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Items: 47


Repurposing Drugs for Acute Myeloid Leukemia: A Worthy Cause or a Futile Pursuit?

Wojcicki AV, Kadapakkam M, Frymoyer A, Lacayo N, Chae HD, Sakamoto KM.

Cancers (Basel). 2020 Feb 13;12(2). pii: E441. doi: 10.3390/cancers12020441. Review.


Serial clinical observation for management of newborns at risk of early-onset sepsis.

Berardi A, Bedetti L, Spada C, Lucaccioni L, Frymoyer A.

Curr Opin Pediatr. 2019 Dec 16. doi: 10.1097/MOP.0000000000000864. [Epub ahead of print]


Antimicrobial Disposition During Pediatric Continuous Renal Replacement Therapy Using an Ex Vivo Model.

Purohit PJ, Elkomy MH, Frymoyer A, Sutherland SM, Drover DR, Hammer GB, Su F.

Crit Care Med. 2019 Sep;47(9):e767-e773. doi: 10.1097/CCM.0000000000003895.


4-Methylumbelliferyl glucuronide contributes to hyaluronan synthesis inhibition.

Nagy N, Gurevich I, Kuipers HF, Ruppert SM, Marshall PL, Xie BJ, Sun W, Malkovskiy AV, Rajadas J, Grandoch M, Fischer JW, Frymoyer AR, Kaber G, Bollyky PL.

J Biol Chem. 2019 May 10;294(19):7864-7877. doi: 10.1074/jbc.RA118.006166. Epub 2019 Mar 26.


Management of Chorioamnionitis-Exposed Infants in the Newborn Nursery Using a Clinical Examination-Based Approach.

Joshi NS, Gupta A, Allan JM, Cohen RS, Aby JL, Kim JL, Benitz WE, Frymoyer A.

Hosp Pediatr. 2019 Apr;9(4):227-233. doi: 10.1542/hpeds.2018-0201. Epub 2019 Mar 4.


An Evaluation of Vancomycin Area Under the Curve Estimation Methods for Children Treated for Acute Pulmonary Exacerbations of Cystic Fibrosis Due to Methicillin-Resistant Staphylococcus aureus.

Stockmann C, Olson J, Rashid J, Lubsch L, Young DC, Hersh AL, Frymoyer A, Ampofo K, Liu X, Wang Y, Sherwin CMT, Zobell JT.

J Clin Pharmacol. 2019 Feb;59(2):198-205. doi: 10.1002/jcph.1323. Epub 2018 Oct 29.


Model-Informed Precision Dosing at the Bedside: Scientific Challenges and Opportunities.

Keizer RJ, Ter Heine R, Frymoyer A, Lesko LJ, Mangat R, Goswami S.

CPT Pharmacometrics Syst Pharmacol. 2018 Dec;7(12):785-787. doi: 10.1002/psp4.12353. Epub 2018 Oct 16.


Pharmacokinetics of Dexmedetomidine in Infants and Children After Orthotopic Liver Transplantation.

Damian MA, Hammer GB, Elkomy MH, Frymoyer A, Drover DR, Su F.

Anesth Analg. 2020 Jan;130(1):209-216. doi: 10.1213/ANE.0000000000003761.


A safety, tolerability, and pharmacokinetic analysis of two phase I studies of multitargeted small molecule tyrosine kinase inhibitor XL647 with an intermittent and continuous dosing schedule in patients with advanced solid malignancies.

Das M, Padda SK, Frymoyer A, Molina J, Adjei A, Lensing JL, Miles D, Sikic BI, Wakelee HA.

Cancer Chemother Pharmacol. 2018 Sep;82(3):541-550. doi: 10.1007/s00280-018-3646-0. Epub 2018 Jul 20.


Renal Saturation and Acute Kidney Injury in Neonates with Hypoxic Ischemic Encephalopathy Undergoing Therapeutic Hypothermia.

Chock VY, Frymoyer A, Yeh CG, Van Meurs KP.

J Pediatr. 2018 Sep;200:232-239.e1. doi: 10.1016/j.jpeds.2018.04.076. Epub 2018 Jun 1.


Clinical Monitoring of Well-Appearing Infants Born to Mothers With Chorioamnionitis.

Joshi NS, Gupta A, Allan JM, Cohen RS, Aby JL, Weldon B, Kim JL, Benitz WE, Frymoyer A.

Pediatrics. 2018 Apr;141(4). pii: e20172056. doi: 10.1542/peds.2017-2056.


A Mobile Infliximab Dosing Calculator for Therapy Optimization in Inflammatory Bowel Disease.

Piester T, Frymoyer A, Christofferson M, Yu H, Bass D, Park KT.

Inflamm Bowel Dis. 2018 Jan 18;24(2):227-234. doi: 10.1093/ibd/izx037.


Individualized Empiric Vancomycin Dosing in Neonates Using a Model-Based Approach.

Frymoyer A, Stockmann C, Hersh AL, Goswami S, Keizer RJ.

J Pediatric Infect Dis Soc. 2019 May 11;8(2):97-104. doi: 10.1093/jpids/pix109.


Application of Population Pharmacokinetic Modeling for Individualized Infliximab Dosing Strategies in Crohn Disease.

Frymoyer A, Hoekman DR, Piester TL, de Meij TG, Hummel TZ, Benninga MA, Kindermann A, Park KT.

J Pediatr Gastroenterol Nutr. 2017 Dec;65(6):639-645. doi: 10.1097/MPG.0000000000001620.


Early career investigator highlight.

Frymoyer A.

Pediatr Res. 2017 Jun;81(6):850. doi: 10.1038/pr.2017.60. Epub 2017 May 10. No abstract available.


High-dose erythropoietin population pharmacokinetics in neonates with hypoxic-ischemic encephalopathy receiving hypothermia.

Frymoyer A, Juul SE, Massaro AN, Bammler TK, Wu YW.

Pediatr Res. 2017 Jun;81(6):865-872. doi: 10.1038/pr.2017.15. Epub 2017 Jan 18.


Letter to the Editor regarding "Arrhythmias in the paediatric ICU: a prospective study of the rates and predictors of arrhythmias in children without underlying cardiac disease" by Cassel-Choudhury et al.

Axelrod DM, Frymoyer AR, Sutherland SM.

Cardiol Young. 2017 Jan;27(1):203-204. doi: 10.1017/S1047951116001128. Epub 2016 Jul 15. No abstract available.


Decreased Morphine Clearance in Neonates With Hypoxic Ischemic Encephalopathy Receiving Hypothermia.

Frymoyer A, Bonifacio SL, Drover DR, Su F, Wustoff CJ, Van Meurs KP.

J Clin Pharmacol. 2017 Jan;57(1):64-76. doi: 10.1002/jcph.775. Epub 2016 Jun 26.


The pharmacokinetics and dosing of oral 4-methylumbelliferone for inhibition of hyaluronan synthesis in mice.

Kuipers HF, Nagy N, Ruppert SM, Sunkari VG, Marshall PL, Gebe JA, Ishak HD, Keswani SG, Bollyky J, Frymoyer AR, Wight TN, Steinman L, Bollyky PL.

Clin Exp Immunol. 2016 Sep;185(3):372-81. doi: 10.1111/cei.12815.


Infliximab Dosing Strategies and Predicted Trough Exposure in Children With Crohn Disease.

Frymoyer A, Piester TL, Park KT.

J Pediatr Gastroenterol Nutr. 2016 May;62(5):723-7. doi: 10.1097/MPG.0000000000001123.


Theophylline Population Pharmacokinetics and Dosing in Children Following Congenital Heart Surgery With Cardiopulmonary Bypass.

Frymoyer A, Su F, Grimm PC, Sutherland SM, Axelrod DM.

J Clin Pharmacol. 2016 Sep;56(9):1084-93. doi: 10.1002/jcph.697. Epub 2016 Feb 18.


Pharmacokinetics of Morphine and Its Metabolites in Infants and Young Children After Congenital Heart Surgery.

Elkomy MH, Drover DR, Glotzbach KL, Galinkin JL, Frymoyer A, Su F, Hammer GB.

AAPS J. 2016 Jan;18(1):124-33. doi: 10.1208/s12248-015-9826-5. Epub 2015 Sep 9.


Dovitinib and erlotinib in patients with metastatic non-small cell lung cancer: A drug-drug interaction.

Das M, Padda SK, Frymoyer A, Zhou L, Riess JW, Neal JW, Wakelee HA.

Lung Cancer. 2015 Sep;89(3):280-6. doi: 10.1016/j.lungcan.2015.06.011. Epub 2015 Jun 22.


Predictive Performance of a Vancomycin Population Pharmacokinetic Model in Neonates.

Stockmann C, Hersh AL, Roberts JK, Bhongsatiern J, Korgenski EK, Spigarelli MG, Sherwin CM, Frymoyer A.

Infect Dis Ther. 2015 Jun;4(2):187-98. doi: 10.1007/s40121-015-0067-9. Epub 2015 May 22.


4-methylumbelliferone treatment and hyaluronan inhibition as a therapeutic strategy in inflammation, autoimmunity, and cancer.

Nagy N, Kuipers HF, Frymoyer AR, Ishak HD, Bollyky JB, Wight TN, Bollyky PL.

Front Immunol. 2015 Mar 23;6:123. doi: 10.3389/fimmu.2015.00123. eCollection 2015. Review.


Pharmacokinetics, Pharmacodynamics, and Safety of Lisinopril in Pediatric Kidney Transplant Patients: Implications for Starting Dose Selection.

Trachtman H, Frymoyer A, Lewandowski A, Greenbaum LA, Feig DI, Gipson DS, Warady BA, Goebel JW, Schwartz GJ, Lewis K, Anand R, Patel UD; Best Pharmaceuticals for Children Act-Pediatric Trials Network Administrative Core Committee.

Clin Pharmacol Ther. 2015 Jul;98(1):25-33. doi: 10.1002/cpt.127. Epub 2015 May 2.


Population pharmacokinetics of etomidate in neonates and infants with congenital heart disease.

Su F, El-Komy MH, Hammer GB, Frymoyer A, Cohane CA, Drover DR.

Biopharm Drug Dispos. 2015 Mar;36(2):104-14. doi: 10.1002/bdd.1924. Epub 2015 Jan 21.


The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria.

Yago MR, Frymoyer A, Benet LZ, Smelick GS, Frassetto LA, Ding X, Dean B, Salphati L, Budha N, Jin JY, Dresser MJ, Ware JA.

AAPS J. 2014 Nov;16(6):1358-65. doi: 10.1208/s12248-014-9673-9. Epub 2014 Oct 2.


Predictive performance of a gentamicin population pharmacokinetic model in neonates receiving full-body hypothermia.

Sampson MR, Frymoyer A, Rattray B, Cotten CM, Smith PB, Capparelli E, Bonifacio SL, Cohen-Wolkowiez M.

Ther Drug Monit. 2014 Oct;36(5):584-9. doi: 10.1097/FTD.0000000000000056.


Association between vancomycin trough concentration and area under the concentration-time curve in neonates.

Frymoyer A, Hersh AL, El-Komy MH, Gaskari S, Su F, Drover DR, Van Meurs K.

Antimicrob Agents Chemother. 2014 Nov;58(11):6454-61. doi: 10.1128/AAC.03620-14. Epub 2014 Aug 18.


Reply: To PMID 23652479.

Frymoyer A, Hersh AL.

Pediatr Infect Dis J. 2013 Dec;32(12):1404. doi: 10.1097/INF.0000000000000037. No abstract available.


Prevalence of acid-reducing agents (ARA) in cancer populations and ARA drug-drug interaction potential for molecular targeted agents in clinical development.

Smelick GS, Heffron TP, Chu L, Dean B, West DA, Duvall SL, Lum BL, Budha N, Holden SN, Benet LZ, Frymoyer A, Dresser MJ, Ware JA.

Mol Pharm. 2013 Nov 4;10(11):4055-62. doi: 10.1021/mp400403s. Epub 2013 Oct 24.


Vancomycin Dosing Practices, Trough Concentrations, and Predicted Area Under the Curve in Children With Suspected Invasive Staphylococcal Infections.

Frymoyer A.

J Pediatric Infect Dis Soc. 2013 Sep;2(3):291-2. doi: 10.1093/jpids/pit031. Epub 2013 May 16. No abstract available.


Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria.

Yago MR, Frymoyer AR, Smelick GS, Frassetto LA, Budha NR, Dresser MJ, Ware JA, Benet LZ.

Mol Pharm. 2013 Nov 4;10(11):4032-7. doi: 10.1021/mp4003738. Epub 2013 Sep 10.


Every 36-h gentamicin dosing in neonates with hypoxic-ischemic encephalopathy receiving hypothermia.

Frymoyer A, Lee S, Bonifacio SL, Meng L, Lucas SS, Guglielmo BJ, Sun Y, Verotta D.

J Perinatol. 2013 Oct;33(10):778-82. doi: 10.1038/jp.2013.59. Epub 2013 May 23.


Desired vancomycin trough serum concentration for treating invasive methicillin-resistant Staphylococcal infections.

Frymoyer A, Guglielmo BJ, Hersh AL.

Pediatr Infect Dis J. 2013 Oct;32(10):1077-9. doi: 10.1097/INF.0b013e318299f75c.


Gentamicin pharmacokinetics and dosing in neonates with hypoxic ischemic encephalopathy receiving hypothermia.

Frymoyer A, Meng L, Bonifacio SL, Verotta D, Guglielmo BJ.

Pharmacotherapy. 2013 Jul;33(7):718-26. doi: 10.1002/phar.1263. Epub 2013 Apr 1.


Population pharmacokinetics of unbound mycophenolic acid in adult allogeneic haematopoietic cell transplantation: effect of pharmacogenetic factors.

Frymoyer A, Verotta D, Jacobson P, Long-Boyle J.

Br J Clin Pharmacol. 2013 Feb;75(2):463-75. doi: 10.1111/j.1365-2125.2012.04372.x.


Drug absorption interactions between oral targeted anticancer agents and PPIs: is pH-dependent solubility the Achilles heel of targeted therapy?

Budha NR, Frymoyer A, Smelick GS, Jin JY, Yago MR, Dresser MJ, Holden SN, Benet LZ, Ware JA.

Clin Pharmacol Ther. 2012 Aug;92(2):203-13. doi: 10.1038/clpt.2012.73. Epub 2012 Jun 27. Review.


Nevirapine pharmacokinetics and risk of rash and hepatitis among HIV-infected sub-Saharan African women.

Dong BJ, Zheng Y, Hughes MD, Frymoyer A, Verotta D, Lizak P, Sawe F, Currier JS, Lockman S, Aweeka FT; AIDS Clinical Trials Group Study 5208 Team.

AIDS. 2012 Apr 24;26(7):833-41. doi: 10.1097/QAD.0b013e328351a521.


Impact of a hospitalwide increase in empiric pediatric vancomycin dosing on initial trough concentrations.

Frymoyer A, Guglielmo BJ, Wilson SD, Scarpace SB, Benet LZ, Hersh AL.

Pharmacotherapy. 2011 Sep;31(9):871-6. doi: 10.1592/phco.31.9.871.


Effect of single-dose rifampin on the pharmacokinetics of warfarin in healthy volunteers.

Frymoyer A, Shugarts S, Browne M, Wu AH, Frassetto L, Benet LZ.

Clin Pharmacol Ther. 2010 Oct;88(4):540-7. doi: 10.1038/clpt.2010.142. Epub 2010 Aug 11.


Prediction of vancomycin pharmacodynamics in children with invasive methicillin-resistant Staphylococcus aureus infections: a Monte Carlo simulation.

Frymoyer A, Hersh AL, Coralic Z, Benet LZ, Joseph Guglielmo B.

Clin Ther. 2010 Mar;32(3):534-42. doi: 10.1016/j.clinthera.2010.03.005.


Current recommended dosing of vancomycin for children with invasive methicillin-resistant Staphylococcus aureus infections is inadequate.

Frymoyer A, Hersh AL, Benet LZ, Guglielmo BJ.

Pediatr Infect Dis J. 2009 May;28(5):398-402. doi: 10.1097/INF.0b013e3181906e40.


Delayed distribution of active vasodilation and altered vascular conductance in aged skin.

Pierzga JM, Frymoyer A, Kenney WL.

J Appl Physiol (1985). 2003 Mar;94(3):1045-53. Epub 2002 Oct 25.


The isolation and properties of the dimeric subunit of concanavalin A.

Pazur JH, Perloff MD, Frymoyer AR, Jensen CJ, Micolochick H, Mastro A.

J Protein Chem. 2000 Jul;19(5):353-9.


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