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Items: 49


Structure-Based in Silico Screening Identifies a Potent Ebolavirus Inhibitor from a Traditional Chinese Medicine Library.

Shaikh F, Zhao Y, Alvarez L, Iliopoulou M, Lohans C, Schofield CJ, Padilla-Parra S, Siu SWI, Fry EE, Ren J, Stuart DI.

J Med Chem. 2019 Mar 28;62(6):2928-2937. doi: 10.1021/acs.jmedchem.8b01328. Epub 2019 Mar 6.


Unexpected mode of engagement between enterovirus 71 and its receptor SCARB2.

Zhou D, Zhao Y, Kotecha A, Fry EE, Kelly JT, Wang X, Rao Z, Rowlands DJ, Ren J, Stuart DI.

Nat Microbiol. 2019 Mar;4(3):414-419. doi: 10.1038/s41564-018-0319-z. Epub 2018 Dec 10.


Seneca Valley virus attachment and uncoating mediated by its receptor anthrax toxin receptor 1.

Cao L, Zhang R, Liu T, Sun Z, Hu M, Sun Y, Cheng L, Guo Y, Fu S, Hu J, Li X, Yu C, Wang H, Chen H, Li X, Fry EE, Stuart DI, Qian P, Lou Z, Rao Z.

Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):13087-13092. doi: 10.1073/pnas.1814309115. Epub 2018 Dec 4.


Redundant Late Domain Functions of Tandem VP2 YPX3L Motifs in Nonlytic Cellular Egress of Quasi-enveloped Hepatitis A Virus.

González-López O, Rivera-Serrano EE, Hu F, Hensley L, McKnight KL, Ren J, Stuart DI, Fry EE, Lemon SM.

J Virol. 2018 Nov 12;92(23). pii: e01308-18. doi: 10.1128/JVI.01308-18. Print 2018 Dec 1.


Chimeric O1K foot-and-mouth disease virus with SAT2 outer capsid as an FMD vaccine candidate.

Kotecha A, Perez-Martin E, Harvey Y, Zhang F, Ilca SL, Fry EE, Jackson B, Maree F, Scott K, Hecksel CW, Harmsen MM, Mioulet V, Wood B, Juleff N, Stuart DI, Charleston B, Seago J.

Sci Rep. 2018 Sep 12;8(1):13654. doi: 10.1038/s41598-018-31856-x.


Generation and characterisation of recombinant FMDV antibodies: Applications for advancing diagnostic and laboratory assays.

Shimmon G, Kotecha A, Ren J, Asfor AS, Newman J, Berryman S, Cottam EM, Gold S, Tuthill TJ, King DP, Brocchi E, King AMQ, Owens R, Fry EE, Stuart DI, Burman A, Jackson T.

PLoS One. 2018 Aug 16;13(8):e0201853. doi: 10.1371/journal.pone.0201853. eCollection 2018.


Hepatitis A Virus Capsid Structure.

Stuart DI, Ren J, Wang X, Rao Z, Fry EE.

Cold Spring Harb Perspect Med. 2019 May 1;9(5). pii: a031807. doi: 10.1101/cshperspect.a031807. Review.


Neutralization Mechanisms of Two Highly Potent Antibodies against Human Enterovirus 71.

Zhu L, Xu K, Wang N, Cao L, Wu J, Gao Q, Fry EE, Stuart DI, Rao Z, Wang J, Wang X.

MBio. 2018 Jul 3;9(4). pii: e01013-18. doi: 10.1128/mBio.01013-18.


Structures of Ebola Virus Glycoprotein Complexes with Tricyclic Antidepressant and Antipsychotic Drugs.

Zhao Y, Ren J, Fry EE, Xiao J, Townsend AR, Stuart DI.

J Med Chem. 2018 Jun 14;61(11):4938-4945. doi: 10.1021/acs.jmedchem.8b00350. Epub 2018 May 21.


Target Identification and Mode of Action of Four Chemically Divergent Drugs against Ebolavirus Infection.

Ren J, Zhao Y, Fry EE, Stuart DI.

J Med Chem. 2018 Feb 8;61(3):724-733. doi: 10.1021/acs.jmedchem.7b01249. Epub 2018 Jan 16.


Structures of foot and mouth disease virus pentamers: Insight into capsid dissociation and unexpected pentamer reassociation.

Malik N, Kotecha A, Gold S, Asfor A, Ren J, Huiskonen JT, Tuthill TJ, Fry EE, Stuart DI.

PLoS Pathog. 2017 Sep 22;13(9):e1006607. doi: 10.1371/journal.ppat.1006607. eCollection 2017 Sep.


Plant-made polio type 3 stabilized VLPs-a candidate synthetic polio vaccine.

Marsian J, Fox H, Bahar MW, Kotecha A, Fry EE, Stuart DI, Macadam AJ, Rowlands DJ, Lomonossoff GP.

Nat Commun. 2017 Aug 15;8(1):245. doi: 10.1038/s41467-017-00090-w.


High-speed fixed-target serial virus crystallography.

Roedig P, Ginn HM, Pakendorf T, Sutton G, Harlos K, Walter TS, Meyer J, Fischer P, Duman R, Vartiainen I, Reime B, Warmer M, Brewster AS, Young ID, Michels-Clark T, Sauter NK, Kotecha A, Kelly J, Rowlands DJ, Sikorsky M, Nelson S, Damiani DS, Alonso-Mori R, Ren J, Fry EE, David C, Stuart DI, Wagner A, Meents A.

Nat Methods. 2017 Aug;14(8):805-810. doi: 10.1038/nmeth.4335. Epub 2017 Jun 19.


Rules of engagement between αvβ6 integrin and foot-and-mouth disease virus.

Kotecha A, Wang Q, Dong X, Ilca SL, Ondiviela M, Zihe R, Seago J, Charleston B, Fry EE, Abrescia NGA, Springer TA, Huiskonen JT, Stuart DI.

Nat Commun. 2017 May 23;8:15408. doi: 10.1038/ncomms15408.


Near-atomic structure of Japanese encephalitis virus reveals critical determinants of virulence and stability.

Wang X, Li SH, Zhu L, Nian QG, Yuan S, Gao Q, Hu Z, Ye Q, Li XF, Xie DY, Shaw N, Wang J, Walter TS, Huiskonen JT, Fry EE, Qin CF, Stuart DI, Rao Z.

Nat Commun. 2017 Apr 26;8(1):14. doi: 10.1038/s41467-017-00024-6.


SAT2 Foot-and-Mouth Disease Virus Structurally Modified for Increased Thermostability.

Scott KA, Kotecha A, Seago J, Ren J, Fry EE, Stuart DI, Charleston B, Maree FF.

J Virol. 2017 Apr 28;91(10). pii: e02312-16. doi: 10.1128/JVI.02312-16. Print 2017 May 15.


Potent neutralization of hepatitis A virus reveals a receptor mimic mechanism and the receptor recognition site.

Wang X, Zhu L, Dang M, Hu Z, Gao Q, Yuan S, Sun Y, Zhang B, Ren J, Kotecha A, Walter TS, Wang J, Fry EE, Stuart DI, Rao Z.

Proc Natl Acad Sci U S A. 2017 Jan 24;114(4):770-775. doi: 10.1073/pnas.1616502114. Epub 2017 Jan 10.


Structure of human Aichi virus and implications for receptor binding.

Zhu L, Wang X, Ren J, Kotecha A, Walter TS, Yuan S, Yamashita T, Tuthill TJ, Fry EE, Rao Z, Stuart DI.

Nat Microbiol. 2016 Sep 5;1(11):16150. doi: 10.1038/nmicrobiol.2016.150.


Tracking the Antigenic Evolution of Foot-and-Mouth Disease Virus.

Reeve R, Borley DW, Maree FF, Upadhyaya S, Lukhwareni A, Esterhuysen JJ, Harvey WT, Blignaut B, Fry EE, Parida S, Paton DJ, Mahapatra M.

PLoS One. 2016 Jul 22;11(7):e0159360. doi: 10.1371/journal.pone.0159360. eCollection 2016.


Toremifene interacts with and destabilizes the Ebola virus glycoprotein.

Zhao Y, Ren J, Harlos K, Jones DM, Zeltina A, Bowden TA, Padilla-Parra S, Fry EE, Stuart DI.

Nature. 2016 Jul 7;535(7610):169-172. doi: 10.1038/nature18615. Epub 2016 Jun 29.


Potent antiviral agents fail to elicit genetically-stable resistance mutations in either enterovirus 71 or Coxsackievirus A16.

Kelly JT, De Colibus L, Elliott L, Fry EE, Stuart DI, Rowlands DJ, Stonehouse NJ.

Antiviral Res. 2015 Dec;124:77-82. doi: 10.1016/j.antiviral.2015.10.006. Epub 2015 Oct 30.


Structure Elucidation of Coxsackievirus A16 in Complex with GPP3 Informs a Systematic Review of Highly Potent Capsid Binders to Enteroviruses.

De Colibus L, Wang X, Tijsma A, Neyts J, Spyrou JA, Ren J, Grimes JM, Puerstinger G, Leyssen P, Fry EE, Rao Z, Stuart DI.

PLoS Pathog. 2015 Oct 20;11(10):e1005165. doi: 10.1371/journal.ppat.1005165. eCollection 2015 Oct.


Structure of Ljungan virus provides insight into genome packaging of this picornavirus.

Zhu L, Wang X, Ren J, Porta C, Wenham H, Ekström JO, Panjwani A, Knowles NJ, Kotecha A, Siebert CA, Lindberg AM, Fry EE, Rao Z, Tuthill TJ, Stuart DI.

Nat Commun. 2015 Oct 8;6:8316. doi: 10.1038/ncomms9316.


Structure-based energetics of protein interfaces guides foot-and-mouth disease virus vaccine design.

Kotecha A, Seago J, Scott K, Burman A, Loureiro S, Ren J, Porta C, Ginn HM, Jackson T, Perez-Martin E, Siebert CA, Paul G, Huiskonen JT, Jones IM, Esnouf RM, Fry EE, Maree FF, Charleston B, Stuart DI.

Nat Struct Mol Biol. 2015 Oct;22(10):788-94. doi: 10.1038/nsmb.3096. Epub 2015 Sep 21.


Structures of Coxsackievirus A16 Capsids with Native Antigenicity: Implications for Particle Expansion, Receptor Binding, and Immunogenicity.

Ren J, Wang X, Zhu L, Hu Z, Gao Q, Yang P, Li X, Wang J, Shen X, Fry EE, Rao Z, Stuart DI.

J Virol. 2015 Oct;89(20):10500-11. doi: 10.1128/JVI.01102-15. Epub 2015 Aug 12.


Tandem fusion of hepatitis B core antigen allows assembly of virus-like particles in bacteria and plants with enhanced capacity to accommodate foreign proteins.

Peyret H, Gehin A, Thuenemann EC, Blond D, El Turabi A, Beales L, Clarke D, Gilbert RJ, Fry EE, Stuart DI, Holmes K, Stonehouse NJ, Whelan M, Rosenberg W, Lomonossoff GP, Rowlands DJ.

PLoS One. 2015 Apr 1;10(4):e0120751. doi: 10.1371/journal.pone.0120751. eCollection 2015.


Hepatitis A virus and the origins of picornaviruses.

Wang X, Ren J, Gao Q, Hu Z, Sun Y, Li X, Rowlands DJ, Yin W, Wang J, Stuart DI, Rao Z, Fry EE.

Nature. 2015 Jan 1;517(7532):85-88. doi: 10.1038/nature13806. Epub 2014 Oct 19.


Lysosome sorting of β-glucocerebrosidase by LIMP-2 is targeted by the mannose 6-phosphate receptor.

Zhao Y, Ren J, Padilla-Parra S, Fry EE, Stuart DI.

Nat Commun. 2014 Jul 14;5:4321. doi: 10.1038/ncomms5321.


Exploiting fast detectors to enter a new dimension in room-temperature crystallography.

Owen RL, Paterson N, Axford D, Aishima J, Schulze-Briese C, Ren J, Fry EE, Stuart DI, Evans G.

Acta Crystallogr D Biol Crystallogr. 2014 May;70(Pt 5):1248-56. doi: 10.1107/S1399004714005379. Epub 2014 Apr 26.


More-powerful virus inhibitors from structure-based analysis of HEV71 capsid-binding molecules.

De Colibus L, Wang X, Spyrou JAB, Kelly J, Ren J, Grimes J, Puerstinger G, Stonehouse N, Walter TS, Hu Z, Wang J, Li X, Peng W, Rowlands D, Fry EE, Rao Z, Stuart DI.

Nat Struct Mol Biol. 2014 Mar;21(3):282-288. doi: 10.1038/nsmb.2769. Epub 2014 Feb 9.


Picornavirus uncoating intermediate captured in atomic detail.

Ren J, Wang X, Hu Z, Gao Q, Sun Y, Li X, Porta C, Walter TS, Gilbert RJ, Zhao Y, Axford D, Williams M, McAuley K, Rowlands DJ, Yin W, Wang J, Stuart DI, Rao Z, Fry EE.

Nat Commun. 2013;4:1929. doi: 10.1038/ncomms2889.


Evaluation and use of in-silico structure-based epitope prediction with foot-and-mouth disease virus.

Borley DW, Mahapatra M, Paton DJ, Esnouf RM, Stuart DI, Fry EE.

PLoS One. 2013 May 7;8(5):e61122. doi: 10.1371/journal.pone.0061122. Print 2013.


Rational engineering of recombinant picornavirus capsids to produce safe, protective vaccine antigen.

Porta C, Kotecha A, Burman A, Jackson T, Ren J, Loureiro S, Jones IM, Fry EE, Stuart DI, Charleston B.

PLoS Pathog. 2013 Mar;9(3):e1003255. doi: 10.1371/journal.ppat.1003255. Epub 2013 Mar 27.


Structure determination from a single high-pressure-frozen virus crystal.

Burkhardt A, Wagner A, Warmer M, Reimer R, Hohenberg H, Ren J, Fry EE, Stuart DI, Meents A.

Acta Crystallogr D Biol Crystallogr. 2013 Feb;69(Pt 2):308-12. doi: 10.1107/S090744491204543X. Epub 2013 Jan 19.


Outrunning free radicals in room-temperature macromolecular crystallography.

Owen RL, Axford D, Nettleship JE, Owens RJ, Robinson JI, Morgan AW, Doré AS, Lebon G, Tate CG, Fry EE, Ren J, Stuart DI, Evans G.

Acta Crystallogr D Biol Crystallogr. 2012 Jul;68(Pt 7):810-8. doi: 10.1107/S0907444912012553. Epub 2012 Jun 15.


A plate-based high-throughput assay for virus stability and vaccine formulation.

Walter TS, Ren J, Tuthill TJ, Rowlands DJ, Stuart DI, Fry EE.

J Virol Methods. 2012 Oct;185(1):166-70. doi: 10.1016/j.jviromet.2012.06.014. Epub 2012 Jun 26.


In situ macromolecular crystallography using microbeams.

Axford D, Owen RL, Aishima J, Foadi J, Morgan AW, Robinson JI, Nettleship JE, Owens RJ, Moraes I, Fry EE, Grimes JM, Harlos K, Kotecha A, Ren J, Sutton G, Walter TS, Stuart DI, Evans G.

Acta Crystallogr D Biol Crystallogr. 2012 May;68(Pt 5):592-600. doi: 10.1107/S0907444912006749. Epub 2012 Apr 17.


A sensor-adaptor mechanism for enterovirus uncoating from structures of EV71.

Wang X, Peng W, Ren J, Hu Z, Xu J, Lou Z, Li X, Yin W, Shen X, Porta C, Walter TS, Evans G, Axford D, Owen R, Rowlands DJ, Wang J, Stuart DI, Fry EE, Rao Z.

Nat Struct Mol Biol. 2012 Mar 4;19(4):424-9. doi: 10.1038/nsmb.2255.


Sequence-based prediction for vaccine strain selection and identification of antigenic variability in foot-and-mouth disease virus.

Reeve R, Blignaut B, Esterhuysen JJ, Opperman P, Matthews L, Fry EE, de Beer TA, Theron J, Rieder E, Vosloo W, O'Neill HG, Haydon DT, Maree FF.

PLoS Comput Biol. 2010 Dec 9;6(12):e1001027. doi: 10.1371/journal.pcbi.1001027.


Crystal structure of equine rhinitis A virus in complex with its sialic acid receptor.

Fry EE, Tuthill TJ, Harlos K, Walter TS, Rowlands DJ, Stuart DI.

J Gen Virol. 2010 Aug;91(Pt 8):1971-7. doi: 10.1099/vir.0.020420-0. Epub 2010 Apr 28.


Equine rhinitis A virus and its low pH empty particle: clues towards an aphthovirus entry mechanism?

Tuthill TJ, Harlos K, Walter TS, Knowles NJ, Groppelli E, Rowlands DJ, Stuart DI, Fry EE.

PLoS Pathog. 2009 Oct;5(10):e1000620. doi: 10.1371/journal.ppat.1000620. Epub 2009 Oct 9.


Specificity of the VP1 GH loop of Foot-and-Mouth Disease virus for alphav integrins.

Burman A, Clark S, Abrescia NG, Fry EE, Stuart DI, Jackson T.

J Virol. 2006 Oct;80(19):9798-810.


Fitness cost of escape mutations in p24 Gag in association with control of human immunodeficiency virus type 1.

Martinez-Picado J, Prado JG, Fry EE, Pfafferott K, Leslie A, Chetty S, Thobakgale C, Honeyborne I, Crawford H, Matthews P, Pillay T, Rousseau C, Mullins JI, Brander C, Walker BD, Stuart DI, Kiepiela P, Goulder P.

J Virol. 2006 Apr;80(7):3617-23.


Kelp fly virus: a novel group of insect picorna-like viruses as defined by genome sequence analysis and a distinctive virion structure.

Hartley CJ, Greenwood DR, Gilbert RJ, Masoumi A, Gordon KH, Hanzlik TN, Fry EE, Stuart DI, Scotti PD.

J Virol. 2005 Nov;79(21):13385-98.


Structure of Foot-and-mouth disease virus serotype A10 61 alone and complexed with oligosaccharide receptor: receptor conservation in the face of antigenic variation.

Fry EE, Newman JW, Curry S, Najjam S, Jackson T, Blakemore W, Lea SM, Miller L, Burman A, King AM, Stuart DI.

J Gen Virol. 2005 Jul;86(Pt 7):1909-20.


The structure of foot-and-mouth disease virus.

Fry EE, Stuart DI, Rowlands DJ.

Curr Top Microbiol Immunol. 2005;288:71-101. Review.


Crystal structure of Swine vesicular disease virus and implications for host adaptation.

Fry EE, Knowles NJ, Newman JW, Wilsden G, Rao Z, King AM, Stuart DI.

J Virol. 2003 May;77(9):5475-86.


Virus crystallography.

Fry EE, Grimes J, Stuart DI.

Mol Biotechnol. 1999 Aug;12(1):13-23. Review.


The structure and function of a foot-and-mouth disease virus-oligosaccharide receptor complex.

Fry EE, Lea SM, Jackson T, Newman JW, Ellard FM, Blakemore WE, Abu-Ghazaleh R, Samuel A, King AM, Stuart DI.

EMBO J. 1999 Feb 1;18(3):543-54.

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