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Effect of pterostilbene on in vitro drug metabolizing enzyme activity.

Albassam AA, Frye RF.

Saudi Pharm J. 2019 Mar;27(3):406-412. doi: 10.1016/j.jsps.2019.01.001. Epub 2019 Jan 7.


A Genetic Score Associates With Pioglitazone Response in Patients With Non-alcoholic Steatohepatitis.

Kawaguchi-Suzuki M, Cusi K, Bril F, Gong Y, Langaee T, Frye RF.

Front Pharmacol. 2018 Jul 17;9:752. doi: 10.3389/fphar.2018.00752. eCollection 2018.


Pioglitazone improves hepatic mitochondrial function in a mouse model of nonalcoholic steatohepatitis.

Kalavalapalli S, Bril F, Koelmel JP, Abdo K, Guingab J, Andrews P, Li WY, Jose D, Yost RA, Frye RF, Garrett TJ, Cusi K, Sunny NE.

Am J Physiol Endocrinol Metab. 2018 Aug 1;315(2):E163-E173. doi: 10.1152/ajpendo.00023.2018. Epub 2018 Apr 10.


Metabolomic association between venous thromboembolism in critically ill trauma patients and kynurenine pathway of tryptophan metabolism.

Voils SA, Shahin MH, Garrett TJ, Frye RF.

Thromb Res. 2018 May;165:6-13. doi: 10.1016/j.thromres.2018.03.003. Epub 2018 Mar 8.


Sphingolipid Metabolic Pathway Impacts Thiazide Diuretics Blood Pressure Response: Insights From Genomics, Metabolomics, and Lipidomics.

Shahin MH, Gong Y, Frye RF, Rotroff DM, Beitelshees AL, Baillie RA, Chapman AB, Gums JG, Turner ST, Boerwinkle E, Motsinger-Reif A, Fiehn O, Cooper-DeHoff RM, Han X, Kaddurah-Daouk R, Johnson JA.

J Am Heart Assoc. 2017 Dec 29;7(1). pii: e006656. doi: 10.1161/JAHA.117.006656.


Relative Bioavailability of Silybin A and Silybin B From 2 Multiconstituent Dietary Supplement Formulations Containing Milk Thistle Extract: A Single-dose Study.

Li WY, Yu G, Hogan RM, Mohandas R, Frye RF, Gumpricht E, Markowitz JS.

Clin Ther. 2018 Jan;40(1):103-113.e1. doi: 10.1016/j.clinthera.2017.11.013. Epub 2017 Dec 19.


Concentration-dependent response to pioglitazone in nonalcoholic steatohepatitis.

Kawaguchi-Suzuki M, Bril F, Kalavalapalli S, Cusi K, Frye RF.

Aliment Pharmacol Ther. 2017 Jul;46(1):56-61. doi: 10.1111/apt.14111. Epub 2017 May 3.


The effect of milk thistle (Silybum marianum) and its main flavonolignans on CYP2C8 enzyme activity in human liver microsomes.

Albassam AA, Frye RF, Markowitz JS.

Chem Biol Interact. 2017 Jun 1;271:24-29. doi: 10.1016/j.cbi.2017.04.025. Epub 2017 Apr 27.


Presence of arachidonoyl-carnitine is associated with adverse cardiometabolic responses in hypertensive patients treated with atenolol.

Weng L, Gong Y, Culver J, Gardell SJ, Petucci C, Morse AM, Frye RF, Turner ST, Chapman A, Boerwinkle E, Gums J, Beitelshees AL, Borum PR, Johnson JA, Garrett TJ, McIntyre LM, Cooper-DeHoff RM.

Metabolomics. 2016 Oct;12(10). pii: 160. doi: 10.1007/s11306-016-1098-2. Epub 2016 Sep 15.


Novel plasma biomarker of atenolol-induced hyperglycemia identified through a metabolomics-genomics integrative approach.

de Oliveira FA, Shahin MH, Gong Y, McDonough CW, Beitelshees AL, Gums JG, Chapman AB, Boerwinkle E, Turner ST, Frye RF, Fiehn O, Kaddurah-Daouk R, Johnson JA, Cooper-DeHoff RM.

Metabolomics. 2016 Aug;12(8). pii: 129. doi: 10.1007/s11306-016-1076-8. Epub 2016 Jul 13.


Pharmacogenomics competencies in pharmacy practice: A blueprint for change.

Roederer MW, Kuo GM, Kisor DF, Frye RF, Hoffman JM, Jenkins J, Weitzel KW.

J Am Pharm Assoc (2003). 2017 Jan - Feb;57(1):120-125. doi: 10.1016/j.japh.2016.08.014. Epub 2016 Nov 3.


Effect of Low-Furanocoumarin Hybrid Grapefruit Juice Consumption on Midazolam Pharmacokinetics.

Kawaguchi-Suzuki M, Nasiri-Kenari N, Shuster J, Gmitter FG Jr, Cancalon P, de Oliveria F, Kight J, Handberg EM, Pepine CJ, Frye RF, Cooper-DeHoff RM.

J Clin Pharmacol. 2017 Mar;57(3):305-311. doi: 10.1002/jcph.807. Epub 2016 Sep 6.


A Genetic Response Score for Hydrochlorothiazide Use: Insights From Genomics and Metabolomics Integration.

Shahin MH, Gong Y, McDonough CW, Rotroff DM, Beitelshees AL, Garrett TJ, Gums JG, Motsinger-Reif A, Chapman AB, Turner ST, Boerwinkle E, Frye RF, Fiehn O, Cooper-DeHoff RM, Kaddurah-Daouk R, Johnson JA.

Hypertension. 2016 Sep;68(3):621-9. doi: 10.1161/HYPERTENSIONAHA.116.07328. Epub 2016 Jul 5.


Pharmacometabolomic Assessments of Atenolol and Hydrochlorothiazide Treatment Reveal Novel Drug Response Phenotypes.

Rotroff DM, Shahin MH, Gurley SB, Zhu H, Motsinger-Reif A, Meisner M, Beitelshees AL, Fiehn O, Johnson JA, Elbadawi-Sidhu M, Frye RF, Gong Y, Weng L, Cooper-DeHoff RM, Kaddurah-Daouk R.

CPT Pharmacometrics Syst Pharmacol. 2015 Nov;4(11):669-79. doi: 10.1002/psp4.12017. Epub 2015 Oct 29.


Enzyme- and transporter-mediated beverage-drug interactions: An update on fruit juices and green tea.

An G, Mukker JK, Derendorf H, Frye RF.

J Clin Pharmacol. 2015 Dec;55(12):1313-31. doi: 10.1002/jcph.563. Epub 2015 Jul 30. Review.


Association of branched and aromatic amino acids levels with metabolic syndrome and impaired fasting glucose in hypertensive patients.

Weng L, Quinlivan E, Gong Y, Beitelshees AL, Shahin MH, Turner ST, Chapman AB, Gums JG, Johnson JA, Frye RF, Garrett TJ, Cooper-DeHoff RM.

Metab Syndr Relat Disord. 2015 Jun;13(5):195-202. doi: 10.1089/met.2014.0132. Epub 2015 Feb 9.


Inhibitory effect of six herbal extracts on CYP2C8 enzyme activity in human liver microsomes.

Albassam AA, Mohamed ME, Frye RF.

Xenobiotica. 2015 May;45(5):406-12. doi: 10.3109/00498254.2014.989935. Epub 2014 Nov 28.


A validated liquid chromatography tandem mass spectrometry method for simultaneous determination of pioglitazone, hydroxypioglitazone, and ketopioglitazone in human plasma and its application to a clinical study.

Kawaguchi-Suzuki M, Bril F, Sanchez PP, Cusi K, Frye RF.

J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Oct 15;969:219-23. doi: 10.1016/j.jchromb.2014.08.019. Epub 2014 Aug 21.


The effects of milk thistle (Silybum marianum) on human cytochrome P450 activity.

Kawaguchi-Suzuki M, Frye RF, Zhu HJ, Brinda BJ, Chavin KD, Bernstein HJ, Markowitz JS.

Drug Metab Dispos. 2014 Oct;42(10):1611-6. doi: 10.1124/dmd.114.057232. Epub 2014 Jul 15.


Is diabetes mellitus-linked amino acid signature associated with β-blocker-induced impaired fasting glucose?

Cooper-Dehoff RM, Hou W, Weng L, Baillie RA, Beitelshees AL, Gong Y, Shahin MH, Turner ST, Chapman A, Gums JG, Boyle SH, Zhu H, Wikoff WR, Boerwinkle E, Fiehn O, Frye RF, Kaddurah-Daouk R, Johnson JA.

Circ Cardiovasc Genet. 2014 Apr;7(2):199-205. doi: 10.1161/CIRCGENETICS.113.000421. Epub 2014 Mar 13.


Current clinical evidence on pioglitazone pharmacogenomics.

Kawaguchi-Suzuki M, Frye RF.

Front Pharmacol. 2013 Nov 26;4:147. doi: 10.3389/fphar.2013.00147. eCollection 2013.


The role of pharmacogenetics in the treatment of chronic hepatitis C infection.

Kawaguchi-Suzuki M, Frye RF.

Pharmacotherapy. 2014 Feb;34(2):185-201. doi: 10.1002/phar.1349. Epub 2013 Sep 30. Review.


In vivo alterations in drug metabolism and transport pathways in patients with chronic kidney diseases.

Joy MS, Frye RF, Nolin TD, Roberts BV, La MK, Wang J, Brouwer KL, Dooley MA, Falk RJ.

Pharmacotherapy. 2014 Feb;34(2):114-22. doi: 10.1002/phar.1347. Epub 2013 Sep 6.


Pharmacokinetic properties of pure xanthones in comparison to a mangosteen fruit extract in rats.

Li L, Han AR, Kinghorn AD, Frye RF, Derendorf H, Butterweck V.

Planta Med. 2013 May;79(8):646-53. doi: 10.1055/s-0032-1328543. Epub 2013 May 14.


Pharmacometabolomics reveals racial differences in response to atenolol treatment.

Wikoff WR, Frye RF, Zhu H, Gong Y, Boyle S, Churchill E, Cooper-Dehoff RM, Beitelshees AL, Chapman AB, Fiehn O, Johnson JA, Kaddurah-Daouk R; Pharmacometabolomics Research Network.

PLoS One. 2013;8(3):e57639. doi: 10.1371/journal.pone.0057639. Epub 2013 Mar 11.


A Preliminary Study on the Effects of Self-Reported Dietary Caffeine on Pain Experience and Postoperative Analgesia.

Karunathilake NP, Frye RF, Stavropoulos MF, Herman MA, Hastie BA.

J Caffeine Res. 2012 Dec;2(4):159-166.


Cyclophosphamide and 4-hydroxycyclophosphamide pharmacokinetics in patients with glomerulonephritis secondary to lupus and small vessel vasculitis.

Joy MS, La M, Wang J, Bridges AS, Hu Y, Hogan SL, Frye RF, Blaisdell J, Goldstein JA, Dooley MA, Brouwer KL, Falk RJ.

Br J Clin Pharmacol. 2012 Sep;74(3):445-55. doi: 10.1111/j.1365-2125.2012.04223.x.


Effects of high-fructose corn syrup and sucrose on the pharmacokinetics of fructose and acute metabolic and hemodynamic responses in healthy subjects.

Le MT, Frye RF, Rivard CJ, Cheng J, McFann KK, Segal MS, Johnson RJ, Johnson JA.

Metabolism. 2012 May;61(5):641-51. doi: 10.1016/j.metabol.2011.09.013. Epub 2011 Dec 5.


Effect of cytochrome P450 3A5 genotype on atorvastatin pharmacokinetics and its interaction with clarithromycin.

Shin J, Pauly DF, Pacanowski MA, Langaee T, Frye RF, Johnson JA.

Pharmacotherapy. 2011 Oct;31(10):942-50. doi: 10.1592/phco.31.10.942.


Inhibitory effects of commonly used herbal extracts on UDP-glucuronosyltransferase 1A4, 1A6, and 1A9 enzyme activities.

Mohamed ME, Frye RF.

Drug Metab Dispos. 2011 Sep;39(9):1522-8. doi: 10.1124/dmd.111.039602. Epub 2011 Jun 1.


Absolute/relative bioavailability and metabolism of dodeca-2E,4E,8Z,10E/Z-tetraenoic acid isobutylamides (tetraenes) after intravenous and oral single doses to rats.

Ardjomand-Woelkart K, Kollroser M, Magnes C, Sinner F, Frye RF, Derendorf H, Bauer R, Butterweck V.

Planta Med. 2011 Nov;77(16):1794-9. doi: 10.1055/s-0030-1271120. Epub 2011 May 20.


Interaction of sorafenib and cytochrome P450 isoenzymes in patients with advanced melanoma: a phase I/II pharmacokinetic interaction study.

Flaherty KT, Lathia C, Frye RF, Schuchter L, Redlinger M, Rosen M, O'Dwyer PJ.

Cancer Chemother Pharmacol. 2011 Nov;68(5):1111-8. doi: 10.1007/s00280-011-1585-0. Epub 2011 Feb 25.


Effects of herbal supplements on drug glucuronidation. Review of clinical, animal, and in vitro studies.

Mohamed ME, Frye RF.

Planta Med. 2011 Mar;77(4):311-21. doi: 10.1055/s-0030-1250457. Epub 2010 Nov 3. Review.


Nicotine as a factor in stress responsiveness among detoxified alcoholics.

Gilbertson R, Frye RF, Nixon SJ.

Alcohol Alcohol. 2011 Jan-Feb;46(1):39-51. doi: 10.1093/alcalc/agq070. Epub 2010 Nov 2.


Atenolol exposure and risk for development of adverse metabolic effects: a pilot study.

Navare HA, Frye RF, Cooper-Dehoff RM, Shuster JJ, Hall K, Schmidt SO, Turner ST, Johnson JA.

Pharmacotherapy. 2010 Sep;30(9):872-8. doi: 10.1592/phco.30.9.872.


Inhibitory effects of commonly used herbal extracts on UGT1A1 enzyme activity.

Mohamed MF, Tseng T, Frye RF.

Xenobiotica. 2010 Oct;40(10):663-9. doi: 10.3109/00498254.2010.505669.


Use of enantiomeric bupropion and hydroxybupropion to assess CYP2B6 activity in glomerular kidney diseases.

Joy MS, Frye RF, Stubbert K, Brouwer KR, Falk RJ, Kharasch ED.

J Clin Pharmacol. 2010 Jun;50(6):714-20. doi: 10.1177/0091270009353031. Epub 2010 Jan 26. No abstract available.


Validation and application of a liquid chromatography-tandem mass spectrometric method for quantification of the drug transport probe fexofenadine in human plasma using 96-well filter plates.

Stanton ML, Joy MS, Frye RF.

J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Feb 1;878(3-4):497-501. doi: 10.1016/j.jchromb.2009.12.022. Epub 2009 Dec 24.


Inhibition of intestinal and hepatic glucuronidation of mycophenolic acid by Ginkgo biloba extract and flavonoids.

Mohamed MF, Frye RF.

Drug Metab Dispos. 2010 Feb;38(2):270-5. doi: 10.1124/dmd.109.030080. Epub 2009 Nov 4.


ESRD impairs nonrenal clearance of fexofenadine but not midazolam.

Nolin TD, Frye RF, Le P, Sadr H, Naud J, Leblond FA, Pichette V, Himmelfarb J.

J Am Soc Nephrol. 2009 Oct;20(10):2269-76. doi: 10.1681/ASN.2009010082. Epub 2009 Aug 20.


Plasma Coenzyme Q10 Predicts Lipid-lowering Response to High-Dose Atorvastatin.

Pacanowski MA, Frye RF, Enogieru O, Schofield RS, Zineh I.

J Clin Lipidol. 2008 Aug;2(4):289-97. doi: 10.1016/j.jacl.2008.05.001.


A sensitive and specific liquid chromatography-tandem mass spectrometry method for the determination of intracellular and extracellular uric acid.

Kim KM, Henderson GN, Ouyang X, Frye RF, Sautin YY, Feig DI, Johnson RJ.

J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Jul 15;877(22):2032-8. doi: 10.1016/j.jchromb.2009.05.037. Epub 2009 May 27.


Early atorvastatin reduces hemorrhage after acute cerebral ischemia in diabetic rats.

Elewa HF, Kozak A, El-Remessy AB, Frye RF, Johnson MH, Ergul A, Fagan SC.

J Pharmacol Exp Ther. 2009 Aug;330(2):532-40. doi: 10.1124/jpet.108.146951. Epub 2009 May 28.


Pharmacokinetics and tissue distribution of dodeca-2E,4E,8E,10E/Z-tetraenoic acid isobutylamides after oral administration in rats.

Woelkart K, Frye RF, Derendorf H, Bauer R, Butterweck V.

Planta Med. 2009 Oct;75(12):1306-13. doi: 10.1055/s-0029-1185631. Epub 2009 Apr 27.


Effect of the acute phase response induced by endotoxin administration on the expression and activity of UGT isoforms in rats.

Alkharfy KM, Poloyac SM, Congiu M, Desmond PV, Frye RF.

Drug Metab Lett. 2008 Dec;2(4):248-55.


Determination of visnagin in rat plasma by liquid chromatography with tandem mass spectrometry and its application to in vivo pharmacokinetic studies.

Vanachayangkul P, Butterweck V, Frye RF.

J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Mar 1;877(7):653-6. doi: 10.1016/j.jchromb.2009.01.014. Epub 2009 Jan 21.


Simultaneous determination of uric acid metabolites allantoin, 6-aminouracil, and triuret in human urine using liquid chromatography-mass spectrometry.

Kim KM, Henderson GN, Frye RF, Galloway CD, Brown NJ, Segal MS, Imaram W, Angerhofer A, Johnson RJ.

J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Jan 1;877(1-2):65-70. doi: 10.1016/j.jchromb.2008.11.029. Epub 2008 Nov 25.


Interpopulation variation frequency of human inosine 5'-monophosphate dehydrogenase type II (IMPDH2) genetic polymorphisms.

Mohamed MF, Frye RF, Langaee TY.

Genet Test. 2008 Dec;12(4):513-6. doi: 10.1089/gte.2008.0049.


Simplified method for determination of clarithromycin in human plasma using protein precipitation in a 96-well format and liquid chromatography-tandem mass spectrometry.

Shin J, Pauly DF, Johnson JA, Frye RF.

J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Aug 1;871(1):130-4. doi: 10.1016/j.jchromb.2008.06.050. Epub 2008 Jul 5.


Determination of mycophenolic acid glucuronide in microsomal incubations using high performance liquid chromatography-tandem mass spectrometry.

Mohamed MF, Harvey SS, Frye RF.

J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Jul 15;870(2):251-4. doi: 10.1016/j.jchromb.2008.06.020. Epub 2008 Jun 20.


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