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Items: 1 to 50 of 85


Lack of nsP2-specific nuclear functions attenuates chikungunya virus replication both in vitro and in vivo.

Meshram CD, Lukash T, Phillips AT, Akhrymuk I, Frolova EI, Frolov I.

Virology. 2019 Aug;534:14-24. doi: 10.1016/j.virol.2019.05.016. Epub 2019 May 28.


Molecular Virology of Chikungunya Virus.

Frolov I, Frolova EI.

Curr Top Microbiol Immunol. 2019 Jan 1. doi: 10.1007/82_2018_146. [Epub ahead of print]


Novel Mutations in nsP2 Abolish Chikungunya Virus-Induced Transcriptional Shutoff and Make the Virus Less Cytopathic without Affecting Its Replication Rates.

Akhrymuk I, Lukash T, Frolov I, Frolova EI.

J Virol. 2019 Feb 5;93(4). pii: e02062-18. doi: 10.1128/JVI.02062-18. Print 2019 Feb 15.


Sindbis Virus Infection Causes Cell Death by nsP2-Induced Transcriptional Shutoff or by nsP3-Dependent Translational Shutoff.

Akhrymuk I, Frolov I, Frolova EI.

J Virol. 2018 Nov 12;92(23). pii: e01388-18. doi: 10.1128/JVI.01388-18. Print 2018 Dec 1.


Multiple Host Factors Interact with the Hypervariable Domain of Chikungunya Virus nsP3 and Determine Viral Replication in Cell-Specific Mode.

Meshram CD, Agback P, Shiliaev N, Urakova N, Mobley JA, Agback T, Frolova EI, Frolov I.

J Virol. 2018 Jul 31;92(16). pii: e00838-18. doi: 10.1128/JVI.00838-18. Print 2018 Aug 15.


β-d-N 4-Hydroxycytidine Is a Potent Anti-alphavirus Compound That Induces a High Level of Mutations in the Viral Genome.

Urakova N, Kuznetsova V, Crossman DK, Sokratian A, Guthrie DB, Kolykhalov AA, Lockwood MA, Natchus MG, Crowley MR, Painter GR, Frolova EI, Frolov I.

J Virol. 2018 Jan 17;92(3). pii: e01965-17. doi: 10.1128/JVI.01965-17. Print 2018 Feb 1.


[CD47 receptor as a primary target for cancer therapy].

Ratnikova NM, Lezhnin YN, Frolova EI, Kravchenko JE, Chumakov SP.

Mol Biol (Mosk). 2017 Mar-Apr;51(2):251-261. doi: 10.7868/S0026898417010153. Review. Russian.


Hypervariable Domain of Eastern Equine Encephalitis Virus nsP3 Redundantly Utilizes Multiple Cellular Proteins for Replication Complex Assembly.

Frolov I, Kim DY, Akhrymuk M, Mobley JA, Frolova EI.

J Virol. 2017 Jun 26;91(14). pii: e00371-17. doi: 10.1128/JVI.00371-17. Print 2017 Jul 15.


New World and Old World Alphaviruses Have Evolved to Exploit Different Components of Stress Granules, FXR and G3BP Proteins, for Assembly of Viral Replication Complexes.

Kim DY, Reynaud JM, Rasalouskaya A, Akhrymuk I, Mobley JA, Frolov I, Frolova EI.

PLoS Pathog. 2016 Aug 10;12(8):e1005810. doi: 10.1371/journal.ppat.1005810. eCollection 2016 Aug.


[Role of PDLIM4 and c-Src in Breast Cancer Progression].

Kravchenko DS, Frolova EI, Kravchenko JE, Chumakov SP.

Mol Biol (Mosk). 2016 Jan-Feb;50(1):69-79. doi: 10.7868/S0026898416010092. Review. Russian.


The SD1 Subdomain of Venezuelan Equine Encephalitis Virus Capsid Protein Plays a Critical Role in Nucleocapsid and Particle Assembly.

Reynaud JM, Lulla V, Kim DY, Frolova EI, Frolov I.

J Virol. 2015 Dec 9;90(4):2008-20. doi: 10.1128/JVI.02680-15. Print 2016 Feb 15.


Both RIG-I and MDA5 detect alphavirus replication in concentration-dependent mode.

Akhrymuk I, Frolov I, Frolova EI.

Virology. 2016 Jan;487:230-41. doi: 10.1016/j.virol.2015.09.023. Epub 2015 Nov 6.


[Oncotoxic proteins in cancer therapy: mechanisms of action].

Lezhnin YN, Kravchenko JE, Frolova EI, Chumakov PM, Chumakov SP.

Mol Biol (Mosk). 2015 Mar-Apr;49(2):264-78. Review. Russian.


IFIT1 Differentially Interferes with Translation and Replication of Alphavirus Genomes and Promotes Induction of Type I Interferon.

Reynaud JM, Kim DY, Atasheva S, Rasalouskaya A, White JP, Diamond MS, Weaver SC, Frolova EI, Frolov I.

PLoS Pathog. 2015 Apr 30;11(4):e1004863. doi: 10.1371/journal.ppat.1004863. eCollection 2015 Apr.


Venezuelan equine encephalitis virus variants lacking transcription inhibitory functions demonstrate highly attenuated phenotype.

Atasheva S, Kim DY, Frolova EI, Frolov I.

J Virol. 2015 Jan;89(1):71-82. doi: 10.1128/JVI.02252-14. Epub 2014 Oct 15.


Enhancement of protein expression by alphavirus replicons by designing self-replicating subgenomic RNAs.

Kim DY, Atasheva S, McAuley AJ, Plante JA, Frolova EI, Beasley DW, Frolov I.

Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):10708-13. doi: 10.1073/pnas.1408677111. Epub 2014 Jul 7.


Interferon-stimulated poly(ADP-Ribose) polymerases are potent inhibitors of cellular translation and virus replication.

Atasheva S, Frolova EI, Frolov I.

J Virol. 2014 Feb;88(4):2116-30. doi: 10.1128/JVI.03443-13. Epub 2013 Dec 11.


Hypervariable domain of nonstructural protein nsP3 of Venezuelan equine encephalitis virus determines cell-specific mode of virus replication.

Foy NJ, Akhrymuk M, Shustov AV, Frolova EI, Frolov I.

J Virol. 2013 Jul;87(13):7569-84. doi: 10.1128/JVI.00720-13. Epub 2013 May 1.


Venezuelan equine encephalitis virus nsP2 protein regulates packaging of the viral genome into infectious virions.

Kim DY, Atasheva S, Frolova EI, Frolov I.

J Virol. 2013 Apr;87(8):4202-13. doi: 10.1128/JVI.03142-12. Epub 2013 Jan 30.


Hypervariable domains of nsP3 proteins of New World and Old World alphaviruses mediate formation of distinct, virus-specific protein complexes.

Foy NJ, Akhrymuk M, Akhrymuk I, Atasheva S, Bopda-Waffo A, Frolov I, Frolova EI.

J Virol. 2013 Feb;87(4):1997-2010. doi: 10.1128/JVI.02853-12. Epub 2012 Dec 5.


Pseudoinfectious Venezuelan equine encephalitis virus: a new means of alphavirus attenuation.

Atasheva S, Kim DY, Akhrymuk M, Morgan DG, Frolova EI, Frolov I.

J Virol. 2013 Feb;87(4):2023-35. doi: 10.1128/JVI.02881-12. Epub 2012 Dec 5.


New PARP gene with an anti-alphavirus function.

Atasheva S, Akhrymuk M, Frolova EI, Frolov I.

J Virol. 2012 Aug;86(15):8147-60. doi: 10.1128/JVI.00733-12. Epub 2012 May 23.


Evasion of the innate immune response: the Old World alphavirus nsP2 protein induces rapid degradation of Rpb1, a catalytic subunit of RNA polymerase II.

Akhrymuk I, Kulemzin SV, Frolova EI.

J Virol. 2012 Jul;86(13):7180-91. doi: 10.1128/JVI.00541-12. Epub 2012 Apr 18.


Early events in alphavirus replication determine the outcome of infection.

Frolov I, Akhrymuk M, Akhrymuk I, Atasheva S, Frolova EI.

J Virol. 2012 May;86(9):5055-66. doi: 10.1128/JVI.07223-11. Epub 2012 Feb 15.


Conservation of a packaging signal and the viral genome RNA packaging mechanism in alphavirus evolution.

Kim DY, Firth AE, Atasheva S, Frolova EI, Frolov I.

J Virol. 2011 Aug;85(16):8022-36. doi: 10.1128/JVI.00644-11. Epub 2011 Jun 15.


Actin cytoskeleton remodeling by the alternatively spliced isoform of PDLIM4/RIL protein.

Guryanova OA, Drazba JA, Frolova EI, Chumakov PM.

J Biol Chem. 2011 Jul 29;286(30):26849-59. doi: 10.1074/jbc.M111.241554. Epub 2011 Jun 2.


Design of chimeric alphaviruses with a programmed, attenuated, cell type-restricted phenotype.

Kim DY, Atasheva S, Foy NJ, Wang E, Frolova EI, Weaver S, Frolov I.

J Virol. 2011 May;85(9):4363-76. doi: 10.1128/JVI.00065-11. Epub 2011 Feb 23.


Functional Sindbis virus replicative complexes are formed at the plasma membrane.

Frolova EI, Gorchakov R, Pereboeva L, Atasheva S, Frolov I.

J Virol. 2010 Nov;84(22):11679-95. doi: 10.1128/JVI.01441-10. Epub 2010 Sep 8.


Venezuelan equine Encephalitis virus capsid protein forms a tetrameric complex with CRM1 and importin alpha/beta that obstructs nuclear pore complex function.

Atasheva S, Fish A, Fornerod M, Frolova EI.

J Virol. 2010 May;84(9):4158-71. doi: 10.1128/JVI.02554-09. Epub 2010 Feb 10.


Efficient downregulation of multiple mRNA targets with a single shRNA-expressing lentiviral vector.

Chumakov SP, Kravchenko JE, Prassolov VS, Frolova EI, Chumakov PM.

Plasmid. 2010 May;63(3):143-9. doi: 10.1016/j.plasmid.2009.12.003. Epub 2010 Jan 11.


Random insertion mutagenesis of sindbis virus nonstructural protein 2 and selection of variants incapable of downregulating cellular transcription.

Frolov I, Garmashova N, Atasheva S, Frolova EI.

J Virol. 2009 Sep;83(18):9031-44. doi: 10.1128/JVI.00850-09. Epub 2009 Jul 1.


[A lentivirus vector based assay system for quantitative detection of intracellular translocations of recombinant proteins].

Chumakov SP, Il'inskaia GV, Kravchenko IuE, Frolova EI, Prasolov VS, Chumakov PM.

Mol Biol (Mosk). 2008 Nov-Dec;42(6):1004-11. Russian.


Small-molecule RETRA suppresses mutant p53-bearing cancer cells through a p73-dependent salvage pathway.

Kravchenko JE, Ilyinskaya GV, Komarov PG, Agapova LS, Kochetkov DV, Strom E, Frolova EI, Kovriga I, Gudkov AV, Feinstein E, Chumakov PM.

Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6302-7. doi: 10.1073/pnas.0802091105. Epub 2008 Apr 18.


[Transcriptional inhibition of human papilloma virus in cervical carcinoma cells reactivates functions of the tumor suppressor p53].

Kochetkov DV, Il'inskaia GV, Komarov PG, Strom E, Agapova LS, Ivanov AV, Budanov AV, Frolova EI, Chumakov PM.

Mol Biol (Mosk). 2007 May-Jun;41(3):515-23. Russian.


[Genome-wide lentivector-based pooled shRNA library optimization].

Gur'ianova OA, Makhanov M, Chenchik AA, Chumakov PM, Frolova EI.

Mol Biol (Mosk). 2006 May-Jun;40(3):448-59. Russian.


Optimization of a Genome-Wide Disordered Lentivector-Based Short Hairpin RNA Library.

Guryanova OA, Makhanov M, Chenchik AA, Chumakov PM, Frolova EI.

Mol Biol. 2006 May 1;40(3):396-405.


[Down-regulation of TRIP6 expression induces actin cytoskeleton rearrangements in human carcinoma cell lines].

Gur'ianova OA, Sablina AA, Chumakov PM, Frolova EI.

Mol Biol (Mosk). 2005 Sep-Oct;39(5):905-9. Russian.


[Intensive therapy for multiple organ dysfunction in neonatal infants after cardiosurgical interventions].

Bokeriia LA, Lobacheva GV, Iarustovskiĭ MB, Khar'kin AV, Aksenov VA, Grigor'iants RG, Mannerova AF, Kvasnikov BB, Frolova EI.

Anesteziol Reanimatol. 2005 Mar-Apr;(2):62-6. Russian.


[Functional studying of promoter region of the human mrpl37 gene].

Levshenkova EV, Ukraintsev KE, Zhugdernamzhilyn O, Kovriga IE, Alibaeva RA, Frolova EI.

Mol Biol (Mosk). 2005 Jan-Feb;39(1):159-62. Russian. No abstract available.


[The structure and specific features of the cDNA expression of the human gene MRPL37].

Levshenkova EV, Ukraintsev KE, Orlova VV, Alibaeva RA, Kovriga IE, Zhugdernamzhilyn O, Frolova EI.

Bioorg Khim. 2004 Sep-Oct;30(5):499-506. Russian.


Purification and primary structure of two isoforms of arenicin, a novel antimicrobial peptide from marine polychaeta Arenicola marina.

Ovchinnikova TV, Aleshina GM, Balandin SV, Krasnosdembskaya AD, Markelov ML, Frolova EI, Leonova YF, Tagaev AA, Krasnodembsky EG, Kokryakov VN.

FEBS Lett. 2004 Nov 5;577(1-2):209-14.


The expression pattern of opticin during chicken embryogenesis.

Frolova EI, Fokina VM, Beebe DC.

Gene Expr Patterns. 2004 May;4(3):335-8.


Roles of nonstructural protein nsP2 and Alpha/Beta interferons in determining the outcome of Sindbis virus infection.

Frolova EI, Fayzulin RZ, Cook SH, Griffin DE, Rice CM, Frolov I.

J Virol. 2002 Nov;76(22):11254-64.


The human RIL gene: mapping to human chromosome 5q31.1, genomic organization and alternative transcripts.

Bashirova AA, Markelov ML, Shlykova TV, Levshenkova EV, Alibaeva RA, Frolova EI.

Gene. 1998 Apr 14;210(2):239-45.


Tandem arrangement of human genes for interleukin-4 and interleukin-13: resemblance in their organization.

Smirnov DV, Smirnova MG, Korobko VG, Frolova EI.

Gene. 1995 Apr 3;155(2):277-81.


[Suppression of influenza virus NP-protein mRNA translation in vitro with derivatives of an antisense oligonucleotide].

Abramova TV, Vlasov VV, Ivanova EM, Zarytova VF, Fokina TN, Frolova EI, Iurchenko LV.

Mol Biol (Mosk). 1994 Mar-Apr;28(2):307-12. Russian.


[The effect of various substituents, joined through the 5'- and 3'-ends of the primer, initiating properties during the polymerization reaction, catalyzed by AMV-revertase].

Lokhova IA, Nevinskiĭ GA, Amirkhanov NV, Godovikova TS, Ivanova EM, Kavsan VM, Koshkin AA, Levina AS, Frolova EI, Zarytova VF, et al.

Mol Biol (Mosk). 1993 Jul-Aug;27(4):781-9. Russian.


Comparison of interactions of 5'-derivatives of deoxyoctathymidylate with human DNA polymerize alpha and HIV reverse transcriptase.

Khodyreva SN, Podust VN, Sergeev DS, Ivanova EM, Frolova EI, Koshkin AA, Godovikova TS, Zarytova VF, Ricchetti M, Lavrik OI.

Mol Biol Rep. 1993 Jun;18(1):43-7.


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