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Low-energy total diet replacement intervention in patients with type 2 diabetes mellitus and obesity treated with insulin: a randomized trial.

Brown A, Dornhorst A, McGowan B, Omar O, Leeds AR, Taheri S, Frost GS.

BMJ Open Diabetes Res Care. 2020 Jan;8(1). pii: e001012. doi: 10.1136/bmjdrc-2019-001012.


Effect of semolina pudding prepared from starch branching enzyme IIa and b mutant wheat on glycaemic response in vitro and in vivo: a randomised controlled pilot study.

Corrado M, Cherta-Murillo A, Chambers ES, Wood AJ, Plummer A, Lovegrove A, Edwards CH, Frost GS, Hazard BA.

Food Funct. 2020 Jan 29;11(1):617-627. doi: 10.1039/c9fo02460c.


Exploration of muscle loss and metabolic state during prolonged critical illness: Implications for intervention?

Wandrag L, Brett SJ, Frost GS, Bountziouka V, Hickson M.

PLoS One. 2019 Nov 14;14(11):e0224565. doi: 10.1371/journal.pone.0224565. eCollection 2019.


Leucine-enriched essential amino acid supplementation in mechanically ventilated trauma patients: a feasibility study.

Wandrag L, Brett SJ, Frost GS, To M, Loubo EA, Jackson NC, Umpleby AM, Bountziouka V, Hickson M.

Trials. 2019 Sep 11;20(1):561. doi: 10.1186/s13063-019-3639-2.


Validation of the Oxford WebQ Online 24-Hour Dietary Questionnaire Using Biomarkers.

Greenwood DC, Hardie LJ, Frost GS, Alwan NA, Bradbury KE, Carter M, Elliott P, Evans CEL, Ford HE, Hancock N, Key TJ, Liu B, Morris MA, Mulla UZ, Petropoulou K, Potter GDM, Riboli E, Young H, Wark PA, Cade JE.

Am J Epidemiol. 2019 Oct 1;188(10):1858-1867. doi: 10.1093/aje/kwz165.


Measuring phenotypic flexibility by transcriptome time-course analyses during challenge tests before and after energy restriction.

van Bussel IPG, Fazelzadeh P, Frost GS, Rundle M, Afman LA.

FASEB J. 2019 Sep;33(9):10280-10290. doi: 10.1096/fj.201900148R. Epub 2019 Jun 25.


Effects of Inulin Propionate Ester Incorporated into Palatable Food Products on Appetite and Resting Energy Expenditure: A Randomised Crossover Study.

Byrne CS, Chambers ES, Preston T, Tedford C, Brignardello J, Garcia-Perez I, Holmes E, Wallis GA, Morrison DJ, Frost GS.

Nutrients. 2019 Apr 16;11(4). pii: E861. doi: 10.3390/nu11040861.


Dietary supplementation with inulin-propionate ester or inulin improves insulin sensitivity in adults with overweight and obesity with distinct effects on the gut microbiota, plasma metabolome and systemic inflammatory responses: a randomised cross-over trial.

Chambers ES, Byrne CS, Morrison DJ, Murphy KG, Preston T, Tedford C, Garcia-Perez I, Fountana S, Serrano-Contreras JI, Holmes E, Reynolds CJ, Roberts JF, Boyton RJ, Altmann DM, McDonald JAK, Marchesi JR, Akbar AN, Riddell NE, Wallis GA, Frost GS.

Gut. 2019 Aug;68(8):1430-1438. doi: 10.1136/gutjnl-2019-318424. Epub 2019 Apr 10.


APOE4 Genotype Exerts Greater Benefit in Lowering Plasma Cholesterol and Apolipoprotein B than Wild Type (E3/E3), after Replacement of Dietary Saturated Fats with Low Glycaemic Index Carbohydrates.

Griffin BA, Walker CG, Jebb SA, Moore C, Frost GS, Goff L, Sanders TAB, Lewis F, Griffin M, Gitau R, Lovegrove JA.

Nutrients. 2018 Oct 17;10(10). pii: E1524. doi: 10.3390/nu10101524.


Validity of an online 24-h recall tool (myfood24) for dietary assessment in population studies: comparison with biomarkers and standard interviews.

Wark PA, Hardie LJ, Frost GS, Alwan NA, Carter M, Elliott P, Ford HE, Hancock N, Morris MA, Mulla UZ, Noorwali EA, Petropoulou K, Murphy D, Potter GDM, Riboli E, Greenwood DC, Cade JE.

BMC Med. 2018 Aug 9;16(1):136. doi: 10.1186/s12916-018-1113-8.


The effect of L-rhamnose on intestinal transit time, short chain fatty acids and appetite regulation: a pilot human study using combined 13CO2/H2 breath tests.

Byrne CS, Preston T, Brignardello J, Garcia-Perez I, Holmes E, Frost GS, Morrison DJ.

J Breath Res. 2018 Aug 6;12(4):046006. doi: 10.1088/1752-7163/aad3f1.


Cationic lipid-based nanoparticles mediate functional delivery of acetate to tumor cells in vivo leading to significant anticancer effects.

Brody LP, Sahuri-Arisoylu M, Parkinson JR, Parkes HG, So PW, Hajji N, Thomas EL, Frost GS, Miller AD, Bell JD.

Int J Nanomedicine. 2017 Sep 8;12:6677-6685. doi: 10.2147/IJN.S135968. eCollection 2017.


Impact of liver fat on the differential partitioning of hepatic triacylglycerol into VLDL subclasses on high and low sugar diets.

Umpleby AM, Shojaee-Moradie F, Fielding B, Li X, Marino A, Alsini N, Isherwood C, Jackson N, Ahmad A, Stolinski M, Lovegrove JA, Johnsen S, Jeewaka R Mendis AS, Wright J, Wilinska ME, Hovorka R, Bell JD, Thomas EL, Frost GS, Griffin BA.

Clin Sci (Lond). 2017 Oct 17;131(21):2561-2573. doi: 10.1042/CS20171208. Print 2017 Nov 1.


Exploring the Links between Diet and Health in an Irish Cohort: A Lipidomic Approach.

O'Gorman A, Gibbons H, Ryan MF, Gibney ER, Gibney MJ, Frost GS, Roche HM, Brennan L.

J Proteome Res. 2017 Mar 3;16(3):1280-1287. doi: 10.1021/acs.jproteome.6b00912. Epub 2017 Feb 13.


Development of a New Branded UK Food Composition Database for an Online Dietary Assessment Tool.

Carter MC, Hancock N, Albar SA, Brown H, Greenwood DC, Hardie LJ, Frost GS, Wark PA, Cade JE.

Nutrients. 2016 Aug 5;8(8). pii: E480. doi: 10.3390/nu8080480.


Randomised clinical study: inulin short-chain fatty acid esters for targeted delivery of short-chain fatty acids to the human colon.

Polyviou T, MacDougall K, Chambers ES, Viardot A, Psichas A, Jawaid S, Harris HC, Edwards CA, Simpson L, Murphy KG, Zac-Varghese SE, Blundell JE, Dhillo WS, Bloom SR, Frost GS, Preston T, Tedford MC, Morrison DJ.

Aliment Pharmacol Ther. 2016 Oct;44(7):662-72. doi: 10.1111/apt.13749. Epub 2016 Jul 28.


Resection of the large bowel suppresses hunger and food intake and modulates gastrointestinal fermentation.

Hettiarachchi P, Wickremasinghe AR, Frost GS, Deen KI, Pathirana AA, Murphy KG, Jayaratne SD.

Obesity (Silver Spring). 2016 Aug;24(8):1723-30. doi: 10.1002/oby.21550.


Mycoprotein reduces energy intake and postprandial insulin release without altering glucagon-like peptide-1 and peptide tyrosine-tyrosine concentrations in healthy overweight and obese adults: a randomised-controlled trial.

Bottin JH, Swann JR, Cropp E, Chambers ES, Ford HE, Ghatei MA, Frost GS.

Br J Nutr. 2016 Jul;116(2):360-74. doi: 10.1017/S0007114516001872. Epub 2016 May 20.


Increased colonic propionate reduces anticipatory reward responses in the human striatum to high-energy foods.

Byrne CS, Chambers ES, Alhabeeb H, Chhina N, Morrison DJ, Preston T, Tedford C, Fitzpatrick J, Irani C, Busza A, Garcia-Perez I, Fountana S, Holmes E, Goldstone AP, Frost GS.

Am J Clin Nutr. 2016 Jul;104(1):5-14. doi: 10.3945/ajcn.115.126706. Epub 2016 May 11.


L-rhamnose as a source of colonic propionate inhibits insulin secretion but does not influence measures of appetite or food intake.

Darzi J, Frost GS, Swann JR, Costabile A, Robertson MD.

Appetite. 2016 Mar 1;98:142-9. doi: 10.1016/j.appet.2015.12.011. Epub 2015 Dec 17.


A Randomised Crossover Trial: The Effect of Inulin on Glucose Homeostasis in Subtypes of Prediabetes.

Guess ND, Dornhorst A, Oliver N, Frost GS.

Ann Nutr Metab. 2016;68(1):26-34. doi: 10.1159/000441626. Epub 2015 Nov 17.


A randomized controlled trial: the effect of inulin on weight management and ectopic fat in subjects with prediabetes.

Guess ND, Dornhorst A, Oliver N, Bell JD, Thomas EL, Frost GS.

Nutr Metab (Lond). 2015 Oct 24;12:36. doi: 10.1186/s12986-015-0033-2. eCollection 2015.


Total, insoluble and soluble dietary fibre intake in relation to blood pressure: the INTERMAP Study - CORRIGENDUM.

Aljuraiban GS, Griep LM, Chan Q, Daviglus ML, Stamler J, Van Horn L, Elliott P, Frost GS.

Br J Nutr. 2015 Nov 14;114(9):1534. doi: 10.1017/S0007114515003876. Epub 2015 Sep 21. No abstract available.


Manipulation of starch bioaccessibility in wheat endosperm to regulate starch digestion, postprandial glycemia, insulinemia, and gut hormone responses: a randomized controlled trial in healthy ileostomy participants.

Edwards CH, Grundy MM, Grassby T, Vasilopoulou D, Frost GS, Butterworth PJ, Berry SE, Sanderson J, Ellis PR.

Am J Clin Nutr. 2015 Oct;102(4):791-800. doi: 10.3945/ajcn.114.106203. Epub 2015 Sep 2.


Total, insoluble and soluble dietary fibre intake in relation to blood pressure: the INTERMAP Study.

Aljuraiban GS, Griep LM, Chan Q, Daviglus ML, Stamler J, Van Horn L, Elliott P, Frost GS.

Br J Nutr. 2015 Nov 14;114(9):1480-6. doi: 10.1017/S0007114515003098. Epub 2015 Sep 2. Erratum in: Br J Nutr. 2015 Nov 14;114(9):1534. Griep, Linda M O [corrected to Griep, Linda M Oude].


Prebiotics Modulate the Effects of Antibiotics on Gut Microbial Diversity and Functioning in Vitro.

Johnson LP, Walton GE, Psichas A, Frost GS, Gibson GR, Barraclough TG.

Nutrients. 2015 Jun 4;7(6):4480-97. doi: 10.3390/nu7064480.


Development of a UK Online 24-h Dietary Assessment Tool: myfood24.

Carter MC, Albar SA, Morris MA, Mulla UZ, Hancock N, Evans CE, Alwan NA, Greenwood DC, Hardie LJ, Frost GS, Wark PA, Cade JE; myfood24 Consortium.

Nutrients. 2015 May 27;7(6):4016-32. doi: 10.3390/nu7064016.


Adherence to NICE guidelines on diabetes prevention in the UK: Effect on patient knowledge and perceived risk.

Guess ND, Caengprasath N, Dornhorst A, Frost GS.

Prim Care Diabetes. 2015 Dec;9(6):407-11. doi: 10.1016/j.pcd.2015.04.005. Epub 2015 May 13.


Maximal fat oxidation during exercise is positively associated with 24-hour fat oxidation and insulin sensitivity in young, healthy men.

Robinson SL, Hattersley J, Frost GS, Chambers ES, Wallis GA.

J Appl Physiol (1985). 2015 Jun 1;118(11):1415-22. doi: 10.1152/japplphysiol.00058.2015. Epub 2015 Mar 26.


The impact of eating frequency and time of intake on nutrient quality and Body Mass Index: the INTERMAP Study, a Population-Based Study.

Aljuraiban GS, Chan Q, Oude Griep LM, Brown IJ, Daviglus ML, Stamler J, Van Horn L, Elliott P, Frost GS; INTERMAP Research Group.

J Acad Nutr Diet. 2015 Apr;115(4):528-36.e1. doi: 10.1016/j.jand.2014.11.017. Epub 2015 Jan 22.


Circulating pancreatic polypeptide concentrations predict visceral and liver fat content.

Sam AH, Sleeth ML, Thomas EL, Ismail NA, Mat Daud N, Chambers E, Shojaee-Moradie F, Umpleby M, Goldstone AP, Le Roux CW, Bech P, Busbridge M, Laurie R, Cuthbertson DJ, Buckley A, Ghatei MA, Bloom SR, Frost GS, Bell JD, Murphy KG.

J Clin Endocrinol Metab. 2015 Mar;100(3):1048-52. doi: 10.1210/jc.2014-3450. Epub 2014 Dec 9.


The effects of a diet rich in inulin or wheat fibre on markers of cardiovascular disease in overweight male subjects.

Tripkovic L, Muirhead NC, Hart KH, Frost GS, Lodge JK.

J Hum Nutr Diet. 2015 Oct;28(5):476-85. doi: 10.1111/jhn.12251. Epub 2014 Jun 12.


Impacts of plant-based foods in ancestral hominin diets on the metabolism and function of gut microbiota in vitro.

Frost GS, Walton GE, Swann JR, Psichas A, Costabile A, Johnson LP, Sponheimer M, Gibson GR, Barraclough TG.

mBio. 2014 May 20;5(3):e00853-14. doi: 10.1128/mBio.00853-14.


Interindividual and intraindividual variation in pulse wave velocity measurements in a male population.

Tripkovic L, Hart KH, Frost GS, Lodge JK.

Blood Press Monit. 2014 Aug;19(4):233-41. doi: 10.1097/MBP.0000000000000052.


Ghrelin mimics fasting to enhance human hedonic, orbitofrontal cortex, and hippocampal responses to food.

Goldstone AP, Prechtl CG, Scholtz S, Miras AD, Chhina N, Durighel G, Deliran SS, Beckmann C, Ghatei MA, Ashby DR, Waldman AD, Gaylinn BD, Thorner MO, Frost GS, Bloom SR, Bell JD.

Am J Clin Nutr. 2014 Jun;99(6):1319-30. doi: 10.3945/ajcn.113.075291. Epub 2014 Apr 23.


The impact of oligofructose on stimulation of gut hormones, appetite regulation and adiposity.

Daud NM, Ismail NA, Thomas EL, Fitzpatrick JA, Bell JD, Swann JR, Costabile A, Childs CE, Pedersen C, Goldstone AP, Frost GS.

Obesity (Silver Spring). 2014 Jun;22(6):1430-8. doi: 10.1002/oby.20754. Epub 2014 Apr 8.


Influence of the tolerability of vinegar as an oral source of short-chain fatty acids on appetite control and food intake.

Darzi J, Frost GS, Montaser R, Yap J, Robertson MD.

Int J Obes (Lond). 2014 May;38(5):675-81. doi: 10.1038/ijo.2013.157. Epub 2013 Aug 27.


Obese patients after gastric bypass surgery have lower brain-hedonic responses to food than after gastric banding.

Scholtz S, Miras AD, Chhina N, Prechtl CG, Sleeth ML, Daud NM, Ismail NA, Durighel G, Ahmed AR, Olbers T, Vincent RP, Alaghband-Zadeh J, Ghatei MA, Waldman AD, Frost GS, Bell JD, le Roux CW, Goldstone AP.

Gut. 2014 Jun;63(6):891-902. doi: 10.1136/gutjnl-2013-305008. Epub 2013 Aug 20.


Gut hormone release and appetite regulation in healthy non-obese participants following oligofructose intake. A dose-escalation study.

Pedersen C, Lefevre S, Peters V, Patterson M, Ghatei MA, Morgan LM, Frost GS.

Appetite. 2013 Jul;66:44-53. doi: 10.1016/j.appet.2013.02.017. Epub 2013 Mar 5.


Ethnic differences in beta-cell function, dietary intake and expression of the metabolic syndrome among UK adults of South Asian, black African-Caribbean and white-European origin at high risk of metabolic syndrome.

Goff LM, Griffin BA, Lovegrove JA, Sanders TA, Jebb SA, Bluck LJ, Frost GS; RISCK Study Group.

Diab Vasc Dis Res. 2013 Jul;10(4):315-23. doi: 10.1177/1479164112467545. Epub 2013 Jan 3.


Coadministration of glucagon-like peptide-1 during glucagon infusion in humans results in increased energy expenditure and amelioration of hyperglycemia.

Tan TM, Field BC, McCullough KA, Troke RC, Chambers ES, Salem V, Gonzalez Maffe J, Baynes KC, De Silva A, Viardot A, Alsafi A, Frost GS, Ghatei MA, Bloom SR.

Diabetes. 2013 Apr;62(4):1131-8. doi: 10.2337/db12-0797. Epub 2012 Dec 17.


Low glycaemic index diets and blood lipids: a systematic review and meta-analysis of randomised controlled trials.

Goff LM, Cowland DE, Hooper L, Frost GS.

Nutr Metab Cardiovasc Dis. 2013 Jan;23(1):1-10. doi: 10.1016/j.numecd.2012.06.002. Epub 2012 Jul 25. Review.


Dietary fibre improves first-phase insulin secretion in overweight individuals.

Bodinham CL, Smith L, Wright J, Frost GS, Robertson MD.

PLoS One. 2012;7(7):e40834. doi: 10.1371/journal.pone.0040834. Epub 2012 Jul 16.


Fatty acid flux and oxidation are increased by rimonabant in obese women.

Backhouse K, Sarac I, Shojaee-Moradie F, Stolinski M, Robertson MD, Frost GS, Bell JD, Thomas EL, Wright J, Russell-Jones D, Umpleby AM.

Metabolism. 2012 Sep;61(9):1220-3. doi: 10.1016/j.metabol.2012.02.012. Epub 2012 Mar 24. Erratum in: Metabolism. 2014 Apr;63(4):e7.


PPARγ2 gene Pro12Ala and PPARα gene Leu162Val single nucleotide polymorphisms interact with dietary intake of fat in determination of plasma lipid concentrations.

Alsaleh A, Frost GS, Griffin BA, Lovegrove JA, Jebb SA, Sanders TA, O'Dell SD; RISCK Study investigators.

J Nutrigenet Nutrigenomics. 2011;4(6):354-66. doi: 10.1159/000336362. Epub 2012 Feb 29.


Genetic predisposition to type 2 diabetes is associated with impaired insulin secretion but does not modify insulin resistance or secretion in response to an intervention to lower dietary saturated fat.

Walker CG, Loos RJ, Mander AP, Jebb SA, Frost GS, Griffin BA, Lovegrove JA, Sanders TA, Bluck LJ.

Genes Nutr. 2012 Oct;7(4):529-36. Epub 2012 Feb 21.


Effects of a novel propionate-rich sourdough bread on appetite and food intake.

Darzi J, Frost GS, Robertson MD.

Eur J Clin Nutr. 2012 Jul;66(7):789-94. doi: 10.1038/ejcn.2012.1. Epub 2012 Feb 1.


Interaction of PPARG Pro12Ala with dietary fat influences plasma lipids in subjects at cardiometabolic risk.

Alsaleh A, O'Dell SD, Frost GS, Griffin BA, Lovegrove JA, Jebb SA, Sanders TA; RISCK Study investigators.

J Lipid Res. 2011 Dec;52(12):2298-303. doi: 10.1194/jlr.P019281. Epub 2011 Sep 23.


The missing risk: MRI and MRS phenotyping of abdominal adiposity and ectopic fat.

Thomas EL, Parkinson JR, Frost GS, Goldstone AP, Doré CJ, McCarthy JP, Collins AL, Fitzpatrick JA, Durighel G, Taylor-Robinson SD, Bell JD.

Obesity (Silver Spring). 2012 Jan;20(1):76-87. doi: 10.1038/oby.2011.142. Epub 2011 Jun 9.


Single nucleotide polymorphisms at the ADIPOQ gene locus interact with age and dietary intake of fat to determine serum adiponectin in subjects at risk of the metabolic syndrome.

AlSaleh A, O'Dell SD, Frost GS, Griffin BA, Lovegrove JA, Jebb SA, Sanders TA; RISCK Study Group.

Am J Clin Nutr. 2011 Jul;94(1):262-9. doi: 10.3945/ajcn.111.014209. Epub 2011 May 11.

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