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Items: 1 to 50 of 52

1.

Rationally designed high-affinity 2-amino-6-halopurine heat shock protein 90 inhibitors that exhibit potent antitumor activity.

Kasibhatla SR, Hong K, Biamonte MA, Busch DJ, Karjian PL, Sensintaffar JL, Kamal A, Lough RE, Brekken J, Lundgren K, Grecko R, Timony GA, Ran Y, Mansfield R, Fritz LC, Ulm E, Burrows FJ, Boehm MF.

J Med Chem. 2007 Jun 14;50(12):2767-78. Epub 2007 May 8.

PMID:
17488003
2.

The heat-shock protein 90 inhibitor 17-allylamino-17-demethoxygeldanamycin suppresses glial inflammatory responses and ameliorates experimental autoimmune encephalomyelitis.

Dello Russo C, Polak PE, Mercado PR, Spagnolo A, Sharp A, Murphy P, Kamal A, Burrows FJ, Fritz LC, Feinstein DL.

J Neurochem. 2006 Dec;99(5):1351-62. Epub 2006 Oct 25.

3.

First-in-class pan caspase inhibitor developed for the treatment of liver disease.

Linton SD, Aja T, Armstrong RA, Bai X, Chen LS, Chen N, Ching B, Contreras P, Diaz JL, Fisher CD, Fritz LC, Gladstone P, Groessl T, Gu X, Herrmann J, Hirakawa BP, Hoglen NC, Jahangiri KG, Kalish VJ, Karanewsky DS, Kodandapani L, Krebs J, McQuiston J, Meduna SP, Nalley K, Robinson ED, Sayers RO, Sebring K, Spada AP, Ternansky RJ, Tomaselli KJ, Ullman BR, Valentino KL, Weeks S, Winn D, Wu JC, Yeo P, Zhang CZ.

J Med Chem. 2005 Nov 3;48(22):6779-82.

PMID:
16250635
4.

Mutational analysis of the interacting cell death regulators CED-9 and CED-4.

Ottilie S, Wang Y, Banks S, Chang J, Vigna NJ, Weeks S, Armstrong RC, Fritz LC, Oltersdorf T.

Cell Death Differ. 1997 Oct;4(7):526-33.

5.

A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors.

Kamal A, Thao L, Sensintaffar J, Zhang L, Boehm MF, Fritz LC, Burrows FJ.

Nature. 2003 Sep 25;425(6956):407-10.

6.

Acyl dipeptides as reversible caspase inhibitors. Part 2: further optimization.

Linton SD, Karanewsky DS, Ternansky RJ, Chen N, Guo X, Jahangiri KG, Kalish VJ, Meduna SP, Robinson ED, Ullman BR, Wu JC, Pham B, Kodandapani L, Smidt R, Diaz JL, Fritz LC, von Krosigk U, Roggo S, Schmitz A, Tomaselli KJ.

Bioorg Med Chem Lett. 2002 Oct 21;12(20):2973-5.

PMID:
12270186
7.

Acyl dipeptides as reversible caspase inhibitors. Part 1: initial lead optimization.

Linton SD, Karanewsky DS, Ternansky RJ, Wu JC, Pham B, Kodandapani L, Smidt R, Diaz JL, Fritz LC, Tomaselli KJ.

Bioorg Med Chem Lett. 2002 Oct 21;12(20):2969-71.

PMID:
12270185
8.

Heavy membrane-associated caspase 3: identification, isolation, and characterization.

Krebs JF, Srinivasan A, Wong AM, Tomaselli KJ, Fritz LC, Wu JC.

Biochemistry. 2000 Dec 26;39(51):16056-63.

PMID:
11123933
9.

Monitoring interactions of Bcl-2 family proteins in 96-well plate assays.

Diaz JL, Oltersdorf T, Fritz LC.

Methods Enzymol. 2000;322:255-66. No abstract available.

PMID:
10914023
10.

Peptidomimetic fluoromethylketone rescues mice from lethal endotoxic shock.

Grobmyer SR, Armstrong RC, Nicholson SC, Gabay C, Arend WP, Potter SH, Melchior M, Fritz LC, Nathan CF.

Mol Med. 1999 Sep;5(9):585-94.

11.

Apoptosis of sinusoidal endothelial cells occurs during liver preservation injury by a caspase-dependent mechanism.

Natori S, Selzner M, Valentino KL, Fritz LC, Srinivasan A, Clavien PA, Gores GJ.

Transplantation. 1999 Jul 15;68(1):89-96.

PMID:
10428274
12.

Irreversible caspase inhibitors: tools for studying apoptosis.

Wu JC, Fritz LC.

Methods. 1999 Apr;17(4):320-8.

PMID:
10196103
13.

Activation of membrane-associated procaspase-3 is regulated by Bcl-2.

Krebs JF, Armstrong RC, Srinivasan A, Aja T, Wong AM, Aboy A, Sayers R, Pham B, Vu T, Hoang K, Karanewsky DS, Leist C, Schmitz A, Wu JC, Tomaselli KJ, Fritz LC.

J Cell Biol. 1999 Mar 8;144(5):915-26.

14.

In situ immunodetection of activated caspase-3 in apoptotic neurons in the developing nervous system.

Srinivasan A, Roth KA, Sayers RO, Shindler KS, Wong AM, Fritz LC, Tomaselli KJ.

Cell Death Differ. 1998 Dec;5(12):1004-16.

15.

Bcl-xL functions downstream of caspase-8 to inhibit Fas- and tumor necrosis factor receptor 1-induced apoptosis of MCF7 breast carcinoma cells.

Srinivasan A, Li F, Wong A, Kodandapani L, Smidt R Jr, Krebs JF, Fritz LC, Wu JC, Tomaselli KJ.

J Biol Chem. 1998 Feb 20;273(8):4523-9.

16.

Dimerization properties of human BAD. Identification of a BH-3 domain and analysis of its binding to mutant BCL-2 and BCL-XL proteins.

Ottilie S, Diaz JL, Horne W, Chang J, Wang Y, Wilson G, Chang S, Weeks S, Fritz LC, Oltersdorf T.

J Biol Chem. 1997 Dec 5;272(49):30866-72.

17.

Cell-specific induction of apoptosis by microinjection of cytochrome c. Bcl-xL has activity independent of cytochrome c release.

Li F, Srinivasan A, Wang Y, Armstrong RC, Tomaselli KJ, Fritz LC.

J Biol Chem. 1997 Nov 28;272(48):30299-305.

18.

Structural and functional complementation of an inactive Bcl-2 mutant by Bax truncation.

Ottilie S, Diaz JL, Chang J, Wilson G, Tuffo KM, Weeks S, McConnell M, Wang Y, Oltersdorf T, Fritz LC.

J Biol Chem. 1997 Jul 4;272(27):16955-61.

19.

A common binding site mediates heterodimerization and homodimerization of Bcl-2 family members.

Diaz JL, Oltersdorf T, Horne W, McConnell M, Wilson G, Weeks S, Garcia T, Fritz LC.

J Biol Chem. 1997 Apr 25;272(17):11350-5.

20.

Bax- and Bak-induced cell death in the fission yeast Schizosaccharomyces pombe.

Jürgensmeier JM, Krajewski S, Armstrong RC, Wilson GM, Oltersdorf T, Fritz LC, Reed JC, Ottilie S.

Mol Biol Cell. 1997 Feb;8(2):325-39.

21.

Activation of the CED3/ICE-related protease CPP32 in cerebellar granule neurons undergoing apoptosis but not necrosis.

Armstrong RC, Aja TJ, Hoang KD, Gaur S, Bai X, Alnemri ES, Litwack G, Karanewsky DS, Fritz LC, Tomaselli KJ.

J Neurosci. 1997 Jan 15;17(2):553-62.

22.

Humanization of a mouse antibody against human alpha-4 integrin: a potential therapeutic for the treatment of multiple sclerosis.

Léger OJ, Yednock TA, Tanner L, Horner HC, Hines DK, Keen S, Saldanha J, Jones ST, Fritz LC, Bendig MM.

Hum Antibodies. 1997;8(1):3-16.

PMID:
9265500
23.

In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains.

Fernandes-Alnemri T, Armstrong RC, Krebs J, Srinivasula SM, Wang L, Bullrich F, Fritz LC, Trapani JA, Tomaselli KJ, Litwack G, Alnemri ES.

Proc Natl Acad Sci U S A. 1996 Jul 23;93(15):7464-9.

24.

Fas-induced activation of the cell death-related protease CPP32 Is inhibited by Bcl-2 and by ICE family protease inhibitors.

Armstrong RC, Aja T, Xiang J, Gaur S, Krebs JF, Hoang K, Bai X, Korsmeyer SJ, Karanewsky DS, Fritz LC, Tomaselli KJ.

J Biol Chem. 1996 Jul 12;271(28):16850-5.

25.

Alpha 4 beta 1 integrin-dependent cell adhesion is regulated by a low affinity receptor pool that is conformationally responsive to ligand.

Yednock TA, Cannon C, Vandevert C, Goldbach EG, Shaw G, Ellis DK, Liaw C, Fritz LC, Tanner LI.

J Biol Chem. 1995 Dec 1;270(48):28740-50.

26.

T-lymphocyte subsets in acute illness.

Feeney C, Bryzman S, Kong L, Brazil H, Deutsch R, Fritz LC.

Crit Care Med. 1995 Oct;23(10):1680-5.

PMID:
7587233
27.

Peptide inhibitors of the ICE protease family arrest programmed cell death of motoneurons in vivo and in vitro.

Milligan CE, Prevette D, Yaginuma H, Homma S, Cardwell C, Fritz LC, Tomaselli KJ, Oppenheim RW, Schwartz LM.

Neuron. 1995 Aug;15(2):385-93.

28.

A monoclonal antibody to alpha 4 integrin suppresses and reverses active experimental allergic encephalomyelitis.

Kent SJ, Karlik SJ, Cannon C, Hines DK, Yednock TA, Fritz LC, Horner HC.

J Neuroimmunol. 1995 Apr;58(1):1-10.

PMID:
7730443
29.

Secretion of beta-amyloid precursor protein cleaved at the amino terminus of the beta-amyloid peptide.

Seubert P, Oltersdorf T, Lee MG, Barbour R, Blomquist C, Davis DL, Bryant K, Fritz LC, Galasko D, Thal LJ, et al.

Nature. 1993 Jan 21;361(6409):260-3.

PMID:
7678698
30.

Prevention of experimental autoimmune encephalomyelitis by antibodies against alpha 4 beta 1 integrin.

Yednock TA, Cannon C, Fritz LC, Sanchez-Madrid F, Steinman L, Karin N.

Nature. 1992 Mar 5;356(6364):63-6.

PMID:
1538783
31.

The beta-amyloid precursor protein is not processed by the regulated secretory pathway.

Overly CC, Fritz LC, Lieberburg I, McConlogue L.

Biochem Biophys Res Commun. 1991 Dec 16;181(2):513-9.

PMID:
1661581
32.

Analysis and quantitation of the beta-amyloid precursor protein in the cerebrospinal fluid of Alzheimer's disease patients with a monoclonal antibody-based immunoassay.

Henriksson T, Barbour RM, Braa S, Ward P, Fritz LC, Johnson-Wood K, Chung HD, Burke W, Reinikainen KJ, Riekkinen P, et al.

J Neurochem. 1991 Mar;56(3):1037-42.

PMID:
1899691
33.

The Alzheimer amyloid precursor protein. Identification of a stable intermediate in the biosynthetic/degradative pathway.

Oltersdorf T, Ward PJ, Henriksson T, Beattie EC, Neve R, Lieberburg I, Fritz LC.

J Biol Chem. 1990 Mar 15;265(8):4492-7.

34.

The secreted form of the Alzheimer's amyloid precursor protein with the Kunitz domain is protease nexin-II.

Oltersdorf T, Fritz LC, Schenk DB, Lieberburg I, Johnson-Wood KL, Beattie EC, Ward PJ, Blacher RW, Dovey HF, Sinha S.

Nature. 1989 Sep 14;341(6238):144-7.

PMID:
2506449
35.

Beta-amyloid precursor protein of Alzheimer disease occurs as 110- to 135-kilodalton membrane-associated proteins in neural and nonneural tissues.

Selkoe DJ, Podlisny MB, Joachim CL, Vickers EA, Lee G, Fritz LC, Oltersdorf T.

Proc Natl Acad Sci U S A. 1988 Oct;85(19):7341-5.

36.

Human renin is correctly processed and targeted to the regulated secretory pathway in mouse pituitary AtT-20 cells.

Fritz LC, Haidar MA, Arfsten AE, Schilling JW, Carilli C, Shine J, Baxter JD, Reudelhuber TL.

J Biol Chem. 1987 Sep 15;262(26):12409-12.

37.

Messenger RNA coding for only the alpha subunit of the rat brain Na channel is sufficient for expression of functional channels in Xenopus oocytes.

Goldin AL, Snutch T, Lübbert H, Dowsett A, Marshall J, Auld V, Downey W, Fritz LC, Lester HA, Dunn R, et al.

Proc Natl Acad Sci U S A. 1986 Oct;83(19):7503-7.

38.

Biochemical similarity of expressed human prorenin and native inactive renin.

Hsueh WA, Do YS, Shinagawa T, Tam H, Ponte PA, Baxter JD, Shine J, Fritz LC.

Hypertension. 1986 Jun;8(6 Pt 2):II78-83.

PMID:
3522420
39.

Characterization of human prorenin expressed in mammalian cells from cloned cDNA.

Fritz LC, Arfsten AE, Dzau VJ, Atlas SA, Baxter JD, Fiddes JC, Shine J, Cofer CL, Kushner P, Ponte PA.

Proc Natl Acad Sci U S A. 1986 Jun;83(12):4114-8.

40.

Two RFLPs at the human renin (ren) gene locus.

Frossard PM, Gonzalez PA, Fritz LC, Ponte PA, Fiddes JC, Atlas SA.

Nucleic Acids Res. 1986 May 27;14(10):4380. No abstract available.

41.

Immunological evidence that inactive renin is prorenin.

Atlas SA, Christofalo P, Hesson T, Sealey JE, Fritz LC.

Biochem Biophys Res Commun. 1985 Nov 15;132(3):1038-45.

PMID:
3907628
43.

Immunochemical studies of the voltage-sensitive sodium channel from the electroplax of the eel Electrophorus electricus.

Fritz LC, Moore HP, Raftery MA, Brockes JP.

Cold Spring Harb Symp Quant Biol. 1983;48 Pt 1:181-5. No abstract available.

PMID:
6327151
45.
46.

The effect of diamide on transmitter release and on synaptic vesicle population at vertebrate synapses.

Wade PD, Fritz LC, Siekevitz P.

Brain Res. 1981 Nov 30;225(2):357-72.

PMID:
6118196
47.

Clustering of ion channels at the node of Ranvier.

Fritz LC, Brockes JP.

Nature. 1981 May 21;291(5812):190. No abstract available.

PMID:
6262652
48.
49.

Studies on the mechanism of action of avermectin B1a: stimulation of release of gamma-aminobutyric acid from brain synaptosomes.

Pong SS, Wang CC, Fritz LC.

J Neurochem. 1980 Feb;34(2):351-8. No abstract available.

PMID:
7411150
50.

Different components of black widow spider venom mediate transmitter release at vertebrate and lobster neuromuscular junctions.

Fritz LC, Tzen MC, Mauro A.

Nature. 1980 Jan 31;283(5746):486-7. No abstract available.

PMID:
6243402

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