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Understanding the Early Biological Effects of Isoprene-Derived Particulate Matter Enhanced by Anthropogenic Pollutants.

Surratt JD, Lin YH, Arashiro M, Vizuete WG, Zhang Z, Gold A, Jaspers I, Fry RC.

Res Rep Health Eff Inst. 2019 Mar;(198):1-54.


Isoprene-Derived Secondary Organic Aerosol Induces the Expression of MicroRNAs Associated with Inflammatory/Oxidative Stress Response in Lung Cells.

Eaves LA, Smeester L, Hartwell HJ, Lin YH, Arashiro M, Zhang Z, Gold A, Surratt JD, Fry RC.

Chem Res Toxicol. 2019 Dec 13. doi: 10.1021/acs.chemrestox.9b00322. [Epub ahead of print]


Use of Genome Editing Tools in Environmental Health Research.

Rager JE, Carberry C, Fry RC.

Curr Opin Toxicol. 2019 Dec;18:13-17. doi: 10.1016/j.cotox.2019.02.007. Epub 2019 Mar 2.


Neurocognitive and social-communicative function of children born very preterm at 10 years of age: Associations with microorganisms recovered from the placenta parenchyma.

Tomlinson MS, Santos HP, Stewart JR, Joseph R, Leviton A, Onderdonk AB, Kuban KCK, Heeren T, O'Shea TM, Fry RC; ELGAN Study Investigators.

J Perinatol. 2019 Oct 17. doi: 10.1038/s41372-019-0505-8. [Epub ahead of print]


Targeting epigenetic nuclear reprogramming in aggregated cloned equine embryos.

Damasceno Teixeira TV, Fry RC, McKinnon A, Fry KL, Kelly JM, Verma PJ, Burden C, Salamone DF, Gambini A.

Reprod Fertil Dev. 2019 Oct 4. doi: 10.1071/RD19239. [Epub ahead of print]


Understanding positive child health.

Bangma JT, Kwiatkowski E, Psioda M, Santos HP Jr, Hooper SR, Douglass L, Joseph RM, Frazier JA, Kuban KCK, O'Shea TM, Fry RC; ELGAN Investigators.

Pediatr Res. 2019 Dec;86(6):690-691. doi: 10.1038/s41390-019-0564-8. Epub 2019 Sep 14. No abstract available.


Assessment of inorganic contamination of private wells and demonstration of effective filter-based reduction: A pilot-study in Stokes County, North Carolina.

Tomlinson MS, Bommarito P, George A, Yelton S, Cable P, Coyte R, Karr J, Vengosh A, Gray KM, Fry RC.

Environ Res. 2019 Oct;177:108618. doi: 10.1016/j.envres.2019.108618. Epub 2019 Aug 2.


Acetaminophen use during pregnancy and DNA methylation in the placenta of the extremely low gestational age newborn (ELGAN) cohort.

Addo KA, Bulka C, Dhingra R, Santos HP Jr, Smeester L, O'Shea TM, Fry RC.

Environ Epigenet. 2019 Aug 6;5(2):dvz010. doi: 10.1093/eep/dvz010. eCollection 2019 Apr.


Urinary trace metals, maternal circulating angiogenic biomarkers, and preeclampsia: a single-contaminant and mixture-based approach.

Bommarito PA, Kim SS, Meeker JD, Fry RC, Cantonwine DE, McElrath TF, Ferguson KK.

Environ Health. 2019 Jul 12;18(1):63. doi: 10.1186/s12940-019-0503-5.


Placental CpG Methylation of Inflammation, Angiogenic, and Neurotrophic Genes and Retinopathy of Prematurity.

Bulka CM, Dammann O, Santos HP Jr, VanderVeen DK, Smeester L, Fichorova R, O'Shea TM, Fry RC.

Invest Ophthalmol Vis Sci. 2019 Jul 1;60(8):2888-2894. doi: 10.1167/iovs.18-26466.


Effects of Preconception and in Utero Inorganic Arsenic Exposure on the Metabolic Phenotype of Genetically Diverse Collaborative Cross Mice.

Fry RC, Addo KA, Bell TA, Douillet C, Martin E, Stýblo M, Pardo-Manuel de Villena F.

Chem Res Toxicol. 2019 Aug 19;32(8):1487-1490. doi: 10.1021/acs.chemrestox.9b00107. Epub 2019 Jul 8.


Predictors of toxic metal exposures among US women of reproductive age.

Bulka CM, Bommarito PA, Fry RC.

J Expo Sci Environ Epidemiol. 2019 Sep;29(5):597-612. doi: 10.1038/s41370-019-0152-3. Epub 2019 Jun 24.


Developing novel in vitro methods for the risk assessment of developmental and placental toxicants in the environment.

Fry RC, Bangma J, Szilagyi J, Rager JE.

Toxicol Appl Pharmacol. 2019 Sep 1;378:114635. doi: 10.1016/j.taap.2019.114635. Epub 2019 Jun 22.


Associations between placental CpG methylation of metastable epialleles and childhood body mass index across ages one, two and ten in the Extremely Low Gestational Age Newborns (ELGAN) cohort.

Clark J, Martin E, Bulka CM, Smeester L, Santos HP, O'Shea TM, Fry RC.

Epigenetics. 2019 Nov;14(11):1102-1111. doi: 10.1080/15592294.2019.1633865. Epub 2019 Jul 2.


Correction to: Maternal one carbon metabolism and arsenic methylation in a pregnancy cohort in Mexico.

Laine JE, Ilievski V, Richardson DB, Herring AH, Stýblo M, Rubio-Andrade M, Garcia-Vargas G, Gamble MV, Fry RC.

J Expo Sci Environ Epidemiol. 2019 Sep;29(5):732. doi: 10.1038/s41370-019-0147-0.


Epigenome-wide DNA methylation in placentas from preterm infants: association with maternal socioeconomic status.

Santos HP Jr, Bhattacharya A, Martin EM, Addo K, Psioda M, Smeester L, Joseph RM, Hooper SR, Frazier JA, Kuban KC, O'Shea TM, Fry RC.

Epigenetics. 2019 Aug;14(8):751-765. doi: 10.1080/15592294.2019.1614743. Epub 2019 May 21.


Microorganisms in the Placenta: Links to Early-Life Inflammation and Neurodevelopment in Children.

Tomlinson MS, Lu K, Stewart JR, Marsit CJ, O'Shea TM, Fry RC.

Clin Microbiol Rev. 2019 May 1;32(3). pii: e00103-18. doi: 10.1128/CMR.00103-18. Print 2019 Jun 19. Review.


Early life antecedents of positive child health among 10-year-old children born extremely preterm.

Bangma JT, Kwiatkowski E, Psioda M, Santos HP Jr, Hooper SR, Douglass L, Joseph RM, Frazier JA, Kuban KCK, O'Shea TM, Fry RC; ELGAN Investigators.

Pediatr Res. 2019 Dec;86(6):758-765. doi: 10.1038/s41390-019-0404-x. Epub 2019 Apr 20.


RNA-Sequencing of Umbilical Cord Blood to Investigate Spontaneous Preterm Birth: A Pilot Study.

Vora NL, Parker JS, Mieckowski PA, Smeester L, Fry RC, Boggess KA.

AJP Rep. 2019 Jan;9(1):e60-e66. doi: 10.1055/s-0039-1678717. Epub 2019 Mar 7.


Inorganic Arsenic as an Endocrine Disruptor: Modulation of the Glucocorticoid Receptor Pathway in Placental Cells via CpG Methylation.

Meakin CJ, Martin EM, Szilagyi JT, Nylander-French LA, Fry RC.

Chem Res Toxicol. 2019 Mar 18;32(3):493-499. doi: 10.1021/acs.chemrestox.8b00352. Epub 2019 Mar 4.


Evaluation of plasma arsenicals as potential biomarkers of exposure to inorganic arsenic.

Bommarito PA, Beck R, Douillet C, Del Razo LM, Garcia-Vargas GG, Valenzuela OL, Sanchez-Peña LC, Styblo M, Fry RC.

J Expo Sci Environ Epidemiol. 2019 Sep;29(5):718-729. doi: 10.1038/s41370-019-0121-x. Epub 2019 Feb 6.


Disinfection Byproducts Bind Human Estrogen Receptor-α.

Holmes BE, Smeester L, Fry RC, Weinberg HS.

Environ Toxicol Chem. 2019 May;38(5):956-964. doi: 10.1002/etc.4377. Epub 2019 Mar 20.


One-carbon metabolism nutrient intake and the association between body mass index and urinary arsenic metabolites in adults in the Chihuahua cohort.

Bommarito PA, Xu X, González-Horta C, Sánchez-Ramirez B, Ballinas-Casarrubias L, Luna RS, Pérez SR, Ávila JEH, García-Vargas GG, Del Razo LM, Stýblo M, Mendez MA, Fry RC.

Environ Int. 2019 Feb;123:292-300. doi: 10.1016/j.envint.2018.12.004. Epub 2018 Dec 13.


Circulating miRNAs Associated with Arsenic Exposure.

Beck R, Bommarito P, Douillet C, Kanke M, Del Razo LM, García-Vargas G, Fry RC, Sethupathy P, Stýblo M.

Environ Sci Technol. 2018 Dec 18;52(24):14487-14495. doi: 10.1021/acs.est.8b06457. Epub 2018 Dec 4.


Discrimination exposure and DNA methylation of stress-related genes in Latina mothers.

Santos HP Jr, Nephew BC, Bhattacharya A, Tan X, Smith L, Alyamani RAS, Martin EM, Perreira K, Fry RC, Murgatroyd C.

Psychoneuroendocrinology. 2018 Dec;98:131-138. doi: 10.1016/j.psyneuen.2018.08.014. Epub 2018 Aug 16.


Assessing Positive Child Health among Individuals Born Extremely Preterm.

Bangma JT, Kwiatkowski E, Psioda M, Santos HP Jr, Hooper SR, Douglass L, Joseph RM, Frazier JA, Kuban KCK, O'Shea TM, Fry RC.

J Pediatr. 2018 Nov;202:44-49.e4. doi: 10.1016/j.jpeds.2018.06.037. Epub 2018 Aug 2.


Maternal one carbon metabolism and arsenic methylation in a pregnancy cohort in Mexico.

Laine JE, Ilievski V, Richardson DB, Herring AH, Stýblo M, Rubio-Andrade M, Garcia-Vargas G, Gamble MV, Fry RC.

J Expo Sci Environ Epidemiol. 2018 Sep;28(5):505-514. doi: 10.1038/s41370-018-0041-1. Epub 2018 Aug 1. Erratum in: J Expo Sci Environ Epidemiol. 2019 Jun 6;:.


Targeted Multiplex Gene Expression Profiling to Measure High-Fat Diet and Metformin Effects on Fetal Gene Expression in a Mouse Model.

Vora NL, Grace MR, Smeester L, Dotters-Katz SK, Fry RC, Bae-Jump V, Boggess K.

Reprod Sci. 2019 May;26(5):683-689. doi: 10.1177/1933719118786453. Epub 2018 Jul 5.


Characterizing the effects of missing data and evaluating imputation methods for chemical prioritization applications using ToxPi.

To KT, Fry RC, Reif DM.

BioData Min. 2018 Jun 13;11:10. doi: 10.1186/s13040-018-0169-5. eCollection 2018.


Quality Improvement in Perinatal Medicine and Translation of Preterm Birth Research Findings into Clinical Care.

Manuck TA, Fry RC, McFarlin BL.

Clin Perinatol. 2018 Jun;45(2):155-163. doi: 10.1016/j.clp.2018.01.003. Epub 2018 Feb 23. Review.


Placental CpG methylation of infants born extremely preterm predicts cognitive impairment later in life.

Tilley SK, Martin EM, Smeester L, Joseph RM, Kuban KCK, Heeren TC, Dammann OU, O'Shea TM, Fry RC.

PLoS One. 2018 Mar 7;13(3):e0193271. doi: 10.1371/journal.pone.0193271. eCollection 2018.


Placental CpG methylation of HPA-axis genes is associated with cognitive impairment at age 10 among children born extremely preterm.

Meakin CJ, Martin EM, Santos HP Jr, Mokrova I, Kuban K, O'Shea TM, Joseph RM, Smeester L, Fry RC.

Horm Behav. 2018 May;101:29-35. doi: 10.1016/j.yhbeh.2018.02.007. Epub 2018 Mar 5. No abstract available.


Long-Term Health Effects and Underlying Biological Mechanisms of Developmental Exposure to Arsenic.

Smeester L, Fry RC.

Curr Environ Health Rep. 2018 Mar;5(1):134-144. doi: 10.1007/s40572-018-0184-1. Review.


Cadmium disrupts signaling of the hypoxia-inducible (HIF) and transforming growth factor (TGF-β) pathways in placental JEG-3 trophoblast cells via reactive oxygen species.

Adebambo OA, Shea D, Fry RC.

Toxicol Appl Pharmacol. 2018 Mar 1;342:108-115. doi: 10.1016/j.taap.2018.01.010. Epub 2018 Feb 9.


Environmental Influences on the Epigenome: Exposure- Associated DNA Methylation in Human Populations.

Martin EM, Fry RC.

Annu Rev Public Health. 2018 Apr 1;39:309-333. doi: 10.1146/annurev-publhealth-040617-014629. Epub 2018 Jan 12. Review.


Effect of secondary organic aerosol from isoprene-derived hydroxyhydroperoxides on the expression of oxidative stress response genes in human bronchial epithelial cells.

Arashiro M, Lin YH, Zhang Z, Sexton KG, Gold A, Jaspers I, Fry RC, Surratt JD.

Environ Sci Process Impacts. 2018 Feb 21;20(2):332-339. doi: 10.1039/c7em00439g.


Epigenetic Regulation of the Nitric Oxide Pathway, 17-α Hydroxyprogesterone Caproate, and Recurrent Preterm Birth.

Manuck TA, Smeester L, Martin EM, Tomlinson MS, Smith C, Varner MW, Fry RC.

Am J Perinatol. 2018 Jul;35(8):721-728. doi: 10.1055/s-0037-1613682. Epub 2017 Dec 14.


Microorganisms in the human placenta are associated with altered CpG methylation of immune and inflammation-related genes.

Tomlinson MS, Bommarito PA, Martin EM, Smeester L, Fichorova RN, Onderdonk AB, Kuban KCK, O'Shea TM, Fry RC.

PLoS One. 2017 Dec 14;12(12):e0188664. doi: 10.1371/journal.pone.0188664. eCollection 2017.


Toxic metals in amniotic fluid and altered gene expression in cell-free fetal RNA.

Smeester L, Martin EM, Cable P, Bodnar W, Boggess K, Vora NL, Fry RC.

Prenat Diagn. 2017 Dec;37(13):1364-1366. doi: 10.1002/pd.5183.


Benchmark Dose Modeling Estimates of the Concentrations of Inorganic Arsenic That Induce Changes to the Neonatal Transcriptome, Proteome, and Epigenome in a Pregnancy Cohort.

Rager JE, Auerbach SS, Chappell GA, Martin E, Thompson CM, Fry RC.

Chem Res Toxicol. 2017 Oct 16;30(10):1911-1920. doi: 10.1021/acs.chemrestox.7b00221. Epub 2017 Sep 27.


Identification of endocrine active disinfection by-products (DBPs) that bind to the androgen receptor.

Holmes BE, Smeester L, Fry RC, Weinberg HS.

Chemosphere. 2017 Nov;187:114-122. doi: 10.1016/j.chemosphere.2017.08.105. Epub 2017 Aug 22.


Fetal-sex dependent genomic responses in the circulating lymphocytes of arsenic-exposed pregnant women in New Hampshire.

Bommarito PA, Martin E, Smeester L, Palys T, Baker ER, Karagas MR, Fry RC.

Reprod Toxicol. 2017 Oct;73:184-195. doi: 10.1016/j.reprotox.2017.07.023. Epub 2017 Aug 6.


Cadmium inhibits placental trophoblast cell migration via miRNA regulation of the transforming growth factor beta (TGF-β) pathway.

Brooks SA, Fry RC.

Food Chem Toxicol. 2017 Nov;109(Pt 1):721-726. doi: 10.1016/j.fct.2017.07.059. Epub 2017 Aug 1.


Gene Expression Profiling in Human Lung Cells Exposed to Isoprene-Derived Secondary Organic Aerosol.

Lin YH, Arashiro M, Clapp PW, Cui T, Sexton KG, Vizuete W, Gold A, Jaspers I, Fry RC, Surratt JD.

Environ Sci Technol. 2017 Jul 18;51(14):8166-8175. doi: 10.1021/acs.est.7b01967. Epub 2017 Jul 5.


Genomic biomarkers of prenatal intrauterine inflammation in umbilical cord tissue predict later life neurological outcomes.

Tilley SK, Joseph RM, Kuban KCK, Dammann OU, O'Shea TM, Fry RC.

PLoS One. 2017 May 11;12(5):e0176953. doi: 10.1371/journal.pone.0176953. eCollection 2017.


High-Throughput Screening Data Interpretation in the Context of In Vivo Transcriptomic Responses to Oral Cr(VI) Exposure.

Rager JE, Ring CL, Fry RC, Suh M, Proctor DM, Haws LC, Harris MA, Thompson CM.

Toxicol Sci. 2017 Jul 1;158(1):199-212. doi: 10.1093/toxsci/kfx085.


Genetic and epigenetic mechanisms underlying arsenic-associated diabetes mellitus: a perspective of the current evidence.

Martin EM, Stýblo M, Fry RC.

Epigenomics. 2017 May;9(5):701-710. doi: 10.2217/epi-2016-0097. Epub 2017 May 4. Review.


Chronic early childhood exposure to arsenic is associated with a TNF-mediated proteomic signaling response.

Smeester L, Bommarito PA, Martin EM, Recio-Vega R, Gonzalez-Cortes T, Olivas-Calderon E, Lantz RC, Fry RC.

Environ Toxicol Pharmacol. 2017 Jun;52:183-187. doi: 10.1016/j.etap.2017.04.007. Epub 2017 Apr 8.


Effects of prenatal exposure to endocrine disruptors and toxic metals on the fetal epigenome.

Bommarito PA, Martin E, Fry RC.

Epigenomics. 2017 Mar;9(3):333-350. doi: 10.2217/epi-2016-0112. Epub 2017 Feb 17. Review.

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