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Polycyclic aromatic hydrocarbons can trigger hepatocyte release of extracellular vesicles by various mechanisms of action depending on their affinity for the aryl hydrocarbon receptor.

van Meteren N, Lagadic-Gossmann D, Chevanne M, Gallais I, Gobart D, Burel A, Bucher S, Grova N, Fromenty B, Appenzeller BMR, Chevance S, Gauffre F, Le Ferrec E, Sergent O.

Toxicol Sci. 2019 Jul 31. pii: kfz157. doi: 10.1093/toxsci/kfz157. [Epub ahead of print]


Drug-induced liver injury in obesity and nonalcoholic fatty liver disease.

Allard J, Le Guillou D, Begriche K, Fromenty B.

Adv Pharmacol. 2019;85:75-107. doi: 10.1016/bs.apha.2019.01.003. Epub 2019 Feb 20.


Moderate chronic ethanol consumption exerts beneficial effects on nonalcoholic fatty liver in mice fed a high-fat diet: possible role of higher formation of triglycerides enriched in monounsaturated fatty acids.

Bucher S, Begriche K, Catheline D, Trak-Smayra V, Tiaho F, Coulouarn C, Pinon G, Lagadic-Gossmann D, Rioux V, Fromenty B.

Eur J Nutr. 2019 Jun 3. doi: 10.1007/s00394-019-02017-1. [Epub ahead of print]


Retrodifferentiation of Human Tumor Hepatocytes to Stem Cells Leads to Metabolic Reprogramming and Chemoresistance.

Fekir K, Dubois-Pot-Schneider H, Désert R, Daniel Y, Glaise D, Rauch C, Morel F, Fromenty B, Musso O, Cabillic F, Corlu A.

Cancer Res. 2019 Apr 15;79(8):1869-1883. doi: 10.1158/0008-5472.CAN-18-2110. Epub 2019 Mar 5.


Large-Scale Modeling Approach Reveals Functional Metabolic Shifts during Hepatic Differentiation.

Poupin N, Corlu A, Cabaton NJ, Dubois-Pot-Schneider H, Canlet C, Person E, Bruel S, Frainay C, Vinson F, Maurier F, Morel F, Robin MA, Fromenty B, Zalko D, Jourdan F.

J Proteome Res. 2019 Jan 4;18(1):204-216. doi: 10.1021/acs.jproteome.8b00524. Epub 2018 Nov 19.


Mechanisms involved in the death of steatotic WIF-B9 hepatocytes co-exposed to benzo[a]pyrene and ethanol: a possible key role for xenobiotic metabolism and nitric oxide.

Tête A, Gallais I, Imran M, Chevanne M, Liamin M, Sparfel L, Bucher S, Burel A, Podechard N, Appenzeller BMR, Fromenty B, Grova N, Sergent O, Lagadic-Gossmann D.

Free Radic Biol Med. 2018 Dec;129:323-337. doi: 10.1016/j.freeradbiomed.2018.09.042. Epub 2018 Sep 27.


Possible Involvement of Mitochondrial Dysfunction and Oxidative Stress in a Cellular Model of NAFLD Progression Induced by Benzo[a]pyrene/Ethanol CoExposure.

Bucher S, Le Guillou D, Allard J, Pinon G, Begriche K, Tête A, Sergent O, Lagadic-Gossmann D, Fromenty B.

Oxid Med Cell Longev. 2018 Jul 26;2018:4396403. doi: 10.1155/2018/4396403. eCollection 2018.


Drug-Induced Alterations of Mitochondrial DNA Homeostasis in Steatotic and Nonsteatotic HepaRG Cells.

Le Guillou D, Bucher S, Begriche K, Hoët D, Lombès A, Labbe G, Fromenty B.

J Pharmacol Exp Ther. 2018 Jun;365(3):711-726. doi: 10.1124/jpet.117.246751. Epub 2018 Apr 18.


Co-exposure to benzo[a]pyrene and ethanol induces a pathological progression of liver steatosis in vitro and in vivo.

Bucher S, Tête A, Podechard N, Liamin M, Le Guillou D, Chevanne M, Coulouarn C, Imran M, Gallais I, Fernier M, Hamdaoui Q, Robin MA, Sergent O, Fromenty B, Lagadic-Gossmann D.

Sci Rep. 2018 Apr 13;8(1):5963. doi: 10.1038/s41598-018-24403-1.


Role of nonalcoholic fatty liver disease as risk factor for drug-induced hepatotoxicity.

Massart J, Begriche K, Moreau C, Fromenty B.

J Clin Transl Res. 2017 Feb;3(Suppl 1):212-232. doi: 10.18053/jctres.03.2017S1.006. Epub 2017 Feb 12.


Gamma-glutamyltransferase, fatty liver index and hepatic insulin resistance are associated with incident hypertension in two longitudinal studies.

Bonnet F, Gastaldelli A, Pihan-Le Bars F, Natali A, Roussel R, Petrie J, Tichet J, Marre M, Fromenty B, Balkau B; D.E.S.I.R., RISC Study Groups.

J Hypertens. 2017 Mar;35(3):493-500. doi: 10.1097/HJH.0000000000001204.


Mid-infrared fibre evanescent wave spectroscopy of serum allows fingerprinting of the hepatic metabolic status in mice.

Le Corvec M, Allain C, Lardjane S, Cavey T, Turlin B, Fautrel A, Begriche K, Monbet V, Fromenty B, Leroyer P, Guggenbuhl P, Ropert M, Sire O, Loréal O.

Analyst. 2016 Oct 24;141(22):6259-6269.


Chronic and low exposure to a pharmaceutical cocktail induces mitochondrial dysfunction in liver and hyperglycemia: Differential responses between lean and obese mice.

Buron N, Porceddu M, Roussel C, Begriche K, Trak-Smayra V, Gicquel T, Fromenty B, Borgne-Sanchez A.

Environ Toxicol. 2017 Apr;32(4):1375-1389. doi: 10.1002/tox.22331. Epub 2016 Aug 8.


Bisphenol a induces steatosis in HepaRG cells using a model of perinatal exposure.

Bucher S, Jalili P, Le Guillou D, Begriche K, Rondel K, Martinais S, Zalko D, Corlu A, Robin MA, Fromenty B.

Environ Toxicol. 2017 Mar;32(3):1024-1036. doi: 10.1002/tox.22301. Epub 2016 Jun 20.


Role of endoplasmic reticulum stress in drug-induced toxicity.

Foufelle F, Fromenty B.

Pharmacol Res Perspect. 2016 Feb 4;4(1):e00211. doi: 10.1002/prp2.211. eCollection 2016 Feb. Review.


A cellular model to study drug-induced liver injury in nonalcoholic fatty liver disease: Application to acetaminophen.

Michaut A, Le Guillou D, Moreau C, Bucher S, McGill MR, Martinais S, Gicquel T, Morel I, Robin MA, Jaeschke H, Fromenty B.

Toxicol Appl Pharmacol. 2016 Feb 1;292:40-55. doi: 10.1016/j.taap.2015.12.020. Epub 2015 Dec 29.


Indicators of iron status are correlated with adiponectin expression in adipose tissue of patients with morbid obesity.

Pihan-Le Bars F, Bonnet F, Loréal O, Le Loupp AG, Ropert M, Letessier E, Prieur X, Bach K, Deugnier Y, Fromenty B, Cariou B.

Diabetes Metab. 2016 Apr;42(2):105-11. doi: 10.1016/j.diabet.2015.10.007. Epub 2015 Dec 8.


The effect of water suppression on the hepatic lipid quantification, as assessed by the LCModel, in a preclinical and clinical scenario.

Coum A, Noury F, Bannier E, Begriche K, Fromenty B, Gandon Y, Saint-Jalmes H, Gambarota G.

MAGMA. 2016 Feb;29(1):29-37. doi: 10.1007/s10334-015-0508-1. Epub 2015 Nov 21.


Oxidative stress promotes pathologic polyploidization in nonalcoholic fatty liver disease.

Gentric G, Maillet V, Paradis V, Couton D, L'Hermitte A, Panasyuk G, Fromenty B, Celton-Morizur S, Desdouets C.

J Clin Invest. 2015 Mar 2;125(3):981-92. doi: 10.1172/JCI73957. Epub 2015 Jan 26.


Modulation of metabolizing enzymes by bisphenol a in human and animal models.

Quesnot N, Bucher S, Fromenty B, Robin MA.

Chem Res Toxicol. 2014 Sep 15;27(9):1463-73. doi: 10.1021/tx500087p. Epub 2014 Aug 29. Review.


Burn after feeding. An old uncoupler of oxidative phosphorylation is redesigned for the treatment of nonalcoholic fatty liver disease.

Fromenty B.

Clin Res Hepatol Gastroenterol. 2014 Oct;38(5):545-9. doi: 10.1016/j.clinre.2014.04.013. Epub 2014 Jun 9.


Acetaminophen-induced liver injury in obesity and nonalcoholic fatty liver disease.

Michaut A, Moreau C, Robin MA, Fromenty B.

Liver Int. 2014 Aug;34(7):e171-9. doi: 10.1111/liv.12514. Epub 2014 Mar 21. Review.


Chronic exposure to low doses of pharmaceuticals disturbs the hepatic expression of circadian genes in lean and obese mice.

Anthérieu S, Le Guillou D, Coulouarn C, Begriche K, Trak-Smayra V, Martinais S, Porceddu M, Robin MA, Fromenty B.

Toxicol Appl Pharmacol. 2014 Apr 1;276(1):63-72. doi: 10.1016/j.taap.2014.01.019. Epub 2014 Feb 11.


Fat accretion in a subpopulation of hepatocytes as a strategy to protect the whole liver against oxidative stress and lipotoxicity.

Fromenty B.

Clin Res Hepatol Gastroenterol. 2013 Dec;37(6):553-5. doi: 10.1016/j.clinre.2013.08.005. Epub 2013 Sep 25.


Bridging the gap between old and new concepts in drug-induced liver injury.

Fromenty B.

Clin Res Hepatol Gastroenterol. 2013 Feb;37(1):6-9. doi: 10.1016/j.clinre.2012.12.003. Epub 2013 Jan 18.


Quantitative analysis of acetaminophen and its primary metabolites in small plasma volumes by liquid chromatography-tandem mass spectrometry.

Gicquel T, Aubert J, Lepage S, Fromenty B, Morel I.

J Anal Toxicol. 2013 Mar;37(2):110-6. doi: 10.1093/jat/bks139. Epub 2013 Jan 12.


Mitochondrial adaptations and dysfunctions in nonalcoholic fatty liver disease.

Begriche K, Massart J, Robin MA, Bonnet F, Fromenty B.

Hepatology. 2013 Oct;58(4):1497-507. doi: 10.1002/hep.26226. Epub 2013 Aug 7. Review.


Drug-induced liver injury in obesity.

Fromenty B.

J Hepatol. 2013 Apr;58(4):824-6. doi: 10.1016/j.jhep.2012.12.018. Epub 2013 Jan 5. Review. No abstract available.


Oxidative stress plays a major role in chlorpromazine-induced cholestasis in human HepaRG cells.

Anthérieu S, Bachour-El Azzi P, Dumont J, Abdel-Razzak Z, Guguen-Guillouzo C, Fromenty B, Robin MA, Guillouzo A.

Hepatology. 2013 Apr;57(4):1518-29. doi: 10.1002/hep.26160. Epub 2013 Mar 4.


Prediction of liver injury induced by chemicals in human with a multiparametric assay on isolated mouse liver mitochondria.

Porceddu M, Buron N, Roussel C, Labbe G, Fromenty B, Borgne-Sanchez A.

Toxicol Sci. 2012 Oct;129(2):332-45. doi: 10.1093/toxsci/kfs197.


Moringa oleifera Lam. leaf extract prevents early liver injury and restores antioxidant status in mice fed with high-fat diet.

Das N, Sikder K, Ghosh S, Fromenty B, Dey S.

Indian J Exp Biol. 2012 Jun;50(6):404-12.


Differences in early acetaminophen hepatotoxicity between obese ob/ob and db/db mice.

Aubert J, Begriche K, Delannoy M, Morel I, Pajaud J, Ribault C, Lepage S, McGill MR, Lucas-Clerc C, Turlin B, Robin MA, Jaeschke H, Fromenty B.

J Pharmacol Exp Ther. 2012 Sep;342(3):676-87. doi: 10.1124/jpet.112.193813. Epub 2012 May 30.


Regulation of hepatic mitochondrial metabolism in response to a high fat diet: a longitudinal study in rats.

Flamment M, Rieusset J, Vidal H, Simard G, Malthièry Y, Fromenty B, Ducluzeau PH.

J Physiol Biochem. 2012 Sep;68(3):335-44. doi: 10.1007/s13105-012-0145-3. Epub 2012 Jan 26.


Carbon tetrachloride-mediated lipid peroxidation induces early mitochondrial alterations in mouse liver.

Knockaert L, Berson A, Ribault C, Prost PE, Fautrel A, Pajaud J, Lepage S, Lucas-Clerc C, Bégué JM, Fromenty B, Robin MA.

Lab Invest. 2012 Mar;92(3):396-410. doi: 10.1038/labinvest.2011.193. Epub 2011 Dec 12.


Pathology of the liver in obese and diabetic ob/ob and db/db mice fed a standard or high-calorie diet.

Trak-Smayra V, Paradis V, Massart J, Nasser S, Jebara V, Fromenty B.

Int J Exp Pathol. 2011 Dec;92(6):413-21. doi: 10.1111/j.1365-2613.2011.00793.x. Epub 2011 Nov 25.


Mechanisms of mitochondrial targeting of cytochrome P450 2E1: physiopathological role in liver injury and obesity.

Knockaert L, Fromenty B, Robin MA.

FEBS J. 2011 Nov;278(22):4252-60. doi: 10.1111/j.1742-4658.2011.08357.x. Epub 2011 Oct 12. Review.


Central role of mitochondria in drug-induced liver injury.

Pessayre D, Fromenty B, Berson A, Robin MA, Lettéron P, Moreau R, Mansouri A.

Drug Metab Rev. 2012 Feb;44(1):34-87. doi: 10.3109/03602532.2011.604086. Epub 2011 Sep 6. Review.


Pentoxifylline aggravates fatty liver in obese and diabetic ob/ob mice by increasing intestinal glucose absorption and activating hepatic lipogenesis.

Massart J, Robin MA, Noury F, Fautrel A, Lettéron P, Bado A, Eliat PA, Fromenty B.

Br J Pharmacol. 2012 Mar;165(5):1361-74. doi: 10.1111/j.1476-5381.2011.01580.x.


Increased expression of cytochrome P450 2E1 in nonalcoholic fatty liver disease: mechanisms and pathophysiological role.

Aubert J, Begriche K, Knockaert L, Robin MA, Fromenty B.

Clin Res Hepatol Gastroenterol. 2011 Oct;35(10):630-7. doi: 10.1016/j.clinre.2011.04.015. Epub 2011 Jun 12. Review.


Increased susceptibility to liver fibrosis with age is correlated with an altered inflammatory response.

Mahrouf-Yorgov M, Collin de l'Hortet A, Cosson C, Slama A, Abdoun E, Guidotti JE, Fromenty B, Mitchell C, Gilgenkrantz H.

Rejuvenation Res. 2011 Aug;14(4):353-63. doi: 10.1089/rej.2010.1146. Epub 2011 May 6.


Induction of vesicular steatosis by amiodarone and tetracycline is associated with up-regulation of lipogenic genes in HepaRG cells.

Anthérieu S, Rogue A, Fromenty B, Guillouzo A, Robin MA.

Hepatology. 2011 Jun;53(6):1895-905. doi: 10.1002/hep.24290. Epub 2011 May 2.


Drug-induced toxicity on mitochondria and lipid metabolism: mechanistic diversity and deleterious consequences for the liver.

Begriche K, Massart J, Robin MA, Borgne-Sanchez A, Fromenty B.

J Hepatol. 2011 Apr;54(4):773-94. doi: 10.1016/j.jhep.2010.11.006. Epub 2010 Nov 17. Review.


Mitochondrial CYP2E1 is sufficient to mediate oxidative stress and cytotoxicity induced by ethanol and acetaminophen.

Knockaert L, Descatoire V, Vadrot N, Fromenty B, Robin MA.

Toxicol In Vitro. 2011 Mar;25(2):475-84. doi: 10.1016/j.tiv.2010.11.019. Epub 2010 Dec 2.


Overexpression of Bcl-2 in hepatocytes protects against injury but does not attenuate fibrosis in a mouse model of chronic cholestatic liver disease.

Mitchell C, Mahrouf-Yorgov M, Mayeuf A, Robin MA, Mansouri A, Fromenty B, Gilgenkrantz H.

Lab Invest. 2011 Feb;91(2):273-82. doi: 10.1038/labinvest.2010.163. Epub 2010 Sep 20.


MnSOD overexpression prevents liver mitochondrial DNA depletion after an alcohol binge but worsens this effect after prolonged alcohol consumption in mice.

Mansouri A, Tarhuni A, Larosche I, Reyl-Desmars F, Demeilliers C, Degoul F, Nahon P, Sutton A, Moreau R, Fromenty B, Pessayre D.

Dig Dis. 2010;28(6):756-75. doi: 10.1159/000324284. Epub 2011 Apr 27. Review.


Mitochondrial involvement in drug-induced liver injury.

Pessayre D, Mansouri A, Berson A, Fromenty B.

Handb Exp Pharmacol. 2010;(196):311-65. doi: 10.1007/978-3-642-00663-0_11. Review.


Hepatic mitochondrial DNA depletion after an alcohol binge in mice: probable role of peroxynitrite and modulation by manganese superoxide dismutase.

Larosche I, Lettéron P, Berson A, Fromenty B, Huang TT, Moreau R, Pessayre D, Mansouri A.

J Pharmacol Exp Ther. 2010 Mar;332(3):886-97. doi: 10.1124/jpet.109.160879. Epub 2009 Dec 16.


Protection against hepatocyte mitochondrial dysfunction delays fibrosis progression in mice.

Mitchell C, Robin MA, Mayeuf A, Mahrouf-Yorgov M, Mansouri A, Hamard M, Couton D, Fromenty B, Gilgenkrantz H.

Am J Pathol. 2009 Nov;175(5):1929-37. doi: 10.2353/ajpath.2009.090332. Epub 2009 Oct 1.


Effects of β-aminoisobutyric acid on leptin production and lipid homeostasis: mechanisms and possible relevance for the prevention of obesity.

Begriche K, Massart J, Fromenty B.

Fundam Clin Pharmacol. 2010 Jun;24(3):269-82. doi: 10.1111/j.1472-8206.2009.00765.x. Epub 2009 Sep 3. Review.


Chronic ethanol consumption lessens the gain of body weight, liver triglycerides, and diabetes in obese ob/ob mice.

Fromenty B, Vadrot N, Massart J, Turlin B, Barri-Ova N, Lettéron P, Fautrel A, Robin MA.

J Pharmacol Exp Ther. 2009 Oct;331(1):23-34. doi: 10.1124/jpet.109.155168. Epub 2009 Jul 8.


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