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Items: 44

1.

In Vivo Editing of the Adult Mouse Liver Using CRISPR/Cas9 and Hydrodynamic Tail Vein Injection.

Niola F, Dagnæs-Hansen F, Frödin M.

Methods Mol Biol. 2019;1961:329-341. doi: 10.1007/978-1-4939-9170-9_20.

PMID:
30912055
2.

A minority-group of renal cell cancer patients with high infiltration of CD20+B-cells is associated with poor prognosis.

Sjöberg E, Frödin M, Lövrot J, Mezheyeuski A, Johansson M, Harmenberg U, Egevad L, Sandström P, Östman A.

Br J Cancer. 2018 Oct;119(7):840-846. doi: 10.1038/s41416-018-0266-8. Epub 2018 Oct 8.

PMID:
30293996
3.

Neurite Growth and Polarization on Vitronectin Substrate after in Vitro Trauma is not Enhanced after IGF Treatment.

Bergen K, Frödin M, von Gertten C, Sandberg-Nordqvist A-, Sköld MK.

Brain Sci. 2018 Aug 11;8(8). pii: E151. doi: 10.3390/brainsci8080151.

4.

Correction: p190 RhoGAP promotes contact inhibition in epithelial cells by repressing YAP activity.

Frank SR, Köllmann CP, Luong P, Galli GG, Zou L, Bernards A, Getz G, Calogero RA, Frödin M, Hansen SH.

J Cell Biol. 2018 Sep 3;217(9):3313. doi: 10.1083/JCB.20171005807172018c. Epub 2018 Jul 25. No abstract available.

5.

p190 RhoGAP promotes contact inhibition in epithelial cells by repressing YAP activity.

Frank SR, Köllmann CP, Luong P, Galli GG, Zou L, Bernards A, Getz G, Calogero RA, Frödin M, Hansen SH.

J Cell Biol. 2018 Sep 3;217(9):3183-3201. doi: 10.1083/jcb.201710058. Epub 2018 Jun 22. Erratum in: J Cell Biol. 2018 Jul 25;:.

6.

Iterative co-creation for improved hand hygiene and aseptic techniques in the operating room: experiences from the safe hands study.

Erichsen Andersson A, Frödin M, Dellenborg L, Wallin L, Hök J, Gillespie BM, Wikström E.

BMC Health Serv Res. 2018 Jan 4;18(1):2. doi: 10.1186/s12913-017-2783-1.

7.

De novo expression of human polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6) in colon adenocarcinoma inhibits the differentiation of colonic epithelium.

Lavrsen K, Dabelsteen S, Vakhrushev SY, Levann AMR, Haue AD, Dylander A, Mandel U, Hansen L, Frödin M, Bennett EP, Wandall HH.

J Biol Chem. 2018 Jan 26;293(4):1298-1314. doi: 10.1074/jbc.M117.812826. Epub 2017 Nov 29.

8.

CRISPR/Cas9 Engineering of Adult Mouse Liver Demonstrates That the Dnajb1-Prkaca Gene Fusion Is Sufficient to Induce Tumors Resembling Fibrolamellar Hepatocellular Carcinoma.

Engelholm LH, Riaz A, Serra D, Dagnæs-Hansen F, Johansen JV, Santoni-Rugiu E, Hansen SH, Niola F, Frödin M.

Gastroenterology. 2017 Dec;153(6):1662-1673.e10. doi: 10.1053/j.gastro.2017.09.008. Epub 2017 Sep 18.

9.

Multi-parametric profiling of renal cell, colorectal, and ovarian cancer identifies tumour-type-specific stroma phenotypes and a novel vascular biomarker.

Corvigno S, Frödin M, Wisman GBA, Nijman HW, Van der Zee AG, Jirström K, Nodin B, Hrynchyk I, Edler D, Ragnhammar P, Johansson M, Dahlstrand H, Mezheyeuski A, Östman A.

J Pathol Clin Res. 2017 Jul 24;3(3):214-224. doi: 10.1002/cjp2.74. eCollection 2017 Jul.

10.

Genome editing using FACS enrichment of nuclease-expressing cells and indel detection by amplicon analysis.

Lonowski LA, Narimatsu Y, Riaz A, Delay CE, Yang Z, Niola F, Duda K, Ober EA, Clausen H, Wandall HH, Hansen SH, Bennett EP, Frödin M.

Nat Protoc. 2017 Mar;12(3):581-603. doi: 10.1038/nprot.2016.165. Epub 2017 Feb 16.

PMID:
28207001
11.

Perivascular PDGFR-β is an independent marker for prognosis in renal cell carcinoma.

Frödin M, Mezheyeuski A, Corvigno S, Harmenberg U, Sandström P, Egevad L, Johansson M, Östman A.

Br J Cancer. 2017 Jan 17;116(2):195-201. doi: 10.1038/bjc.2016.407. Epub 2016 Dec 8.

12.

The focal adhesion-associated proteins DOCK5 and GIT2 comprise a rheostat in control of epithelial invasion.

Frank SR, Köllmann CP, van Lidth de Jeude JF, Thiagarajah JR, Engelholm LH, Frödin M, Hansen SH.

Oncogene. 2017 Mar 30;36(13):1816-1828. doi: 10.1038/onc.2016.345. Epub 2016 Sep 26.

13.

A Novel Locus Harbouring a Functional CD164 Nonsense Mutation Identified in a Large Danish Family with Nonsyndromic Hearing Impairment.

Nyegaard M, Rendtorff ND, Nielsen MS, Corydon TJ, Demontis D, Starnawska A, Hedemand A, Buniello A, Niola F, Overgaard MT, Leal SM, Ahmad W, Wikman FP, Petersen KB, Crüger DG, Oostrik J, Kremer H, Tommerup N, Frödin M, Steel KP, Tranebjærg L, Børglum AD.

PLoS Genet. 2015 Jul 21;11(7):e1005386. doi: 10.1371/journal.pgen.1005386. eCollection 2015 Jul.

14.

Engineered CHO cells for production of diverse, homogeneous glycoproteins.

Yang Z, Wang S, Halim A, Schulz MA, Frodin M, Rahman SH, Vester-Christensen MB, Behrens C, Kristensen C, Vakhrushev SY, Bennett EP, Wandall HH, Clausen H.

Nat Biotechnol. 2015 Aug;33(8):842-4. doi: 10.1038/nbt.3280. Epub 2015 Jul 20.

PMID:
26192319
15.

Fast and sensitive detection of indels induced by precise gene targeting.

Yang Z, Steentoft C, Hauge C, Hansen L, Thomsen AL, Niola F, Vester-Christensen MB, Frödin M, Clausen H, Wandall HH, Bennett EP.

Nucleic Acids Res. 2015 May 19;43(9):e59. doi: 10.1093/nar/gkv126. Epub 2015 Mar 9.

16.

High-efficiency genome editing via 2A-coupled co-expression of fluorescent proteins and zinc finger nucleases or CRISPR/Cas9 nickase pairs.

Duda K, Lonowski LA, Kofoed-Nielsen M, Ibarra A, Delay CM, Kang Q, Yang Z, Pruett-Miller SM, Bennett EP, Wandall HH, Davis GD, Hansen SH, Frödin M.

Nucleic Acids Res. 2014 Jun;42(10):e84. doi: 10.1093/nar/gku251. Epub 2014 Apr 21.

17.

A βPIX-PAK2 complex confers protection against Scrib-dependent and cadherin-mediated apoptosis.

Frank SR, Bell JH, Frödin M, Hansen SH.

Curr Biol. 2012 Oct 9;22(19):1747-54. doi: 10.1016/j.cub.2012.07.011. Epub 2012 Aug 2.

18.

Reversible targeting of noncatalytic cysteines with chemically tuned electrophiles.

Serafimova IM, Pufall MA, Krishnan S, Duda K, Cohen MS, Maglathlin RL, McFarland JM, Miller RM, Frödin M, Taunton J.

Nat Chem Biol. 2012 Apr 1;8(5):471-6. doi: 10.1038/nchembio.925.

19.

High-frequency genome editing using ssDNA oligonucleotides with zinc-finger nucleases.

Chen F, Pruett-Miller SM, Huang Y, Gjoka M, Duda K, Taunton J, Collingwood TN, Frodin M, Davis GD.

Nat Methods. 2011 Jul 17;8(9):753-5. doi: 10.1038/nmeth.1653.

20.

Regulation of the interaction between protein kinase C-related protein kinase 2 (PRK2) and its upstream kinase, 3-phosphoinositide-dependent protein kinase 1 (PDK1).

Dettori R, Sonzogni S, Meyer L, Lopez-Garcia LA, Morrice NA, Zeuzem S, Engel M, Piiper A, Neimanis S, Frödin M, Biondi RM.

J Biol Chem. 2009 Oct 30;284(44):30318-27. doi: 10.1074/jbc.M109.051151. Epub 2009 Sep 1.

21.

RSK is a principal effector of the RAS-ERK pathway for eliciting a coordinate promotile/invasive gene program and phenotype in epithelial cells.

Doehn U, Hauge C, Frank SR, Jensen CJ, Duda K, Nielsen JV, Cohen MS, Johansen JV, Winther BR, Lund LR, Winther O, Taunton J, Hansen SH, Frödin M.

Mol Cell. 2009 Aug 28;35(4):511-22. doi: 10.1016/j.molcel.2009.08.002.

22.

Heregulin-induced epigenetic regulation of the utrophin-A promoter.

Basu U, Gyrd-Hansen M, Baby SM, Lozynska O, Krag TO, Jensen CJ, Frödin M, Khurana TS.

FEBS Lett. 2007 Sep 4;581(22):4153-8. Epub 2007 Jul 23.

23.

Mechanism for activation of the growth factor-activated AGC kinases by turn motif phosphorylation.

Hauge C, Antal TL, Hirschberg D, Doehn U, Thorup K, Idrissova L, Hansen K, Jensen ON, Jørgensen TJ, Biondi RM, Frödin M.

EMBO J. 2007 May 2;26(9):2251-61. Epub 2007 Apr 19.

24.

A RSK kinase inhibitor reporting its selectivity in vivo.

Frödin M.

Nat Chem Biol. 2007 Mar;3(3):138-9. No abstract available.

PMID:
17301799
25.

BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo.

Sapkota GP, Cummings L, Newell FS, Armstrong C, Bain J, Frodin M, Grauert M, Hoffmann M, Schnapp G, Steegmaier M, Cohen P, Alessi DR.

Biochem J. 2007 Jan 1;401(1):29-38.

26.

RSK and MSK in MAP kinase signalling.

Hauge C, Frödin M.

J Cell Sci. 2006 Aug 1;119(Pt 15):3021-3. No abstract available.

27.

Analysis of 65 tuberous sclerosis complex (TSC) patients by TSC2 DGGE, TSC1/TSC2 MLPA, and TSC1 long-range PCR sequencing, and report of 28 novel mutations.

Rendtorff ND, Bjerregaard B, Frödin M, Kjaergaard S, Hove H, Skovby F, Brøndum-Nielsen K, Schwartz M; Danish Tuberous Sclerosis Group.

Hum Mutat. 2005 Oct;26(4):374-83.

PMID:
16114042
28.

Impaired mitotic progression and preimplantation lethality in mice lacking OMCG1, a new evolutionarily conserved nuclear protein.

Artus J, Vandormael-Pournin S, Frödin M, Nacerddine K, Babinet C, Cohen-Tannoudji M.

Mol Cell Biol. 2005 Jul;25(14):6289-302.

29.

Functional characterization of human RSK4, a new 90-kDa ribosomal S6 kinase, reveals constitutive activation in most cell types.

Dümmler BA, Hauge C, Silber J, Yntema HG, Kruse LS, Kofoed B, Hemmings BA, Alessi DR, Frödin M.

J Biol Chem. 2005 Apr 8;280(14):13304-14. Epub 2005 Jan 4.

30.

Activation of p90 Rsk1 is sufficient for differentiation of PC12 cells.

Silverman E, Frödin M, Gammeltoft S, Maller JL.

Mol Cell Biol. 2004 Dec;24(24):10573-83.

31.

Xp38gamma/SAPK3 promotes meiotic G(2)/M transition in Xenopus oocytes and activates Cdc25C.

Perdiguero E, Pillaire MJ, Bodart JF, Hennersdorf F, Frödin M, Duesbery NS, Alonso G, Nebreda AR.

EMBO J. 2003 Nov 3;22(21):5746-56.

33.

A phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation.

Frödin M, Antal TL, Dümmler BA, Jensen CJ, Deak M, Gammeltoft S, Biondi RM.

EMBO J. 2002 Oct 15;21(20):5396-407.

34.
35.

A phosphoserine-regulated docking site in the protein kinase RSK2 that recruits and activates PDK1.

Frödin M, Jensen CJ, Merienne K, Gammeltoft S.

EMBO J. 2000 Jun 15;19(12):2924-34.

36.

90-kDa ribosomal S6 kinase is phosphorylated and activated by 3-phosphoinositide-dependent protein kinase-1.

Jensen CJ, Buch MB, Krag TO, Hemmings BA, Gammeltoft S, Frödin M.

J Biol Chem. 1999 Sep 17;274(38):27168-76.

37.

Role and regulation of 90 kDa ribosomal S6 kinase (RSK) in signal transduction.

Frödin M, Gammeltoft S.

Mol Cell Endocrinol. 1999 May 25;151(1-2):65-77. Review.

PMID:
10411321
38.

Transforming growth factor-beta, but not ciliary neurotrophic factor, inhibits DNA synthesis of adrenal medullary cells in vitro.

Wolf N, Krohn K, Bieger S, Frödin M, Gammeltoft S, Krieglstein K, Unsicker K.

Neuroscience. 1999 May;90(2):629-41.

PMID:
10215165
39.

Glucose, other secretagogues, and nerve growth factor stimulate mitogen-activated protein kinase in the insulin-secreting beta-cell line, INS-1.

Frödin M, Sekine N, Roche E, Filloux C, Prentki M, Wollheim CB, Van Obberghen E.

J Biol Chem. 1995 Apr 7;270(14):7882-9.

40.

Neuronal localization of pituitary adenylate cyclase-activating polypeptide 38 in the adrenal medulla and growth-inhibitory effect on chromaffin cells.

Frödin M, Hannibal J, Wulff BS, Gammeltoft S, Fahrenkrug J.

Neuroscience. 1995 Mar;65(2):599-608.

PMID:
7777172
41.

Regulation of the MAP kinase cascade in PC12 cells: B-Raf activates MEK-1 (MAP kinase or ERK kinase) and is inhibited by cAMP.

Peraldi P, Frödin M, Barnier JV, Calleja V, Scimeca JC, Filloux C, Calothy G, Van Obberghen E.

FEBS Lett. 1995 Jan 9;357(3):290-6.

43.

Cyclic AMP activates the mitogen-activated protein kinase cascade in PC12 cells.

Frödin M, Peraldi P, Van Obberghen E.

J Biol Chem. 1994 Feb 25;269(8):6207-14.

44.

[Follow-up of patients discharged from a psychiatric rehabilitation hospital; 1969].

Frostensson M, Frödin M, Raben K, Zerne-Rost K.

Tidskr Sver Sjukskot. 1972 Apr 27;39(8):56-7. Swedish. No abstract available.

PMID:
4482325

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