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Items: 1 to 50 of 144

1.

Nascent Polypeptide Domain Topology and Elongation Rate Direct the Cotranslational Hierarchy of Hsp70 and TRiC/CCT.

Stein KC, Kriel A, Frydman J.

Mol Cell. 2019 Sep 19;75(6):1117-1130.e5. doi: 10.1016/j.molcel.2019.06.036. Epub 2019 Aug 7.

PMID:
31400849
2.

Dosage compensation plans: protein aggregation provides additional insurance against aneuploidy.

Samant RS, Masto VB, Frydman J.

Genes Dev. 2019 Aug 1;33(15-16):1027-1030. doi: 10.1101/gad.329383.119. Review.

PMID:
31371460
3.

A Descriptive Analysis of an Ambulatory Kidney Palliative Care Program.

Scherer JS, Harwood K, Frydman JL, Moriyama D, Brody AA, Modersitzki F, Blaum CS, Chodosh J.

J Palliat Med. 2019 Jul 11. doi: 10.1089/jpm.2018.0647. [Epub ahead of print]

PMID:
31295050
4.

Dual Role of Ribosome-Binding Domain of NAC as a Potent Suppressor of Protein Aggregation and Aging-Related Proteinopathies.

Shen K, Gamerdinger M, Chan R, Gense K, Martin EM, Sachs N, Knight PD, Schlömer R, Calabrese AN, Stewart KL, Leiendecker L, Baghel A, Radford SE, Frydman J, Deuerling E.

Mol Cell. 2019 May 16;74(4):729-741.e7. doi: 10.1016/j.molcel.2019.03.012. Epub 2019 Apr 11.

5.

The ATP-powered gymnastics of TRiC/CCT: an asymmetric protein folding machine with a symmetric origin story.

Gestaut D, Limatola A, Joachimiak L, Frydman J.

Curr Opin Struct Biol. 2019 Apr;55:50-58. doi: 10.1016/j.sbi.2019.03.002. Epub 2019 Apr 9. Review.

PMID:
30978594
6.

The Chaperonin TRiC/CCT Associates with Prefoldin through a Conserved Electrostatic Interface Essential for Cellular Proteostasis.

Gestaut D, Roh SH, Ma B, Pintilie G, Joachimiak LA, Leitner A, Walzthoeni T, Aebersold R, Chiu W, Frydman J.

Cell. 2019 Apr 18;177(3):751-765.e15. doi: 10.1016/j.cell.2019.03.012. Epub 2019 Apr 4.

PMID:
30955883
7.

Methods for measuring misfolded protein clearance in the budding yeast Saccharomyces cerevisiae.

Samant RS, Frydman J.

Methods Enzymol. 2019;619:27-45. doi: 10.1016/bs.mie.2018.12.039. Epub 2019 Feb 8.

PMID:
30910025
8.

Proteostasis in Viral Infection: Unfolding the Complex Virus-Chaperone Interplay.

Aviner R, Frydman J.

Cold Spring Harb Perspect Biol. 2019 Mar 11. pii: a034090. doi: 10.1101/cshperspect.a034090. [Epub ahead of print]

PMID:
30858229
9.

Zika Virus Dependence on Host Hsp70 Provides a Protective Strategy against Infection and Disease.

Taguwa S, Yeh MT, Rainbolt TK, Nayak A, Shao H, Gestwicki JE, Andino R, Frydman J.

Cell Rep. 2019 Jan 22;26(4):906-920.e3. doi: 10.1016/j.celrep.2018.12.095.

10.

The stop-and-go traffic regulating protein biogenesis: How translation kinetics controls proteostasis.

Stein KC, Frydman J.

J Biol Chem. 2019 Feb 8;294(6):2076-2084. doi: 10.1074/jbc.REV118.002814. Epub 2018 Nov 30. Review.

11.

Distinct proteostasis circuits cooperate in nuclear and cytoplasmic protein quality control.

Samant RS, Livingston CM, Sontag EM, Frydman J.

Nature. 2018 Nov;563(7731):407-411. doi: 10.1038/s41586-018-0678-x. Epub 2018 Oct 31.

12.

A Viral Protein Restricts Drosophila RNAi Immunity by Regulating Argonaute Activity and Stability.

Nayak A, Kim DY, Trnka MJ, Kerr CH, Lidsky PV, Stanley DJ, Rivera BM, Li KH, Burlingame AL, Jan E, Frydman J, Gross JD, Andino R.

Cell Host Microbe. 2018 Oct 10;24(4):542-557.e9. doi: 10.1016/j.chom.2018.09.006.

13.

Post-extubation non-invasive ventilation in the pediatric intensive care unit: a multicenter study.

Bonora JP, Frydman J, Retta A, Canepari A.

Arch Argent Pediatr. 2018 Oct 1;116(5):333-339. doi: 10.5546/aap.2018.eng.333. English, Spanish.

14.

Huntingtin's N-Terminus Rearrangements in the Presence of Membranes: A Joint Spectroscopic and Computational Perspective.

Levy GR, Shen K, Gavrilov Y, Smith PES, Levy Y, Chan R, Frydman J, Frydman L.

ACS Chem Neurosci. 2019 Jan 16;10(1):472-481. doi: 10.1021/acschemneuro.8b00353. Epub 2018 Sep 17.

PMID:
30149694
15.

Hsp90 shapes protein and RNA evolution to balance trade-offs between protein stability and aggregation.

Geller R, Pechmann S, Acevedo A, Andino R, Frydman J.

Nat Commun. 2018 May 3;9(1):1781. doi: 10.1038/s41467-018-04203-x.

16.

Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging.

Leeman DS, Hebestreit K, Ruetz T, Webb AE, McKay A, Pollina EA, Dulken BW, Zhao X, Yeo RW, Ho TT, Mahmoudi S, Devarajan K, Passegué E, Rando TA, Frydman J, Brunet A.

Science. 2018 Mar 16;359(6381):1277-1283. doi: 10.1126/science.aag3048. Epub 2018 Mar 15.

17.

Time-Resolved Measurement of the ATP-Dependent Motion of the Group II Chaperonin by Diffracted Electron Tracking.

Ogawa N, Yamamoto YY, Abe K, Sekiguchi H, Sasaki YC, Ishikawa A, Frydman J, Yohda M.

Int J Mol Sci. 2018 Mar 22;19(4). pii: E950. doi: 10.3390/ijms19040950.

18.

The TRiC chaperonin controls reovirus replication through outer-capsid folding.

Knowlton JJ, Fernández de Castro I, Ashbrook AW, Gestaut DR, Zamora PF, Bauer JA, Forrest JC, Frydman J, Risco C, Dermody TS.

Nat Microbiol. 2018 Apr;3(4):481-493. doi: 10.1038/s41564-018-0122-x. Epub 2018 Mar 12.

19.

An information theoretic framework reveals a tunable allosteric network in group II chaperonins.

Lopez T, Dalton K, Tomlinson A, Pande V, Frydman J.

Nat Struct Mol Biol. 2017 Sep;24(9):726-733. doi: 10.1038/nsmb.3440. Epub 2017 Jul 24.

20.

Mechanisms and Functions of Spatial Protein Quality Control.

Sontag EM, Samant RS, Frydman J.

Annu Rev Biochem. 2017 Jun 20;86:97-122. doi: 10.1146/annurev-biochem-060815-014616. Epub 2017 May 10. Review.

PMID:
28489421
21.

Protein misfolding in neurodegenerative diseases: implications and strategies.

Sweeney P, Park H, Baumann M, Dunlop J, Frydman J, Kopito R, McCampbell A, Leblanc G, Venkateswaran A, Nurmi A, Hodgson R.

Transl Neurodegener. 2017 Mar 13;6:6. doi: 10.1186/s40035-017-0077-5. eCollection 2017. Review.

22.

Mistreatment and the learning environment for medical students on general surgery clerkship rotations: What do key stakeholders think?

Castillo-Angeles M, Watkins AA, Acosta D, Frydman JL, Flier L, Garces-Descovich A, Cahalane MJ, Gangadharan SP, Atkins KM, Kent TS.

Am J Surg. 2017 Feb;213(2):307-312. doi: 10.1016/j.amjsurg.2016.10.013. Epub 2016 Nov 23.

PMID:
28131325
23.

Structure and Dynamics of the Huntingtin Exon-1 N-Terminus: A Solution NMR Perspective.

Baias M, Smith PE, Shen K, Joachimiak LA, Żerko S, Koźmiński W, Frydman J, Frydman L.

J Am Chem Soc. 2017 Jan 25;139(3):1168-1176. doi: 10.1021/jacs.6b10893. Epub 2017 Jan 13.

PMID:
28085263
24.

Multivalent contacts of the Hsp70 Ssb contribute to its architecture on ribosomes and nascent chain interaction.

Hanebuth MA, Kityk R, Fries SJ, Jain A, Kriel A, Albanese V, Frickey T, Peter C, Mayer MP, Frydman J, Deuerling E.

Nat Commun. 2016 Dec 5;7:13695. doi: 10.1038/ncomms13695.

25.

Control of the structural landscape and neuronal proteotoxicity of mutant Huntingtin by domains flanking the polyQ tract.

Shen K, Calamini B, Fauerbach JA, Ma B, Shahmoradian SH, Serrano Lachapel IL, Chiu W, Lo DC, Frydman J.

Elife. 2016 Oct 18;5. pii: e18065. doi: 10.7554/eLife.18065.

26.

Cotranslational signal-independent SRP preloading during membrane targeting.

Chartron JW, Hunt KC, Frydman J.

Nature. 2016 Aug 11;536(7615):224-8. Epub 2016 Aug 3.

27.

Surgeons' Perspectives on Avoiding Nonbeneficial Treatments in Seriously Ill Older Patients with Surgical Emergencies: A Qualitative Study.

Cauley CE, Block SD, Koritsanszky LA, Gass JD, Frydman JL, Nurudeen SM, Bernacki RE, Cooper Z.

J Palliat Med. 2016 May;19(5):529-37. doi: 10.1089/jpm.2015.0450. Epub 2016 Apr 22.

28.

Recommendations for Best Communication Practices to Facilitate Goal-concordant Care for Seriously Ill Older Patients With Emergency Surgical Conditions.

Cooper Z, Koritsanszky LA, Cauley CE, Frydman JL, Bernacki RE, Mosenthal AC, Gawande AA, Block SD.

Ann Surg. 2016 Jan;263(1):1-6. doi: 10.1097/SLA.0000000000001491.

PMID:
26649587
29.

Defining Hsp70 Subnetworks in Dengue Virus Replication Reveals Key Vulnerability in Flavivirus Infection.

Taguwa S, Maringer K, Li X, Bernal-Rubio D, Rauch JN, Gestwicki JE, Andino R, Fernandez-Sesma A, Frydman J.

Cell. 2015 Nov 19;163(5):1108-1123. doi: 10.1016/j.cell.2015.10.046. Epub 2015 Nov 12.

30.

xTract: software for characterizing conformational changes of protein complexes by quantitative cross-linking mass spectrometry.

Walzthoeni T, Joachimiak LA, Rosenberger G, Röst HL, Malmström L, Leitner A, Frydman J, Aebersold R.

Nat Methods. 2015 Dec;12(12):1185-90. doi: 10.1038/nmeth.3631. Epub 2015 Oct 26.

31.

Delayed emergence of subdiffraction-sized mutant huntingtin fibrils following inclusion body formation.

Sahl SJ, Lau L, Vonk WI, Weiss LE, Frydman J, Moerner WE.

Q Rev Biophys. 2016 Jan;49:e2. Epub 2015 Sep 9.

32.

The Mechanism and Function of Group II Chaperonins.

Lopez T, Dalton K, Frydman J.

J Mol Biol. 2015 Sep 11;427(18):2919-30. doi: 10.1016/j.jmb.2015.04.013. Epub 2015 Apr 30. Review.

33.

The dynamic conformational cycle of the group I chaperonin C-termini revealed via molecular dynamics simulation.

Dalton KM, Frydman J, Pande VS.

PLoS One. 2015 Mar 30;10(3):e0117724. doi: 10.1371/journal.pone.0117724. eCollection 2015.

34.

The significance of Hsp70 subnetwork for Dengue virus lifecycle.

Taguwa S, Frydman J.

Uirusu. 2015;65(2):179-186. Review. Japanese.

35.

Parkinson's disease genes VPS35 and EIF4G1 interact genetically and converge on α-synuclein.

Dhungel N, Eleuteri S, Li LB, Kramer NJ, Chartron JW, Spencer B, Kosberg K, Fields JA, Stafa K, Adame A, Lashuel H, Frydman J, Shen K, Masliah E, Gitler AD.

Neuron. 2015 Jan 7;85(1):76-87. doi: 10.1016/j.neuron.2014.11.027. Epub 2014 Dec 18. Erratum in: Neuron. 2015 Feb 4;85(3):657.

36.

IgG4-related disease manifesting as an acute gastric-pericardial fistula.

Frydman J, Grunner S, Kluger Y.

World J Gastroenterol. 2014 Nov 28;20(44):16782-5. doi: 10.3748/wjg.v20.i44.16782.

37.

Proteostatic control of telomerase function through TRiC-mediated folding of TCAB1.

Freund A, Zhong FL, Venteicher AS, Meng Z, Veenstra TD, Frydman J, Artandi SE.

Cell. 2014 Dec 4;159(6):1389-403. doi: 10.1016/j.cell.2014.10.059. Epub 2014 Nov 20.

38.

A direct regulatory interaction between chaperonin TRiC and stress-responsive transcription factor HSF1.

Neef DW, Jaeger AM, Gomez-Pastor R, Willmund F, Frydman J, Thiele DJ.

Cell Rep. 2014 Nov 6;9(3):955-66. doi: 10.1016/j.celrep.2014.09.056. Epub 2014 Oct 30.

39.

Local slowdown of translation by nonoptimal codons promotes nascent-chain recognition by SRP in vivo.

Pechmann S, Chartron JW, Frydman J.

Nat Struct Mol Biol. 2014 Dec;21(12):1100-5. doi: 10.1038/nsmb.2919. Epub 2014 Nov 24.

40.

The structural basis of substrate recognition by the eukaryotic chaperonin TRiC/CCT.

Joachimiak LA, Walzthoeni T, Liu CW, Aebersold R, Frydman J.

Cell. 2014 Nov 20;159(5):1042-1055. doi: 10.1016/j.cell.2014.10.042.

41.

Super-resolution fluorescence of huntingtin reveals growth of globular species into short fibers and coexistence of distinct aggregates.

Duim WC, Jiang Y, Shen K, Frydman J, Moerner WE.

ACS Chem Biol. 2014 Dec 19;9(12):2767-78. doi: 10.1021/cb500335w. Epub 2014 Oct 20.

42.

Interplay between chaperones and protein disorder promotes the evolution of protein networks.

Pechmann S, Frydman J.

PLoS Comput Biol. 2014 Jun 26;10(6):e1003674. doi: 10.1371/journal.pcbi.1003674. eCollection 2014 Jun.

43.

Chemical cross-linking/mass spectrometry targeting acidic residues in proteins and protein complexes.

Leitner A, Joachimiak LA, Unverdorben P, Walzthoeni T, Frydman J, Förster F, Aebersold R.

Proc Natl Acad Sci U S A. 2014 Jul 1;111(26):9455-60. doi: 10.1073/pnas.1320298111. Epub 2014 Jun 17.

44.

Modulation of STAT3 folding and function by TRiC/CCT chaperonin.

Kasembeli M, Lau WC, Roh SH, Eckols TK, Frydman J, Chiu W, Tweardy DJ.

PLoS Biol. 2014 Apr 22;12(4):e1001844. doi: 10.1371/journal.pbio.1001844. eCollection 2014 Apr.

45.

Methylene Blue injection via superior mesenteric artery microcatheter for focused enterectomy in the treatment of a bleeding small intestinal arteriovenous malformation.

Frydman J, Bahouth H, Leiderman M, Ofer A, Kluger Y.

World J Emerg Surg. 2014 Feb 19;9(1):17. doi: 10.1186/1749-7922-9-17.

46.

Sorting out the trash: the spatial nature of eukaryotic protein quality control.

Sontag EM, Vonk WIM, Frydman J.

Curr Opin Cell Biol. 2014 Feb;26:139-146. doi: 10.1016/j.ceb.2013.12.006. Epub 2014 Jan 23. Review.

47.

Total ileocolic intussusception with rectal prolapse presenting in an adult: a case report and review of the literature.

Frydman J, Ben-Ishay O, Kluger Y.

World J Emerg Surg. 2013 Sep 23;8(1):37. doi: 10.1186/1749-7922-8-37.

48.

Spatial sequestration of misfolded proteins by a dynamic chaperone pathway enhances cellular fitness during stress.

Escusa-Toret S, Vonk WI, Frydman J.

Nat Cell Biol. 2013 Oct;15(10):1231-43. doi: 10.1038/ncb2838. Epub 2013 Sep 15.

49.

TRiC's tricks inhibit huntingtin aggregation.

Shahmoradian SH, Galaz-Montoya JG, Schmid MF, Cong Y, Ma B, Spiess C, Frydman J, Ludtke SJ, Chiu W.

Elife. 2013 Jul 9;2:e00710. doi: 10.7554/eLife.00710.

50.

Principles of cotranslational ubiquitination and quality control at the ribosome.

Duttler S, Pechmann S, Frydman J.

Mol Cell. 2013 May 9;50(3):379-93. doi: 10.1016/j.molcel.2013.03.010. Epub 2013 Apr 11.

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