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Items: 45


SNARE proteins rescue impaired autophagic flux in Down syndrome.

Aivazidis S, Jain A, Rauniyar AK, Anderson CC, Marentette JO, Orlicky DJ, Fritz KS, Harris PS, Siegel D, Maclean KN, Roede JR.

PLoS One. 2019 Nov 12;14(11):e0223254. doi: 10.1371/journal.pone.0223254. eCollection 2019.


Lysine malonylation and propionylation are prevalent in human lens proteins.

Nahomi RB, Nandi SK, Rakete S, Michel C, Fritz KS, Nagaraj RH.

Exp Eye Res. 2019 Oct 31;190:107864. doi: 10.1016/j.exer.2019.107864. [Epub ahead of print]


Lipid peroxidation derived reactive aldehydes in alcoholic liver disease.

Ali H, Assiri MA, Shearn CT, Fritz KS.

Curr Opin Toxicol. 2019 Feb;13:110-117. doi: 10.1016/j.cotox.2018.10.003. Epub 2018 Oct 15.


Multi-omics Analysis of Liver Infiltrating Macrophages Following Ethanol Consumption.

Marentette JO, Wang M, Michel CR, Powell R, Zhang X, Reisdorph N, Fritz KS, Ju C.

Sci Rep. 2019 May 23;9(1):7776. doi: 10.1038/s41598-019-43240-4.


The absence of SIRT3 and SIRT5 promotes the acetylation of lens proteins and improves the chaperone activity of α-crystallin in mouse lenses.

Nandi SK, Nahomi RB, Harris PS, Michel CR, Fritz KS, Nagaraj RH.

Exp Eye Res. 2019 May;182:1-9. doi: 10.1016/j.exer.2019.02.024. Epub 2019 Mar 5.


Succinylation Is a Gain-of-Function Modification in Human Lens αB-Crystallin.

Nandi SK, Rakete S, Nahomi RB, Michel C, Dunbar A, Fritz KS, Nagaraj RH.

Biochemistry. 2019 Mar 5;58(9):1260-1274. doi: 10.1021/acs.biochem.8b01053. Epub 2019 Feb 20.


Quantifying Competition among Mitochondrial Protein Acylation Events Induced by Ethanol Metabolism.

Ali HR, Assiri MA, Harris PS, Michel CR, Yun Y, Marentette JO, Huynh FK, Orlicky DJ, Shearn CT, Saba LM, Reisdorph R, Reisdorph N, Hirschey MD, Fritz KS.

J Proteome Res. 2019 Apr 5;18(4):1513-1531. doi: 10.1021/acs.jproteome.8b00800. Epub 2019 Jan 31.


SIRT3 deficiency-induced mitochondrial dysfunction and inflammasome formation in the brain.

Tyagi A, Nguyen CU, Chong T, Michel CR, Fritz KS, Reisdorph N, Knaub L, Reusch JEB, Pugazhenthi S.

Sci Rep. 2018 Dec 3;8(1):17547. doi: 10.1038/s41598-018-35890-7.


Utilizing Ion Mobility to Identify Isobaric Post-Translational Modifications: Resolving Acrolein and Propionyl Lysine Adducts by TIMS Mass Spectrometry.

Gomez JD, Ridgeway ME, Park MA, Fritz KS.

Int J Ion Mobil Spectrom. 2018 Sep;21(3):65-69. doi: 10.1007/s12127-018-0237-z. Epub 2018 Aug 9.


Altered mitochondrial acetylation profiles in a kainic acid model of temporal lobe epilepsy.

Gano LB, Liang LP, Ryan K, Michel CR, Gomez J, Vassilopoulos A, Reisdorph N, Fritz KS, Patel M.

Free Radic Biol Med. 2018 Aug 1;123:116-124. doi: 10.1016/j.freeradbiomed.2018.05.063. Epub 2018 May 17.


Chronic Ethanol Metabolism Inhibits Hepatic Mitochondrial Superoxide Dismutase via Lysine Acetylation.

Assiri MA, Roy SR, Harris PS, Ali H, Liang Y, Shearn CT, Orlicky DJ, Roede JR, Hirschey MD, Backos DS, Fritz KS.

Alcohol Clin Exp Res. 2017 Oct;41(10):1705-1714. doi: 10.1111/acer.13473. Epub 2017 Sep 14.


Characterizing Sirtuin 3 Deacetylase Affinity for Aldehyde Dehydrogenase 2.

Harris PS, Gomez JD, Backos DS, Fritz KS.

Chem Res Toxicol. 2017 Mar 20;30(3):785-793. doi: 10.1021/acs.chemrestox.6b00315. Epub 2017 Mar 1.


Quantitative Analysis and Discovery of Lysine and Arginine Modifications.

Galligan JJ, Kingsley PJ, Wauchope OR, Mitchener MM, Camarillo JM, Wepy JA, Harris PS, Fritz KS, Marnett LJ.

Anal Chem. 2017 Jan 17;89(2):1299-1306. doi: 10.1021/acs.analchem.6b04105. Epub 2016 Dec 30.


Catalase deletion promotes prediabetic phenotype in mice.

Heit C, Marshall S, Singh S, Yu X, Charkoftaki G, Zhao H, Orlicky DJ, Fritz KS, Thompson DC, Vasiliou V.

Free Radic Biol Med. 2017 Feb;103:48-56. doi: 10.1016/j.freeradbiomed.2016.12.011. Epub 2016 Dec 8.


Quantification of Neural Ethanol and Acetaldehyde Using Headspace GC-MS.

Heit C, Eriksson P, Thompson DC, Charkoftaki G, Fritz KS, Vasiliou V.

Alcohol Clin Exp Res. 2016 Sep;40(9):1825-31. doi: 10.1111/acer.13156. Epub 2016 Aug 8.


From the Cover: Disease-Induced Disparities in Formation of the Nanoparticle-Biocorona and the Toxicological Consequences.

Shannahan JH, Fritz KS, Raghavendra AJ, Podila R, Persaud I, Brown JM.

Toxicol Sci. 2016 Aug;152(2):406-16. doi: 10.1093/toxsci/kfw097. Epub 2016 Jun 2.


Deletion of GSTA4-4 results in increased mitochondrial post-translational modification of proteins by reactive aldehydes following chronic ethanol consumption in mice.

Shearn CT, Fritz KS, Shearn AH, Saba LM, Mercer KE, Engi B, Galligan JJ, Zimniak P, Orlicky DJ, Ronis MJ, Petersen DR.

Redox Biol. 2016 Apr;7:68-77. doi: 10.1016/j.redox.2015.11.013. Epub 2015 Nov 27.


Comparative Proteomic Analysis of Carbonylated Proteins from the Striatum and Cortex of Pesticide-Treated Mice.

Coughlan C, Walker DI, Lohr KM, Richardson JR, Saba LM, Caudle WM, Fritz KS, Roede JR.

Parkinsons Dis. 2015;2015:812532. doi: 10.1155/2015/812532. Epub 2015 Aug 9.


Chronic ethanol consumption induces mitochondrial protein acetylation and oxidative stress in the kidney.

Harris PS, Roy SR, Coughlan C, Orlicky DJ, Liang Y, Shearn CT, Roede JR, Fritz KS.

Redox Biol. 2015 Dec;6:33-40. doi: 10.1016/j.redox.2015.06.021. Epub 2015 Jul 6.


Class I HDAC inhibition stimulates cardiac protein SUMOylation through a post-translational mechanism.

Blakeslee WW, Wysoczynski CL, Fritz KS, Nyborg JK, Churchill ME, McKinsey TA.

Cell Signal. 2014 Dec;26(12):2912-20. doi: 10.1016/j.cellsig.2014.09.005. Epub 2014 Sep 16.


Oxidative stress-mediated aldehyde adduction of GRP78 in a mouse model of alcoholic liver disease: functional independence of ATPase activity and chaperone function.

Galligan JJ, Fritz KS, Backos DS, Shearn CT, Smathers RL, Jiang H, MacLean KN, Reigan PR, Petersen DR.

Free Radic Biol Med. 2014 Aug;73:411-20. doi: 10.1016/j.freeradbiomed.2014.06.002. Epub 2014 Jun 9.


Methods to detect protein glutathionylation.

Poerschke RL, Fritz KS, Franklin CC.

Curr Protoc Toxicol. 2013 Sep 23;57:6.17.1-6.17.18. doi: 10.1002/0471140856.tx0617s57.


Ethanol metabolism modifies hepatic protein acylation in mice.

Fritz KS, Green MF, Petersen DR, Hirschey MD.

PLoS One. 2013 Sep 20;8(9):e75868. doi: 10.1371/journal.pone.0075868. eCollection 2013.


Chemical acetylation and deacetylation.

Fritz KS.

Methods Mol Biol. 2013;1077:191-201. doi: 10.1007/978-1-62703-637-5_13.


Glycation of glutamate cysteine ligase by 2-deoxy-d-ribose and its potential impact on chemoresistance in glioblastoma.

Backos DS, Fritz KS, McArthur DG, Kepa JK, Donson AM, Petersen DR, Foreman NK, Franklin CC, Reigan P.

Neurochem Res. 2013 Sep;38(9):1838-49. doi: 10.1007/s11064-013-1090-4. Epub 2013 Jun 7.


Susceptibility of L-FABP-/- mice to oxidative stress in early-stage alcoholic liver.

Smathers RL, Galligan JJ, Shearn CT, Fritz KS, Mercer K, Ronis M, Orlicky DJ, Davidson NO, Petersen DR.

J Lipid Res. 2013 May;54(5):1335-45. doi: 10.1194/jlr.M034892. Epub 2013 Jan 28.


Oxidative Stress and the ER Stress Response in a Murine Model for Early-Stage Alcoholic Liver Disease.

Galligan JJ, Smathers RL, Shearn CT, Fritz KS, Backos DS, Jiang H, Franklin CC, Orlicky DJ, Maclean KN, Petersen DR.

J Toxicol. 2012;2012:207594. doi: 10.1155/2012/207594. Epub 2012 Jul 5.


An overview of the chemistry and biology of reactive aldehydes.

Fritz KS, Petersen DR.

Free Radic Biol Med. 2013 Jun;59:85-91. doi: 10.1016/j.freeradbiomed.2012.06.025. Epub 2012 Jun 28. Review.


Characterization of 4-HNE modified L-FABP reveals alterations in structural and functional dynamics.

Smathers RL, Fritz KS, Galligan JJ, Shearn CT, Reigan P, Marks MJ, Petersen DR.

PLoS One. 2012;7(6):e38459. doi: 10.1371/journal.pone.0038459. Epub 2012 Jun 6.


Protein carbonylation in a murine model for early alcoholic liver disease.

Galligan JJ, Smathers RL, Fritz KS, Epperson LE, Hunter LE, Petersen DR.

Chem Res Toxicol. 2012 May 21;25(5):1012-21. doi: 10.1021/tx300002q. Epub 2012 May 1.


4-HNE adduct stability characterized by collision-induced dissociation and electron transfer dissociation mass spectrometry.

Fritz KS, Kellersberger KA, Gomez JD, Petersen DR.

Chem Res Toxicol. 2012 Apr 16;25(4):965-70. doi: 10.1021/tx300100w. Epub 2012 Mar 28.


Mitochondrial acetylome analysis in a mouse model of alcohol-induced liver injury utilizing SIRT3 knockout mice.

Fritz KS, Galligan JJ, Hirschey MD, Verdin E, Petersen DR.

J Proteome Res. 2012 Mar 2;11(3):1633-43. doi: 10.1021/pr2008384. Epub 2012 Feb 21.


Exploring the biology of lipid peroxidation-derived protein carbonylation.

Fritz KS, Petersen DR.

Chem Res Toxicol. 2011 Sep 19;24(9):1411-9. doi: 10.1021/tx200169n. Epub 2011 Aug 18. Review.


The human sirtuin family: evolutionary divergences and functions.

Vassilopoulos A, Fritz KS, Petersen DR, Gius D.

Hum Genomics. 2011 Jul;5(5):485-96.


Protein damage from electrophiles and oxidants in lungs of mice chronically exposed to the tumor promoter butylated hydroxytoluene.

Shearn CT, Fritz KS, Thompson JA.

Chem Biol Interact. 2011 Jul 15;192(3):278-86. doi: 10.1016/j.cbi.2011.04.005. Epub 2011 Apr 21.


4-Hydroxynonenal inhibits SIRT3 via thiol-specific modification.

Fritz KS, Galligan JJ, Smathers RL, Roede JR, Shearn CT, Reigan P, Petersen DR.

Chem Res Toxicol. 2011 May 16;24(5):651-62. doi: 10.1021/tx100355a. Epub 2011 Apr 14.


Modification of Akt2 by 4-hydroxynonenal inhibits insulin-dependent Akt signaling in HepG2 cells.

Shearn CT, Fritz KS, Reigan P, Petersen DR.

Biochemistry. 2011 May 17;50(19):3984-96. doi: 10.1021/bi200029w. Epub 2011 Apr 20.


Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibition by 4-hydroxynonenal leads to increased Akt activation in hepatocytes.

Shearn CT, Smathers RL, Stewart BJ, Fritz KS, Galligan JJ, Hail N Jr, Petersen DR.

Mol Pharmacol. 2011 Jun;79(6):941-52. doi: 10.1124/mol.110.069534. Epub 2011 Mar 17.


Profiling impaired hepatic endoplasmic reticulum glycosylation as a consequence of ethanol ingestion.

Galligan JJ, Fritz KS, Tipney H, Smathers RL, Roede JR, Shearn CT, Hunter LE, Petersen DR.

J Proteome Res. 2011 Apr 1;10(4):1837-47. doi: 10.1021/pr101101s. Epub 2011 Mar 7.


Posttranslational modification and regulation of glutamate-cysteine ligase by the α,β-unsaturated aldehyde 4-hydroxy-2-nonenal.

Backos DS, Fritz KS, Roede JR, Petersen DR, Franklin CC.

Free Radic Biol Med. 2011 Jan 1;50(1):14-26. doi: 10.1016/j.freeradbiomed.2010.10.694. Epub 2010 Oct 21.


Carbonyl reductase inactivation may contribute to mouse lung tumor promotion by electrophilic metabolites of butylated hydroxytoluene: protein alkylation in vivo and in vitro.

Shearn CT, Fritz KS, Meier BW, Kirichenko OV, Thompson JA.

Chem Res Toxicol. 2008 Aug;21(8):1631-41. doi: 10.1021/tx800162p. Epub 2008 Jul 3.


Analog-based free testosterone test results linked to total testosterone concentrations, not free testosterone concentrations.

Fritz KS, McKean AJ, Nelson JC, Wilcox RB.

Clin Chem. 2008 Mar;54(3):512-6. doi: 10.1373/clinchem.2007.094870. Epub 2008 Jan 2.


Unequal concentrations of free T3 and free T4 after ultrafiltration.

Fritz KS, Weiss RM, Nelson JC, Wilcox RB.

Clin Chem. 2007 Jul;53(7):1384-5. No abstract available.


A direct free thyroxine (T4) immunoassay with the characteristics of a total T4 immunoassay.

Fritz KS, Wilcox RB, Nelson JC.

Clin Chem. 2007 May;53(5):911-5. Epub 2007 Mar 15.

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