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A Machine Learning Algorithm to Predict Severe Sepsis and Septic Shock: Development, Implementation, and Impact on Clinical Practice.

Giannini HM, Ginestra JC, Chivers C, Draugelis M, Hanish A, Schweickert WD, Fuchs BD, Meadows L, Lynch M, Donnelly PJ, Pavan K, Fishman NO, Hanson CW 3rd, Umscheid CA.

Crit Care Med. 2019 Nov;47(11):1485-1492. doi: 10.1097/CCM.0000000000003891.


Burnout, and Fulfillment, in the Profession of Critical Care Medicine.

Mikkelsen ME, Anderson BJ, Bellini L, Schweickert WD, Fuchs BD, Kerlin MP.

Am J Respir Crit Care Med. 2019 Oct 1;200(7):931-933. doi: 10.1164/rccm.201903-0662LE. No abstract available.


Clinician Perception of a Machine Learning-Based Early Warning System Designed to Predict Severe Sepsis and Septic Shock.

Ginestra JC, Giannini HM, Schweickert WD, Meadows L, Lynch MJ, Pavan K, Chivers CJ, Draugelis M, Donnelly PJ, Fuchs BD, Umscheid CA.

Crit Care Med. 2019 Nov;47(11):1477-1484. doi: 10.1097/CCM.0000000000003803.


Combined Biomarkers Predict Acute Mortality Among Critically Ill Patients With Suspected Sepsis.

Kelly BJ, Lautenbach E, Nachamkin I, Coffin SE, Gerber JS, Fuchs BD, Garrigan C, Han X, Bilker WB, Wise J, Tolomeo P, Han JH; Centers for Disease Control and Prevention (CDC) Prevention Epicenters Program.

Crit Care Med. 2018 Jul;46(7):1106-1113. doi: 10.1097/CCM.0000000000003137.


Accuracy of Acid-Base Diagnoses Using the Central Venous Blood Gas in the Medical Intensive Care Unit.

Schrauben SJ, Negoianu D, Costa C, Cohen RM, Goldfarb S, Fuchs BD, Berns JS.

Nephron. 2018;139(4):293-298. doi: 10.1159/000488501. Epub 2018 Apr 12.


Natural Language Processing to Assess Documentation of Features of Critical Illness in Discharge Documents of Acute Respiratory Distress Syndrome Survivors.

Weissman GE, Harhay MO, Lugo RM, Fuchs BD, Halpern SD, Mikkelsen ME.

Ann Am Thorac Soc. 2016 Sep;13(9):1538-45. doi: 10.1513/AnnalsATS.201602-131OC.


Combined biomarkers discriminate a low likelihood of bacterial infection among surgical intensive care unit patients with suspected sepsis.

Kelly BJ, Lautenbach E, Nachamkin I, Coffin SE, Gerber JS, Fuchs BD, Garrigan C, Han X, Bilker WB, Wise J, Tolomeo P, Han JH; Centers for Disease Control and Prevention (CDC) Prevention Epicenters Program.

Diagn Microbiol Infect Dis. 2016 May;85(1):109-15. doi: 10.1016/j.diagmicrobio.2016.01.003. Epub 2016 Jan 8.


Using a Post-Intubation Checklist and Time Out to Expedite Mechanical Ventilation Monitoring: Observational Study of a Quality Improvement Intervention.

McConnell RA, Kerlin MP, Schweickert WD, Ahmad F, Patel MS, Fuchs BD.

Respir Care. 2016 Jul;61(7):902-12. doi: 10.4187/respcare.04191. Epub 2016 Mar 1.


Composition and dynamics of the respiratory tract microbiome in intubated patients.

Kelly BJ, Imai I, Bittinger K, Laughlin A, Fuchs BD, Bushman FD, Collman RG.

Microbiome. 2016 Feb 11;4:7. doi: 10.1186/s40168-016-0151-8.


Association Between Index Hospitalization and Hospital Readmission in Sepsis Survivors.

Sun A, Netzer G, Small DS, Hanish A, Fuchs BD, Gaieski DF, Mikkelsen ME.

Crit Care Med. 2016 Mar;44(3):478-87. doi: 10.1097/CCM.0000000000001464.


Clinician Perception of the Effectiveness of an Automated Early Warning and Response System for Sepsis in an Academic Medical Center.

Guidi JL, Clark K, Upton MT, Faust H, Umscheid CA, Lane-Fall MB, Mikkelsen ME, Schweickert WD, Vanzandbergen CA, Betesh J, Tait G, Hanish A, Smith K, Feeley D, Fuchs BD.

Ann Am Thorac Soc. 2015 Oct;12(10):1514-9. doi: 10.1513/AnnalsATS.201503-129OC.


Post-Acute Care Use and Hospital Readmission after Sepsis.

Jones TK, Fuchs BD, Small DS, Halpern SD, Hanish A, Umscheid CA, Baillie CA, Kerlin MP, Gaieski DF, Mikkelsen ME.

Ann Am Thorac Soc. 2015 Jun;12(6):904-13. doi: 10.1513/AnnalsATS.201411-504OC.


Hospital-based acute care use in survivors of septic shock.

Ortego A, Gaieski DF, Fuchs BD, Jones T, Halpern SD, Small DS, Sante SC, Drumheller B, Christie JD, Mikkelsen ME.

Crit Care Med. 2015 Apr;43(4):729-37. doi: 10.1097/CCM.0000000000000693.


Development, implementation, and impact of an automated early warning and response system for sepsis.

Umscheid CA, Betesh J, VanZandbergen C, Hanish A, Tait G, Mikkelsen ME, French B, Fuchs BD.

J Hosp Med. 2015 Jan;10(1):26-31. doi: 10.1002/jhm.2259. Epub 2014 Sep 26.


Epidemiology and outcomes in patients with severe sepsis admitted to the hospital wards.

Whittaker SA, Fuchs BD, Gaieski DF, Christie JD, Goyal M, Meyer NJ, Kean C, Small DS, Bellamy SL, Mikkelsen ME.

J Crit Care. 2015 Feb;30(1):78-84. doi: 10.1016/j.jcrc.2014.07.012. Epub 2014 Jul 22.


The association of body mass index with time to target temperature and outcomes following post-arrest targeted temperature management.

Leary M, Cinousis MJ, Mikkelsen ME, Gaieski DF, Abella BS, Fuchs BD.

Resuscitation. 2014 Feb;85(2):244-7. doi: 10.1016/j.resuscitation.2013.10.027. Epub 2013 Nov 11.


The Mortality Review Committee: a novel and scalable approach to reducing inpatient mortality.

Barbieri JS, Fuchs BD, Fishman N, Cutilli CC, Umscheid CA, Kean C, Koshy S, Sullivan PG, Brennan PJ, Kelz RR.

Jt Comm J Qual Patient Saf. 2013 Sep;39(9):387-95.


The impact of documentation of severe acute kidney injury on mortality.

Wilson FP, Bansal AD, Jasti SK, Lin JJ, Shashaty MG, Berns JS, Feldman HI, Fuchs BD.

Clin Nephrol. 2013 Dec;80(6):417-25. doi: 10.5414/CN108072.


Time to awakening and neurologic outcome in therapeutic hypothermia-treated cardiac arrest patients.

Grossestreuer AV, Abella BS, Leary M, Perman SM, Fuchs BD, Kolansky DM, Beylin ME, Gaieski DF.

Resuscitation. 2013 Dec;84(12):1741-6. doi: 10.1016/j.resuscitation.2013.07.009. Epub 2013 Aug 1.


The epidemiology of acute respiratory distress syndrome in patients presenting to the emergency department with severe sepsis.

Mikkelsen ME, Shah CV, Meyer NJ, Gaieski DF, Lyon S, Miltiades AN, Goyal M, Fuchs BD, Bellamy SL, Christie JD.

Shock. 2013 Nov;40(5):375-81. doi: 10.1097/SHK.0b013e3182a64682.


A randomized trial of nighttime physician staffing in an intensive care unit.

Kerlin MP, Small DS, Cooney E, Fuchs BD, Bellini LM, Mikkelsen ME, Schweickert WD, Bakhru RN, Gabler NB, Harhay MO, Hansen-Flaschen J, Halpern SD.

N Engl J Med. 2013 Jun 6;368(23):2201-9. doi: 10.1056/NEJMoa1302854. Epub 2013 May 20.


Use of therapeutic hypothermia after in-hospital cardiac arrest.

Mikkelsen ME, Christie JD, Abella BS, Kerlin MP, Fuchs BD, Schweickert WD, Berg RA, Mosesso VN, Shofer FS, Gaieski DF; American Heart Association’s Get With the Guidelines-Resuscitation Investigators.

Crit Care Med. 2013 Jun;41(6):1385-95. doi: 10.1097/CCM.0b013e318287f2c4.


Accuracy of Handheld Point-of-Care Fingertip Lactate Measurement in the Emergency Department.

Gaieski DF, Drumheller BC, Goyal M, Fuchs BD, Shofer FS, Zogby K.

West J Emerg Med. 2013 Feb;14(1):58-62. doi: 10.5811/westjem.2011.5.6706.


Severe sepsis cohorts derived from claims-based strategies appear to be biased toward a more severely ill patient population.

Whittaker SA, Mikkelsen ME, Gaieski DF, Koshy S, Kean C, Fuchs BD.

Crit Care Med. 2013 Apr;41(4):945-53. doi: 10.1097/CCM.0b013e31827466f1.


Improving physician clinical documentation quality: evaluating two self-efficacy-based training programs.

Russo R, Fitzgerald SP, Eveland JD, Fuchs BD, Redmon DP.

Health Care Manage Rev. 2013 Jan-Mar;38(1):29-39. doi: 10.1097/HMR.0b013e31824c4c61.


Timing of neuroprognostication in postcardiac arrest therapeutic hypothermia*.

Perman SM, Kirkpatrick JN, Reitsma AM, Gaieski DF, Lau B, Smith TM, Leary M, Fuchs BD, Levine JM, Abella BS, Becker LB, Merchant RM.

Crit Care Med. 2012 Mar;40(3):719-24. doi: 10.1097/CCM.0b013e3182372f93.


ANGPT2 genetic variant is associated with trauma-associated acute lung injury and altered plasma angiopoietin-2 isoform ratio.

Meyer NJ, Li M, Feng R, Bradfield J, Gallop R, Bellamy S, Fuchs BD, Lanken PN, Albelda SM, Rushefski M, Aplenc R, Abramova H, Atochina-Vasserman EN, Beers MF, Calfee CS, Cohen MJ, Pittet JF, Christiani DC, O'Keefe GE, Ware LB, May AK, Wurfel MM, Hakonarson H, Christie JD.

Am J Respir Crit Care Med. 2011 May 15;183(10):1344-53. doi: 10.1164/rccm.201005-0701OC. Epub 2011 Jan 21.


Performance of an automated electronic acute lung injury screening system in intensive care unit patients.

Koenig HC, Finkel BB, Khalsa SS, Lanken PN, Prasad M, Urbani R, Fuchs BD.

Crit Care Med. 2011 Jan;39(1):98-104. doi: 10.1097/CCM.0b013e3181feb4a0.


Neurologic prognostication and bispectral index monitoring after resuscitation from cardiac arrest.

Leary M, Fried DA, Gaieski DF, Merchant RM, Fuchs BD, Kolansky DM, Edelson DP, Abella BS.

Resuscitation. 2010 Sep;81(9):1133-7. doi: 10.1016/j.resuscitation.2010.04.021. Epub 2010 Jul 2.


An alternative method of acute lung injury classification for use in observational studies.

Shah CV, Lanken PN, Localio AR, Gallop R, Bellamy S, Ma SF, Flores C, Kahn JM, Finkel B, Fuchs BD, Garcia JG, Christie JD.

Chest. 2010 Nov;138(5):1054-61. doi: 10.1378/chest.09-2697. Epub 2010 Jun 24.


A systematic review to inform institutional decisions about the use of extracorporeal membrane oxygenation during the H1N1 influenza pandemic.

Mitchell MD, Mikkelsen ME, Umscheid CA, Lee I, Fuchs BD, Halpern SD.

Crit Care Med. 2010 Jun;38(6):1398-404. doi: 10.1097/CCM.0b013e3181de45db. Review.


Factors associated with nonadherence to early goal-directed therapy in the ED.

Mikkelsen ME, Gaieski DF, Goyal M, Miltiades AN, Munson JC, Pines JM, Fuchs BD, Shah CV, Bellamy SL, Christie JD.

Chest. 2010 Sep;138(3):551-8. doi: 10.1378/chest.09-2210. Epub 2010 Feb 19.


Elevation in serum lactate at the time of febrile neutropenia (FN) in hemodynamically-stable patients with hematologic malignancies (HM) is associated with the development of septic shock within 48 hours.

Mato AR, Luger SM, Heitjan DF, Mikkelsen ME, Olson E, Ujjani C, Jacobs S, Miltiades AN, Shah P, Schuster SJ, Carroll M, Chauffe AD, Fuchs BD.

Cancer Biol Ther. 2010 Apr 15;9(8):585-9. Epub 2010 Apr 20.


Utility of the systemic inflammatory response syndrome (SIRS) criteria in predicting the onset of septic shock in hospitalized patients with hematologic malignancies.

Mato A, Fuchs BD, Heitjan DF, Mick R, Halpern SD, Shah PD, Jacobs S, Olson EM, Schuster SJ, Ujjani C, Chong EA, Loren AW, Miltiades AN, Luger S.

Cancer Biol Ther. 2009 Jun;8(12):1095-1100.


Necrotizing fasciitis in a plaster-casted limb: case report.

Netzer G, Fuchs BD.

Am J Crit Care. 2009 May;18(3):288-7. doi: 10.4037/ajcc2009363.


Validation study of an automated electronic acute lung injury screening tool.

Azzam HC, Khalsa SS, Urbani R, Shah CV, Christie JD, Lanken PN, Fuchs BD.

J Am Med Inform Assoc. 2009 Jul-Aug;16(4):503-8. doi: 10.1197/jamia.M3120. Epub 2009 Apr 23.


Serum lactate is associated with mortality in severe sepsis independent of organ failure and shock.

Mikkelsen ME, Miltiades AN, Gaieski DF, Goyal M, Fuchs BD, Shah CV, Bellamy SL, Christie JD.

Crit Care Med. 2009 May;37(5):1670-7. doi: 10.1097/CCM.0b013e31819fcf68.


Cost savings attributable to reductions in intensive care unit length of stay for mechanically ventilated patients.

Kahn JM, Rubenfeld GD, Rohrbach J, Fuchs BD.

Med Care. 2008 Dec;46(12):1226-33. doi: 10.1097/MLR.0b013e31817d9342.


Early goal-directed hemodynamic optimization combined with therapeutic hypothermia in comatose survivors of out-of-hospital cardiac arrest.

Gaieski DF, Band RA, Abella BS, Neumar RW, Fuchs BD, Kolansky DM, Merchant RM, Carr BG, Becker LB, Maguire C, Klair A, Hylton J, Goyal M.

Resuscitation. 2009 Apr;80(4):418-24. doi: 10.1016/j.resuscitation.2008.12.015. Epub 2009 Feb 12.


Outcomes using extracorporeal life support for adult respiratory failure due to status asthmaticus.

Mikkelsen ME, Woo YJ, Sager JS, Fuchs BD, Christie JD.

ASAIO J. 2009 Jan-Feb;55(1):47-52. doi: 10.1097/MAT.0b013e3181901ea5.


The impact of development of acute lung injury on hospital mortality in critically ill trauma patients.

Shah CV, Localio AR, Lanken PN, Kahn JM, Bellamy S, Gallop R, Finkel B, Gracias VH, Fuchs BD, Christie JD.

Crit Care Med. 2008 Aug;36(8):2309-15. doi: 10.1097/CCM.0b013e318180dc74.


Recognition and importance of forced exhalation on the measurement of intraabdominal pressure: a subgroup analysis from a prospective cohort study on the incidence of abdominal compartment syndrome in medical patients.

Hongyan Liang, Daugherty EL, Taichman D, Hansen-Flaschen J, Fuchs BD.

J Intensive Care Med. 2008 Jul-Aug;23(4):268-74. doi: 10.1177/0885066608318512. Epub 2008 May 27.


Adverse events during rotary-wing transport of mechanically ventilated patients: a retrospective cohort study.

Seymour CW, Kahn JM, Schwab CW, Fuchs BD.

Crit Care. 2008;12(3):R71. doi: 10.1186/cc6909. Epub 2008 May 22.


Improving sepsis care through systems change: the impact of a medical emergency team.

Sarani B, Brenner SR, Gabel B, Myers JS, Gibson G, Phillips J, Fuchs BD.

Jt Comm J Qual Patient Saf. 2008 Mar;34(3):179-82, 125.


Potential reasons why physicians underuse lung-protective ventilation: a retrospective cohort study using physician documentation.

Mikkelsen ME, Dedhiya PM, Kalhan R, Gallop RJ, Lanken PN, Fuchs BD.

Respir Care. 2008 Apr;53(4):455-61.


Minute ventilation recovery time measured using a new, simplified methodology predicts extubation outcome.

Seymour CW, Halpern S, Christie JD, Gallop R, Fuchs BD.

J Intensive Care Med. 2008 Jan-Feb;23(1):52-60.


Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial): a randomised controlled trial.

Girard TD, Kress JP, Fuchs BD, Thomason JW, Schweickert WD, Pun BT, Taichman DB, Dunn JG, Pohlman AS, Kinniry PA, Jackson JC, Canonico AE, Light RW, Shintani AK, Thompson JL, Gordon SM, Hall JB, Dittus RS, Bernard GR, Ely EW.

Lancet. 2008 Jan 12;371(9607):126-34. doi: 10.1016/S0140-6736(08)60105-1.


Nonconsented human immunodeficiency virus testing among critically ill patients: intensivists' practices and the influence of state laws.

Halpern SD, Metkus TS, Fuchs BD, Ward NS, Siegel MD, Luce JM, Curtis JR.

Arch Intern Med. 2007 Nov 26;167(21):2323-8.


Identifying and implementing quality improvement measures in the intensive care unit.

Kahn JM, Fuchs BD.

Curr Opin Crit Care. 2007 Dec;13(6):709-13. Review.


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