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Repeatability of tumor blood flow quantification with 82Rubidium PET/CT in prostate cancer - a test-retest study.

Jochumsen MR, Bouchelouche K, Nielsen KB, Frøkiær J, Borre M, Sörensen J, Tolbod LP.

EJNMMI Res. 2019 Jul 4;9(1):58. doi: 10.1186/s13550-019-0529-2.


Cardiovascular Effects of Treatment With the Ketone Body 3-Hydroxybutyrate in Chronic Heart Failure Patients.

Nielsen R, Møller N, Gormsen LC, Tolbod LP, Hansson NH, Sorensen J, Harms HJ, Frøkiær J, Eiskjaer H, Jespersen NR, Mellemkjaer S, Lassen TR, Pryds K, Bøtker HE, Wiggers H.

Circulation. 2019 Apr 30;139(18):2129-2141. doi: 10.1161/CIRCULATIONAHA.118.036459.


Quantitative tumor perfusion imaging with 82Rubidium-PET/CT in prostate cancer - analytical and clinical validation.

Jochumsen MR, Tolbod LP, Pedersen BG, Nielsen MM, Høyer S, Frøkiær J, Borre M, Bouchelouche K, Sorensen J.

J Nucl Med. 2019 Jan 25. pii: jnumed.118.219188. doi: 10.2967/jnumed.118.219188. [Epub ahead of print]


Non-invasive quantification of tumor blood flow in prostate cancer using 15O-H2O PET/CT.

Tolbod LP, Nielsen MM, Pedersen BG, Høyer S, Harms HJ, Borre M, Borghammer P, Bouchelouche K, Frøkiær J, Sørensen J.

Am J Nucl Med Mol Imaging. 2018 Oct 20;8(5):292-302. eCollection 2018.


APD-Containing Cyclolipodepsipeptides Target Mitochondrial Function in Hypoxic Cancer Cells.

Jacobsen KM, Villadsen NL, Tørring T, Nielsen CB, Salomón T, Nielsen MM, Tsakos M, Sibbersen C, Scavenius C, Nielsen R, Christensen EI, Guerra PF, Bross P, Pedersen JS, Enghild JJ, Johannsen M, Frøkiær J, Overgaard J, Horsman MR, Busk M, Poulsen TB.

Cell Chem Biol. 2018 Nov 15;25(11):1337-1349.e12. doi: 10.1016/j.chembiol.2018.07.010. Epub 2018 Aug 16.


Tamoxifen Decreases Lithium-Induced Natriuresis in Rats With Nephrogenic Diabetes Insipidus.

Tingskov SJ, Kwon TH, Frøkiær J, Nørregaard R.

Front Physiol. 2018 Jul 12;9:903. doi: 10.3389/fphys.2018.00903. eCollection 2018.


Publisher Correction: Hyperpolarized [1-13C]-acetate Renal Metabolic Clearance Rate Mapping.

Mikkelsen EFR, Mariager CØ, Nørlinger T, Qi H, Schulte RF, Jakobsen S, Frøkiær J, Pedersen M, Stødkilde-Jørgensen H, Laustsen C.

Sci Rep. 2018 Jul 20;8(1):11235. doi: 10.1038/s41598-018-29057-7.


Automatic calculation of myocardial external efficiency using a single 11C-acetate PET scan.

Harms HJ, Hansson NHS, Kero T, Baron T, Tolbod LP, Kim WY, Frøkiær J, Flachskampf FA, Wiggers H, Sörensen J.

J Nucl Cardiol. 2018 Dec;25(6):1937-1944. doi: 10.1007/s12350-018-1338-0. Epub 2018 Jun 26.


Test-retest repeatability of myocardial oxidative metabolism and efficiency using standalone dynamic 11C-acetate PET and multimodality approaches in healthy controls.

Hansson NH, Harms HJ, Kim WY, Nielsen R, Tolbod LP, Frøkiær J, Bouchelouche K, Poulsen SH, Wiggers H, Parner ET, Sörensen J.

J Nucl Cardiol. 2018 Dec;25(6):1929-1936. doi: 10.1007/s12350-018-1302-z. Epub 2018 May 31.


Assessment of very early response evaluation with 18F-FDG-PET/CT predicts survival in erlotinib treated NSCLC patients-A comparison of methods.

Fledelius J, Winther-Larsen A, Khalil AA, Hjorthaug K, Frøkiær J, Meldgaard P.

Am J Nucl Med Mol Imaging. 2018 Feb 5;8(1):50-61. eCollection 2018.


Report from the Bodil Schmidt-Nielsen Honorary Symposium.

Frøkiær J.

Physiologist. 2017 Mar;60(2):78-80. No abstract available.


Cerebral blood flow measured by positron emission tomography during normothermic cardiopulmonary bypass: an experimental porcine study.

Thomassen SA, Kjærgaard B, Alstrup AKO, Munk OL, Frøkiær J, Larsson A, Rasmussen BS.

Perfusion. 2018 Jul;33(5):346-353. doi: 10.1177/0267659118755271. Epub 2018 Jan 30.


Tamoxifen attenuates development of lithium-induced nephrogenic diabetes insipidus in rats.

Tingskov SJ, Hu S, Frøkiær J, Kwon TH, Wang W, Nørregaard R.

Am J Physiol Renal Physiol. 2018 May 1;314(5):F1020-F1025. doi: 10.1152/ajprenal.00604.2017. Epub 2018 Jan 10. Erratum in: Am J Physiol Renal Physiol. 2019 Jan 1;316(1):F219.


Oral Contraceptives and Renal Water Handling: A diurnal study in young women.

Graugaard-Jensen C, Hvistendahl GM, Frøkiær J, Bie P, Djurhuus JC.

Physiol Rep. 2017 Dec;5(23). pii: e13547. doi: 10.14814/phy2.13547.


Hyperpolarized [1-13C]-acetate Renal Metabolic Clearance Rate Mapping.

Mikkelsen EFR, Mariager CØ, Nørlinger T, Qi H, Schulte RF, Jakobsen S, Frøkiær J, Pedersen M, Stødkilde-Jørgensen H, Laustsen C.

Sci Rep. 2017 Nov 22;7(1):16002. doi: 10.1038/s41598-017-15929-x. Erratum in: Sci Rep. 2018 Jul 20;8(1):11235.


Metoprolol Reduces Hemodynamic and Metabolic Overload in Asymptomatic Aortic Valve Stenosis Patients: A Randomized Trial.

Hansson NH, Sörensen J, Harms HJ, Kim WY, Nielsen R, Tolbod LP, Frøkiær J, Bouchelouche K, Dodt KK, Sihm I, Poulsen SH, Wiggers H.

Circ Cardiovasc Imaging. 2017 Oct;10(10). pii: e006557. doi: 10.1161/CIRCIMAGING.117.006557.


Results from 11C-metformin-PET scans, tissue analysis and cellular drug-sensitivity assays questions the view that biguanides affects tumor respiration directly.

Iversen AB, Horsman MR, Jakobsen S, Jensen JB, Garm C, Jessen N, Breining P, Frøkiær J, Busk M.

Sci Rep. 2017 Aug 25;7(1):9436. doi: 10.1038/s41598-017-10010-z.


Muscle Tissue Saturation Compared With Muscle Tissue Perfusion During Low Blood Flows: An Experimental Study.

Thomassen SA, Kjærgaard B, Olsen Alstrup AK, Munk OL, Frøkiær J, Larsson A, Rasmussen BS.

J Cardiothorac Vasc Anesth. 2017 Dec;31(6):2065-2071. doi: 10.1053/j.jvca.2017.03.027. Epub 2017 Mar 22.


18F-FDG PET/CT for Very Early Response Evaluation Predicts CT Response in Erlotinib-Treated Non-Small Cell Lung Cancer Patients: A Comparison of Assessment Methods.

Fledelius J, Winther-Larsen A, Khalil AA, Bylov CM, Hjorthaug K, Bertelsen A, Frøkiær J, Meldgaard P.

J Nucl Med. 2017 Dec;58(12):1931-1937. doi: 10.2967/jnumed.117.193003. Epub 2017 May 10.


Genetic Polymorphisms in Organic Cation Transporter 1 Attenuates Hepatic Metformin Exposure in Humans.

Sundelin E, Gormsen LC, Jensen JB, Vendelbo MH, Jakobsen S, Munk OL, Christensen M, Brøsen K, Frøkiaer J, Jessen N.

Clin Pharmacol Ther. 2017 Nov;102(5):841-848. doi: 10.1002/cpt.701. Epub 2017 Jun 1.


Myocardial Oxygen Consumption and Efficiency in Aortic Valve Stenosis Patients With and Without Heart Failure.

Hansson NH, Sörensen J, Harms HJ, Kim WY, Nielsen R, Tolbod LP, Frøkiær J, Bouchelouche K, Dodt KK, Sihm I, Poulsen SH, Wiggers H.

J Am Heart Assoc. 2017 Feb 6;6(2). pii: e004810. doi: 10.1161/JAHA.116.004810.


FDG-PET reproducibility in tumor-bearing mice: comparing a traditional SUV approach with a tumor-to-brain tissue ratio approach.

Busk M, Munk OL, Jakobsen S, Frøkiær J, Overgaard J, Horsman MR.

Acta Oncol. 2017 May;56(5):706-712. doi: 10.1080/0284186X.2016.1276620. Epub 2017 Jan 17.


Effect of remote ischemic conditioning on myocardial perfusion in patients with suspected ischemic coronary artery disease.

Pryds K, Nielsen RR, Hoff CM, Tolbod LP, Bouchelouche K, Li J, Schmidt MR, Redington AN, Frøkiær J, Bøtker HE.

J Nucl Cardiol. 2018 Jun;25(3):887-896. doi: 10.1007/s12350-016-0709-7. Epub 2016 Nov 1.


Renoprotective Effects of Metformin are Independent of Organic Cation Transporters 1 &2 and AMP-activated Protein Kinase in the Kidney.

Christensen M, Jensen JB, Jakobsen S, Jessen N, Frøkiær J, Kemp BE, Marciszyn AL, Li H, Pastor-Soler NM, Hallows KR, Nørregaard R.

Sci Rep. 2016 Oct 26;6:35952. doi: 10.1038/srep35952.


Arterial Clamping Increases Central Renal Cryoablation Efficacy: An Animal Study.

Nonboe LL, Nielsen TK, Høyer S, Graumann O, Frøkiær J, Borre M.

Technol Cancer Res Treat. 2017 Aug;16(4):414-420. doi: 10.1177/1533034616663365. Epub 2016 Aug 25.


In Vivo Imaging of Human 11C-Metformin in Peripheral Organs: Dosimetry, Biodistribution, and Kinetic Analyses.

Gormsen LC, Sundelin EI, Jensen JB, Vendelbo MH, Jakobsen S, Munk OL, Hougaard Christensen MM, Brøsen K, Frøkiær J, Jessen N.

J Nucl Med. 2016 Dec;57(12):1920-1926. Epub 2016 Jul 28.


Renal PET-imaging with (11)C-metformin in a transgenic mouse model for chronic kidney disease.

Pedersen L, Jensen JB, Wogensen L, Munk OL, Jessen N, Frøkiær J, Jakobsen S.

EJNMMI Res. 2016 Dec;6(1):54. doi: 10.1186/s13550-016-0211-x. Epub 2016 Jun 23.


The frequently used intraperitoneal hyponatraemia model induces hypovolaemic hyponatraemia with possible model-dependent brain sodium loss.

Overgaard-Steensen C, Stødkilde-Jørgensen H, Larsson A, Tønnesen E, Frøkiaer J, Ring T.

Exp Physiol. 2016 Jul 1;101(7):932-45. doi: 10.1113/EP085751. Epub 2016 Jun 16.


Erratum to: Evaluation of ECG-gated [11C]acetate PET for measuring left ventricular volumes, mass, and myocardial external efficiency.

Hansson NH, Tolbod L, Harms HJ, Wiggers H, Kim WY, Hansen E, Zaremba T, Frøkiær J, Jakobsen S, Sørensen J.

J Nucl Cardiol. 2016 Oct;23(5):1232. doi: 10.1007/s12350-016-0537-9. No abstract available.


Treatment with a human recombinant monoclonal IgG antibody against oxidized LDL in atherosclerosis-prone pigs reduces cathepsin S in coronary lesions.

Poulsen CB, Al-Mashhadi AL, von Wachenfeldt K, Bentzon JF, Nielsen LB, Al-Mashhadi RH, Thygesen J, Tolbod L, Larsen JR, Frøkiær J, Tawakol A, Vucic E, Fredrickson J, Baruch A, Frendéus B, Robertson AK, Moestrup SK, Drouet L, Falk E.

Int J Cardiol. 2016 Jul 15;215:506-15. doi: 10.1016/j.ijcard.2016.03.222. Epub 2016 Apr 2.


Automatic Extraction of Myocardial Mass and Volume Using Parametric Images from Dynamic Nongated PET.

Harms HJ, Stubkjær Hansson NH, Tolbod LP, Kim WY, Jakobsen S, Bouchelouche K, Wiggers H, Frøkiaer J, Sörensen J.

J Nucl Med. 2016 Sep;57(9):1382-7. doi: 10.2967/jnumed.115.170613. Epub 2016 Apr 28.


Evaluation of ECG-gated [(11)C]acetate PET for measuring left ventricular volumes, mass, and myocardial external efficiency.

Hansson NH, Tolbod L, Harms HJ, Wiggers H, Kim WY, Hansen E, Zaremba T, Frøkiær J, Jakobsen S, Sørensen J.

J Nucl Cardiol. 2016 Aug;23(4):670-9. doi: 10.1007/s12350-015-0331-0. Epub 2016 Apr 19. Erratum in: J Nucl Cardiol. 2016 Oct;23(5):1232.


[11C]-Labeled Metformin Distribution in the Liver and Small Intestine Using Dynamic Positron Emission Tomography in Mice Demonstrates Tissue-Specific Transporter Dependency.

Jensen JB, Sundelin EI, Jakobsen S, Gormsen LC, Munk OL, Frøkiær J, Jessen N.

Diabetes. 2016 Jun;65(6):1724-30. doi: 10.2337/db16-0032. Epub 2016 Mar 18.


Short-term effects of liraglutide on kidney function and vasoactive hormones in type 2 diabetes: a randomized clinical trial.

Skov J, Pedersen M, Holst JJ, Madsen B, Goetze JP, Rittig S, Jonassen T, Frøkiaer J, Dejgaard A, Christiansen JS.

Diabetes Obes Metab. 2016 Jun;18(6):581-9. doi: 10.1111/dom.12651. Epub 2016 Mar 22.


Noninvasive Detection of Cardiac Allograft Vasculopathy by Stress Exercise Echocardiographic Assessment of Myocardial Deformation.

Clemmensen TS, Eiskjær H, Løgstrup BB, Tolbod LP, Harms HJ, Bouchelouche K, Hoff C, Frøkiær J, Poulsen SH.

J Am Soc Echocardiogr. 2016 May;29(5):480-90. doi: 10.1016/j.echo.2016.01.012. Epub 2016 Feb 18.


Physiology and pathophysiology of cyclooxygenase-2 and prostaglandin E2 in the kidney.

Nørregaard R, Kwon TH, Frøkiær J.

Kidney Res Clin Pract. 2015 Dec;34(4):194-200. doi: 10.1016/j.krcp.2015.10.004. Epub 2015 Nov 12. Review.


A PET Tracer for Renal Organic Cation Transporters, ¹¹C-Metformin: Radiosynthesis and Preclinical Proof-of-Concept Studies.

Jakobsen S, Busk M, Jensen JB, Munk OL, Zois NE, Alstrup AK, Jessen N, Frøkiær J.

J Nucl Med. 2016 Apr;57(4):615-21. doi: 10.2967/jnumed.115.169292. Epub 2016 Jan 14.


Disruption of cyclooxygenase type 2 exacerbates apoptosis and renal damage during obstructive nephropathy.

Nilsson L, Madsen K, Krag S, Frøkiær J, Jensen BL, Nørregaard R.

Am J Physiol Renal Physiol. 2015 Dec 15;309(12):F1035-48. doi: 10.1152/ajprenal.00253.2015. Epub 2015 Oct 14.


Unilateral ureteral obstruction induces DNA repair by APE1.

Aamann MD, Nørregaard R, Kristensen ML, Stevnsner T, Frøkiær J.

Am J Physiol Renal Physiol. 2016 Apr 15;310(8):F763-F776. doi: 10.1152/ajprenal.00613.2014. Epub 2015 Nov 25.


Automatic extraction of forward stroke volume using dynamic PET/CT: a dual-tracer and dual-scanner validation in patients with heart valve disease.

Harms HJ, Tolbod LP, Hansson NH, Kero T, Orndahl LH, Kim WY, Bjerner T, Bouchelouche K, Wiggers H, Frøkiær J, Sörensen J.

EJNMMI Phys. 2015 Dec;2(1):25. doi: 10.1186/s40658-015-0133-0. Epub 2015 Oct 26.


Molecular imaging of cholinergic processes in prostate cancer using ¹¹C-donepezil and ¹⁸F-FEOBV.

Stokholm MG, Høyer S, Borre M, Bender D, Jakobsen S, Frøkiær J, Borghammer P.

Eur J Nucl Med Mol Imaging. 2016 May;43(5):906-10. doi: 10.1007/s00259-015-3143-1. Epub 2015 Aug 1.


Estradiol regulates AQP2 expression in the collecting duct: a novel inhibitory role for estrogen receptor α.

Cheema MU, Irsik DL, Wang Y, Miller-Little W, Hyndman KA, Marks ES, Frøkiær J, Boesen EI, Norregaard R.

Am J Physiol Renal Physiol. 2015 Aug 15;309(4):F305-17. doi: 10.1152/ajprenal.00685.2014. Epub 2015 Jun 10.


Quercetin attenuates cyclooxygenase-2 expression in response to acute ureteral obstruction.

Carlsen I, Frøkiær J, Nørregaard R.

Am J Physiol Renal Physiol. 2015 Jun 1;308(11):F1297-305. doi: 10.1152/ajprenal.00514.2014. Epub 2015 Mar 25.


AVP-induced increase in AQP2 and p-AQP2 is blunted in heart failure during cardiac remodeling and is associated with decreased AT1R abundance in rat kidney.

Lütken SC, Frøkiær J, Nielsen S.

PLoS One. 2015 Feb 6;10(2):e0116501. doi: 10.1371/journal.pone.0116501. eCollection 2015.


Chitosan/siRNA nanoparticles targeting cyclooxygenase type 2 attenuate unilateral ureteral obstruction-induced kidney injury in mice.

Yang C, Nilsson L, Cheema MU, Wang Y, Frøkiær J, Gao S, Kjems J, Nørregaard R.

Theranostics. 2015 Jan 1;5(2):110-23. doi: 10.7150/thno.9717. eCollection 2015.


Tankyrase-mediated β-catenin activity regulates vasopressin-induced AQP2 expression in kidney collecting duct mpkCCDc14 cells.

Jung HJ, Kim SY, Choi HJ, Park EJ, Lim JS, Frøkiaer J, Nielsen S, Kwon TH.

Am J Physiol Renal Physiol. 2015 Mar 1;308(5):F473-86. doi: 10.1152/ajprenal.00052.2014. Epub 2014 Dec 17.


Ontogeny of the mammalian kidney: expression of aquaporins 1, 2, 3, and 4.

Xing L, Wen JG, Frøkiær J, Djurhuus JC, Nørregaard R.

World J Pediatr. 2014 Nov;10(4):306-12. doi: 10.1007/s12519-014-0508-7. Epub 2014 Dec 17. Review.


Monitoring Kidney Function in Neuroendocrine Tumor Patients Treated with (90)Y-DOTATOC: Associations with Risk Factors.

Arveschoug AK, Kramer SM, Iversen P, Frøkiær J, Grønbæk H.

Curr Radiopharm. 2015;8(1):49-55.


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