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Microtubule number and length determine cellular shape and function in Plasmodium.

Spreng B, Fleckenstein H, Kübler P, Di Biagio C, Benz M, Patra P, Schwarz US, Cyrklaff M, Frischknecht F.

EMBO J. 2019 Aug 1;38(15):e100984. doi: 10.15252/embj.2018100984. Epub 2019 May 24.


Microtubule number and length determine cellular shape and function in Plasmodium.

Spreng B, Fleckenstein H, Kübler P, Di Biagio C, Benz M, Patra P, Schwarz US, Cyrklaff M, Frischknecht F.

EMBO J. 2019 May 24. pii: e100984. doi: 10.15252/embj.2018100984. [Epub ahead of print]


Combining proteomics and bioinformatics to explore novel tegumental antigens as vaccine candidates against Echinococcus granulosus infection.

Miles S, Portela M, Cyrklaff M, Ancarola ME, Frischknecht F, Durán R, Dematteis S, Mourglia-Ettlin G.

J Cell Biochem. 2019 Sep;120(9):15320-15336. doi: 10.1002/jcb.28799. Epub 2019 Apr 30.


Intravital microscopy: Imaging host-parasite interactions in the brain.

De Niz M, Nacer A, Frischknecht F.

Cell Microbiol. 2019 May;21(5):e13024. doi: 10.1111/cmi.13024. Epub 2019 Mar 28. Review.


Intravital imaging of host-parasite interactions in skin and adipose tissues.

De Niz M, Meehan GR, Brancucci NMB, Marti M, Rotureau B, Figueiredo LM, Frischknecht F.

Cell Microbiol. 2019 May;21(5):e13023. doi: 10.1111/cmi.13023. Epub 2019 Apr 3. Review.


Toolbox for In Vivo Imaging of Host-Parasite Interactions at Multiple Scales.

De Niz M, Spadin F, Marti M, Stein JV, Frenz M, Frischknecht F.

Trends Parasitol. 2019 Mar;35(3):193-212. doi: 10.1016/ Epub 2019 Feb 10. Review.


Functional genetic evaluation of DNA house-cleaning enzymes in the malaria parasite: dUTPase and Ap4AH are essential in Plasmodium berghei but ITPase and NDH are dispensable.

Kumar H, Kehrer J, Singer M, Reinig M, Santos JM, Mair GR, Frischknecht F.

Expert Opin Ther Targets. 2019 Mar;23(3):251-261. doi: 10.1080/14728222.2019.1575810. Epub 2019 Feb 13.


Pathways of host cell exit by intracellular pathogens.

Flieger A, Frischknecht F, Häcker G, Hornef MW, Pradel G.

Microb Cell. 2018 Oct 18;5(12):525-544. doi: 10.15698/mic2018.12.659. Review.


A synthetic promoter for multi-stage expression to probe complementary functions of Plasmodium adhesins.

Klug D, Kehrer J, Frischknecht F, Singer M.

J Cell Sci. 2018 Oct 22;131(20). pii: jcs210971. doi: 10.1242/jcs.210971.


Screening for potential prophylactics targeting sporozoite motility through the skin.

Douglas RG, Reinig M, Neale M, Frischknecht F.

Malar J. 2018 Aug 31;17(1):319. doi: 10.1186/s12936-018-2469-0.


Nuclear Pore Complex Components in the Malaria Parasite Plasmodium berghei.

Kehrer J, Kuss C, Andres-Pons A, Reustle A, Dahan N, Devos D, Kudryashev M, Beck M, Mair GR, Frischknecht F.

Sci Rep. 2018 Jul 26;8(1):11249. doi: 10.1038/s41598-018-29590-5.


Inter-subunit interactions drive divergent dynamics in mammalian and Plasmodium actin filaments.

Douglas RG, Nandekar P, Aktories JE, Kumar H, Weber R, Sattler JM, Singer M, Lepper S, Sadiq SK, Wade RC, Frischknecht F.

PLoS Biol. 2018 Jul 16;16(7):e2005345. doi: 10.1371/journal.pbio.2005345. eCollection 2018 Jul.


Plasmodium gametocytes display homing and vascular transmigration in the host bone marrow.

De Niz M, Meibalan E, Mejia P, Ma S, Brancucci NMB, Agop-Nersesian C, Mandt R, Ngotho P, Hughes KR, Waters AP, Huttenhower C, Mitchell JR, Martinelli R, Frischknecht F, Seydel KB, Taylor T, Milner D, Heussler VT, Marti M.

Sci Adv. 2018 May 23;4(5):eaat3775. doi: 10.1126/sciadv.aat3775. eCollection 2018 May.


Immunization efficacy of cryopreserved genetically attenuated Plasmodium berghei sporozoites.

Prinz H, Sattler JM, Roth A, Ripp J, Adams JH, Frischknecht F.

Parasitol Res. 2018 Aug;117(8):2487-2497. doi: 10.1007/s00436-018-5937-0. Epub 2018 May 24.


Identification of a Golgi apparatus protein complex important for the asexual erythrocytic cycle of the malaria parasite Plasmodium falciparum.

Hallée S, Thériault C, Gagnon D, Kehrer J, Frischknecht F, Mair GR, Richard D.

Cell Microbiol. 2018 Aug;20(8):e12843. doi: 10.1111/cmi.12843. Epub 2018 Apr 24.


Discovery of Plasmodium (M)TRAP-Aldolase Interaction Stabilizers Interfering with Sporozoite Motility and Invasion.

Boucher LE, Hopp CS, Muthinja JM, Frischknecht F, Bosch J.

ACS Infect Dis. 2018 Apr 13;4(4):620-634. doi: 10.1021/acsinfecdis.7b00225. Epub 2018 Feb 19.


Tailored environments to study motile cells and pathogens.

Muthinja JM, Ripp J, Krüger T, Imle A, Haraszti T, Fackler OT, Spatz JP, Engstler M, Frischknecht F.

Cell Microbiol. 2018 Mar;20(3). doi: 10.1111/cmi.12820. Epub 2018 Jan 29. Review.


Functional insights into pathogen biology from 3D electron microscopy.

Cyrklaff M, Frischknecht F, Kudryashev M.

FEMS Microbiol Rev. 2017 Nov 1;41(6):828-853. doi: 10.1093/femsre/fux041. Review.


A unique profilin-actin interface is important for malaria parasite motility.

Moreau CA, Bhargav SP, Kumar H, Quadt KA, Piirainen H, Strauss L, Kehrer J, Streichfuss M, Spatz JP, Wade RC, Kursula I, Frischknecht F.

PLoS Pathog. 2017 May 26;13(5):e1006412. doi: 10.1371/journal.ppat.1006412. eCollection 2017 May.


Malaria parasite LIMP protein regulates sporozoite gliding motility and infectivity in mosquito and mammalian hosts.

Santos JM, Egarter S, Zuzarte-Luís V, Kumar H, Moreau CA, Kehrer J, Pinto A, Costa MD, Franke-Fayard B, Janse CJ, Frischknecht F, Mair GR.

Elife. 2017 May 2;6. pii: e24109. doi: 10.7554/eLife.24109.


Microstructured Blood Vessel Surrogates Reveal Structural Tropism of Motile Malaria Parasites.

Muthinja MJ, Ripp J, Hellmann JK, Haraszti T, Dahan N, Lemgruber L, Battista A, Schütz L, Fackler OT, Schwarz US, Spatz JP, Frischknecht F.

Adv Healthc Mater. 2017 Mar;6(6). doi: 10.1002/adhm.201601178. Epub 2017 Jan 24.


Motility precedes egress of malaria parasites from oocysts.

Klug D, Frischknecht F.

Elife. 2017 Jan 24;6. pii: e19157. doi: 10.7554/eLife.19157.


Plasmodium Sporozoite Biology.

Frischknecht F, Matuschewski K.

Cold Spring Harb Perspect Med. 2017 May 1;7(5). pii: a025478. doi: 10.1101/cshperspect.a025478. Review.


Progress in imaging methods: insights gained into Plasmodium biology.

De Niz M, Burda PC, Kaiser G, Del Portillo HA, Spielmann T, Frischknecht F, Heussler VT.

Nat Rev Microbiol. 2017 Jan;15(1):37-54. doi: 10.1038/nrmicro.2016.158. Epub 2016 Nov 28. Review.


Oxidative insult can induce malaria-protective trait of sickle and fetal erythrocytes.

Cyrklaff M, Srismith S, Nyboer B, Burda K, Hoffmann A, Lasitschka F, Adjalley S, Bisseye C, Simpore J, Mueller AK, Sanchez CP, Frischknecht F, Lanzer M.

Nat Commun. 2016 Nov 8;7:13401. doi: 10.1038/ncomms13401.


Time for Genome Editing: Next-Generation Attenuated Malaria Parasites.

Singer M, Frischknecht F.

Trends Parasitol. 2017 Mar;33(3):202-213. doi: 10.1016/ Epub 2016 Oct 25. Review.


A Putative Small Solute Transporter Is Responsible for the Secretion of G377 and TRAP-Containing Secretory Vesicles during Plasmodium Gamete Egress and Sporozoite Motility.

Kehrer J, Singer M, Lemgruber L, Silva PA, Frischknecht F, Mair GR.

PLoS Pathog. 2016 Jul 18;12(7):e1005734. doi: 10.1371/journal.ppat.1005734. eCollection 2016 Jul.


The Actin Filament-Binding Protein Coronin Regulates Motility in Plasmodium Sporozoites.

Bane KS, Lepper S, Kehrer J, Sattler JM, Singer M, Reinig M, Klug D, Heiss K, Baum J, Mueller AK, Frischknecht F.

PLoS Pathog. 2016 Jul 13;12(7):e1005710. doi: 10.1371/journal.ppat.1005710. eCollection 2016 Jul. Erratum in: PLoS Pathog. 2016 Aug;12(8):e1005818.


Maternally supplied S-acyl-transferase is required for crystalloid organelle formation and transmission of the malaria parasite.

Santos JM, Duarte N, Kehrer J, Ramesar J, Avramut MC, Koster AJ, Dessens JT, Frischknecht F, Chevalley-Maurel S, Janse CJ, Franke-Fayard B, Mair GR.

Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):7183-8. doi: 10.1073/pnas.1522381113. Epub 2016 Jun 14.


Protective efficacy and safety of liver stage attenuated malaria parasites.

Kumar H, Sattler JM, Singer M, Heiss K, Reinig M, Hammerschmidt-Kamper C, Heussler V, Mueller AK, Frischknecht F.

Sci Rep. 2016 May 31;6:26824. doi: 10.1038/srep26824.


A small mitochondrial protein present in myzozoans is essential for malaria transmission.

Klug D, Mair GR, Frischknecht F, Douglas RG.

Open Biol. 2016 Apr;6(4):160034. doi: 10.1098/rsob.160034.


Experimental systems for studying Plasmodium/HIV coinfection.

Frischknecht F, Fackler OT.

FEBS Lett. 2016 Jul;590(13):2000-13. doi: 10.1002/1873-3468.12151. Epub 2016 Apr 15. Review.


Coupling of Retrograde Flow to Force Production During Malaria Parasite Migration.

Quadt KA, Streichfuss M, Moreau CA, Spatz JP, Frischknecht F.

ACS Nano. 2016 Feb 23;10(2):2091-102. doi: 10.1021/acsnano.5b06417. Epub 2016 Jan 27.


Zinc finger nuclease-based double-strand breaks attenuate malaria parasites and reveal rare microhomology-mediated end joining.

Singer M, Marshall J, Heiss K, Mair GR, Grimm D, Mueller AK, Frischknecht F.

Genome Biol. 2015 Nov 17;16:249. doi: 10.1186/s13059-015-0811-1.


The Plasmodium palmitoyl-S-acyl-transferase DHHC2 is essential for ookinete morphogenesis and malaria transmission.

Santos JM, Kehrer J, Franke-Fayard B, Frischknecht F, Janse CJ, Mair GR.

Sci Rep. 2015 Nov 3;5:16034. doi: 10.1038/srep16034.


Motorizing pathogens.

Baum J, Frischknecht F.

Semin Cell Dev Biol. 2015 Oct;46:78-81. doi: 10.1016/j.semcdb.2015.09.019. Epub 2015 Sep 30. No abstract available.


In silico identification of genetically attenuated vaccine candidate genes for Plasmodium liver stage.

Kumar H, Frischknecht F, Mair GR, Gomes J.

Infect Genet Evol. 2015 Dec;36:72-81. doi: 10.1016/j.meegid.2015.09.002. Epub 2015 Sep 6.


Plasmodium falciparum coronin organizes arrays of parallel actin filaments potentially guiding directional motility in invasive malaria parasites.

Olshina MA, Angrisano F, Marapana DS, Riglar DT, Bane K, Wong W, Catimel B, Yin MX, Holmes AB, Frischknecht F, Kovar DR, Baum J.

Malar J. 2015 Jul 18;14:280. doi: 10.1186/s12936-015-0801-5.


Active migration and passive transport of malaria parasites.

Douglas RG, Amino R, Sinnis P, Frischknecht F.

Trends Parasitol. 2015 Aug;31(8):357-62. doi: 10.1016/ Epub 2015 May 20. Review.


Chemical attenuation of Plasmodium in the liver modulates severe malaria disease progression.

Lewis MD, Behrends J, Sá E Cunha C, Mendes AM, Lasitschka F, Sattler JM, Heiss K, Kooij TW, Prudêncio M, Bringmann G, Frischknecht F, Mueller AK.

J Immunol. 2015 May 15;194(10):4860-70. doi: 10.4049/jimmunol.1400863. Epub 2015 Apr 10.


Nanoscopic Localization of Surface-Exposed Antigens of Borrelia burgdorferi.

Lemgruber L, Sant'Anna C, Griffths C, Abud Y, Mhlanga M, Wallich R, Frischknecht F.

Microsc Microanal. 2015 Jun;21(3):680-8. doi: 10.1017/S1431927615000318. Epub 2015 Mar 5.


Host cell phosphatidylcholine is a key mediator of malaria parasite survival during liver stage infection.

Itoe MA, Sampaio JL, Cabal GG, Real E, Zuzarte-Luis V, March S, Bhatia SN, Frischknecht F, Thiele C, Shevchenko A, Mota MM.

Cell Host Microbe. 2014 Dec 10;16(6):778-86. doi: 10.1016/j.chom.2014.11.006.


Geometrical model for malaria parasite migration in structured environments.

Battista A, Frischknecht F, Schwarz US.

Phys Rev E Stat Nonlin Soft Matter Phys. 2014 Oct;90(4):042720. Epub 2014 Oct 22.


A cysteine protease inhibitor of plasmodium berghei is essential for exo-erythrocytic development.

Lehmann C, Heitmann A, Mishra S, Burda PC, Singer M, Prado M, Niklaus L, Lacroix C, Ménard R, Frischknecht F, Stanway R, Sinnis P, Heussler V.

PLoS Pathog. 2014 Aug 28;10(8):e1004336. doi: 10.1371/journal.ppat.1004336. eCollection 2014 Aug.


Export of virulence proteins by malaria-infected erythrocytes involves remodeling of host actin cytoskeleton.

Rug M, Cyrklaff M, Mikkonen A, Lemgruber L, Kuelzer S, Sanchez CP, Thompson J, Hanssen E, O'Neill M, Langer C, Lanzer M, Frischknecht F, Maier AG, Cowman AF.

Blood. 2014 Nov 27;124(23):3459-68. doi: 10.1182/blood-2014-06-583054. Epub 2014 Aug 19.


Structural differences explain diverse functions of Plasmodium actins.

Vahokoski J, Bhargav SP, Desfosses A, Andreadaki M, Kumpula EP, Martinez SM, Ignatev A, Lepper S, Frischknecht F, Sidén-Kiamos I, Sachse C, Kursula I.

PLoS Pathog. 2014 Apr 17;10(4):e1004091. doi: 10.1371/journal.ppat.1004091. eCollection 2014 Apr.


Biology of the malaria parasite--on the special issue for the 10th BioMalPar conference.

Frischknecht F, Mota M, Scherf A, Waters A.

Cell Microbiol. 2014 May;16(5):599-601. doi: 10.1111/cmi.12295. No abstract available.


Calcium dynamics of Plasmodium berghei sporozoite motility.

Carey AF, Singer M, Bargieri D, Thiberge S, Frischknecht F, Ménard R, Amino R.

Cell Microbiol. 2014 May;16(5):768-83. doi: 10.1111/cmi.12289. Epub 2014 Apr 4.


Expression profiling of Plasmodium berghei HSP70 genes for generation of bright red fluorescent parasites.

Hliscs M, Nahar C, Frischknecht F, Matuschewski K.

PLoS One. 2013 Aug 27;8(8):e72771. doi: 10.1371/journal.pone.0072771. eCollection 2013.

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