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Items: 19


Discovery and Characterization of SY-1365, a Selective, Covalent Inhibitor of CDK7.

Hu S, Marineau JJ, Rajagopal N, Hamman KB, Choi YJ, Schmidt DR, Ke N, Johannessen L, Bradley MJ, Orlando DA, Alnemy SR, Ren Y, Ciblat S, Winter DK, Kabro A, Sprott KT, Hodgson JG, Fritz CC, Carulli JP, di Tomaso E, Olson ER.

Cancer Res. 2019 Jul 1;79(13):3479-3491. doi: 10.1158/0008-5472.CAN-19-0119. Epub 2019 May 7.


Superenhancer Analysis Defines Novel Epigenomic Subtypes of Non-APL AML, Including an RARα Dependency Targetable by SY-1425, a Potent and Selective RARα Agonist.

McKeown MR, Corces MR, Eaton ML, Fiore C, Lee E, Lopez JT, Chen MW, Smith D, Chan SM, Koenig JL, Austgen K, Guenther MG, Orlando DA, Lovén J, Fritz CC, Majeti R.

Cancer Discov. 2017 Oct;7(10):1136-1153. doi: 10.1158/2159-8290.CD-17-0399. Epub 2017 Jul 20.


HSP90 inhibition enhances antimitotic drug-induced mitotic arrest and cell death in preclinical models of non-small cell lung cancer.

O'Connell BC, O'Callaghan K, Tillotson B, Douglas M, Hafeez N, West KA, Stern H, Ali JA, Changelian P, Fritz CC, Palombella VJ, McGovern K, Kutok JL.

PLoS One. 2014 Dec 26;9(12):e115228. doi: 10.1371/journal.pone.0115228. eCollection 2014.


Quantitative ChIP-Seq normalization reveals global modulation of the epigenome.

Orlando DA, Chen MW, Brown VE, Solanki S, Choi YJ, Olson ER, Fritz CC, Bradner JE, Guenther MG.

Cell Rep. 2014 Nov 6;9(3):1163-70. doi: 10.1016/j.celrep.2014.10.018. Epub 2014 Oct 30.


PI3K-δ and PI3K-γ inhibition by IPI-145 abrogates immune responses and suppresses activity in autoimmune and inflammatory disease models.

Winkler DG, Faia KL, DiNitto JP, Ali JA, White KF, Brophy EE, Pink MM, Proctor JL, Lussier J, Martin CM, Hoyt JG, Tillotson B, Murphy EL, Lim AR, Thomas BD, Macdougall JR, Ren P, Liu Y, Li LS, Jessen KA, Fritz CC, Dunbar JL, Porter JR, Rommel C, Palombella VJ, Changelian PS, Kutok JL.

Chem Biol. 2013 Nov 21;20(11):1364-74. doi: 10.1016/j.chembiol.2013.09.017. Epub 2013 Nov 7.


The Hsp90 inhibitor IPI-504 rapidly lowers EML4-ALK levels and induces tumor regression in ALK-driven NSCLC models.

Normant E, Paez G, West KA, Lim AR, Slocum KL, Tunkey C, McDougall J, Wylie AA, Robison K, Caliri K, Palombella VJ, Fritz CC.

Oncogene. 2011 Jun 2;30(22):2581-6. doi: 10.1038/onc.2010.625. Epub 2011 Jan 24.


Hsp90 (heat shock protein 90) inhibitor occupancy is a direct determinant of client protein degradation and tumor growth arrest in vivo.

Tillotson B, Slocum K, Coco J, Whitebread N, Thomas B, West KA, MacDougall J, Ge J, Ali JA, Palombella VJ, Normant E, Adams J, Fritz CC.

J Biol Chem. 2010 Dec 17;285(51):39835-43. doi: 10.1074/jbc.M110.141580. Epub 2010 Oct 12.


Discovery and development of Hsp90 inhibitors: a promising pathway for cancer therapy.

Porter JR, Fritz CC, Depew KM.

Curr Opin Chem Biol. 2010 Jun;14(3):412-20. doi: 10.1016/j.cbpa.2010.03.019. Epub 2010 Apr 19. Review.


The antiproliferative activity of the heat shock protein 90 inhibitor IPI-504 is not dependent on NAD(P)H:quinone oxidoreductase 1 activity in vivo.

Douglas M, Lim AR, Porter JR, West K, Pink MM, Ge J, Wylie AA, Tibbits TT, Biggs K, Curtis M, Palombella VJ, Adams J, Fritz CC, Normant E.

Mol Cancer Ther. 2009 Dec;8(12):3369-78. doi: 10.1158/1535-7163.MCT-09-0568.


Use of structure-based drug design approaches to obtain novel anthranilic acid acyl carrier protein synthase inhibitors.

Joseph-McCarthy D, Parris K, Huang A, Failli A, Quagliato D, Dushin EG, Novikova E, Severina E, Tuckman M, Petersen PJ, Dean C, Fritz CC, Meshulam T, DeCenzo M, Dick L, McFadyen IJ, Somers WS, Lovering F, Gilbert AM.

J Med Chem. 2005 Dec 15;48(25):7960-9.


Anthranilate 4H-oxazol-5-ones: novel small molecule antibacterial acyl carrier protein synthase (AcpS) inhibitors.

Gilbert AM, Kirisits M, Toy P, Nunn DS, Failli A, Dushin EG, Novikova E, Petersen PJ, Joseph-McCarthy D, McFadyen I, Fritz CC.

Bioorg Med Chem Lett. 2004 Jan 5;14(1):37-41.


Solution structure of B. subtilis acyl carrier protein.

Xu GY, Tam A, Lin L, Hixon J, Fritz CC, Powers R.

Structure. 2001 Apr 4;9(4):277-87.


A human nucleoporin-like protein that specifically interacts with HIV Rev.

Fritz CC, Zapp ML, Green MR.

Nature. 1995 Aug 10;376(6540):530-3.


The gene family encoding the ribulose-(1,5)-bisphosphate carboxylase/oxygenase (Rubisco) small subunit of potato.

Fritz CC, Wolter FP, Schenkemeyer V, Herget T, Schreier PH.

Gene. 1993 Dec 31;137(2):271-4.


Fishing for partners.

Fritz CC, Green MR.

Curr Biol. 1992 Aug;2(8):403-5. No abstract available.


Reduced steady-state levels of rbcS mRNA in plants kept in the dark are due to differential degradation.

Fritz CC, Herget T, Wolter FP, Schell J, Schreier PH.

Proc Natl Acad Sci U S A. 1991 May 15;88(10):4458-62.


rbcS genes in Solanum tuberosum: conservation of transit peptide and exon shuffling during evolution.

Wolter FP, Fritz CC, Willmitzer L, Schell J, Schreier PH.

Proc Natl Acad Sci U S A. 1988 Feb;85(3):846-50.

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