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Items: 40

1.

68Ga-Sienna+ for PET-MRI Guided Sentinel Lymph Node Biopsy: Synthesis and Preclinical Evaluation in a Metastatic Breast Cancer Model.

Savolainen H, Volpe A, Phinikaridou A, Douek M, Fruhwirth G, de Rosales RTM.

Nanotheranostics. 2019 Jun 6;3(3):255-265. doi: 10.7150/ntno.34727. eCollection 2019.

2.

Integrin-Mediated Macrophage Adhesion Promotes Lymphovascular Dissemination in Breast Cancer.

Evans R, Flores-Borja F, Nassiri S, Miranda E, Lawler K, Grigoriadis A, Monypenny J, Gillet C, Owen J, Gordon P, Male V, Cheung A, Noor F, Barber P, Marlow R, Francesch-Domenech E, Fruhwirth G, Squadrito M, Vojnovic B, Tutt A, Festy F, De Palma M, Ng T.

Cell Rep. 2019 May 14;27(7):1967-1978.e4. doi: 10.1016/j.celrep.2019.04.076.

3.

Regional Activation of Myosin II in Cancer Cells Drives Tumor Progression via a Secretory Cross-Talk with the Immune Microenvironment.

Georgouli M, Herraiz C, Crosas-Molist E, Fanshawe B, Maiques O, Perdrix A, Pandya P, Rodriguez-Hernandez I, Ilieva KM, Cantelli G, Karagiannis P, Mele S, Lam H, Josephs DH, Matias-Guiu X, Marti RM, Nestle FO, Orgaz JL, Malanchi I, Fruhwirth GO, Karagiannis SN, Sanz-Moreno V.

Cell. 2019 Feb 7;176(4):757-774.e23. doi: 10.1016/j.cell.2018.12.038. Epub 2019 Jan 31.

4.

In Vivo PET Tracking of 89Zr-Labeled Vγ9Vδ2 T Cells to Mouse Xenograft Breast Tumors Activated with Liposomal Alendronate.

Man F, Lim L, Volpe A, Gabizon A, Shmeeda H, Draper B, Parente-Pereira AC, Maher J, Blower PJ, Fruhwirth GO, T M de Rosales R.

Mol Ther. 2019 Jan 2;27(1):219-229. doi: 10.1016/j.ymthe.2018.10.006. Epub 2018 Oct 16.

5.

The Potential of In Vivo Imaging for Optimization of Molecular and Cellular Anti-cancer Immunotherapies.

Fruhwirth GO, Kneilling M, de Vries IJM, Weigelin B, Srinivas M, Aarntzen EHJG.

Mol Imaging Biol. 2018 Oct;20(5):696-704. doi: 10.1007/s11307-018-1254-3. Review.

6.

Cousins at work: How combining medical with optical imaging enhances in vivo cell tracking.

Volpe A, Kurtys E, Fruhwirth GO.

Int J Biochem Cell Biol. 2018 Sep;102:40-50. doi: 10.1016/j.biocel.2018.06.008. Epub 2018 Jun 28. Review.

7.

Radionuclide-fluorescence Reporter Gene Imaging to Track Tumor Progression in Rodent Tumor Models.

Volpe A, Man F, Lim L, Khoshnevisan A, Blower J, Blower PJ, Fruhwirth GO.

J Vis Exp. 2018 Mar 13;(133). doi: 10.3791/57088.

8.

[18F]tetrafluoroborate-PET/CT enables sensitive tumor and metastasis in vivo imaging in a sodium iodide symporter-expressing tumor model.

Diocou S, Volpe A, Jauregui-Osoro M, Boudjemeline M, Chuamsaamarkkee K, Man F, Blower PJ, Ng T, Mullen GED, Fruhwirth GO.

Sci Rep. 2017 Apr 19;7(1):946. doi: 10.1038/s41598-017-01044-4.

9.

Detecting intratumoral heterogeneity of EGFR activity by liposome-based in vivo transfection of a fluorescent biosensor.

Weitsman G, Mitchell NJ, Evans R, Cheung A, Kalber TL, Bofinger R, Fruhwirth GO, Keppler M, Wright ZVF, Barber PR, Gordon P, de Koning T, Wulaningsih W, Sander K, Vojnovic B, Ameer-Beg S, Lythgoe M, Arnold JN, Årstad E, Festy F, Hailes HC, Tabor AB, Ng T.

Oncogene. 2017 Jun 22;36(25):3618-3628. doi: 10.1038/onc.2016.522. Epub 2017 Feb 6.

10.

MET-EGFR dimerization in lung adenocarcinoma is dependent on EGFR mtations and altered by MET kinase inhibition.

Ortiz-Zapater E, Lee RW, Owen W, Weitsman G, Fruhwirth G, Dunn RG, Neat MJ, McCaughan F, Parker P, Ng T, Santis G.

PLoS One. 2017 Jan 31;12(1):e0170798. doi: 10.1371/journal.pone.0170798. eCollection 2017.

11.

RORγt+ Innate Lymphoid Cells Promote Lymph Node Metastasis of Breast Cancers.

Irshad S, Flores-Borja F, Lawler K, Monypenny J, Evans R, Male V, Gordon P, Cheung A, Gazinska P, Noor F, Wong F, Grigoriadis A, Fruhwirth GO, Barber PR, Woodman N, Patel D, Rodriguez-Justo M, Owen J, Martin SG, Pinder SE, Gillett CE, Poland SP, Ameer-Beg S, McCaughan F, Carlin LM, Hasan U, Withers DR, Lane P, Vojnovic B, Quezada SA, Ellis P, Tutt AN, Ng T.

Cancer Res. 2017 Mar 1;77(5):1083-1096. doi: 10.1158/0008-5472.CAN-16-0598. Epub 2017 Jan 12.

12.

Expression of a Chimeric Antigen Receptor Specific for Donor HLA Class I Enhances the Potency of Human Regulatory T Cells in Preventing Human Skin Transplant Rejection.

Boardman DA, Philippeos C, Fruhwirth GO, Ibrahim MA, Hannen RF, Cooper D, Marelli-Berg FM, Watt FM, Lechler RI, Maher J, Smyth LA, Lombardi G.

Am J Transplant. 2017 Apr;17(4):931-943. doi: 10.1111/ajt.14185. Epub 2017 Feb 1.

13.

Probing the Heterogeneity of Protein Kinase Activation in Cells by Super-resolution Microscopy.

Zhang R, Fruhwirth GO, Coban O, Barrett JE, Burgoyne T, Lee SH, Simonson PD, Baday M, Kholodenko BN, Futter CE, Ng T, Selvin PR.

ACS Nano. 2017 Jan 24;11(1):249-257. doi: 10.1021/acsnano.6b05356. Epub 2016 Nov 3.

14.

Exploiting the Metal-Chelating Properties of the Drug Cargo for In Vivo Positron Emission Tomography Imaging of Liposomal Nanomedicines.

Edmonds S, Volpe A, Shmeeda H, Parente-Pereira AC, Radia R, Baguña-Torres J, Szanda I, Severin GW, Livieratos L, Blower PJ, Maher J, Fruhwirth GO, Gabizon A, T M de Rosales R.

ACS Nano. 2016 Nov 22;10(11):10294-10307. Epub 2016 Oct 26.

15.

18F-Fluorosulfate for PET Imaging of the Sodium-Iodide Symporter: Synthesis and Biologic Evaluation In Vitro and In Vivo.

Khoshnevisan A, Chuamsaamarkkee K, Boudjemeline M, Jackson A, Smith GE, Gee AD, Fruhwirth GO, Blower PJ.

J Nucl Med. 2017 Jan;58(1):156-161. doi: 10.2967/jnumed.116.177519. Epub 2016 Aug 18.

16.

Hydrodynamic Radii of Ranibizumab, Aflibercept and Bevacizumab Measured by Time-Resolved Phosphorescence Anisotropy.

Hirvonen LM, Fruhwirth GO, Srikantha N, Barber MJ, Neffendorf JE, Suhling K, Jackson TL.

Pharm Res. 2016 Aug;33(8):2025-32. doi: 10.1007/s11095-016-1940-2. Epub 2016 May 25.

17.

Opportunities and challenges for metal chemistry in molecular imaging: from gamma camera imaging to PET and multimodality imaging.

Southworth R, Torres Martin de Rosales R, Meszaros LK, Ma MT, Mullen GED, Fruhwirth G, Young JD, Imberti C, Bagunya-Torres J, Andreozzi E, Blower PJ.

Adv Inorg Chem. 2016;68:1-41. doi: 10.1016/bs.adioch.2015.09.001. Epub 2015 Nov 16.

18.

Simultaneous FRAP, FLIM and FAIM for measurements of protein mobility and interaction in living cells.

Levitt JA, Morton PE, Fruhwirth GO, Santis G, Chung PH, Parsons M, Suhling K.

Biomed Opt Express. 2015 Sep 8;6(10):3842-54. doi: 10.1364/BOE.6.003842. eCollection 2015 Oct 1.

19.

Fluorescence axial nanotomography with plasmonics.

Cade NI, Fruhwirth GO, Krasavin AV, Ng T, Richards D.

Faraday Discuss. 2015;178:371-81. doi: 10.1039/c4fd00198b. Epub 2015 Feb 25.

PMID:
25712026
20.

Imaging tumour heterogeneity of the consequences of a PKCα-substrate interaction in breast cancer patients.

Weitsman G, Lawler K, Kelleher MT, Barrett JE, Barber PR, Shamil E, Festy F, Patel G, Fruhwirth GO, Huang L, Tullis ID, Woodman N, Ofo E, Ameer-Beg SM, Irshad S, Condeelis J, Gillett CE, Ellis PA, Vojnovic B, Coolen AC, Ng T.

Biochem Soc Trans. 2014 Dec;42(6):1498-505. doi: 10.1042/BST20140165. Review.

21.

The ErbB4 CYT2 variant protects EGFR from ligand-induced degradation to enhance cancer cell motility.

Kiuchi T, Ortiz-Zapater E, Monypenny J, Matthews DR, Nguyen LK, Barbeau J, Coban O, Lawler K, Burford B, Rolfe DJ, de Rinaldis E, Dafou D, Simpson MA, Woodman N, Pinder S, Gillett CE, Devauges V, Poland SP, Fruhwirth G, Marra P, Boersma YL, Plückthun A, Gullick WJ, Yarden Y, Santis G, Winn M, Kholodenko BN, Martin-Fernandez ML, Parker P, Tutt A, Ameer-Beg SM, Ng T.

Sci Signal. 2014 Aug 19;7(339):ra78. doi: 10.1126/scisignal.2005157.

PMID:
25140053
22.

A whole-body dual-modality radionuclide optical strategy for preclinical imaging of metastasis and heterogeneous treatment response in different microenvironments.

Fruhwirth GO, Diocou S, Blower PJ, Ng T, Mullen GE.

J Nucl Med. 2014 Apr;55(4):686-94. doi: 10.2967/jnumed.113.127480. Epub 2014 Mar 6.

23.

3D super-resolution imaging with blinking quantum dots.

Wang Y, Fruhwirth G, Cai E, Ng T, Selvin PR.

Nano Lett. 2013 Nov 13;13(11):5233-41. doi: 10.1021/nl4026665. Epub 2013 Oct 10.

24.

A multi-functional imaging approach to high-content protein interaction screening.

Matthews DR, Fruhwirth GO, Weitsman G, Carlin LM, Ofo E, Keppler M, Barber PR, Tullis ID, Vojnovic B, Ng T, Ameer-Beg SM.

PLoS One. 2012;7(4):e33231. doi: 10.1371/journal.pone.0033231. Epub 2012 Apr 10.

25.

NMR metabolomics of MTLn3E breast cancer cells identifies a role for CXCR4 in lipid and choline regulation.

Vermeer LS, Fruhwirth GO, Pandya P, Ng T, Mason AJ.

J Proteome Res. 2012 May 4;11(5):2996-3003. doi: 10.1021/pr300111x. Epub 2012 Apr 2.

26.

Two-photon 3D FIONA of individual quantum dots in an aqueous environment.

Zhang R, Rothenberg E, Fruhwirth G, Simonson PD, Ye F, Golding I, Ng T, Lopes W, Selvin PR.

Nano Lett. 2011 Oct 12;11(10):4074-8. doi: 10.1021/nl201225r. Epub 2011 Sep 13.

27.

RhoA and RhoC have distinct roles in migration and invasion by acting through different targets.

Vega FM, Fruhwirth G, Ng T, Ridley AJ.

J Cell Biol. 2011 May 16;193(4):655-65. doi: 10.1083/jcb.201011038.

28.

The challenges of integrating molecular imaging into the optimization of cancer therapy.

Patel GS, Kiuchi T, Lawler K, Ofo E, Fruhwirth GO, Kelleher M, Shamil E, Zhang R, Selvin PR, Santis G, Spicer J, Woodman N, Gillett CE, Barber PR, Vojnovic B, Kéri G, Schaeffter T, Goh V, O'Doherty MJ, Ellis PA, Ng T.

Integr Biol (Camb). 2011 Jun;3(6):603-31. doi: 10.1039/c0ib00131g. Epub 2011 May 4. Review.

PMID:
21541433
29.

How Förster resonance energy transfer imaging improves the understanding of protein interaction networks in cancer biology.

Fruhwirth GO, Fernandes LP, Weitsman G, Patel G, Kelleher M, Lawler K, Brock A, Poland SP, Matthews DR, Kéri G, Barber PR, Vojnovic B, Ameer-Beg SM, Coolen AC, Fraternali F, Ng T.

Chemphyschem. 2011 Feb 25;12(3):442-61. doi: 10.1002/cphc.201000866. Epub 2011 Feb 15. Review.

PMID:
21328516
30.

Kinase-mediated quasi-dimers of EGFR.

Bublil EM, Pines G, Patel G, Fruhwirth G, Ng T, Yarden Y.

FASEB J. 2010 Dec;24(12):4744-55. doi: 10.1096/fj.10-166199. Epub 2010 Aug 3.

31.

Fluorescence lifetime endoscopy using TCSPC for the measurement of FRET in live cells.

Fruhwirth GO, Ameer-Beg S, Cook R, Watson T, Ng T, Festy F.

Opt Express. 2010 May 24;18(11):11148-58. doi: 10.1364/OE.18.011148.

32.

A cellular screening assay using analysis of metal-modified fluorescence lifetime.

Cade NI, Fruhwirth G, Archibald SJ, Ng T, Richards D.

Biophys J. 2010 Jun 2;98(11):2752-7. doi: 10.1016/j.bpj.2010.03.016.

33.

Visualisation of signalling in immune cells.

Carlin LM, Makrogianneli K, Keppler M, Fruhwirth GO, Ng T.

Methods Mol Biol. 2010;616:97-113. doi: 10.1007/978-1-60761-461-6_7.

PMID:
20379871
34.

The potential of optical proteomic technologies to individualize prognosis and guide rational treatment for cancer patients.

Kelleher MT, Fruhwirth G, Patel G, Ofo E, Festy F, Barber PR, Ameer-Beg SM, Vojnovic B, Gillett C, Coolen A, Kéri G, Ellis PA, Ng T.

Target Oncol. 2009 Sep;4(3):235-52. doi: 10.1007/s11523-009-0116-y. Epub 2009 Sep 16. Review.

35.

Mediation of apoptosis by oxidized phospholipids.

Fruhwirth GO, Hermetter A.

Subcell Biochem. 2008;49:351-67. doi: 10.1007/978-1-4020-8831-5_13. Review.

PMID:
18751918
36.

Oxidized phospholipids: from molecular properties to disease.

Fruhwirth GO, Loidl A, Hermetter A.

Biochim Biophys Acta. 2007 Jul;1772(7):718-36. Epub 2007 May 6. Review.

37.

The oxidized phospholipids POVPC and PGPC inhibit growth and induce apoptosis in vascular smooth muscle cells.

Fruhwirth GO, Moumtzi A, Loidl A, Ingolic E, Hermetter A.

Biochim Biophys Acta. 2006 Sep;1761(9):1060-9. Epub 2006 Jul 4.

PMID:
16904371
38.

The alphaPROX assay: fluorescence screening of the inhibitory effects of hydrophilic antioxidants on protein oxidation.

Fruhwirth GO, Wagner FS, Hermetter A.

Anal Bioanal Chem. 2006 Feb;384(3):703-12. Epub 2006 Jan 27.

PMID:
16440197
39.

An immobilised catalase peroxidase from the alkalothermophilic Bacillus SF for the treatment of textile-bleaching effluents.

Fruhwirth GO, Paar A, Gudelj M, Cavaco-Paulo A, Robra KH, Gübitz GM.

Appl Microbiol Biotechnol. 2002 Nov;60(3):313-9. Epub 2002 Oct 5.

PMID:
12436313
40.

A catalase-peroxidase from a newly isolated thermoalkaliphilic Bacillus sp. with potential for the treatment of textile bleaching effluents.

Gudelj M, Fruhwirth GO, Paar A, Lottspeich F, Robra KH, Cavaco-Paulo A, Gübitz GM.

Extremophiles. 2001 Dec;5(6):423-9.

PMID:
11778844

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