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Items: 1 to 50 of 177

1.

Establishment of reference values for the lysine acetylation marker Nɛ-acetyllysine in small volume human plasma samples by a multi-target LC-MS/MS method.

Gessner A, Mieth M, Auge D, Chafai A, Müller F, Fromm MF, Maas R.

Amino Acids. 2019 Sep;51(9):1259-1271. doi: 10.1007/s00726-019-02765-8. Epub 2019 Aug 6.

PMID:
31388851
2.

The renal transport protein OATP4C1 mediates uptake of the uremic toxin asymmetric dimethylarginine (ADMA) and efflux of cardioprotective L-homoarginine.

Taghikhani E, Maas R, Fromm MF, König J.

PLoS One. 2019 Mar 13;14(3):e0213747. doi: 10.1371/journal.pone.0213747. eCollection 2019.

3.

Interplay of the Organic Cation Transporters OCT1 and OCT2 with the Apically Localized Export Protein MATE1 for the Polarized Transport of Trospium.

Deutsch B, Neumeister C, Schwantes U, Fromm MF, König J.

Mol Pharm. 2019 Feb 4;16(2):510-517. doi: 10.1021/acs.molpharmaceut.8b00779. Epub 2019 Jan 18.

PMID:
30656943
4.

Clinical Aspects of Transporter-Mediated Drug-Drug Interactions.

Gessner A, König J, Fromm MF.

Clin Pharmacol Ther. 2019 Jun;105(6):1386-1394. doi: 10.1002/cpt.1360. Epub 2019 Mar 18.

PMID:
30648735
5.

Drugs linked to plasma homoarginine in chronic kidney disease patients-a cross-sectional analysis of the German Chronic Kidney Disease cohort.

Maas R, Mieth M, Titze SI, Hübner S, Fromm MF, Kielstein JT, Schmid M, Köttgen A, Kronenberg F, Krane V, Hausknecht B, Eckardt KU, Schneider MP; GCKD study investigators .

Nephrol Dial Transplant. 2018 Nov 23. doi: 10.1093/ndt/gfy342. [Epub ahead of print]

PMID:
30476224
6.

Efavirenz reduces renal excretion of lamivudine in rats by inhibiting organic cation transporters (OCT, Oct) and multidrug and toxin extrusion proteins (MATE, Mate).

Ceckova M, Reznicek J, Deutsch B, Fromm MF, Staud F.

PLoS One. 2018 Aug 16;13(8):e0202706. doi: 10.1371/journal.pone.0202706. eCollection 2018.

7.

Analysis of naturally occurring mutations in the human uptake transporter NaCT important for bone and brain development and energy metabolism.

Selch S, Chafai A, Sticht H, Birkenfeld AL, Fromm MF, König J.

Sci Rep. 2018 Jul 27;8(1):11330. doi: 10.1038/s41598-018-29547-8.

8.

[Standardized national medication plan : The pilot projects MetropolMediplan 2016, model region Erfurt, and PRIMA].

Dormann H, Maas R, Eickhoff C, Müller U, Schulz M, Brell D, Thürmann PA; MetropolMediplan 2016; Modellregion Erfurt; PRIMA.

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2018 Sep;61(9):1093-1102. doi: 10.1007/s00103-018-2789-9. Review. German.

PMID:
30046864
9.

Importance of OCT2 and MATE1 for the Cimetidine-Metformin Interaction: Insights from Investigations of Polarized Transport in Single- And Double-Transfected MDCK Cells with a Focus on Perpetrator Disposition.

Müller F, Weitz D, Mertsch K, König J, Fromm MF.

Mol Pharm. 2018 Aug 6;15(8):3425-3433. doi: 10.1021/acs.molpharmaceut.8b00416. Epub 2018 Jul 19.

PMID:
29975542
10.

Contribution of multidrug and toxin extrusion protein 1 (MATE1) to renal secretion of trimethylamine-N-oxide (TMAO).

Gessner A, König J, Fromm MF.

Sci Rep. 2018 Apr 27;8(1):6659. doi: 10.1038/s41598-018-25139-8.

11.

Biomarkers for In Vivo Assessment of Transporter Function.

Müller F, Sharma A, König J, Fromm MF.

Pharmacol Rev. 2018 Apr;70(2):246-277. doi: 10.1124/pr.116.013326. Review.

PMID:
29487084
12.

Role of (-)-epigallocatechin gallate in the pharmacokinetic interaction between nadolol and green tea in healthy volunteers.

Abe O, Ono T, Sato H, Müller F, Ogata H, Miura I, Shikama Y, Yabe H, Onoue S, Fromm MF, Kimura J, Misaka S.

Eur J Clin Pharmacol. 2018 Jun;74(6):775-783. doi: 10.1007/s00228-018-2436-2. Epub 2018 Feb 26.

PMID:
29480324
13.

Dose adjustment of cisplatin, etoposide, and ifosfamide according to kidney function: a retrospective analysis and implications for medication safety.

Grafe C, Semrau S, Hein A, Beckmann MW, Mackensen A, Dörje F, Fromm MF.

Naunyn Schmiedebergs Arch Pharmacol. 2018 Feb;391(2):219-229. doi: 10.1007/s00210-017-1456-2. Epub 2018 Jan 2.

PMID:
29294142
14.

Contribution of MATE1 to Renal Secretion of the NMDA Receptor Antagonist Memantine.

Müller F, Weitz D, Derdau V, Sandvoss M, Mertsch K, König J, Fromm MF.

Mol Pharm. 2017 Sep 5;14(9):2991-2998. doi: 10.1021/acs.molpharmaceut.7b00179. Epub 2017 Aug 2.

PMID:
28708400
15.

The prognostic biomarker L-homoarginine is a substrate of the cationic amino acid transporters CAT1, CAT2A and CAT2B.

Chafai A, Fromm MF, König J, Maas R.

Sci Rep. 2017 Jul 6;7(1):4767. doi: 10.1038/s41598-017-04965-2.

16.

Assays for Analyzing the Role of Transport Proteins in the Uptake and the Vectorial Transport of Substances Affecting Cell Viability.

Taghikhani E, Fromm MF, König J.

Methods Mol Biol. 2017;1601:123-135. doi: 10.1007/978-1-4939-6960-9_11.

PMID:
28470523
17.

Anticholinergic burden and cognitive function in a large German cohort of hospitalized geriatric patients.

Pfistermeister B, Tümena T, Gaßmann KG, Maas R, Fromm MF.

PLoS One. 2017 Feb 10;12(2):e0171353. doi: 10.1371/journal.pone.0171353. eCollection 2017.

18.

The human longevity gene homolog INDY and interleukin-6 interact in hepatic lipid metabolism.

von Loeffelholz C, Lieske S, Neuschäfer-Rube F, Willmes DM, Raschzok N, Sauer IM, König J, Fromm MF, Horn P, Chatzigeorgiou A, Pathe-Neuschäfer-Rube A, Jordan J, Pfeiffer AFH, Mingrone G, Bornstein SR, Stroehle P, Harms C, Wunderlich FT, Helfand SL, Bernier M, de Cabo R, Shulman GI, Chavakis T, Püschel GP, Birkenfeld AL.

Hepatology. 2017 Aug;66(2):616-630. doi: 10.1002/hep.29089. Epub 2017 Jun 26.

19.

Development of a Standardized Rating Tool for Drug Alerts to Reduce Information Overload.

Pfistermeister B, Sedlmayr B, Patapovas A, Suttner G, Tektas O, Tarkhov A, Kornhuber J, Fromm MF, Bürkle T, Prokosch HU, Maas R.

Methods Inf Med. 2016 Dec 7;55(6):507-515. Epub 2016 Oct 26.

PMID:
27782288
20.

Analysis of amino acid residues in the predicted transmembrane pore influencing transport kinetics of the hepatic drug transporter organic anion transporting polypeptide 1B1 (OATP1B1).

Gruetz M, Sticht H, Glaeser H, Fromm MF, König J.

Biochim Biophys Acta. 2016 Nov;1858(11):2894-2902. doi: 10.1016/j.bbamem.2016.08.018. Epub 2016 Sep 1.

21.

Role of ABC and Solute Carrier Transporters in the Placental Transport of Lamivudine.

Ceckova M, Reznicek J, Ptackova Z, Cerveny L, Müller F, Kacerovsky M, Fromm MF, Glazier JD, Staud F.

Antimicrob Agents Chemother. 2016 Aug 22;60(9):5563-72. doi: 10.1128/AAC.00648-16. Print 2016 Sep.

22.

Co-Prescription of QT-Interval Prolonging Drugs: An Analysis in a Large Cohort of Geriatric Patients.

Schächtele S, Tümena T, Gaßmann KG, Fromm MF, Maas R.

PLoS One. 2016 May 18;11(5):e0155649. doi: 10.1371/journal.pone.0155649. eCollection 2016.

23.

The Nonmetabolized β-Blocker Nadolol Is a Substrate of OCT1, OCT2, MATE1, MATE2-K, and P-Glycoprotein, but Not of OATP1B1 and OATP1B3.

Misaka S, Knop J, Singer K, Hoier E, Keiser M, Müller F, Glaeser H, König J, Fromm MF.

Mol Pharm. 2016 Feb 1;13(2):512-9. doi: 10.1021/acs.molpharmaceut.5b00733. Epub 2016 Jan 19.

PMID:
26702643
24.

Inhibitory Effects of Green Tea and (-)-Epigallocatechin Gallate on Transport by OATP1B1, OATP1B3, OCT1, OCT2, MATE1, MATE2-K and P-Glycoprotein.

Knop J, Misaka S, Singer K, Hoier E, Müller F, Glaeser H, König J, Fromm MF.

PLoS One. 2015 Oct 1;10(10):e0139370. doi: 10.1371/journal.pone.0139370. eCollection 2015.

25.

Renal tubular secretion of pramipexole.

Knop J, Hoier E, Ebner T, Fromm MF, Müller F.

Eur J Pharm Sci. 2015 Nov 15;79:73-8. doi: 10.1016/j.ejps.2015.09.004. Epub 2015 Sep 7.

PMID:
26360835
26.

Substrate-Dependent Inhibition of the Human Organic Cation Transporter OCT2: A Comparison of Metformin with Experimental Substrates.

Hacker K, Maas R, Kornhuber J, Fromm MF, Zolk O.

PLoS One. 2015 Sep 1;10(9):e0136451. doi: 10.1371/journal.pone.0136451. eCollection 2015.

27.

N(1)-methylnicotinamide as an endogenous probe for drug interactions by renal cation transporters: studies on the metformin-trimethoprim interaction.

Müller F, Pontones CA, Renner B, Mieth M, Hoier E, Auge D, Maas R, Zolk O, Fromm MF.

Eur J Clin Pharmacol. 2015 Jan;71(1):85-94. doi: 10.1007/s00228-014-1770-2. Epub 2014 Oct 22.

PMID:
25552403
28.

Interplay between the prostaglandin transporter OATP2A1 and prostaglandin E2-mediated cellular effects.

Bujok K, Glaeser H, Schuh W, Rau TT, Schmidt I, Fromm MF, Mandery K.

Cell Signal. 2015 Mar;27(3):663-72. doi: 10.1016/j.cellsig.2014.11.027. Epub 2014 Nov 26.

PMID:
25433165
29.

The effect object paradigm--a means to support medication safety with clinical decision support.

Patapovas A, Pfistermeister B, Tarkhov A, Terfloth L, Maas R, Fromm MF, Kornhuber J, Prokosch HU, Bürkle T.

Stud Health Technol Inform. 2014;205:1065-9.

PMID:
25160352
30.

Inconsistencies and misleading information in officially approved prescribing information from three major drug markets.

Pfistermeister B, Saß A, Criegee-Rieck M, Bürkle T, Fromm MF, Maas R.

Clin Pharmacol Ther. 2014 Nov;96(5):616-24. doi: 10.1038/clpt.2014.156. Epub 2014 Jul 25.

PMID:
25062063
31.

Organic anion transporting polypeptides and organic cation transporter 1 contribute to the cellular uptake of the flavonoid quercetin.

Glaeser H, Bujok K, Schmidt I, Fromm MF, Mandery K.

Naunyn Schmiedebergs Arch Pharmacol. 2014 Sep;387(9):883-91. doi: 10.1007/s00210-014-1000-6. Epub 2014 Jun 20.

PMID:
24947867
32.

Implementation of warnings from Dear Doctor Letters (Rote-Hand-Briefe): an analysis of medication data from a large cohort of elderly patients.

Schächtele S, Tümena T, Gaßmann KG, Fromm MF, Maas R.

Dtsch Arztebl Int. 2014 Apr 11;111(15):255-63. doi: 10.3238/arztebl.2014.0255.

33.

Response to "the effect of green tea with exceptionally high catechin content on nadolol plasma concentration".

Misaka S, Yatabe J, Müller F, Takano K, Glaeser H, Yatabe MS, Onoue S, Werba JP, Watanabe H, Yamada S, Fromm MF, Kimura J.

Clin Pharmacol Ther. 2014 Jun;95(6):589. doi: 10.1038/clpt.2014.61. Epub 2014 Mar 12. No abstract available.

PMID:
24739447
34.

Alanine-glyoxylate aminotransferase 2 (AGXT2) polymorphisms have considerable impact on methylarginine and β-aminoisobutyrate metabolism in healthy volunteers.

Kittel A, Müller F, König J, Mieth M, Sticht H, Zolk O, Kralj A, Heinrich MR, Fromm MF, Maas R.

PLoS One. 2014 Feb 24;9(2):e88544. doi: 10.1371/journal.pone.0088544. eCollection 2014.

35.

Green tea ingestion greatly reduces plasma concentrations of nadolol in healthy subjects.

Misaka S, Yatabe J, Müller F, Takano K, Kawabe K, Glaeser H, Yatabe MS, Onoue S, Werba JP, Watanabe H, Yamada S, Fromm MF, Kimura J.

Clin Pharmacol Ther. 2014 Apr;95(4):432-8. doi: 10.1038/clpt.2013.241. Epub 2014 Jan 13.

PMID:
24419562
36.

Clinical relevance of drug efflux pumps in the gut.

Misaka S, Müller F, Fromm MF.

Curr Opin Pharmacol. 2013 Dec;13(6):847-52. doi: 10.1016/j.coph.2013.08.010. Epub 2013 Sep 10. Review.

PMID:
24028838
37.

Role of organic cation transporter OCT2 and multidrug and toxin extrusion proteins MATE1 and MATE2-K for transport and drug interactions of the antiviral lamivudine.

Müller F, König J, Hoier E, Mandery K, Fromm MF.

Biochem Pharmacol. 2013 Sep 15;86(6):808-15. doi: 10.1016/j.bcp.2013.07.008. Epub 2013 Jul 20.

PMID:
23876341
38.

Transport of asymmetric dimethylarginine (ADMA) by cationic amino acid transporter 2 (CAT2), organic cation transporter 2 (OCT2) and multidrug and toxin extrusion protein 1 (MATE1).

Strobel J, Müller F, Zolk O, Endreß B, König J, Fromm MF, Maas R.

Amino Acids. 2013 Oct;45(4):989-1002. doi: 10.1007/s00726-013-1556-3. Epub 2013 Jul 18.

PMID:
23864433
39.

Transporters and drug-drug interactions: important determinants of drug disposition and effects.

König J, Müller F, Fromm MF.

Pharmacol Rev. 2013 May 17;65(3):944-66. doi: 10.1124/pr.113.007518. Print 2013 Jul. Review.

PMID:
23686349
40.

Phase I and II metabolism and MRP2-mediated export of bosentan in a MDCKII-OATP1B1-CYP3A4-UGT1A1-MRP2 quadruple-transfected cell line.

Fahrmayr C, König J, Auge D, Mieth M, Münch K, Segrestaa J, Pfeifer T, Treiber A, Fromm M.

Br J Pharmacol. 2013 May;169(1):21-33. doi: 10.1111/bph.12126.

41.

Different indications, warnings and precautions, and contraindications for the same drug--an international comparison of prescribing information for commonly used psychiatric drugs.

Pfistermeister B, Schenk C, Kornhuber J, Bürkle T, Fromm MF, Maas R.

Pharmacoepidemiol Drug Saf. 2013 Mar;22(3):329-33. doi: 10.1002/pds.3389. Epub 2012 Dec 26.

PMID:
23280570
42.

Transporter gene expression in human head and neck squamous cell carcinoma and associated epigenetic regulatory mechanisms.

Zolk O, Schnepf R, Muschler M, Fromm MF, Wendler O, Traxdorf M, Iro H, Zenk J.

Am J Pathol. 2013 Jan;182(1):234-43. doi: 10.1016/j.ajpath.2012.09.008. Epub 2012 Nov 6.

PMID:
23137910
43.

The influence of oral antidiabetic drugs on cellular drug uptake mediated by hepatic OATP family members.

Klatt S, Fromm MF, König J.

Basic Clin Pharmacol Toxicol. 2013 Apr;112(4):244-50. doi: 10.1111/bcpt.12031. Epub 2012 Dec 6.

44.

Potentially inappropriate medications in a large cohort of patients in geriatric units: association with clinical and functional characteristics.

Fromm MF, Maas R, Tümena T, Gaßmann KG.

Eur J Clin Pharmacol. 2013 Apr;69(4):975-84. doi: 10.1007/s00228-012-1425-0. Epub 2012 Oct 23.

PMID:
23090702
45.

Prediction of transporter-mediated drug-drug interactions using endogenous compounds.

Fromm MF.

Clin Pharmacol Ther. 2012 Nov;92(5):546-8. doi: 10.1038/clpt.2012.145.

PMID:
23085877
46.

Personalizing antiplatelet therapy with clopidogrel.

Trenk D, Zolk O, Fromm MF, Neumann FJ, Hochholzer W.

Clin Pharmacol Ther. 2012 Oct;92(4):476-85. doi: 10.1038/clpt.2012.133. Epub 2012 Sep 5. Review.

PMID:
22948893
47.

Interaction of the cardiovascular risk marker asymmetric dimethylarginine (ADMA) with the human cationic amino acid transporter 1 (CAT1).

Strobel J, Mieth M, Endress B, Auge D, König J, Fromm MF, Maas R.

J Mol Cell Cardiol. 2012 Sep;53(3):392-400. doi: 10.1016/j.yjmcc.2012.06.002. Epub 2012 Jun 15.

PMID:
22705145
48.

Effect of the rs168924 single-nucleotide polymorphism in the SLC6A2 catecholamine transporter gene on blood pressure in Caucasians.

Zolk O, Ott C, Fromm MF, Schmieder RE.

J Clin Hypertens (Greenwich). 2012 May;14(5):293-8. doi: 10.1111/j.1751-7176.2012.00618.x. Epub 2012 Apr 9.

49.

Inhibition of hepatic uptake transporters by flavonoids.

Mandery K, Balk B, Bujok K, Schmidt I, Fromm MF, Glaeser H.

Eur J Pharm Sci. 2012 May 12;46(1-2):79-85. doi: 10.1016/j.ejps.2012.02.014. Epub 2012 Feb 28.

PMID:
22394605
50.

Preoperative administration of etoricoxib in patients undergoing hip replacement causes inhibition of inflammatory mediators and pain relief.

Renner B, Walter G, Strauss J, Fromm MF, Zacher J, Brune K.

Eur J Pain. 2012 Jul;16(6):838-48. doi: 10.1002/j.1532-2149.2011.00062.x. Epub 2011 Dec 19.

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