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Items: 12


Severity of Illness Scores May Misclassify Critically Ill Obese Patients.

Deliberato RO, Ko S, Komorowski M, Armengol de La Hoz MA, Frushicheva MP, Raffa JD, Johnson AEW, Celi LA, Stone DJ.

Crit Care Med. 2018 Mar;46(3):394-400. doi: 10.1097/CCM.0000000000002868.


Dimerization of the adaptor Gads facilitates antigen receptor signaling by promoting the cooperative binding of Gads to the adaptor LAT.

Sukenik S, Frushicheva MP, Waknin-Lellouche C, Hallumi E, Ifrach T, Shalah R, Beach D, Avidan R, Oz I, Libman E, Aronheim A, Lewinson O, Yablonski D.

Sci Signal. 2017 Sep 26;10(498). pii: eaal1482. doi: 10.1126/scisignal.aal1482.


The catalytic activity of the kinase ZAP-70 mediates basal signaling and negative feedback of the T cell receptor pathway.

Goodfellow HS, Frushicheva MP, Ji Q, Cheng DA, Kadlecek TA, Cantor AJ, Kuriyan J, Chakraborty AK, Salomon A, Weiss A.

Sci Signal. 2015 May 19;8(377):ra49. doi: 10.1126/scisignal.2005596.


On the challenge of exploring the evolutionary trajectory from phosphotriesterase to arylesterase using computer simulations.

Bora RP, Mills MJ, Frushicheva MP, Warshel A.

J Phys Chem B. 2015 Feb 26;119(8):3434-45. doi: 10.1021/jp5124025. Epub 2015 Feb 13.


Computer aided enzyme design and catalytic concepts.

Frushicheva MP, Mills MJ, Schopf P, Singh MK, Prasad RB, Warshel A.

Curr Opin Chem Biol. 2014 Aug;21:56-62. doi: 10.1016/j.cbpa.2014.03.022. Epub 2014 May 8. Review.


Monovalent engagement of the BCR activates ovalbumin-specific transnuclear B cells.

Avalos AM, Bilate AM, Witte MD, Tai AK, He J, Frushicheva MP, Thill PD, Meyer-Wentrup F, Theile CS, Chakraborty AK, Zhuang X, Ploegh HL.

J Exp Med. 2014 Feb 10;211(2):365-79. doi: 10.1084/jem.20131603. Epub 2014 Feb 3.


Electrostatic origin of the catalytic effect of a supramolecular host catalyst.

Frushicheva MP, Mukherjee S, Warshel A.

J Phys Chem B. 2012 Nov 15;116(45):13353-60. doi: 10.1021/jp3084327. Epub 2012 Nov 5.


Nitroxide sensing of a DNA microenvironment: mechanistic insights from EPR spectroscopy and molecular dynamics simulations.

Popova AM, Hatmal MM, Frushicheva MP, Price EA, Qin PZ, Haworth IS.

J Phys Chem B. 2012 Jun 7;116(22):6387-96. doi: 10.1021/jp303303v. Epub 2012 May 23.


Validating the vitality strategy for fighting drug resistance.

Singh N, Frushicheva MP, Warshel A.

Proteins. 2012 Apr;80(4):1110-22. doi: 10.1002/prot.24012. Epub 2012 Jan 31.


Towards quantitative computer-aided studies of enzymatic enantioselectivity: the case of Candida antarctica lipase A.

Frushicheva MP, Warshel A.

Chembiochem. 2012 Jan 23;13(2):215-23. doi: 10.1002/cbic.201100600. Epub 2011 Dec 21.


Challenges and advances in validating enzyme design proposals: the case of kemp eliminase catalysis.

Frushicheva MP, Cao J, Warshel A.

Biochemistry. 2011 May 10;50(18):3849-58. doi: 10.1021/bi200063a. Epub 2011 Apr 15.


Exploring challenges in rational enzyme design by simulating the catalysis in artificial kemp eliminase.

Frushicheva MP, Cao J, Chu ZT, Warshel A.

Proc Natl Acad Sci U S A. 2010 Sep 28;107(39):16869-74. doi: 10.1073/pnas.1010381107. Epub 2010 Sep 9.

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