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Reelin controls the positioning of brainstem serotonergic raphe neurons.

Shehabeldin R, Lutz D, Karsak M, Frotscher M, Krieglstein K, Sharaf A.

PLoS One. 2018 Jul 12;13(7):e0200268. doi: 10.1371/journal.pone.0200268. eCollection 2018.


Structure-based design and profiling of novel 17β-HSD14 inhibitors.

Braun F, Bertoletti N, Möller G, Adamski J, Frotscher M, Guragossian N, Madeira Gírio PA, Le Borgne M, Ettouati L, Falson P, Müller S, Vollmer G, Heine A, Klebe G, Marchais-Oberwinkler S.

Eur J Med Chem. 2018 May 22;155:61-76. doi: 10.1016/j.ejmech.2018.05.029. [Epub ahead of print]


Trajectory Analysis Unveils Reelin's Role in the Directed Migration of Granule Cells in the Dentate Gyrus.

Wang S, Brunne B, Zhao S, Chai X, Li J, Lau J, Failla AV, Zobiak B, Sibbe M, Westbrook GL, Lutz D, Frotscher M.

J Neurosci. 2018 Jan 3;38(1):137-148. doi: 10.1523/JNEUROSCI.0988-17.2017. Epub 2017 Nov 14.


Proteolytic cleavage of transmembrane cell adhesion molecule L1 by extracellular matrix molecule Reelin is important for mouse brain development.

Lutz D, Sharaf A, Drexler D, Kataria H, Wolters-Eisfeld G, Brunne B, Kleene R, Loers G, Frotscher M, Schachner M.

Sci Rep. 2017 Nov 10;7(1):15268. doi: 10.1038/s41598-017-15311-x.


Loss of Reelin protects mice against arterial thrombosis by impairing integrin activation and thrombus formation under high shear conditions.

Gowert NS, Krüger I, Klier M, Donner L, Kipkeew F, Gliem M, Bradshaw NJ, Lutz D, Köber S, Langer H, Jander S, Jurk K, Frotscher M, Korth C, Bock HH, Elvers M.

Cell Signal. 2017 Dec;40:210-221. doi: 10.1016/j.cellsig.2017.09.016. Epub 2017 Sep 21.


Presenilins regulate synaptic plasticity and mitochondrial calcium homeostasis in the hippocampal mossy fiber pathway.

Lee SH, Lutz D, Mossalam M, Bolshakov VY, Frotscher M, Shen J.

Mol Neurodegener. 2017 Jun 15;12(1):48. doi: 10.1186/s13024-017-0189-5.


Reelin Signaling Inactivates Cofilin to Stabilize the Cytoskeleton of Migrating Cortical Neurons.

Frotscher M, Zhao S, Wang S, Chai X.

Front Cell Neurosci. 2017 May 23;11:148. doi: 10.3389/fncel.2017.00148. eCollection 2017. Review.


The Endogenous Stress Hormone CRH Modulates Excitatory Transmission and Network Physiology in Hippocampus.

Gunn BG, Cox CD, Chen Y, Frotscher M, Gall CM, Baram TZ, Lynch G.

Cereb Cortex. 2017 Aug 1;27(8):4182-4198. doi: 10.1093/cercor/bhx103.


First Dual Inhibitors of Steroid Sulfatase (STS) and 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1): Designed Multiple Ligands as Novel Potential Therapeutics for Estrogen-Dependent Diseases.

Salah M, Abdelsamie AS, Frotscher M.

J Med Chem. 2017 May 11;60(9):4086-4092. doi: 10.1021/acs.jmedchem.7b00062. Epub 2017 Apr 27.


Proteomics insights into infantile neuronal ceroid lipofuscinosis (CLN1) point to the involvement of cilia pathology in the disease.

Segal-Salto M, Hansson K, Sapir T, Kaplan A, Levy T, Schweizer M, Frotscher M, James P, Reiner O.

Hum Mol Genet. 2017 May 1;26(9):1678. doi: 10.1093/hmg/ddx074.


How does Reelin signaling regulate the neuronal cytoskeleton during migration?

Chai X, Frotscher M.

Neurogenesis (Austin). 2016 Sep 29;3(1):e1242455. doi: 10.1080/23262133.2016.1242455. eCollection 2016. Review.


Presynaptic localization of GluK5 in rod photoreceptors suggests a novel function of high affinity glutamate receptors in the mammalian retina.

Haumann I, Junghans D, Anstötz M, Frotscher M.

PLoS One. 2017 Feb 24;12(2):e0172967. doi: 10.1371/journal.pone.0172967. eCollection 2017.


Altered Connectivity and Synapse Maturation of the Hippocampal Mossy Fiber Pathway in a Mouse Model of the Fragile X Syndrome.

Scharkowski F, Frotscher M, Lutz D, Korte M, Michaelsen-Preusse K.

Cereb Cortex. 2018 Mar 1;28(3):852-867. doi: 10.1093/cercor/bhw408.


Treatment of estrogen-dependent diseases: Design, synthesis and profiling of a selective 17β-HSD1 inhibitor with sub-nanomolar IC50 for a proof-of-principle study.

Abdelsamie AS, van Koppen CJ, Bey E, Salah M, Börger C, Siebenbürger L, Laschke MW, Menger MD, Frotscher M.

Eur J Med Chem. 2017 Feb 15;127:944-957. doi: 10.1016/j.ejmech.2016.11.004. Epub 2016 Nov 4.


Synaptic mechanisms of pattern completion in the hippocampal CA3 network.

Guzman SJ, Schlögl A, Frotscher M, Jonas P.

Science. 2016 Sep 9;353(6304):1117-23. doi: 10.1126/science.aaf1836.


Loss of Reelin protects against atherosclerosis by reducing leukocyte-endothelial cell adhesion and lesion macrophage accumulation.

Ding Y, Huang L, Xian X, Yuhanna IS, Wasser CR, Frotscher M, Mineo C, Shaul PW, Herz J.

Sci Signal. 2016 Mar 15;9(419):ra29. doi: 10.1126/scisignal.aad5578.


Reelin and cofilin cooperate during the migration of cortical neurons: a quantitative morphological analysis.

Chai X, Zhao S, Fan L, Zhang W, Lu X, Shao H, Wang S, Song L, Failla AV, Zobiak B, Mannherz HG, Frotscher M.

Development. 2016 Mar 15;143(6):1029-40. doi: 10.1242/dev.134163. Epub 2016 Feb 18.


Distinct synaptic and neurochemical changes to the granule cell-CA3 projection in Bassoon mutant mice.

Dieni S, Nestel S, Sibbe M, Frotscher M, Hellwig S.

Front Synaptic Neurosci. 2015 Oct 23;7:18. doi: 10.3389/fnsyn.2015.00018. eCollection 2015.


The rostral migratory stream generates hippocampal CA1 pyramidal-like neurons in a novel organotypic slice co-culture model.

Singec I, Knoth R, Vida I, Frotscher M.

Biol Open. 2015 Sep 4;4(10):1222-8. doi: 10.1242/bio.012096.


Towards the evaluation in an animal disease model: Fluorinated 17β-HSD1 inhibitors showing strong activity towards both the human and the rat enzyme.

Abdelsamie AS, Bey E, Gargano EM, van Koppen CJ, Empting M, Frotscher M.

Eur J Med Chem. 2015 Oct 20;103:56-68. doi: 10.1016/j.ejmech.2015.08.030. Epub 2015 Aug 18.


17β-Hydroxysteroid Dehydrogenase Type 2 Inhibition: Discovery of Selective and Metabolically Stable Compounds Inhibiting Both the Human Enzyme and Its Murine Ortholog.

Gargano EM, Allegretta G, Perspicace E, Carotti A, Van Koppen C, Frotscher M, Marchais-Oberwinkler S, Hartmann RW.

PLoS One. 2015 Jul 31;10(7):e0134754. doi: 10.1371/journal.pone.0134754. eCollection 2015.


Reelin protects against amyloid β toxicity in vivo.

Lane-Donovan C, Philips GT, Wasser CR, Durakoglugil MS, Masiulis I, Upadhaya A, Pohlkamp T, Coskun C, Kotti T, Steller L, Hammer RE, Frotscher M, Bock HH, Herz J.

Sci Signal. 2015 Jul 7;8(384):ra67. doi: 10.1126/scisignal.aaa6674.


Pro-aggregant Tau impairs mossy fiber plasticity due to structural changes and Ca(++) dysregulation.

Decker JM, Krüger L, Sydow A, Zhao S, Frotscher M, Mandelkow E, Mandelkow EM.

Acta Neuropathol Commun. 2015 Apr 3;3:23. doi: 10.1186/s40478-015-0193-3.


Stem- and progenitor cell proliferation in the dentate gyrus of the reeler mouse.

Sibbe M, Kuner E, Althof D, Frotscher M.

PLoS One. 2015 Mar 11;10(3):e0119643. doi: 10.1371/journal.pone.0119643. eCollection 2015.


Src controls neuronal migration by regulating the activity of FAK and cofilin.

Wang JT, Song LZ, Li LL, Zhang W, Chai XJ, An L, Chen SL, Frotscher M, Zhao ST.

Neuroscience. 2015 Apr 30;292:90-100. doi: 10.1016/j.neuroscience.2015.02.025. Epub 2015 Feb 21.


The lipoprotein receptor LRP1 modulates sphingosine-1-phosphate signaling and is essential for vascular development.

Nakajima C, Haffner P, Goerke SM, Zurhove K, Adelmann G, Frotscher M, Herz J, Bock HH, May P.

Development. 2014 Dec;141(23):4513-25. doi: 10.1242/dev.109124. Epub 2014 Nov 5.


Fine structure of synapses on dendritic spines.

Frotscher M, Studer D, Graber W, Chai X, Nestel S, Zhao S.

Front Neuroanat. 2014 Sep 9;8:94. doi: 10.3389/fnana.2014.00094. eCollection 2014. Review.


Reelin Induces Branching of Neurons and Radial Glial Cells during Corticogenesis.

Chai X, Fan L, Shao H, Lu X, Zhang W, Li J, Wang J, Chen S, Frotscher M, Zhao S.

Cereb Cortex. 2015 Oct;25(10):3640-53. doi: 10.1093/cercor/bhu216. Epub 2014 Sep 21.


Synaptopodin regulates spine plasticity: mediation by calcium stores.

Korkotian E, Frotscher M, Segal M.

J Neurosci. 2014 Aug 27;34(35):11641-51. doi: 10.1523/JNEUROSCI.0381-14.2014.


6-Hydroxybenzothiophene ketones: potent inhibitors of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) owing to favorable molecule geometry and conformational preorganization.

Miralinaghi P, Schmitt C, Hartmann RW, Frotscher M, Engel M.

ChemMedChem. 2014 Oct;9(10):2294-308. doi: 10.1002/cmdc.201402050. Epub 2014 Jul 14.


Alterations in the hippocampal and striatal catecholaminergic fiber densities of heterozygous reeler mice.

Nullmeier S, Panther P, Frotscher M, Zhao S, Schwegler H.

Neuroscience. 2014 Sep 5;275:404-19. doi: 10.1016/j.neuroscience.2014.06.027. Epub 2014 Jun 23.


Generation and characterization of an Nse-CreERT2 transgenic line suitable for inducible gene manipulation in cerebellar granule cells.

Pohlkamp T, Steller L, May P, Günther T, Schüle R, Frotscher M, Herz J, Bock HH.

PLoS One. 2014 Jun 20;9(6):e100384. doi: 10.1371/journal.pone.0100384. eCollection 2014.


Inhibition of 17β-HSD1: SAR of bicyclic substituted hydroxyphenylmethanones and discovery of new potent inhibitors with thioether linker.

Abdelsamie AS, Bey E, Hanke N, Empting M, Hartmann RW, Frotscher M.

Eur J Med Chem. 2014 Jul 23;82:394-406. doi: 10.1016/j.ejmech.2014.05.074. Epub 2014 Jun 3.


Capture of activity-induced ultrastructural changes at synapses by high-pressure freezing of brain tissue.

Studer D, Zhao S, Chai X, Jonas P, Graber W, Nestel S, Frotscher M.

Nat Protoc. 2014;9(6):1480-95. doi: 10.1038/nprot.2014.099. Epub 2014 May 29.


Role of the postnatal radial glial scaffold for the development of the dentate gyrus as revealed by Reelin signaling mutant mice.

Brunne B, Franco S, Bouché E, Herz J, Howell BW, Pahle J, Müller U, May P, Frotscher M, Bock HH.

Glia. 2013 Aug;61(8):1347-63. doi: 10.1002/glia.22519. Epub 2013 Jul 4.


Characterization and distribution of Reelin-positive interneuron subtypes in the rat barrel cortex.

Pohlkamp T, Dávid C, Cauli B, Gallopin T, Bouché E, Karagiannis A, May P, Herz J, Frotscher M, Staiger JF, Bock HH.

Cereb Cortex. 2014 Nov;24(11):3046-58. doi: 10.1093/cercor/bht161. Epub 2013 Jun 26.


Low density lipoprotein receptor-related protein 1 (LRP1) modulates N-methyl-D-aspartate (NMDA) receptor-dependent intracellular signaling and NMDA-induced regulation of postsynaptic protein complexes.

Nakajima C, Kulik A, Frotscher M, Herz J, Schäfer M, Bock HH, May P.

J Biol Chem. 2013 Jul 26;288(30):21909-23. doi: 10.1074/jbc.M112.444364. Epub 2013 Jun 11.


Differential GABAB-receptor-mediated effects in perisomatic- and dendrite-targeting parvalbumin interneurons.

Booker SA, Gross A, Althof D, Shigemoto R, Bettler B, Frotscher M, Hearing M, Wickman K, Watanabe M, Kulik Á, Vida I.

J Neurosci. 2013 May 1;33(18):7961-74. doi: 10.1523/JNEUROSCI.1186-12.2013.


Design and fabrication of a bending rotation fatigue test rig for in situ electrochemical analysis during fatigue testing of NiTi shape memory alloy wires.

Neelakantan L, Zglinski JK, Frotscher M, Eggeler G.

Rev Sci Instrum. 2013 Mar;84(3):035102. doi: 10.1063/1.4793488.


Epilepsy-induced motility of differentiated neurons.

Chai X, Münzner G, Zhao S, Tinnes S, Kowalski J, Häussler U, Young C, Haas CA, Frotscher M.

Cereb Cortex. 2014 Aug;24(8):2130-40. doi: 10.1093/cercor/bht067. Epub 2013 Mar 15.


Reelin induces EphB activation.

Bouché E, Romero-Ortega MI, Henkemeyer M, Catchpole T, Leemhuis J, Frotscher M, May P, Herz J, Bock HH.

Cell Res. 2013 Apr;23(4):473-90. doi: 10.1038/cr.2013.7. Epub 2013 Jan 15.


Structural plasticity of spines at giant mossy fiber synapses.

Zhao S, Studer D, Chai X, Graber W, Brose N, Nestel S, Young C, Rodriguez EP, Saetzler K, Frotscher M.

Front Neural Circuits. 2012 Dec 18;6:103. doi: 10.3389/fncir.2012.00103. eCollection 2012.


Experimental epilepsy affects Notch1 signalling and the stem cell pool in the dentate gyrus.

Sibbe M, Häussler U, Dieni S, Althof D, Haas CA, Frotscher M.

Eur J Neurosci. 2012 Dec;36(12):3643-52. doi: 10.1111/j.1460-9568.2012.08279.x. Epub 2012 Sep 17.


Abnormal dentate gyrus network circuitry in temporal lobe epilepsy.

Sloviter RS, Bumanglag AV, Schwarcz R, Frotscher M.

In: Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, editors. Jasper's Basic Mechanisms of the Epilepsies [Internet]. 4th edition. Bethesda (MD): National Center for Biotechnology Information (US); 2012.


Fine structure of hippocampal mossy fiber synapses following rapid high-pressure freezing.

Zhao S, Studer D, Graber W, Nestel S, Frotscher M.

Epilepsia. 2012 Jun;53 Suppl 1:4-8. doi: 10.1111/j.1528-1167.2012.03469.x.


Synthesis and biological evaluation of phenyl substituted 1H-1,2,4-triazoles as non-steroidal inhibitors of 17β-hydroxysteroid dehydrogenase type 2.

Al-Soud YA, Marchais-Oberwinkler S, Frotscher M, Hartmann RW.

Arch Pharm (Weinheim). 2012 Aug;345(8):610-21. doi: 10.1002/ardp.201200025. Epub 2012 Apr 25.


Tuning synaptic transmission in the hippocampus by stress: the CRH system.

Chen Y, Andres AL, Frotscher M, Baram TZ.

Front Cell Neurosci. 2012 Apr 3;6:13. doi: 10.3389/fncel.2012.00013. eCollection 2012.


Direct antiproliferative effect of nonsteroidal 17β-hydroxysteroid dehydrogenase type 1 inhibitors in vitro.

Berényi Á, Frotscher M, Marchais-Oberwinkler S, Hartmann RW, Minorics R, Ocsovszki I, Falkay G, Zupkó I.

J Enzyme Inhib Med Chem. 2013 Aug;28(4):695-703. doi: 10.3109/14756366.2012.672414. Epub 2012 Apr 3.


Selective degeneration of septal and hippocampal GABAergic neurons in a mouse model of amyloidosis and tauopathy.

Loreth D, Ozmen L, Revel FG, Knoflach F, Wetzel P, Frotscher M, Metzger F, Kretz O.

Neurobiol Dis. 2012 Jul;47(1):1-12. doi: 10.1016/j.nbd.2012.03.011. Epub 2012 Mar 9.


BDNF and its pro-peptide are stored in presynaptic dense core vesicles in brain neurons.

Dieni S, Matsumoto T, Dekkers M, Rauskolb S, Ionescu MS, Deogracias R, Gundelfinger ED, Kojima M, Nestel S, Frotscher M, Barde YA.

J Cell Biol. 2012 Mar 19;196(6):775-88. doi: 10.1083/jcb.201201038. Epub 2012 Mar 12.

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