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Items: 1 to 50 of 536

1.

New Oral Anti-Cancer Drugs and Medication Safety.

Schlichtig K, Dürr P, Dörje F, Fromm MF.

Dtsch Arztebl Int. 2019 Nov 15;116(46):775-782. doi: 10.3238/arztebl.2019.0775.

2.

Solute Carrier Transporters as Potential Targets for the Treatment of Metabolic Disease.

Schumann T, König J, Henke C, Willmes DM, Bornstein SR, Jordan J, Fromm MF, Birkenfeld AL.

Pharmacol Rev. 2020 Jan;72(1):343-379. doi: 10.1124/pr.118.015735. Review.

PMID:
31882442
3.

Tricellulin Effect on Paracellular Water Transport.

Ayala-Torres C, Krug SM, Schulzke JD, Rosenthal R, Fromm M.

Int J Mol Sci. 2019 Nov 14;20(22). pii: E5700. doi: 10.3390/ijms20225700.

4.

Tilivalline- and Tilimycin-Independent Effects of Klebsiella oxytoca on Tight Junction-Mediated Intestinal Barrier Impairment.

Hering NA, Fromm A, Bücker R, Gorkiewicz G, Zechner E, Högenauer C, Fromm M, Schulzke JD, Troeger H.

Int J Mol Sci. 2019 Nov 8;20(22). pii: E5595. doi: 10.3390/ijms20225595.

5.

Potential for Tight Junction Protein-Directed Drug Development Using Claudin Binders and Angubindin-1.

Hashimoto Y, Tachibana K, Krug SM, Kunisawa J, Fromm M, Kondoh M.

Int J Mol Sci. 2019 Aug 17;20(16). pii: E4016. doi: 10.3390/ijms20164016. Review.

6.

Black carbon lofts wildfire smoke high into the stratosphere to form a persistent plume.

Yu P, Toon OB, Bardeen CG, Zhu Y, Rosenlof KH, Portmann RW, Thornberry TD, Gao RS, Davis SM, Wolf ET, de Gouw J, Peterson DA, Fromm MD, Robock A.

Science. 2019 Aug 9;365(6453):587-590. doi: 10.1126/science.aax1748.

PMID:
31395782
7.

Establishment of reference values for the lysine acetylation marker Nɛ-acetyllysine in small volume human plasma samples by a multi-target LC-MS/MS method.

Gessner A, Mieth M, Auge D, Chafai A, Müller F, Fromm MF, Maas R.

Amino Acids. 2019 Sep;51(9):1259-1271. doi: 10.1007/s00726-019-02765-8. Epub 2019 Aug 6.

PMID:
31388851
8.

Store-operated calcium entry (SOCE) contributes to phosphorylation of p38 MAPK and suppression of TNF-α signalling in the intestinal epithelial cells.

Uwada J, Yazawa T, Nakazawa H, Mikami D, Krug SM, Fromm M, Sada K, Muramatsu I, Taniguchi T.

Cell Signal. 2019 Nov;63:109358. doi: 10.1016/j.cellsig.2019.109358. Epub 2019 Jul 8.

PMID:
31295519
9.

Claudin-15 forms a water channel through the tight junction with distinct function compared to claudin-2.

Rosenthal R, Günzel D, Piontek J, Krug SM, Ayala-Torres C, Hempel C, Theune D, Fromm M.

Acta Physiol (Oxf). 2020 Jan;228(1):e13334. doi: 10.1111/apha.13334. Epub 2019 Jul 8.

PMID:
31188544
10.

Phospholipid effects on SGLT1-mediated glucose transport in rabbit ileum brush border membrane vesicles.

Ebel H, Fromm A, Günzel D, Fromm M, Schulzke JD.

Biochim Biophys Acta Biomembr. 2019 Oct 1;1861(10):182985. doi: 10.1016/j.bbamem.2019.05.007. Epub 2019 May 11.

PMID:
31082355
11.

The renal transport protein OATP4C1 mediates uptake of the uremic toxin asymmetric dimethylarginine (ADMA) and efflux of cardioprotective L-homoarginine.

Taghikhani E, Maas R, Fromm MF, König J.

PLoS One. 2019 Mar 13;14(3):e0213747. doi: 10.1371/journal.pone.0213747. eCollection 2019.

12.

Interplay of the Organic Cation Transporters OCT1 and OCT2 with the Apically Localized Export Protein MATE1 for the Polarized Transport of Trospium.

Deutsch B, Neumeister C, Schwantes U, Fromm MF, König J.

Mol Pharm. 2019 Feb 4;16(2):510-517. doi: 10.1021/acs.molpharmaceut.8b00779. Epub 2019 Jan 18.

PMID:
30656943
13.

Clinical Aspects of Transporter-Mediated Drug-Drug Interactions.

Gessner A, König J, Fromm MF.

Clin Pharmacol Ther. 2019 Jun;105(6):1386-1394. doi: 10.1002/cpt.1360. Epub 2019 Mar 18.

PMID:
30648735
14.

Tissue plasminogen activator and neuropathy open the blood-nerve barrier with upregulation of microRNA-155-5p in male rats.

Reinhold AK, Yang S, Chen JT, Hu L, Sauer RS, Krug SM, Mambretti EM, Fromm M, Brack A, Rittner HL.

Biochim Biophys Acta Mol Basis Dis. 2019 Jun 1;1865(6):1160-1169. doi: 10.1016/j.bbadis.2019.01.008. Epub 2019 Jan 6.

PMID:
30625382
15.

The contribution of hydrogen peroxide to the radiosensitizing effect of gold nanoparticles.

Khalil TT, Bazzi R, Roux S, Fromm M.

Colloids Surf B Biointerfaces. 2019 Mar 1;175:606-613. doi: 10.1016/j.colsurfb.2018.12.041. Epub 2018 Dec 17.

PMID:
30580151
16.

Drugs linked to plasma homoarginine in chronic kidney disease patients-a cross-sectional analysis of the German Chronic Kidney Disease cohort.

Maas R, Mieth M, Titze SI, Hübner S, Fromm MF, Kielstein JT, Schmid M, Köttgen A, Kronenberg F, Krane V, Hausknecht B, Eckardt KU, Schneider MP; GCKD study investigators .

Nephrol Dial Transplant. 2018 Nov 23. doi: 10.1093/ndt/gfy342. [Epub ahead of print]

PMID:
30476224
17.

Methionine oxidation by hydrogen peroxide in peptides and proteins: A theoretical and Raman spectroscopy study.

Sjöberg B, Foley S, Cardey B, Fromm M, Enescu M.

J Photochem Photobiol B. 2018 Nov;188:95-99. doi: 10.1016/j.jphotobiol.2018.09.009. Epub 2018 Sep 12.

PMID:
30240974
18.

Efavirenz reduces renal excretion of lamivudine in rats by inhibiting organic cation transporters (OCT, Oct) and multidrug and toxin extrusion proteins (MATE, Mate).

Ceckova M, Reznicek J, Deutsch B, Fromm MF, Staud F.

PLoS One. 2018 Aug 16;13(8):e0202706. doi: 10.1371/journal.pone.0202706. eCollection 2018.

19.

Dehydration Stress Memory: Gene Networks Linked to Physiological Responses During Repeated Stresses of Zea mays.

Virlouvet L, Avenson TJ, Du Q, Zhang C, Liu N, Fromm M, Avramova Z, Russo SE.

Front Plant Sci. 2018 Jul 24;9:1058. doi: 10.3389/fpls.2018.01058. eCollection 2018.

20.

Analysis of naturally occurring mutations in the human uptake transporter NaCT important for bone and brain development and energy metabolism.

Selch S, Chafai A, Sticht H, Birkenfeld AL, Fromm MF, König J.

Sci Rep. 2018 Jul 27;8(1):11330. doi: 10.1038/s41598-018-29547-8.

21.

Importance of OCT2 and MATE1 for the Cimetidine-Metformin Interaction: Insights from Investigations of Polarized Transport in Single- And Double-Transfected MDCK Cells with a Focus on Perpetrator Disposition.

Müller F, Weitz D, Mertsch K, König J, Fromm MF.

Mol Pharm. 2018 Aug 6;15(8):3425-3433. doi: 10.1021/acs.molpharmaceut.8b00416. Epub 2018 Jul 19.

PMID:
29975542
22.

Contribution of multidrug and toxin extrusion protein 1 (MATE1) to renal secretion of trimethylamine-N-oxide (TMAO).

Gessner A, König J, Fromm MF.

Sci Rep. 2018 Apr 27;8(1):6659. doi: 10.1038/s41598-018-25139-8.

23.

Gelatinolytic activity of autocrine matrix metalloproteinase-9 leads to endothelial de-arrangement in Moyamoya disease.

Blecharz-Lang KG, Prinz V, Burek M, Frey D, Schenkel T, Krug SM, Fromm M, Vajkoczy P.

J Cereb Blood Flow Metab. 2018 Nov;38(11):1940-1953. doi: 10.1177/0271678X18768443. Epub 2018 Apr 10.

24.

Epithelial barrier dysfunction as permissive pathomechanism in human intestinal graft-versus-host disease.

Troeger H, Hering NA, Bojarski C, Fromm A, Barmeyer C, Uharek L, Siegmund B, Fromm M, Rieger K, Schulzke JD.

Bone Marrow Transplant. 2018 Aug;53(8):1083-1086. doi: 10.1038/s41409-018-0144-2. Epub 2018 Mar 9. No abstract available.

PMID:
29523887
25.

Biomarkers for In Vivo Assessment of Transporter Function.

Müller F, Sharma A, König J, Fromm MF.

Pharmacol Rev. 2018 Apr;70(2):246-277. doi: 10.1124/pr.116.013326. Review.

PMID:
29487084
26.

Role of (-)-epigallocatechin gallate in the pharmacokinetic interaction between nadolol and green tea in healthy volunteers.

Abe O, Ono T, Sato H, Müller F, Ogata H, Miura I, Shikama Y, Yabe H, Onoue S, Fromm MF, Kimura J, Misaka S.

Eur J Clin Pharmacol. 2018 Jun;74(6):775-783. doi: 10.1007/s00228-018-2436-2. Epub 2018 Feb 26.

PMID:
29480324
27.

A cytochrome P450 CYP71 enzyme expressed in Sorghum bicolor root hair cells participates in the biosynthesis of the benzoquinone allelochemical sorgoleone.

Pan Z, Baerson SR, Wang M, Bajsa-Hirschel J, Rimando AM, Wang X, Nanayakkara NPD, Noonan BP, Fromm ME, Dayan FE, Khan IA, Duke SO.

New Phytol. 2018 Apr;218(2):616-629. doi: 10.1111/nph.15037. Epub 2018 Feb 20.

28.

Dose adjustment of cisplatin, etoposide, and ifosfamide according to kidney function: a retrospective analysis and implications for medication safety.

Grafe C, Semrau S, Hein A, Beckmann MW, Mackensen A, Dörje F, Fromm MF.

Naunyn Schmiedebergs Arch Pharmacol. 2018 Feb;391(2):219-229. doi: 10.1007/s00210-017-1456-2. Epub 2018 Jan 2.

PMID:
29294142
29.

Wildfire-driven thunderstorms cause a volcano-like stratospheric injection of smoke.

Peterson DA, Campbell JR, Hyer EJ, Fromm MD, Kablick GP 3rd, Cossuth JH, DeLand MT.

NPJ Clim Atmos Sci. 2018;1. doi: 10.1038/s41612-018-0039-3. Epub 2018 Aug 20.

30.

Campylobacter jejuni impairs sodium transport and epithelial barrier function via cytokine release in human colon.

Bücker R, Krug SM, Moos V, Bojarski C, Schweiger MR, Kerick M, Fromm A, Janßen S, Fromm M, Hering NA, Siegmund B, Schneider T, Barmeyer C, Schulzke JD.

Mucosal Immunol. 2018 Mar;11(2):575-577. doi: 10.1038/mi.2017.78. Epub 2017 Nov 1.

PMID:
29091080
31.

In Colon Epithelia, Clostridium perfringens Enterotoxin Causes Focal Leaks by Targeting Claudins Which are Apically Accessible Due to Tight Junction Derangement.

Eichner M, Augustin C, Fromm A, Piontek A, Walther W, Bücker R, Fromm M, Krause G, Schulzke JD, Günzel D, Piontek J.

J Infect Dis. 2017 Dec 27;217(1):147-157. doi: 10.1093/infdis/jix485.

PMID:
28968861
32.

Zinc strengthens the jejunal barrier by reversibly tightening the paracellular route.

Zakrzewski SS, Fromm M, Schulzke JD, Günzel D.

Am J Physiol Gastrointest Liver Physiol. 2017 Dec 1;313(6):G537-G548. doi: 10.1152/ajpgi.00355.2016. Epub 2017 Sep 1.

33.

Campylobacter jejuni impairs sodium transport and epithelial barrier function via cytokine release in human colon.

Bücker R, Krug SM, Moos V, Bojarski C, Schweiger MR, Kerick M, Fromm A, Janßen S, Fromm M, Hering NA, Siegmund B, Schneider T, Barmeyer C, Schulzke JD.

Mucosal Immunol. 2018 Mar;11(2):474-485. doi: 10.1038/mi.2017.66. Epub 2017 Aug 2. Erratum in: Mucosal Immunol. 2017 Nov 01;:.

PMID:
28766554
34.

Contribution of MATE1 to Renal Secretion of the NMDA Receptor Antagonist Memantine.

Müller F, Weitz D, Derdau V, Sandvoss M, Mertsch K, König J, Fromm MF.

Mol Pharm. 2017 Sep 5;14(9):2991-2998. doi: 10.1021/acs.molpharmaceut.7b00179. Epub 2017 Aug 2.

PMID:
28708400
35.

The prognostic biomarker L-homoarginine is a substrate of the cationic amino acid transporters CAT1, CAT2A and CAT2B.

Chafai A, Fromm MF, König J, Maas R.

Sci Rep. 2017 Jul 6;7(1):4767. doi: 10.1038/s41598-017-04965-2.

36.

Campylobacter fetus impairs barrier function in HT-29/B6 cells through focal tight junction alterations and leaks.

Bücker R, Krug SM, Fromm A, Nielsen HL, Fromm M, Nielsen H, Schulzke JD.

Ann N Y Acad Sci. 2017 Oct;1405(1):189-201. doi: 10.1111/nyas.13406. Epub 2017 Jun 29.

PMID:
28662272
37.

Water channels and barriers formed by claudins.

Rosenthal R, Günzel D, Theune D, Czichos C, Schulzke JD, Fromm M.

Ann N Y Acad Sci. 2017 Jun;1397(1):100-109. doi: 10.1111/nyas.13383. Review.

PMID:
28636801
38.

Tricellulin is regulated via interleukin-13-receptor α2, affects macromolecule uptake, and is decreased in ulcerative colitis.

Krug SM, Bojarski C, Fromm A, Lee IM, Dames P, Richter JF, Turner JR, Fromm M, Schulzke JD.

Mucosal Immunol. 2018 Mar;11(2):345-356. doi: 10.1038/mi.2017.52. Epub 2017 Jun 14.

39.

Tight junctions of the proximal tubule and their channel proteins.

Fromm M, Piontek J, Rosenthal R, Günzel D, Krug SM.

Pflugers Arch. 2017 Aug;469(7-8):877-887. doi: 10.1007/s00424-017-2001-3. Epub 2017 Jun 9. Review.

PMID:
28600680
40.

Angubindin-1, a novel paracellular absorption enhancer acting at the tricellular tight junction.

Krug SM, Hayaishi T, Iguchi D, Watari A, Takahashi A, Fromm M, Nagahama M, Takeda H, Okada Y, Sawasaki T, Doi T, Yagi K, Kondoh M.

J Control Release. 2017 Aug 28;260:1-11. doi: 10.1016/j.jconrel.2017.05.024. Epub 2017 May 18.

PMID:
28528740
41.

Assays for Analyzing the Role of Transport Proteins in the Uptake and the Vectorial Transport of Substances Affecting Cell Viability.

Taghikhani E, Fromm MF, König J.

Methods Mol Biol. 2017;1601:123-135. doi: 10.1007/978-1-4939-6960-9_11.

PMID:
28470523
42.

Activation of muscarinic receptors prevents TNF-α-mediated intestinal epithelial barrier disruption through p38 MAPK.

Uwada J, Yazawa T, Islam MT, Khan MRI, Krug SM, Fromm M, Karaki SI, Suzuki Y, Kuwahara A, Yoshiki H, Sada K, Muramatsu I, Taniguchi T.

Cell Signal. 2017 Jul;35:188-196. doi: 10.1016/j.cellsig.2017.04.007. Epub 2017 Apr 12.

PMID:
28412413
43.

Celiac Disease: Role of the Epithelial Barrier.

Schumann M, Siegmund B, Schulzke JD, Fromm M.

Cell Mol Gastroenterol Hepatol. 2017 Jan 14;3(2):150-162. doi: 10.1016/j.jcmgh.2016.12.006. eCollection 2017 Mar. Review.

44.

Anticholinergic burden and cognitive function in a large German cohort of hospitalized geriatric patients.

Pfistermeister B, Tümena T, Gaßmann KG, Maas R, Fromm MF.

PLoS One. 2017 Feb 10;12(2):e0171353. doi: 10.1371/journal.pone.0171353. eCollection 2017.

45.

Architectural and functional alterations of the small intestinal mucosa in classical Whipple's disease.

Epple HJ, Friebel J, Moos V, Troeger H, Krug SM, Allers K, Schinnerling K, Fromm A, Siegmund B, Fromm M, Schulzke JD, Schneider T.

Mucosal Immunol. 2017 Nov;10(6):1542-1552. doi: 10.1038/mi.2017.6. Epub 2017 Feb 8.

PMID:
28176790
46.

Epithelial barrier dysfunction in lymphocytic colitis through cytokine-dependent internalization of claudin-5 and -8.

Barmeyer C, Erko I, Awad K, Fromm A, Bojarski C, Meissner S, Loddenkemper C, Kerick M, Siegmund B, Fromm M, Schweiger MR, Schulzke JD.

J Gastroenterol. 2017 Oct;52(10):1090-1100. doi: 10.1007/s00535-017-1309-2. Epub 2017 Jan 30.

PMID:
28138755
47.

The human longevity gene homolog INDY and interleukin-6 interact in hepatic lipid metabolism.

von Loeffelholz C, Lieske S, Neuschäfer-Rube F, Willmes DM, Raschzok N, Sauer IM, König J, Fromm MF, Horn P, Chatzigeorgiou A, Pathe-Neuschäfer-Rube A, Jordan J, Pfeiffer AFH, Mingrone G, Bornstein SR, Stroehle P, Harms C, Wunderlich FT, Helfand SL, Bernier M, de Cabo R, Shulman GI, Chavakis T, Püschel GP, Birkenfeld AL.

Hepatology. 2017 Aug;66(2):616-630. doi: 10.1002/hep.29089. Epub 2017 Jun 26.

48.

Single- and Double-Strand Breaks of Dry DNA Exposed to Protons at Bragg-Peak Energies.

Souici M, Khalil TT, Muller D, Raffy Q, Barillon R, Belafrites A, Champion C, Fromm M.

J Phys Chem B. 2017 Jan 26;121(3):497-507. doi: 10.1021/acs.jpcb.6b11060. Epub 2017 Jan 17.

PMID:
28045263
49.

Mosaic expression of claudins in thick ascending limbs of Henle results in spatial separation of paracellular Na+ and Mg2+ transport.

Milatz S, Himmerkus N, Wulfmeyer VC, Drewell H, Mutig K, Hou J, Breiderhoff T, Müller D, Fromm M, Bleich M, Günzel D.

Proc Natl Acad Sci U S A. 2017 Jan 10;114(2):E219-E227. doi: 10.1073/pnas.1611684114. Epub 2016 Dec 27.

50.

Auto-assembly of nanometer thick, water soluble layers of plasmid DNA complexed with diamines and basic amino acids on graphite: Greatest DNA protection is obtained with arginine.

Khalil TT, Boulanouar O, Heintz O, Fromm M.

Mater Sci Eng C Mater Biol Appl. 2017 Feb 1;71:231-239. doi: 10.1016/j.msec.2016.10.011. Epub 2016 Oct 11.

PMID:
27987703

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