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Items: 16


Pulmonary vascular mechanical consequences of ischemic heart failure and implications for right ventricular function.

Philip JL, Murphy TM, Schreier DA, Stevens S, Tabima DM, Albrecht M, Frump AL, Hacker TA, Lahm T, Chesler NC.

Am J Physiol Heart Circ Physiol. 2019 May 1;316(5):H1167-H1177. doi: 10.1152/ajpheart.00319.2018. Epub 2019 Feb 15.


The Y Chromosome Takes the Field to Modify BMPR2 Expression.

Frump AL, Lahm T.

Am J Respir Crit Care Med. 2018 Dec 15;198(12):1476-1478. doi: 10.1164/rccm.201809-1682ED. No abstract available.


Hypoxia Upregulates Estrogen Receptor β in Pulmonary Artery Endothelial Cells in a HIF-1α-Dependent Manner.

Frump AL, Selej M, Wood JA, Albrecht M, Yakubov B, Petrache I, Lahm T.

Am J Respir Cell Mol Biol. 2018 Jul;59(1):114-126. doi: 10.1165/rcmb.2017-0167OC.


Emerging role of angiogenesis in adaptive and maladaptive right ventricular remodeling in pulmonary hypertension.

Frump AL, Bonnet S, de Jesus Perez VA, Lahm T.

Am J Physiol Lung Cell Mol Physiol. 2018 Mar 1;314(3):L443-L460. doi: 10.1152/ajplung.00374.2017. Epub 2017 Nov 2. Review.


Isolated heart model demonstrates evidence of contractile and diastolic dysfunction in right ventricles from rats with sugen/hypoxia-induced pulmonary hypertension.

Neto-Neves EM, Frump AL, Vayl A, Kline JA, Lahm T.

Physiol Rep. 2017 Oct;5(19). pii: e13438. doi: 10.14814/phy2.13438. Epub 2017 Oct 16.


Estrogen receptor-dependent attenuation of hypoxia-induced changes in the lung genome of pulmonary hypertension rats.

Frump AL, Albrecht ME, McClintick JN, Lahm T.

Pulm Circ. 2017 Mar 27;7(1):232-243. doi: 10.1177/2045893217702055. eCollection 2017 Mar.


Toward Harnessing Sex Steroid Signaling as a Therapeutic Target in Pulmonary Arterial Hypertension.

Lahm T, Frump AL.

Am J Respir Crit Care Med. 2017 Feb 1;195(3):284-286. doi: 10.1164/rccm.201609-1906ED. No abstract available.


Genotype-phenotype effects of Bmpr2 mutations on disease severity in mouse models of pulmonary hypertension.

Frump AL, Datta A, Ghose S, West J, de Caestecker MP.

Pulm Circ. 2016 Dec;6(4):597-607. doi: 10.1086/688930.


17β-Estradiol mediates superior adaptation of right ventricular function to acute strenuous exercise in female rats with severe pulmonary hypertension.

Lahm T, Frump AL, Albrecht ME, Fisher AJ, Cook TG, Jones TJ, Yakubov B, Whitson J, Fuchs RK, Liu A, Chesler NC, Brown MB.

Am J Physiol Lung Cell Mol Physiol. 2016 Aug 1;311(2):L375-88. doi: 10.1152/ajplung.00132.2016. Epub 2016 Jun 10.


Estradiol improves right ventricular function in rats with severe angioproliferative pulmonary hypertension: effects of endogenous and exogenous sex hormones.

Frump AL, Goss KN, Vayl A, Albrecht M, Fisher A, Tursunova R, Fierst J, Whitson J, Cucci AR, Brown MB, Lahm T.

Am J Physiol Lung Cell Mol Physiol. 2015 May 1;308(9):L873-90. doi: 10.1152/ajplung.00006.2015. Epub 2015 Feb 20.


Heterozygous null bone morphogenetic protein receptor type 2 mutations promote SRC kinase-dependent caveolar trafficking defects and endothelial dysfunction in pulmonary arterial hypertension.

Prewitt AR, Ghose S, Frump AL, Datta A, Austin ED, Kenworthy AK, de Caestecker MP.

J Biol Chem. 2015 Jan 9;290(2):960-71. doi: 10.1074/jbc.M114.591057. Epub 2014 Nov 19.


Abnormal trafficking of endogenously expressed BMPR2 mutant allelic products in patients with heritable pulmonary arterial hypertension.

Frump AL, Lowery JW, Hamid R, Austin ED, de Caestecker M.

PLoS One. 2013 Nov 5;8(11):e80319. doi: 10.1371/journal.pone.0080319. eCollection 2013.


Targeting the Wnt pathway in synovial sarcoma models.

Barham W, Frump AL, Sherrill TP, Garcia CB, Saito-Diaz K, VanSaun MN, Fingleton B, Gleaves L, Orton D, Capecchi MR, Blackwell TS, Lee E, Yull F, Eid JE.

Cancer Discov. 2013 Nov;3(11):1286-301. doi: 10.1158/2159-8290.CD-13-0138. Epub 2013 Aug 6.


ID family protein expression and regulation in hypoxic pulmonary hypertension.

Lowery JW, Frump AL, Anderson L, DiCarlo GE, Jones MT, de Caestecker MP.

Am J Physiol Regul Integr Comp Physiol. 2010 Dec;299(6):R1463-77. doi: 10.1152/ajpregu.00866.2009. Epub 2010 Sep 29.


The proto-oncoprotein SYT (SS18) controls ATP release and regulates cyst formation by polarized MDCK cells.

Chittezhath M, Frump AL, Jourquin J, Lobdell N, Eid JE.

Exp Cell Res. 2008 Nov 15;314(19):3551-62. doi: 10.1016/j.yexcr.2008.09.006. Epub 2008 Sep 20.


The synovial sarcoma SYT-SSX2 oncogene remodels the cytoskeleton through activation of the ephrin pathway.

Barco R, Hunt LB, Frump AL, Garcia CB, Benesh A, Caldwell RL, Eid JE.

Mol Biol Cell. 2007 Oct;18(10):4003-12. Epub 2007 Aug 8.

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