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Items: 1 to 50 of 165

1.

Structural characterization and biological function of bivalent binding of CD2AP to intrinsically disordered domain of chikungunya virus nsP3 protein.

Agback P, Dominguez F, Pustovalova Y, Lukash T, Shiliaev N, Orekhov VY, Frolov I, Agback T, Frolova EI.

Virology. 2019 Aug 22;537:130-142. doi: 10.1016/j.virol.2019.08.022. [Epub ahead of print]

2.

Lack of nsP2-specific nuclear functions attenuates chikungunya virus replication both in vitro and in vivo.

Meshram CD, Lukash T, Phillips AT, Akhrymuk I, Frolova EI, Frolov I.

Virology. 2019 Aug;534:14-24. doi: 10.1016/j.virol.2019.05.016. Epub 2019 May 28.

PMID:
31163352
3.

[Thoracoscopy in combined treatment of thymoma (in Russian only)].

Efteev LA, Rodionov EO, Miller SV, Tuzikov SA, Velichko SA, Frolov IG, Perelmuter VM, Glushchenko SA.

Khirurgiia (Mosk). 2019;(3):84-87. doi: 10.17116/hirurgia201903184. Russian.

PMID:
30938362
4.

Molecular Virology of Chikungunya Virus.

Frolov I, Frolova EI.

Curr Top Microbiol Immunol. 2019 Jan 1. doi: 10.1007/82_2018_146. [Epub ahead of print]

PMID:
30599050
5.

Novel Mutations in nsP2 Abolish Chikungunya Virus-Induced Transcriptional Shutoff and Make the Virus Less Cytopathic without Affecting Its Replication Rates.

Akhrymuk I, Lukash T, Frolov I, Frolova EI.

J Virol. 2019 Feb 5;93(4). pii: e02062-18. doi: 10.1128/JVI.02062-18. Print 2019 Feb 15.

6.

Sindbis Virus Infection Causes Cell Death by nsP2-Induced Transcriptional Shutoff or by nsP3-Dependent Translational Shutoff.

Akhrymuk I, Frolov I, Frolova EI.

J Virol. 2018 Nov 12;92(23). pii: e01388-18. doi: 10.1128/JVI.01388-18. Print 2018 Dec 1.

7.

Multiple Host Factors Interact with the Hypervariable Domain of Chikungunya Virus nsP3 and Determine Viral Replication in Cell-Specific Mode.

Meshram CD, Agback P, Shiliaev N, Urakova N, Mobley JA, Agback T, Frolova EI, Frolov I.

J Virol. 2018 Jul 31;92(16). pii: e00838-18. doi: 10.1128/JVI.00838-18. Print 2018 Aug 15.

8.

Novel Insect-Specific Eilat Virus-Based Chimeric Vaccine Candidates Provide Durable, Mono- and Multivalent, Single-Dose Protection against Lethal Alphavirus Challenge.

Erasmus JH, Seymour RL, Kaelber JT, Kim DY, Leal G, Sherman MB, Frolov I, Chiu W, Weaver SC, Nasar F.

J Virol. 2018 Jan 30;92(4). pii: e01274-17. doi: 10.1128/JVI.01274-17. Print 2018 Feb 15.

9.

β-d-N 4-Hydroxycytidine Is a Potent Anti-alphavirus Compound That Induces a High Level of Mutations in the Viral Genome.

Urakova N, Kuznetsova V, Crossman DK, Sokratian A, Guthrie DB, Kolykhalov AA, Lockwood MA, Natchus MG, Crowley MR, Painter GR, Frolova EI, Frolov I.

J Virol. 2018 Jan 17;92(3). pii: e01965-17. doi: 10.1128/JVI.01965-17. Print 2018 Feb 1.

10.

Hypervariable Domain of Eastern Equine Encephalitis Virus nsP3 Redundantly Utilizes Multiple Cellular Proteins for Replication Complex Assembly.

Frolov I, Kim DY, Akhrymuk M, Mobley JA, Frolova EI.

J Virol. 2017 Jun 26;91(14). pii: e00371-17. doi: 10.1128/JVI.00371-17. Print 2017 Jul 15.

11.

The neurovascular complexity index as a potential indicator of traumatic brain injury severity: A case-series study.

Howard JT, Janak JC, Bukhman V, Robertson C, Frolov I, Nawn CD, Schiller AM, Convertino VA.

J Trauma Acute Care Surg. 2017 Jul;83(1 Suppl 1):S77-S82. doi: 10.1097/TA.0000000000001477.

PMID:
28383469
12.

A chikungunya fever vaccine utilizing an insect-specific virus platform.

Erasmus JH, Auguste AJ, Kaelber JT, Luo H, Rossi SL, Fenton K, Leal G, Kim DY, Chiu W, Wang T, Frolov I, Nasar F, Weaver SC.

Nat Med. 2017 Feb;23(2):192-199. doi: 10.1038/nm.4253. Epub 2016 Dec 19.

13.

New World and Old World Alphaviruses Have Evolved to Exploit Different Components of Stress Granules, FXR and G3BP Proteins, for Assembly of Viral Replication Complexes.

Kim DY, Reynaud JM, Rasalouskaya A, Akhrymuk I, Mobley JA, Frolov I, Frolova EI.

PLoS Pathog. 2016 Aug 10;12(8):e1005810. doi: 10.1371/journal.ppat.1005810. eCollection 2016 Aug.

14.

The SD1 Subdomain of Venezuelan Equine Encephalitis Virus Capsid Protein Plays a Critical Role in Nucleocapsid and Particle Assembly.

Reynaud JM, Lulla V, Kim DY, Frolova EI, Frolov I.

J Virol. 2015 Dec 9;90(4):2008-20. doi: 10.1128/JVI.02680-15. Print 2016 Feb 15.

15.

Both RIG-I and MDA5 detect alphavirus replication in concentration-dependent mode.

Akhrymuk I, Frolov I, Frolova EI.

Virology. 2016 Jan;487:230-41. doi: 10.1016/j.virol.2015.09.023. Epub 2015 Nov 6.

16.

Utilization of an Eilat Virus-Based Chimera for Serological Detection of Chikungunya Infection.

Erasmus JH, Needham J, Raychaudhuri S, Diamond MS, Beasley DW, Morkowski S, Salje H, Fernandez Salas I, Kim DY, Frolov I, Nasar F, Weaver SC.

PLoS Negl Trop Dis. 2015 Oct 22;9(10):e0004119. doi: 10.1371/journal.pntd.0004119. eCollection 2015.

17.

IFIT1 Differentially Interferes with Translation and Replication of Alphavirus Genomes and Promotes Induction of Type I Interferon.

Reynaud JM, Kim DY, Atasheva S, Rasalouskaya A, White JP, Diamond MS, Weaver SC, Frolova EI, Frolov I.

PLoS Pathog. 2015 Apr 30;11(4):e1004863. doi: 10.1371/journal.ppat.1004863. eCollection 2015 Apr.

18.

[Parameters of cardiac muscle repolarization on the electrocardiogram when changing anatomical and electric position of the heart].

Chaĭkovskiĭ IA, Baum OV, Popov LA, Voloshin VI, Budnik NN, Frolov IuA, Kovalenko AS.

Biofizika. 2014 Sep-Oct;59(5):1006-16. Russian.

PMID:
25730987
19.

Venezuelan equine encephalitis virus variants lacking transcription inhibitory functions demonstrate highly attenuated phenotype.

Atasheva S, Kim DY, Frolova EI, Frolov I.

J Virol. 2015 Jan;89(1):71-82. doi: 10.1128/JVI.02252-14. Epub 2014 Oct 15.

20.

Enhancement of protein expression by alphavirus replicons by designing self-replicating subgenomic RNAs.

Kim DY, Atasheva S, McAuley AJ, Plante JA, Frolova EI, Beasley DW, Frolov I.

Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):10708-13. doi: 10.1073/pnas.1408677111. Epub 2014 Jul 7.

21.

Interferon-stimulated poly(ADP-Ribose) polymerases are potent inhibitors of cellular translation and virus replication.

Atasheva S, Frolova EI, Frolov I.

J Virol. 2014 Feb;88(4):2116-30. doi: 10.1128/JVI.03443-13. Epub 2013 Dec 11.

22.

[Long-term dynamics of gastrointestinal symptoms after cholecystectomy for the treatment of cholelithiasis].

Osipenko MF, Litvinova NV, Voloshina NB, Frolov IaA.

Klin Med (Mosk). 2013;91(5):49-52. Russian.

PMID:
24159788
23.
24.

IRES-driven expression of the capsid protein of the Venezuelan equine encephalitis virus TC-83 vaccine strain increases its attenuation and safety.

Guerbois M, Volkova E, Forrester NL, Rossi SL, Frolov I, Weaver SC.

PLoS Negl Trop Dis. 2013 May 9;7(5):e2197. doi: 10.1371/journal.pntd.0002197. Print 2013.

25.

Hypervariable domain of nonstructural protein nsP3 of Venezuelan equine encephalitis virus determines cell-specific mode of virus replication.

Foy NJ, Akhrymuk M, Shustov AV, Frolova EI, Frolov I.

J Virol. 2013 Jul;87(13):7569-84. doi: 10.1128/JVI.00720-13. Epub 2013 May 1.

26.

[The modern approaches to diagnostics of obstructive sleep apnoea syndrome].

Zatoloka DA, Furmanchuk DA, Koliadich ZhV, Tishkevich ES, Andrianova TD, Frolov IuIu, Makarin-Kibak AS.

Vestn Otorinolaringol. 2013;(1):58-60. Russian.

PMID:
23528467
27.

Venezuelan equine encephalitis virus nsP2 protein regulates packaging of the viral genome into infectious virions.

Kim DY, Atasheva S, Frolova EI, Frolov I.

J Virol. 2013 Apr;87(8):4202-13. doi: 10.1128/JVI.03142-12. Epub 2013 Jan 30.

28.

A chimeric Sindbis-based vaccine protects cynomolgus macaques against a lethal aerosol challenge of eastern equine encephalitis virus.

Roy CJ, Adams AP, Wang E, Leal G, Seymour RL, Sivasubramani SK, Mega W, Frolov I, Didier PJ, Weaver SC.

Vaccine. 2013 Mar 1;31(11):1464-70. doi: 10.1016/j.vaccine.2013.01.014. Epub 2013 Jan 16.

29.

Hypervariable domains of nsP3 proteins of New World and Old World alphaviruses mediate formation of distinct, virus-specific protein complexes.

Foy NJ, Akhrymuk M, Akhrymuk I, Atasheva S, Bopda-Waffo A, Frolov I, Frolova EI.

J Virol. 2013 Feb;87(4):1997-2010. doi: 10.1128/JVI.02853-12. Epub 2012 Dec 5.

30.

Pseudoinfectious Venezuelan equine encephalitis virus: a new means of alphavirus attenuation.

Atasheva S, Kim DY, Akhrymuk M, Morgan DG, Frolova EI, Frolov I.

J Virol. 2013 Feb;87(4):2023-35. doi: 10.1128/JVI.02881-12. Epub 2012 Dec 5.

31.

New PARP gene with an anti-alphavirus function.

Atasheva S, Akhrymuk M, Frolova EI, Frolov I.

J Virol. 2012 Aug;86(15):8147-60. doi: 10.1128/JVI.00733-12. Epub 2012 May 23.

32.

[Magnetocardiography in clinical practice: algorithms and technologies for data analysis].

Chaĭkovskiĭ I, Boĭchak M, Sosnitskiĭ V, Miasnikov G, Rykhlik E, Sosnitskaia T, Frolov Iu, Budnik V.

Lik Sprava. 2011 Apr-Jun;(3-4):3-20. Russian.

PMID:
22416359
33.

Early events in alphavirus replication determine the outcome of infection.

Frolov I, Akhrymuk M, Akhrymuk I, Atasheva S, Frolova EI.

J Virol. 2012 May;86(9):5055-66. doi: 10.1128/JVI.07223-11. Epub 2012 Feb 15.

34.

Novel chikungunya vaccine candidate with an IRES-based attenuation and host range alteration mechanism.

Plante K, Wang E, Partidos CD, Weger J, Gorchakov R, Tsetsarkin K, Borland EM, Powers AM, Seymour R, Stinchcomb DT, Osorio JE, Frolov I, Weaver SC.

PLoS Pathog. 2011 Jul;7(7):e1002142. doi: 10.1371/journal.ppat.1002142. Epub 2011 Jul 28.

35.

Chimeric Chikungunya viruses are nonpathogenic in highly sensitive mouse models but efficiently induce a protective immune response.

Wang E, Kim DY, Weaver SC, Frolov I.

J Virol. 2011 Sep;85(17):9249-52. doi: 10.1128/JVI.00844-11. Epub 2011 Jun 22.

36.

Conservation of a packaging signal and the viral genome RNA packaging mechanism in alphavirus evolution.

Kim DY, Firth AE, Atasheva S, Frolova EI, Frolov I.

J Virol. 2011 Aug;85(16):8022-36. doi: 10.1128/JVI.00644-11. Epub 2011 Jun 15.

37.

Characterization of the RepliVax platform for replication-defective flavivirus vaccines.

Rumyantsev AA, Giel-Moloney M, Liu Y, Gao QS, Zhang ZX, Catalan J, Frolov I, Almond J, Kleanthous H, Pugachev KV.

Vaccine. 2011 Jul 18;29(32):5184-94. doi: 10.1016/j.vaccine.2011.05.032. Epub 2011 May 26.

PMID:
21620917
38.

Design of chimeric alphaviruses with a programmed, attenuated, cell type-restricted phenotype.

Kim DY, Atasheva S, Foy NJ, Wang E, Frolova EI, Weaver S, Frolov I.

J Virol. 2011 May;85(9):4363-76. doi: 10.1128/JVI.00065-11. Epub 2011 Feb 23.

39.

Functional Sindbis virus replicative complexes are formed at the plasma membrane.

Frolova EI, Gorchakov R, Pereboeva L, Atasheva S, Frolov I.

J Virol. 2010 Nov;84(22):11679-95. doi: 10.1128/JVI.01441-10. Epub 2010 Sep 8.

40.

Interplay of acute and persistent infections caused by Venezuelan equine encephalitis virus encoding mutated capsid protein.

Atasheva S, Krendelchtchikova V, Liopo A, Frolova E, Frolov I.

J Virol. 2010 Oct;84(19):10004-15. doi: 10.1128/JVI.01151-10. Epub 2010 Jul 28.

41.

Efficient, trans-complementing packaging systems for chimeric, pseudoinfectious dengue 2/yellow fever viruses.

Shustov AV, Frolov I.

Virology. 2010 Apr 25;400(1):8-17. doi: 10.1016/j.virol.2009.12.015.

42.

Infection, dissemination, and transmission of a West Nile virus green fluorescent protein infectious clone by Culex pipiens quinquefasciatus mosquitoes.

McGee CE, Shustov AV, Tsetsarkin K, Frolov IV, Mason PW, Vanlandingham DL, Higgs S.

Vector Borne Zoonotic Dis. 2010 Apr;10(3):267-74. doi: 10.1089/vbz.2009.0067.

43.

Random insertion mutagenesis of sindbis virus nonstructural protein 2 and selection of variants incapable of downregulating cellular transcription.

Frolov I, Garmashova N, Atasheva S, Frolova EI.

J Virol. 2009 Sep;83(18):9031-44. doi: 10.1128/JVI.00850-09. Epub 2009 Jul 1.

44.

Structural and functional elements of the promoter encoded by the 5' untranslated region of the Venezuelan equine encephalitis virus genome.

Kulasegaran-Shylini R, Atasheva S, Gorenstein DG, Frolov I.

J Virol. 2009 Sep;83(17):8327-39. doi: 10.1128/JVI.00586-09. Epub 2009 Jun 10.

45.

Chimeric alphavirus vaccine candidates protect mice from intranasal challenge with western equine encephalitis virus.

Atasheva S, Wang E, Adams AP, Plante KS, Ni S, Taylor K, Miller ME, Frolov I, Weaver SC.

Vaccine. 2009 Jul 9;27(32):4309-19. doi: 10.1016/j.vaccine.2009.05.011. Epub 2009 May 27.

46.

The 5'UTR-specific mutation in VEEV TC-83 genome has a strong effect on RNA replication and subgenomic RNA synthesis, but not on translation of the encoded proteins.

Kulasegaran-Shylini R, Thiviyanathan V, Gorenstein DG, Frolov I.

Virology. 2009 Apr 25;387(1):211-21. doi: 10.1016/j.virol.2009.02.027. Epub 2009 Mar 17.

47.

Third-generation flavivirus vaccines based on single-cycle, encapsidation-defective viruses.

Widman DG, Frolov I, Mason PW.

Adv Virus Res. 2008;72:77-126. doi: 10.1016/S0065-3527(08)00402-8. Review.

PMID:
19081489
48.

Chimeric alphavirus vaccine candidates for chikungunya.

Wang E, Volkova E, Adams AP, Forrester N, Xiao SY, Frolov I, Weaver SC.

Vaccine. 2008 Sep 15;26(39):5030-9. doi: 10.1016/j.vaccine.2008.07.054. Epub 2008 Aug 8.

49.

Different types of nsP3-containing protein complexes in Sindbis virus-infected cells.

Gorchakov R, Garmashova N, Frolova E, Frolov I.

J Virol. 2008 Oct;82(20):10088-101. doi: 10.1128/JVI.01011-08. Epub 2008 Aug 6.

50.

IRES-dependent replication of Venezuelan equine encephalitis virus makes it highly attenuated and incapable of replicating in mosquito cells.

Volkova E, Frolova E, Darwin JR, Forrester NL, Weaver SC, Frolov I.

Virology. 2008 Jul 20;377(1):160-9. doi: 10.1016/j.virol.2008.04.020. Epub 2008 May 22.

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