A, Moustafa T, Wagner M, Zollner G, Halilbasic E, Stöger U, Arrese M, Pizarro M, Solís N, Carrasco G, Caligiuri A, Sombetzki M, Reisinger E, Tsybrovskyy O, Zatloukal K, Denk H, Jaeschke H, Pinzani M, Trauner M.

Am J Pathol. 2009 Dec;175(6):2392-405. doi: 10.2353/ajpath.2009.090114. Epub 2009 Nov 12. Erratum in: Am J Pathol. 2010 May;176(5):2581.

4.

Imbalance of pro- and antifibrogenic genes and bile duct injury in murine Schistosoma mansoni infection-induced liver fibrosis.

Loebermann M, Sombetzki M, Langner C, Fuchsbichler A, Gumhold J, Silbert D, Riebold D, Holtfreter M, Fickert P, Nizze H, Trauner M, Reisinger EC.

Trop Med Int Health. 2009 Nov;14(11):1418-25. doi: 10.1111/j.1365-3156.2009.02387.x. Epub 2009 Sep 11.

5.

The role of the hepatocyte cytokeratin network in bile formation and resistance to bile acid challenge and cholestasis in mice.

Fickert P, Fuchsbichler A, Wagner M, Silbert D, Zatloukal K, Denk H, Trauner M.

Hepatology. 2009 Sep;50(3):893-9. doi: 10.1002/hep.23068.

PMID:
19585611
6.

Impact of experimental colitis on hepatobiliary transporter expression and bile duct injury in mice.

Jahnel J, Fickert P, Langner C, Högenauer C, Silbert D, Gumhold J, Fuchsbichler A, Trauner M.

Liver Int. 2009 Oct;29(9):1316-25. doi: 10.1111/j.1478-3231.2009.02044.x. Epub 2009 Jun 24.

PMID:
19558576
7.

Side chain structure determines unique physiologic and therapeutic properties of norursodeoxycholic acid in Mdr2-/- mice.

Halilbasic E, Fiorotto R, Fickert P, Marschall HU, Moustafa T, Spirli C, Fuchsbichler A, Gumhold J, Silbert D, Zatloukal K, Langner C, Maitra U, Denk H, Hofmann AF, Strazzabosco M, Trauner M.

Hepatology. 2009 Jun;49(6):1972-81. doi: 10.1002/hep.22891.

8.

Role of hepatic phospholipids in development of liver injury in Mdr2 (Abcb4) knockout mice.

Baghdasaryan A, Fickert P, Fuchsbichler A, Silbert D, Gumhold J, Hörl G, Langner C, Moustafa T, Halilbasic E, Claudel T, Trauner M.

Liver Int. 2008 Aug;28(7):948-58. doi: 10.1111/j.1478-3231.2008.01758.x. Epub 2008 Apr 11.

PMID:
18410282
9.

[Alcoholic and non-alcoholic steatohepatitis].

Denk H, Stumptner C, Fuchsbichler A, Zatloukal K.

Verh Dtsch Ges Pathol. 2005;89:137-43. German.

PMID:
18035683
10.

In vitro production of Mallory bodies and intracellular hyaline bodies: the central role of sequestosome 1/p62.

Stumptner C, Fuchsbichler A, Zatloukal K, Denk H.

Hepatology. 2007 Sep;46(3):851-60.

PMID:
17685470
11.

How a cell deals with abnormal proteins. Pathogenetic mechanisms in protein aggregation diseases.

Aigelsreiter A, Janig E, Stumptner C, Fuchsbichler A, Zatloukal K, Denk H.

Pathobiology. 2007;74(3):145-58. Review.

12.

A new xenobiotic-induced mouse model of sclerosing cholangitis and biliary fibrosis.

Fickert P, Stöger U, Fuchsbichler A, Moustafa T, Marschall HU, Weiglein AH, Tsybrovskyy O, Jaeschke H, Zatloukal K, Denk H, Trauner M.

Am J Pathol. 2007 Aug;171(2):525-36. Epub 2007 Jun 28.

13.

Hepatobiliary transporter expression in intercellular adhesion molecule 1 knockout and Fas receptor-deficient mice after common bile duct ligation is independent of the degree of inflammation and oxidative stress.

Wagner M, Zollner G, Fickert P, Gumhold J, Silbert D, Fuchsbichler A, Gujral JS, Zatloukal K, Denk H, Jaeschke H, Trauner M.

Drug Metab Dispos. 2007 Sep;35(9):1694-9. Epub 2007 Jun 18.

14.

Are the Mallory bodies and intracellular hyaline bodies in neoplastic and non-neoplastic hepatocytes related?

Denk H, Stumptner C, Fuchsbichler A, Müller T, Farr G, Müller W, Terracciano L, Zatloukal K.

J Pathol. 2006 Apr;208(5):653-61.

PMID:
16477590
15.

24-norUrsodeoxycholic acid is superior to ursodeoxycholic acid in the treatment of sclerosing cholangitis in Mdr2 (Abcb4) knockout mice.

Fickert P, Wagner M, Marschall HU, Fuchsbichler A, Zollner G, Tsybrovskyy O, Zatloukal K, Liu J, Waalkes MP, Cover C, Denk H, Hofmann AF, Jaeschke H, Trauner M.

Gastroenterology. 2006 Feb;130(2):465-81.

PMID:
16472600
16.

Lithocholic acid feeding induces segmental bile duct obstruction and destructive cholangitis in mice.

Fickert P, Fuchsbichler A, Marschall HU, Wagner M, Zollner G, Krause R, Zatloukal K, Jaeschke H, Denk H, Trauner M.

Am J Pathol. 2006 Feb;168(2):410-22.

17.

Coordinated induction of bile acid detoxification and alternative elimination in mice: role of FXR-regulated organic solute transporter-alpha/beta in the adaptive response to bile acids.

Zollner G, Wagner M, Moustafa T, Fickert P, Silbert D, Gumhold J, Fuchsbichler A, Halilbasic E, Denk H, Marschall HU, Trauner M.

Am J Physiol Gastrointest Liver Physiol. 2006 May;290(5):G923-32. Epub 2005 Dec 15.

18.

Fxr(-/-) mice adapt to biliary obstruction by enhanced phase I detoxification and renal elimination of bile acids.

Marschall HU, Wagner M, Bodin K, Zollner G, Fickert P, Gumhold J, Silbert D, Fuchsbichler A, Sjövall J, Trauner M.

J Lipid Res. 2006 Mar;47(3):582-92. Epub 2005 Dec 4.

19.

Sulfasalazine reduces bile acid induced apoptosis in human hepatoma cells and perfused rat livers.

Rust C, Bauchmuller K, Bernt C, Vennegeerts T, Fickert P, Fuchsbichler A, Beuers U.

Gut. 2006 May;55(5):719-27. Epub 2005 Dec 1.

20.

Complementary stimulation of hepatobiliary transport and detoxification systems by rifampicin and ursodeoxycholic acid in humans.

Marschall HU, Wagner M, Zollner G, Fickert P, Diczfalusy U, Gumhold J, Silbert D, Fuchsbichler A, Benthin L, Grundström R, Gustafsson U, Sahlin S, Einarsson C, Trauner M.

Gastroenterology. 2005 Aug;129(2):476-85.

PMID:
16083704
21.

Role of nuclear receptors and hepatocyte-enriched transcription factors for Ntcp repression in biliary obstruction in mouse liver.

Zollner G, Wagner M, Fickert P, Geier A, Fuchsbichler A, Silbert D, Gumhold J, Zatloukal K, Kaser A, Tilg H, Denk H, Trauner M.

Am J Physiol Gastrointest Liver Physiol. 2005 Nov;289(5):G798-805. Epub 2005 Jul 7.

22.

p62 protein is expressed in pancreatic beta cells.

Lackner C, Dlaska D, Fuchsbichler A, Stumptner C, Gogg-Kamerer M, Zatloukal K, Denk H.

J Pathol. 2005 Aug;206(4):402-8.

PMID:
15926199
23.

Interaction of stress proteins with misfolded keratins.

Janig E, Stumptner C, Fuchsbichler A, Denk H, Zatloukal K.

Eur J Cell Biol. 2005 Mar;84(2-3):329-39.

PMID:
15819411
24.

Hepatobiliary transporter expression in human hepatocellular carcinoma.

Zollner G, Wagner M, Fickert P, Silbert D, Fuchsbichler A, Zatloukal K, Denk H, Trauner M.

Liver Int. 2005 Apr;25(2):367-79.

PMID:
15780063
25.

Phosphatidylinositol 3-kinase-dependent signaling modulates taurochenodeoxycholic acid-induced liver injury and cholestasis in perfused rat livers.

Rust C, Bauchmuller K, Fickert P, Fuchsbichler A, Beuers U.

Am J Physiol Gastrointest Liver Physiol. 2005 Jul;289(1):G88-94. Epub 2005 Mar 3.

26.

Oncosis represents the main type of cell death in mouse models of cholestasis.

Fickert P, Trauner M, Fuchsbichler A, Zollner G, Wagner M, Marschall HU, Zatloukal K, Denk H.

J Hepatol. 2005 Mar;42(3):378-85.

PMID:
15710221
27.

Intermediate filament protein inclusions.

Zatloukal K, Stumptner C, Fuchsbichler A, Janig E, Denk H.

Methods Cell Biol. 2004;78:205-28. No abstract available.

PMID:
15646620
28.

Pathophysiological role of poly(ADP-ribose) polymerase (PARP) activation during acetaminophen-induced liver cell necrosis in mice.

Cover C, Fickert P, Knight TR, Fuchsbichler A, Farhood A, Trauner M, Jaeschke H.

Toxicol Sci. 2005 Mar;84(1):201-8. Epub 2004 Dec 15.

PMID:
15601672
29.

The keratin cytoskeleton in liver diseases.

Zatloukal K, Stumptner C, Fuchsbichler A, Fickert P, Lackner C, Trauner M, Denk H.

J Pathol. 2004 Nov;204(4):367-76. Review.

PMID:
15495250
30.

Regurgitation of bile acids from leaky bile ducts causes sclerosing cholangitis in Mdr2 (Abcb4) knockout mice.

Fickert P, Fuchsbichler A, Wagner M, Zollner G, Kaser A, Tilg H, Krause R, Lammert F, Langner C, Zatloukal K, Marschall HU, Denk H, Trauner M.

Gastroenterology. 2004 Jul;127(1):261-74.

PMID:
15236191
31.

Immunohistochemical analysis of Mallory bodies in Wilsonian and non-Wilsonian hepatic copper toxicosis.

Müller T, Langner C, Fuchsbichler A, Heinz-Erian P, Ellemunter H, Schlenck B, Bavdekar AR, Pradhan AM, Pandit A, Müller-Höcker J, Melter M, Kobayashi K, Nagasaka H, Kikuta H, Müller W, Tanner MS, Sternlieb I, Zatloukal K, Denk H.

Hepatology. 2004 Apr;39(4):963-9.

PMID:
15057900
32.

Role of nuclear bile acid receptor, FXR, in adaptive ABC transporter regulation by cholic and ursodeoxycholic acid in mouse liver, kidney and intestine.

Zollner G, Fickert P, Fuchsbichler A, Silbert D, Wagner M, Arbeiter S, Gonzalez FJ, Marschall HU, Zatloukal K, Denk H, Trauner M.

J Hepatol. 2003 Oct;39(4):480-8.

PMID:
12971955
33.

Role of farnesoid X receptor in determining hepatic ABC transporter expression and liver injury in bile duct-ligated mice.

Wagner M, Fickert P, Zollner G, Fuchsbichler A, Silbert D, Tsybrovskyy O, Zatloukal K, Guo GL, Schuetz JD, Gonzalez FJ, Marschall HU, Denk H, Trauner M.

Gastroenterology. 2003 Sep;125(3):825-38.

PMID:
12949728
34.

Adaptive changes in hepatobiliary transporter expression in primary biliary cirrhosis.

Zollner G, Fickert P, Silbert D, Fuchsbichler A, Marschall HU, Zatloukal K, Denk H, Trauner M.

J Hepatol. 2003 Jun;38(6):717-27.

PMID:
12763363
35.

Mallory body formation in primary biliary cirrhosis is associated with increased amounts and abnormal phosphorylation and ubiquitination of cytokeratins.

Fickert P, Trauner M, Fuchsbichler A, Stumptner C, Zatloukal K, Denk H.

J Hepatol. 2003 Apr;38(4):387-94.

PMID:
12663227
36.

Bile acid-induced Mallory body formation in drug-primed mouse liver.

Fickert P, Trauner M, Fuchsbichler A, Stumptner C, Zatloukal K, Denk H.

Am J Pathol. 2002 Dec;161(6):2019-26.

37.

Ursodeoxycholic acid aggravates bile infarcts in bile duct-ligated and Mdr2 knockout mice via disruption of cholangioles.

Fickert P, Zollner G, Fuchsbichler A, Stumptner C, Weiglein AH, Lammert F, Marschall HU, Tsybrovskyy O, Zatloukal K, Denk H, Trauner M.

Gastroenterology. 2002 Oct;123(4):1238-51.

PMID:
12360485
38.

Mallory body--a disease-associated type of sequestosome.

Stumptner C, Fuchsbichler A, Heid H, Zatloukal K, Denk H.

Hepatology. 2002 May;35(5):1053-62.

PMID:
11981755
39.

Cytokeratins as targets for bile acid-induced toxicity.

Fickert P, Trauner M, Fuchsbichler A, Stumptner C, Zatloukal K, Denk H.

Am J Pathol. 2002 Feb;160(2):491-9.

40.

p62 Is a common component of cytoplasmic inclusions in protein aggregation diseases.

Zatloukal K, Stumptner C, Fuchsbichler A, Heid H, Schnoelzer M, Kenner L, Kleinert R, Prinz M, Aguzzi A, Denk H.

Am J Pathol. 2002 Jan;160(1):255-63.

41.

[Alcoholic and nonalcoholic steatohepatitis. Histopathologic and pathogenetic considerations].

Denk H, Stumptner C, Fuchsbichler A, Zatloukal K.

Pathologe. 2001 Nov;22(6):388-98. German.

PMID:
11766638
42.

Induction of short heterodimer partner 1 precedes downregulation of Ntcp in bile duct-ligated mice.

Zollner G, Fickert P, Silbert D, Fuchsbichler A, Stumptner C, Zatloukal K, Denk H, Trauner M.

Am J Physiol Gastrointest Liver Physiol. 2002 Jan;282(1):G184-91.

43.

Effects of ursodeoxycholic and cholic acid feeding on hepatocellular transporter expression in mouse liver.

Fickert P, Zollner G, Fuchsbichler A, Stumptner C, Pojer C, Zenz R, Lammert F, Stieger B, Meier PJ, Zatloukal K, Denk H, Trauner M.

Gastroenterology. 2001 Jul;121(1):170-83.

PMID:
11438506
44.
45.

Hepatobiliary transporter expression in percutaneous liver biopsies of patients with cholestatic liver diseases.

Zollner G, Fickert P, Zenz R, Fuchsbichler A, Stumptner C, Kenner L, Ferenci P, Stauber RE, Krejs GJ, Denk H, Zatloukal K, Trauner M.

Hepatology. 2001 Mar;33(3):633-46.

PMID:
11230744
46.

Identification of p62, a phosphotyrosine independent ligand of p56lck kinase, as a major component of intracytoplasmic hyaline bodies in hepatocellular carcinoma.

Stumptner C, Heid H, Zatloukal K, Fuchsbichler A, Hauser H, Denk H.

Verh Dtsch Ges Pathol. 1999;83:254-9.

PMID:
10714219
47.

Analysis of intracytoplasmic hyaline bodies in a hepatocellular carcinoma. Demonstration of p62 as major constituent.

Stumptner C, Heid H, Fuchsbichler A, Hauser H, Mischinger HJ, Zatloukal K, Denk H.

Am J Pathol. 1999 Jun;154(6):1701-10.

48.

Functions of c-Jun in liver and heart development.

Eferl R, Sibilia M, Hilberg F, Fuchsbichler A, Kufferath I, Guertl B, Zenz R, Wagner EF, Zatloukal K.

J Cell Biol. 1999 May 31;145(5):1049-61.

49.

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