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Items: 1 to 50 of 96

1.

STarFish: A Stacked Ensemble Target Fishing Approach and its Application to Natural Products.

Cockroft NT, Cheng X, Fuchs JR.

J Chem Inf Model. 2019 Oct 7. doi: 10.1021/acs.jcim.9b00489. [Epub ahead of print]

PMID:
31589422
2.

Evaluation of synergy between host and pathogen-directed therapies against intracellular Leishmania donovani.

Zahid MSH, Johnson MM, Tokarski RJ 2nd, Satoskar AR, Fuchs JR, Bachelder EM, Ainslie KM.

Int J Parasitol Drugs Drug Resist. 2019 Aug;10:125-132. doi: 10.1016/j.ijpddr.2019.08.004. Epub 2019 Aug 21.

3.

HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors.

Koneru PC, Francis AC, Deng N, Rebensburg SV, Hoyte AC, Lindenberger J, Adu-Ampratwum D, Larue RC, Wempe MF, Engelman AN, Lyumkis D, Fuchs JR, Levy RM, Melikyan GB, Kvaratskhelia M.

Elife. 2019 May 23;8. pii: e46344. doi: 10.7554/eLife.46344.

4.

Site-Selective C-H Functionalization of (Hetero)Arenes via Transient, Non-Symmetric Iodanes.

Fosu SC, Hambira CM, Chen AD, Fuchs JR, Nagib DA.

Chem. 2019 Feb 14;5(2):417-428. doi: 10.1016/j.chempr.2018.11.007. Epub 2018 Dec 13.

PMID:
31032461
5.

Novel narrow spectrum benzyl thiophene sulfonamide derivatives to control Campylobacter.

Deblais L, Helmy YA, Kumar A, Antwi J, Kathayat D, Acuna UM, Huang HC, de Blanco EC, Fuchs JR, Rajashekara G.

J Antibiot (Tokyo). 2019 Jul;72(7):555-565. doi: 10.1038/s41429-019-0168-x. Epub 2019 Mar 27.

PMID:
30918323
6.

Potential Anticancer Agents Characterized from Selected Tropical Plants.

Ren Y, de Blanco EJC, Fuchs JR, Soejarto DD, Burdette JE, Swanson SM, Kinghorn AD.

J Nat Prod. 2019 Mar 22;82(3):657-679. doi: 10.1021/acs.jnatprod.9b00018. Epub 2019 Mar 4.

PMID:
30830783
7.

An Isoquinoline Scaffold as a Novel Class of Allosteric HIV-1 Integrase Inhibitors.

Wilson TA, Koneru PC, Rebensburg SV, Lindenberger JJ, Kobe MJ, Cockroft NT, Adu-Ampratwum D, Larue RC, Kvaratskhelia M, Fuchs JR.

ACS Med Chem Lett. 2019 Jan 30;10(2):215-220. doi: 10.1021/acsmedchemlett.8b00633. eCollection 2019 Feb 14.

PMID:
30783506
8.

Novel small molecule IL-6 inhibitor suppresses autoreactive Th17 development and promotes Treg development.

Aqel SI, Kraus EE, Jena N, Kumari V, Granitto MC, Mao L, Farinas MF, Zhao EY, Perottino G, Pei W, Lovett-Racke AE, Racke MK, Fuchs JR, Li C, Yang Y.

Clin Exp Immunol. 2019 May;196(2):215-225. doi: 10.1111/cei.13258. Epub 2019 Jan 24.

PMID:
30615197
9.

Identification of a Small Molecule Anti-biofilm Agent Against Salmonella enterica.

Moshiri J, Kaur D, Hambira CM, Sandala JL, Koopman JA, Fuchs JR, Gunn JS.

Front Microbiol. 2018 Nov 20;9:2804. doi: 10.3389/fmicb.2018.02804. eCollection 2018.

10.

Calothrixamides A and B from the Cultured Cyanobacterium Calothrix sp. UIC 10520.

Crnkovic CM, Krunic A, May DS, Wilson TA, Kao D, Burdette JE, Fuchs JR, Oberlies NH, Orjala J.

J Nat Prod. 2018 Sep 28;81(9):2083-2090. doi: 10.1021/acs.jnatprod.8b00432. Epub 2018 Sep 7.

11.

Phyllanthusmin Derivatives Induce Apoptosis and Reduce Tumor Burden in High-Grade Serous Ovarian Cancer by Late-Stage Autophagy Inhibition.

Young AN, Herrera D, Huntsman AC, Korkmaz MA, Lantvit DD, Mazumder S, Kolli S, Coss CC, King S, Wang H, Swanson SM, Kinghorn AD, Zhang X, Phelps MA, Aldrich LN, Fuchs JR, Burdette JE.

Mol Cancer Ther. 2018 Oct;17(10):2123-2135. doi: 10.1158/1535-7163.MCT-17-1195. Epub 2018 Jul 17.

12.

Synthesis and antiproliferative activity of derivatives of the phyllanthusmin class of arylnaphthalene lignan lactones.

Woodard JL, Huntsman AC, Patel PA, Chai HB, Kanagasabai R, Karmahapatra S, Young AN, Ren Y, Cole MS, Herrera D, Yalowich JC, Kinghorn AD, Burdette JE, Fuchs JR.

Bioorg Med Chem. 2018 May 15;26(9):2354-2364. doi: 10.1016/j.bmc.2018.03.033. Epub 2018 Mar 23.

13.

Total Synthesis of Scytonemide A Employing Weinreb AM Solid-Phase Resin.

Wilson TA, Tokarski RJ 2nd, Sullivan P, Demoret RM, Orjala J, Rakotondraibe LH, Fuchs JR.

J Nat Prod. 2018 Mar 23;81(3):534-542. doi: 10.1021/acs.jnatprod.7b00912. Epub 2018 Feb 5.

14.

Resistance to pyridine-based inhibitor KF116 reveals an unexpected role of integrase in HIV-1 Gag-Pol polyprotein proteolytic processing.

Hoyte AC, Jamin AV, Koneru PC, Kobe MJ, Larue RC, Fuchs JR, Engelman AN, Kvaratskhelia M.

J Biol Chem. 2017 Dec 1;292(48):19814-19825. doi: 10.1074/jbc.M117.816645. Epub 2017 Sep 28.

15.

Pentalinonsterol, a Constituent of Pentalinon andrieuxii, Possesses Potent Immunomodulatory Activity and Primes T Cell Immune Responses.

Oghumu S, Varikuti S, Saljoughian N, Terrazas C, Huntsman AC, Parinandi NL, Fuchs JR, Kinghorn AD, Satoskar AR.

J Nat Prod. 2017 Sep 22;80(9):2515-2523. doi: 10.1021/acs.jnatprod.7b00445. Epub 2017 Sep 6.

16.

Cerebellar learning modulates surface expression of a voltage-gated ion channel in cerebellar cortex.

Fuchs JR, Darlington SW, Green JT, Morielli AD.

Neurobiol Learn Mem. 2017 Jul;142(Pt B):252-262. doi: 10.1016/j.nlm.2017.05.009. Epub 2017 May 13.

PMID:
28512010
17.

Discovery of Anticancer Agents of Diverse Natural Origin.

Kinghorn AD, DE Blanco EJ, Lucas DM, Rakotondraibe HL, Orjala J, Soejarto DD, Oberlies NH, Pearce CJ, Wani MC, Stockwell BR, Burdette JE, Swanson SM, Fuchs JR, Phelps MA, Xu L, Zhang X, Shen YY.

Anticancer Res. 2016 Nov;36(11):5623-5637. Review.

18.

Allosteric HIV-1 integrase inhibitors promote aberrant protein multimerization by directly mediating inter-subunit interactions: Structural and thermodynamic modeling studies.

Deng N, Hoyte A, Mansour YE, Mohamed MS, Fuchs JR, Engelman AN, Kvaratskhelia M, Levy R.

Protein Sci. 2016 Nov;25(11):1911-1917. doi: 10.1002/pro.2997. Epub 2016 Aug 17.

19.

A New Class of Allosteric HIV-1 Integrase Inhibitors Identified by Crystallographic Fragment Screening of the Catalytic Core Domain.

Patel D, Antwi J, Koneru PC, Serrao E, Forli S, Kessl JJ, Feng L, Deng N, Levy RM, Fuchs JR, Olson AJ, Engelman AN, Bauman JD, Kvaratskhelia M, Arnold E.

J Biol Chem. 2016 Nov 4;291(45):23569-23577. Epub 2016 Sep 19.

20.

A Novel Sterol Isolated from a Plant Used by Mayan Traditional Healers Is Effective in Treatment of Visceral Leishmaniasis Caused by Leishmania donovani.

Gupta G, Peine KJ, Abdelhamid D, Snider H, Shelton AB, Rao L, Kotha SR, Huntsman AC, Varikuti S, Oghumu S, Naman CB, Pan L, Parinandi NL, Papenfuss TL, Kinghorn AD, Bachelder EM, Ainslie KM, Fuchs JR, Satoskar AR.

ACS Infect Dis. 2015 Oct 9;1(10):497-506. doi: 10.1021/acsinfecdis.5b00081. Epub 2015 Sep 21.

21.

Indole-based allosteric inhibitors of HIV-1 integrase.

Patel PA, Kvaratskhelia N, Mansour Y, Antwi J, Feng L, Koneru P, Kobe MJ, Jena N, Shi G, Mohamed MS, Li C, Kessl JJ, Fuchs JR.

Bioorg Med Chem Lett. 2016 Oct 1;26(19):4748-4752. doi: 10.1016/j.bmcl.2016.08.037. Epub 2016 Aug 13.

22.

HIV-1 Integrase Binds the Viral RNA Genome and Is Essential during Virion Morphogenesis.

Kessl JJ, Kutluay SB, Townsend D, Rebensburg S, Slaughter A, Larue RC, Shkriabai N, Bakouche N, Fuchs JR, Bieniasz PD, Kvaratskhelia M.

Cell. 2016 Aug 25;166(5):1257-1268.e12. doi: 10.1016/j.cell.2016.07.044.

23.

Computational and synthetic approaches for developing Lavendustin B derivatives as allosteric inhibitors of HIV-1 integrase.

Agharbaoui FE, Hoyte AC, Ferro S, Gitto R, Buemi MR, Fuchs JR, Kvaratskhelia M, De Luca L.

Eur J Med Chem. 2016 Nov 10;123:673-683. doi: 10.1016/j.ejmech.2016.07.077. Epub 2016 Aug 3.

24.

Novel Anti-Campylobacter Compounds Identified Using High Throughput Screening of a Pre-selected Enriched Small Molecules Library.

Kumar A, Drozd M, Pina-Mimbela R, Xu X, Helmy YA, Antwi J, Fuchs JR, Nislow C, Templeton J, Blackall PJ, Rajashekara G.

Front Microbiol. 2016 Apr 6;7:405. doi: 10.3389/fmicb.2016.00405. eCollection 2016.

25.

The Competitive Interplay between Allosteric HIV-1 Integrase Inhibitor BI/D and LEDGF/p75 during the Early Stage of HIV-1 Replication Adversely Affects Inhibitor Potency.

Feng L, Dharmarajan V, Serrao E, Hoyte A, Larue RC, Slaughter A, Sharma A, Plumb MR, Kessl JJ, Fuchs JR, Bushman FD, Engelman AN, Griffin PR, Kvaratskhelia M.

ACS Chem Biol. 2016 May 20;11(5):1313-21. doi: 10.1021/acschembio.6b00167. Epub 2016 Mar 2.

26.

Insertional Mutagenesis Identifies a STAT3/Arid1b/β-catenin Pathway Driving Neurofibroma Initiation.

Wu J, Keng VW, Patmore DM, Kendall JJ, Patel AV, Jousma E, Jessen WJ, Choi K, Tschida BR, Silverstein KA, Fan D, Schwartz EB, Fuchs JR, Zou Y, Kim MO, Dombi E, Levy DE, Huang G, Cancelas JA, Stemmer-Rachamimov AO, Spinner RJ, Largaespada DA, Ratner N.

Cell Rep. 2016 Mar 1;14(8):1979-90. doi: 10.1016/j.celrep.2016.01.074. Epub 2016 Feb 18.

27.

Overcoming chemo/radio-resistance of pancreatic cancer by inhibiting STAT3 signaling.

Wu X, Tang W, Marquez RT, Li K, Highfill CA, He F, Lian J, Lin J, Fuchs JR, Ji M, Li L, Xu L.

Oncotarget. 2016 Mar 8;7(10):11708-23. doi: 10.18632/oncotarget.7336.

28.

Discovery of novel small molecule modulators of Clavibacter michiganensis subsp. michiganensis.

Xu X, Kumar A, Deblais L, Pina-Mimbela R, Nislow C, Fuchs JR, Miller SA, Rajashekara G.

Front Microbiol. 2015 Oct 19;6:1127. doi: 10.3389/fmicb.2015.01127. eCollection 2015.

29.

Preclinical In Vitro, In Vivo, and Pharmacokinetic Evaluations of FLLL12 for the Prevention and Treatment of Head and Neck Cancers.

Anisuzzaman AS, Haque A, Rahman MA, Wang D, Fuchs JR, Hurwitz S, Liu Y, Sica G, Khuri FR, Chen ZG, Shin DM, Amin AR.

Cancer Prev Res (Phila). 2016 Jan;9(1):63-73. doi: 10.1158/1940-6207.CAPR-15-0240. Epub 2015 Oct 28.

30.

Distribution and Redistribution of HIV-1 Nucleocapsid Protein in Immature, Mature, and Integrase-Inhibited Virions: a Role for Integrase in Maturation.

Fontana J, Jurado KA, Cheng N, Ly NL, Fuchs JR, Gorelick RJ, Engelman AN, Steven AC.

J Virol. 2015 Oct;89(19):9765-80. doi: 10.1128/JVI.01522-15. Epub 2015 Jul 15.

31.

Trichormamides C and D, antiproliferative cyclic lipopeptides from the cultured freshwater cyanobacterium cf. Oscillatoria sp. UIC 10045.

Luo S, Kang HS, Krunic A, Chen WL, Yang J, Woodard JL, Fuchs JR, Hyun Cho S, Franzblau SG, Swanson SM, Orjala J.

Bioorg Med Chem. 2015 Jul 1;23(13):3153-62. doi: 10.1016/j.bmc.2015.04.073. Epub 2015 May 1.

32.

FLLL12 induces apoptosis in lung cancer cells through a p53/p73-independent but death receptor 5-dependent pathway.

Haque A, Rahman MA, Fuchs JR, Chen ZG, Khuri FR, Shin DM, Amin AR.

Cancer Lett. 2015 Jul 28;363(2):166-75. doi: 10.1016/j.canlet.2015.04.017. Epub 2015 Apr 24.

33.

Inhibition of the JAK2/STAT3 signaling pathway exerts a therapeutic effect on osteosarcoma.

Yan J, Wang Q, Zou K, Wang L, Schwartz EB, Fuchs JR, Zheng Z, Wu J.

Mol Med Rep. 2015 Jul;12(1):498-502. doi: 10.3892/mmr.2015.3439. Epub 2015 Mar 5.

PMID:
25760445
34.

Cytotoxic and natural killer cell stimulatory constituents of Phyllanthus songboiensis.

Ren Y, Yuan C, Deng Y, Kanagasabai R, Ninh TN, Tu VT, Chai HB, Soejarto DD, Fuchs JR, Yalowich JC, Yu J, Kinghorn AD.

Phytochemistry. 2015 Mar;111:132-40. doi: 10.1016/j.phytochem.2014.12.014. Epub 2015 Jan 14.

35.

The mechanism of H171T resistance reveals the importance of Nδ-protonated His171 for the binding of allosteric inhibitor BI-D to HIV-1 integrase.

Slaughter A, Jurado KA, Deng N, Feng L, Kessl JJ, Shkriabai N, Larue RC, Fadel HJ, Patel PA, Jena N, Fuchs JR, Poeschla E, Levy RM, Engelman A, Kvaratskhelia M.

Retrovirology. 2014 Nov 25;11:100. doi: 10.1186/s12977-014-0100-1.

36.

Cerebellar secretin modulates eyeblink classical conditioning.

Fuchs JR, Robinson GM, Dean AM, Schoenberg HE, Williams MR, Morielli AD, Green JT.

Learn Mem. 2014 Nov 17;21(12):668-75. doi: 10.1101/lm.035766.114. Print 2014 Dec.

37.

A comparison of accidental and nonaccidental trauma: it is worse than you think.

Estroff JM, Foglia RP, Fuchs JR.

J Emerg Med. 2015 Mar;48(3):274-9. doi: 10.1016/j.jemermed.2014.07.030. Epub 2014 Sep 29.

PMID:
25278136
38.

A critical role of the C-terminal segment for allosteric inhibitor-induced aberrant multimerization of HIV-1 integrase.

Shkriabai N, Dharmarajan V, Slaughter A, Kessl JJ, Larue RC, Feng L, Fuchs JR, Griffin PR, Kvaratskhelia M.

J Biol Chem. 2014 Sep 19;289(38):26430-40. doi: 10.1074/jbc.M114.589572. Epub 2014 Aug 12.

39.

Trichormamides A and B with Antiproliferative Activity from the Cultured Freshwater Cyanobacterium Trichormus sp. UIC 10339.

Luo S, Krunic A, Kang HS, Chen WL, Woodard JL, Fuchs JR, Swanson SM, Orjala J.

J Nat Prod. 2014 Aug 22;77(8):1871-80. doi: 10.1021/np5003548. Epub 2014 Aug 4.

40.

TALEN knockout of the PSIP1 gene in human cells: analyses of HIV-1 replication and allosteric integrase inhibitor mechanism.

Fadel HJ, Morrison JH, Saenz DT, Fuchs JR, Kvaratskhelia M, Ekker SC, Poeschla EM.

J Virol. 2014 Sep 1;88(17):9704-17. doi: 10.1128/JVI.01397-14. Epub 2014 Jun 18.

41.

Potent cytotoxic arylnaphthalene lignan lactones from Phyllanthus poilanei.

Ren Y, Lantvit DD, Deng Y, Kanagasabai R, Gallucci JC, Ninh TN, Chai HB, Soejarto DD, Fuchs JR, Yalowich JC, Yu J, Swanson SM, Kinghorn AD.

J Nat Prod. 2014 Jun 27;77(6):1494-504. doi: 10.1021/np5002785. Epub 2014 Jun 12.

42.

Pro-growth role of the JMJD2C histone demethylase in HCT-116 colon cancer cells and identification of curcuminoids as JMJD2 inhibitors.

Kim TD, Fuchs JR, Schwartz E, Abdelhamid D, Etter J, Berry WL, Li C, Ihnat MA, Li PK, Janknecht R.

Am J Transl Res. 2014 May 15;6(3):236-47. eCollection 2014.

43.

A new class of multimerization selective inhibitors of HIV-1 integrase.

Sharma A, Slaughter A, Jena N, Feng L, Kessl JJ, Fadel HJ, Malani N, Male F, Wu L, Poeschla E, Bushman FD, Fuchs JR, Kvaratskhelia M.

PLoS Pathog. 2014 May 29;10(5):e1004171. doi: 10.1371/journal.ppat.1004171. eCollection 2014 May.

44.

Rocaglamide, silvestrol and structurally related bioactive compounds from Aglaia species.

Pan L, Woodard JL, Lucas DM, Fuchs JR, Kinghorn AD.

Nat Prod Rep. 2014 Jul;31(7):924-39. doi: 10.1039/c4np00006d. Epub 2014 May 2. Review.

45.

The A128T resistance mutation reveals aberrant protein multimerization as the primary mechanism of action of allosteric HIV-1 integrase inhibitors.

Feng L, Sharma A, Slaughter A, Jena N, Koh Y, Shkriabai N, Larue RC, Patel PA, Mitsuya H, Kessl JJ, Engelman A, Fuchs JR, Kvaratskhelia M.

J Biol Chem. 2013 May 31;288(22):15813-20. doi: 10.1074/jbc.M112.443390. Epub 2013 Apr 24.

46.

Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation.

Jurado KA, Wang H, Slaughter A, Feng L, Kessl JJ, Koh Y, Wang W, Ballandras-Colas A, Patel PA, Fuchs JR, Kvaratskhelia M, Engelman A.

Proc Natl Acad Sci U S A. 2013 May 21;110(21):8690-5. doi: 10.1073/pnas.1300703110. Epub 2013 Apr 22.

47.

Pancreatic cancer-associated stellate cells promote differentiation of myeloid-derived suppressor cells in a STAT3-dependent manner.

Mace TA, Ameen Z, Collins A, Wojcik S, Mair M, Young GS, Fuchs JR, Eubank TD, Frankel WL, Bekaii-Saab T, Bloomston M, Lesinski GB.

Cancer Res. 2013 May 15;73(10):3007-18. doi: 10.1158/0008-5472.CAN-12-4601. Epub 2013 Mar 20.

48.

EGFR-STAT3 signaling promotes formation of malignant peripheral nerve sheath tumors.

Wu J, Patmore DM, Jousma E, Eaves DW, Breving K, Patel AV, Schwartz EB, Fuchs JR, Cripe TP, Stemmer-Rachamimov AO, Ratner N.

Oncogene. 2014 Jan 9;33(2):173-80. doi: 10.1038/onc.2012.579. Epub 2013 Jan 14.

49.

Bioactive flavaglines and other constituents isolated from Aglaia perviridis.

Pan L, Acuña UM, Li J, Jena N, Ninh TN, Pannell CM, Chai H, Fuchs JR, Carcache de Blanco EJ, Soejarto DD, Kinghorn AD.

J Nat Prod. 2013 Mar 22;76(3):394-404. doi: 10.1021/np3007588. Epub 2013 Jan 9.

50.

Use of the hollow fiber assay for the discovery of novel anticancer agents from fungi.

Pearce CJ, Lantvit DD, Shen Q, Jarjoura D, Zhang X, Oberlies NH, Kroll DJ, Wani MC, Orjala J, Soejarto DD, Farnsworth NR, de Blanco EJ, Fuchs JR, Kinghorn AD, Swanson SM.

Methods Mol Biol. 2012;944:267-77. doi: 10.1007/978-1-62703-122-6_20.

PMID:
23065624

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