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Items: 1 to 50 of 64

1.

Exosomal microRNAs from Longitudinal Liquid Biopsies for the Prediction of Response to Induction Chemotherapy in High-Risk Neuroblastoma Patients: A Proof of Concept SIOPEN Study.

Morini M, Cangelosi D, Segalerba D, Marimpietri D, Raggi F, Castellano A, Fruci D, de Mora JF, Cañete A, Yáñez Y, Viprey V, Corrias MV, Carlini B, Pezzolo A, Schleiermacher G, Mazzocco K, Ladenstein R, Sementa AR, Conte M, Garaventa A, Burchill S, Luksch R, Bosco MC, Eva A, Varesio L.

Cancers (Basel). 2019 Sep 30;11(10). pii: E1476. doi: 10.3390/cancers11101476.

2.

ERAP1 promotes Hedgehog-dependent tumorigenesis by controlling USP47-mediated degradation of βTrCP.

Bufalieri F, Infante P, Bernardi F, Caimano M, Romania P, Moretti M, Lospinoso Severini L, Talbot J, Melaiu O, Tanori M, Di Magno L, Bellavia D, Capalbo C, Puget S, De Smaele E, Canettieri G, Guardavaccaro D, Busino L, Peschiaroli A, Pazzaglia S, Giannini G, Melino G, Locatelli F, Gulino A, Ayrault O, Fruci D, Di Marcotullio L.

Nat Commun. 2019 Jul 24;10(1):3304. doi: 10.1038/s41467-019-11093-0.

3.

Peptide Trimming for MHC Class I Presentation by Endoplasmic Reticulum Aminopeptidases.

Compagnone M, Fruci D.

Methods Mol Biol. 2019;1988:45-57. doi: 10.1007/978-1-4939-9450-2_4.

PMID:
31147931
4.

Redundancy and Complementarity between ERAP1 and ERAP2 Revealed by their Effects on the Behcet's Disease-associated HLA-B*51 Peptidome.

Guasp P, Lorente E, Martín-Esteban A, Barnea E, Romania P, Fruci D, Kuiper JJW, Admon A, López de Castro JA.

Mol Cell Proteomics. 2019 Aug;18(8):1491-1510. doi: 10.1074/mcp.RA119.001515. Epub 2019 May 15.

PMID:
31092671
5.

The BET-bromodomain inhibitor JQ1 renders neuroblastoma cells more resistant to NK cell-mediated recognition and killing by downregulating ligands for NKG2D and DNAM-1 receptors.

Veneziani I, Fruci D, Compagnone M, Pistoia V, Rossi P, Cifaldi L.

Oncotarget. 2019 Mar 15;10(22):2151-2160. doi: 10.18632/oncotarget.26736. eCollection 2019 Mar 15.

6.

Regulation of ERAP1 and ERAP2 genes and their disfunction in human cancer.

Compagnone M, Cifaldi L, Fruci D.

Hum Immunol. 2019 May;80(5):318-324. doi: 10.1016/j.humimm.2019.02.014. Epub 2019 Feb 27. Review.

PMID:
30825518
7.

Counter-regulation of regulatory T cells by autoreactive CD8+ T cells in rheumatoid arthritis.

Cammarata I, Martire C, Citro A, Raimondo D, Fruci D, Melaiu O, D'Oria V, Carone C, Peruzzi G, Cerboni C, Santoni A, Sidney J, Sette A, Paroli M, Caccavale R, Milanetti E, Riminucci M, Timperi E, Piconese S, Manzo A, Montecucco C, Scrivo R, Valesini G, Cariani E, Barnaba V.

J Autoimmun. 2019 May;99:81-97. doi: 10.1016/j.jaut.2019.02.001. Epub 2019 Feb 16.

PMID:
30777378
8.

Tumor-infiltrating T cells and PD-L1 expression in childhood malignant extracranial germ-cell tumors.

Boldrini R, De Pasquale MD, Melaiu O, Chierici M, Jurman G, Benedetti MC, Salfi NC, Castellano A, Collini P, Furlanello C, Pistoia V, Cifaldi L, Terenziani M, Fruci D.

Oncoimmunology. 2018 Dec 13;8(2):e1542245. doi: 10.1080/2162402X.2018.1542245. eCollection 2019.

PMID:
30713803
9.

Role of genetic variations on MHC class I antigen-processing genes in human cancer and viral-mediated diseases.

D'Alicandro V, Romania P, Melaiu O, Fruci D.

Mol Immunol. 2019 Sep;113:11-15. doi: 10.1016/j.molimm.2018.03.024. Epub 2018 Apr 4.

PMID:
29625843
10.

Identification of a Genetic Variation in ERAP1 Aminopeptidase that Prevents Human Cytomegalovirus miR-UL112-5p-Mediated Immunoevasion.

Romania P, Cifaldi L, Pignoloni B, Starc N, D'Alicandro V, Melaiu O, Li Pira G, Giorda E, Carrozzo R, Bergvall M, Bergström T, Alfredsson L, Olsson T, Kockum I, Seppälä I, Lehtimäki T, Hurme MA, Hengel H, Santoni A, Cerboni C, Locatelli F, D'Amato M, Fruci D.

Cell Rep. 2017 Jul 25;20(4):846-853. doi: 10.1016/j.celrep.2017.06.084.

11.

MYCN is an immunosuppressive oncogene dampening the expression of ligands for NK-cell-activating receptors in human high-risk neuroblastoma.

Brandetti E, Veneziani I, Melaiu O, Pezzolo A, Castellano A, Boldrini R, Ferretti E, Fruci D, Moretta L, Pistoia V, Locatelli F, Cifaldi L.

Oncoimmunology. 2017 Apr 20;6(6):e1316439. doi: 10.1080/2162402X.2017.1316439. eCollection 2017.

12.

The Role of HCMV and HIV-1 MicroRNAs: Processing, and Mechanisms of Action during Viral Infection.

Fruci D, Rota R, Gallo A.

Front Microbiol. 2017 Apr 21;8:689. doi: 10.3389/fmicb.2017.00689. eCollection 2017. Review.

13.

PD-L1 Is a Therapeutic Target of the Bromodomain Inhibitor JQ1 and, Combined with HLA Class I, a Promising Prognostic Biomarker in Neuroblastoma.

Melaiu O, Mina M, Chierici M, Boldrini R, Jurman G, Romania P, D'Alicandro V, Benedetti MC, Castellano A, Liu T, Furlanello C, Locatelli F, Fruci D.

Clin Cancer Res. 2017 Aug 1;23(15):4462-4472. doi: 10.1158/1078-0432.CCR-16-2601. Epub 2017 Mar 7.

14.

Drug Transporters and Multiple Drug Resistance in Pediatric Solid Tumors.

Fruci D, Cho WC, Nobili V, Locatelli F, Alisi A.

Curr Drug Metab. 2016;17(4):308-16. Review.

PMID:
26694726
15.

Tumor-infiltrating T lymphocytes improve clinical outcome of therapy-resistant neuroblastoma.

Mina M, Boldrini R, Citti A, Romania P, D'Alicandro V, De Ioris M, Castellano A, Furlanello C, Locatelli F, Fruci D.

Oncoimmunology. 2015 Apr 2;4(9):e1019981. eCollection 2015 Sep.

16.

The MRN complex is transcriptionally regulated by MYCN during neural cell proliferation to control replication stress.

Petroni M, Sardina F, Heil C, Sahún-Roncero M, Colicchia V, Veschi V, Albini S, Fruci D, Ricci B, Soriani A, Di Marcotullio L, Screpanti I, Gulino A, Giannini G.

Cell Death Differ. 2016 Feb;23(2):197-206. doi: 10.1038/cdd.2015.81. Epub 2015 Jun 12.

17.

ERAP1 regulates natural killer cell function by controlling the engagement of inhibitory receptors.

Cifaldi L, Romania P, Falco M, Lorenzi S, Meazza R, Petrini S, Andreani M, Pende D, Locatelli F, Fruci D.

Cancer Res. 2015 Mar 1;75(5):824-34. doi: 10.1158/0008-5472.CAN-14-1643. Epub 2015 Jan 15.

18.

A role for naturally occurring alleles of endoplasmic reticulum aminopeptidases in tumor immunity and cancer pre-disposition.

Stratikos E, Stamogiannos A, Zervoudi E, Fruci D.

Front Oncol. 2014 Dec 19;4:363. doi: 10.3389/fonc.2014.00363. eCollection 2014. Review.

19.
20.

Multidrug resistance and cancer stem cells in neuroblastoma and hepatoblastoma.

Alisi A, Cho WC, Locatelli F, Fruci D.

Int J Mol Sci. 2013 Dec 18;14(12):24706-25. doi: 10.3390/ijms141224706. Review.

21.

High-resolution array CGH profiling identifies Na/K transporting ATPase interacting 2 (NKAIN2) as a predisposing candidate gene in neuroblastoma.

Romania P, Castellano A, Surace C, Citti A, De Ioris MA, Sirleto P, De Mariano M, Longo L, Boldrini R, Angioni A, Locatelli F, Fruci D.

PLoS One. 2013 Oct 25;8(10):e78481. doi: 10.1371/journal.pone.0078481. eCollection 2013.

22.

Epigenetic deregulation of microRNAs in rhabdomyosarcoma and neuroblastoma and translational perspectives.

Romania P, Bertaina A, Bracaglia G, Locatelli F, Fruci D, Rota R.

Int J Mol Sci. 2012 Dec 5;13(12):16554-79. doi: 10.3390/ijms131216554. Review.

23.

T and NK cells: two sides of tumor immunoevasion.

Fruci D, Lo Monaco E, Cifaldi L, Locatelli F, Tremante E, Benevolo M, Giacomini P.

J Transl Med. 2013 Feb 4;11:30. doi: 10.1186/1479-5876-11-30.

24.

IRF1 and NF-kB restore MHC class I-restricted tumor antigen processing and presentation to cytotoxic T cells in aggressive neuroblastoma.

Lorenzi S, Forloni M, Cifaldi L, Antonucci C, Citti A, Boldrini R, Pezzullo M, Castellano A, Russo V, van der Bruggen P, Giacomini P, Locatelli F, Fruci D.

PLoS One. 2012;7(10):e46928. doi: 10.1371/journal.pone.0046928. Epub 2012 Oct 5.

25.

Role of endoplasmic reticulum aminopeptidases in health and disease: from infection to cancer.

Cifaldi L, Romania P, Lorenzi S, Locatelli F, Fruci D.

Int J Mol Sci. 2012;13(7):8338-52. doi: 10.3390/ijms13078338. Epub 2012 Jul 4. Review.

26.

ERAAP modulation: A possible novel strategy for cancer immunotherapy?

Fruci D, Locatelli F, Cifaldi L.

Oncoimmunology. 2012 Jan 1;1(1):81-82.

27.

The putative role of endoplasmic reticulum aminopeptidases in autoimmunity: insights from genomic-wide association studies.

Fierabracci A, Milillo A, Locatelli F, Fruci D.

Autoimmun Rev. 2012 Dec;12(2):281-8. doi: 10.1016/j.autrev.2012.04.007. Epub 2012 May 7. Review.

PMID:
22575366
28.

Hedgehog/hyaluronic acid interaction network in nonalcoholic fatty liver disease, fibrosis, and hepatocellular carcinoma.

Pazzaglia S, Cifaldi L, Saran A, Nobili V, Fruci D, Alisi A.

Hepatology. 2012 Oct;56(4):1589. doi: 10.1002/hep.25783. No abstract available.

PMID:
22505342
29.

Expression of multidrug resistance-associated proteins in paediatric soft tissue sarcomas before and after chemotherapy.

Citti A, Boldrini R, Inserra A, Alisi A, Pessolano R, Mastronuzzi A, Zin A, De Sio L, Rosolen A, Locatelli F, Fruci D.

Int J Oncol. 2012 Jul;41(1):117-24. doi: 10.3892/ijo.2012.1433. Epub 2012 Apr 10.

PMID:
22504834
30.

Major histocompatibility complex class i and tumour immuno-evasion: how to fool T cells and natural killer cells at one time.

Fruci D, Benevolo M, Cifaldi L, Lorenzi S, Lo Monaco E, Tremante E, Giacomini P.

Curr Oncol. 2012 Feb;19(1):39-41. doi: 10.3747/co.19.945. No abstract available.

31.

Human hepatic stellate cells are liver-resident antigen-presenting cells.

Alisi A, Romania P, Nobili V, Locatelli F, Fruci D.

Hepatology. 2011 Sep 2;54(3):1107. doi: 10.1002/hep.24511. No abstract available.

PMID:
21725990
32.

Natural killer cells efficiently reject lymphoma silenced for the endoplasmic reticulum aminopeptidase associated with antigen processing.

Cifaldi L, Lo Monaco E, Forloni M, Giorda E, Lorenzi S, Petrini S, Tremante E, Pende D, Locatelli F, Giacomini P, Fruci D.

Cancer Res. 2011 Mar 1;71(5):1597-606. doi: 10.1158/0008-5472.CAN-10-3326. Epub 2011 Jan 20.

33.

NF-kappaB, and not MYCN, regulates MHC class I and endoplasmic reticulum aminopeptidases in human neuroblastoma cells.

Forloni M, Albini S, Limongi MZ, Cifaldi L, Boldrini R, Nicotra MR, Giannini G, Natali PG, Giacomini P, Fruci D.

Cancer Res. 2010 Feb 1;70(3):916-24. doi: 10.1158/0008-5472.CAN-09-2582. Epub 2010 Jan 26. Erratum in: Cancer Res. 2010 Apr 1;70(7):2995.

34.

HLA-E and the origin of immunogenic self HLA epitopes.

Lo Monaco E, Tremante E, Cifaldi L, Fruci D, Giacomini P.

Mol Immunol. 2010 May;47(9):1661-2; author reply 1163-4. doi: 10.1016/j.molimm.2009.12.018. Epub 2010 Jan 22. No abstract available.

PMID:
20096934
35.

Class I HLA folding and antigen presentation in beta 2-microglobulin-defective Daudi cells.

Martayan A, Sibilio L, Tremante E, Lo Monaco E, Mulder A, Fruci D, Cova A, Rivoltini L, Giacomini P.

J Immunol. 2009 Mar 15;182(6):3609-17. doi: 10.4049/jimmunol.0802316.

36.

Genetic risk factors in typical haemolytic uraemic syndrome.

Taranta A, Gianviti A, Palma A, De Luca V, Mannucci L, Procaccino MA, Ghiggeri GM, Caridi G, Fruci D, Ferracuti S, Ferretti A, Pecoraro C, Gaido M, Penza R, Edefonti A, Murer L, Tozzi AE, Emma F.

Nephrol Dial Transplant. 2009 Jun;24(6):1851-7. doi: 10.1093/ndt/gfn720. Epub 2008 Dec 25.

PMID:
19110485
37.

Antagomir-17-5p abolishes the growth of therapy-resistant neuroblastoma through p21 and BIM.

Fontana L, Fiori ME, Albini S, Cifaldi L, Giovinazzi S, Forloni M, Boldrini R, Donfrancesco A, Federici V, Giacomini P, Peschle C, Fruci D.

PLoS One. 2008 May 21;3(5):e2236. doi: 10.1371/journal.pone.0002236.

38.

N-linked glycosylation selectively regulates the generic folding of HLA-Cw1.

Martayan A, Sibilio L, Setini A, Lo Monaco E, Tremante E, Fruci D, Colonna M, Giacomini P.

J Biol Chem. 2008 Jun 13;283(24):16469-76. doi: 10.1074/jbc.M709175200. Epub 2008 Apr 17.

39.

Altered expression of endoplasmic reticulum aminopeptidases ERAP1 and ERAP2 in transformed non-lymphoid human tissues.

Fruci D, Giacomini P, Nicotra MR, Forloni M, Fraioli R, Saveanu L, van Endert P, Natali PG.

J Cell Physiol. 2008 Sep;216(3):742-9. doi: 10.1002/jcp.21454.

PMID:
18393273
40.

Assembly and selective "in synthesis" labeling of quenched fluorogenic protease substrates.

Chersi A, Ferracuti S, Falasca G, Butler RH, Fruci D.

Anal Biochem. 2006 Oct 15;357(2):194-9. Epub 2006 Aug 7.

PMID:
16930525
41.

Expression of endoplasmic reticulum aminopeptidases in EBV-B cell lines from healthy donors and in leukemia/lymphoma, carcinoma, and melanoma cell lines.

Fruci D, Ferracuti S, Limongi MZ, Cunsolo V, Giorda E, Fraioli R, Sibilio L, Carroll O, Hattori A, van Endert PM, Giacomini P.

J Immunol. 2006 Apr 15;176(8):4869-79.

42.

Effect of the [CCTG]n repeat expansion on ZNF9 expression in myotonic dystrophy type II (DM2).

Botta A, Caldarola S, Vallo L, Bonifazi E, Fruci D, Gullotta F, Massa R, Novelli G, Loreni F.

Biochim Biophys Acta. 2006 Mar;1762(3):329-34. Epub 2005 Dec 6.

43.

Impaired assembly results in the accumulation of multiple HLA-C heavy chain folding intermediates.

Sibilio L, Martayan A, Setini A, Fraioli R, Fruci D, Shabanowitz J, Hunt DF, Giacomini P.

J Immunol. 2005 Nov 15;175(10):6651-8.

44.

Angiotensin-converting enzyme (ACE) haplotypes and cyclosporine A (CsA) response: a model of the complex relationship between ACE quantitative trait locus and pathological phenotypes.

Catarsi P, Ravazzolo R, Emma F, Fruci D, Finos L, Frau A, Morreale G, Carrea A, Ghiggeri GM.

Hum Mol Genet. 2005 Aug 15;14(16):2357-67. Epub 2005 Jul 7.

PMID:
16002416
45.

Concerted peptide trimming by human ERAP1 and ERAP2 aminopeptidase complexes in the endoplasmic reticulum.

Saveanu L, Carroll O, Lindo V, Del Val M, Lopez D, Lepelletier Y, Greer F, Schomburg L, Fruci D, Niedermann G, van Endert PM.

Nat Immunol. 2005 Jul;6(7):689-97. Epub 2005 May 22.

PMID:
15908954
46.

The genetic basis of immune and autoimmune responses.

Bottazzo GF, Locatelli M, Fierabracci A, Fruci D.

Acta Paediatr Suppl. 2004 May;93(445):38-42. Review.

PMID:
15176718
47.

Control of cross-presentation during dendritic cell maturation.

Gil-Torregrosa BC, Lennon-Duménil AM, Kessler B, Guermonprez P, Ploegh HL, Fruci D, van Endert P, Amigorena S.

Eur J Immunol. 2004 Feb;34(2):398-407.

48.

Quantifying recruitment of cytosolic peptides for HLA class I presentation: impact of TAP transport.

Fruci D, Lauvau G, Saveanu L, Amicosante M, Butler RH, Polack A, Ginhoux F, Lemonnier F, Firat H, van Endert PM.

J Immunol. 2003 Mar 15;170(6):2977-84.

49.

Beyond the proteasome: trimming, degradation and generation of MHC class I ligands by auxiliary proteases.

Saveanu L, Fruci D, van Endert P.

Mol Immunol. 2002 Oct;39(3-4):203-15. Review.

PMID:
12200051
50.

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