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Items: 8


The nucleolus functions as a phase-separated protein quality control compartment.

Frottin F, Schueder F, Tiwary S, Gupta R, Körner R, Schlichthaerle T, Cox J, Jungmann R, Hartl FU, Hipp MS.

Science. 2019 Jul 26;365(6451):342-347. doi: 10.1126/science.aaw9157. Epub 2019 Jul 11.


In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment.

Guo Q, Lehmer C, Martínez-Sánchez A, Rudack T, Beck F, Hartmann H, Pérez-Berlanga M, Frottin F, Hipp MS, Hartl FU, Edbauer D, Baumeister W, Fernández-Busnadiego R.

Cell. 2018 Feb 8;172(4):696-705.e12. doi: 10.1016/j.cell.2017.12.030. Epub 2018 Feb 1.


Soluble Oligomers of PolyQ-Expanded Huntingtin Target a Multiplicity of Key Cellular Factors.

Kim YE, Hosp F, Frottin F, Ge H, Mann M, Hayer-Hartl M, Hartl FU.

Mol Cell. 2016 Sep 15;63(6):951-64. doi: 10.1016/j.molcel.2016.07.022. Epub 2016 Aug 25.


MetAP1 and MetAP2 drive cell selectivity for a potent anti-cancer agent in synergy, by controlling glutathione redox state.

Frottin F, Bienvenut WV, Bignon J, Jacquet E, Vaca Jacome AS, Van Dorsselaer A, Cianferani S, Carapito C, Meinnel T, Giglione C.

Oncotarget. 2016 Sep 27;7(39):63306-63323. doi: 10.18632/oncotarget.11216.


Cytoplasmic protein aggregates interfere with nucleocytoplasmic transport of protein and RNA.

Woerner AC, Frottin F, Hornburg D, Feng LR, Meissner F, Patra M, Tatzelt J, Mann M, Winklhofer KF, Hartl FU, Hipp MS.

Science. 2016 Jan 8;351(6269):173-6. doi: 10.1126/science.aad2033. Epub 2015 Dec 3.


Interplay between N-terminal methionine excision and FtsH protease is essential for normal chloroplast development and function in Arabidopsis.

Adam Z, Frottin F, Espagne C, Meinnel T, Giglione C.

Plant Cell. 2011 Oct;23(10):3745-60. doi: 10.1105/tpc.111.087239. Epub 2011 Oct 18.


Cotranslational proteolysis dominates glutathione homeostasis to support proper growth and development.

Frottin F, Espagne C, Traverso JA, Mauve C, Valot B, Lelarge-Trouverie C, Zivy M, Noctor G, Meinnel T, Giglione C.

Plant Cell. 2009 Oct;21(10):3296-314. doi: 10.1105/tpc.109.069757. Epub 2009 Oct 23.


The proteomics of N-terminal methionine cleavage.

Frottin F, Martinez A, Peynot P, Mitra S, Holz RC, Giglione C, Meinnel T.

Mol Cell Proteomics. 2006 Dec;5(12):2336-49. Epub 2006 Sep 8.

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