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Items: 28

1.

Sequential activation of STIM1 links Ca2+ with luminal domain unfolding.

Schober R, Bonhenry D, Lunz V, Zhu J, Krizova A, Frischauf I, Fahrner M, Zhang M, Waldherr L, Schmidt T, Derler I, Stathopulos PB, Romanin C, Ettrich RH, Schindl R.

Sci Signal. 2019 Nov 19;12(608). pii: eaax3194. doi: 10.1126/scisignal.aax3194.

PMID:
31744929
2.

STIM1 phosphorylation at Y316 modulates its interaction with SARAF and the activation of SOCE and I CRAC.

Lopez E, Frischauf I, Jardin I, Derler I, Muik M, Cantonero C, Salido GM, Smani T, Rosado JA, Redondo PC.

J Cell Sci. 2019 May 15;132(10). pii: jcs226019. doi: 10.1242/jcs.226019.

3.

A novel STIM1-Orai1 gating interface essential for CRAC channel activation.

Butorac C, Muik M, Derler I, Stadlbauer M, Lunz V, Krizova A, Lindinger S, Schober R, Frischauf I, Bhardwaj R, Hediger MA, Groschner K, Romanin C.

Cell Calcium. 2019 May;79:57-67. doi: 10.1016/j.ceca.2019.02.009. Epub 2019 Feb 23.

4.

STIM1 activation of Orai1.

Lunz V, Romanin C, Frischauf I.

Cell Calcium. 2019 Jan;77:29-38. doi: 10.1016/j.ceca.2018.11.009. Epub 2018 Nov 30. Review.

5.

Authentic CRAC channel activity requires STIM1 and the conserved portion of the Orai N terminus.

Derler I, Butorac C, Krizova A, Stadlbauer M, Muik M, Fahrner M, Frischauf I, Romanin C.

J Biol Chem. 2018 Jan 26;293(4):1259-1270. doi: 10.1074/jbc.M117.812206. Epub 2017 Dec 13.

6.

Communication between N terminus and loop2 tunes Orai activation.

Fahrner M, Pandey SK, Muik M, Traxler L, Butorac C, Stadlbauer M, Zayats V, Krizova A, Plenk P, Frischauf I, Schindl R, Gruber HJ, Hinterdorfer P, Ettrich R, Romanin C, Derler I.

J Biol Chem. 2018 Jan 26;293(4):1271-1285. doi: 10.1074/jbc.M117.812693. Epub 2017 Dec 13.

7.

Transmembrane helix connectivity in Orai1 controls two gates for calcium-dependent transcription.

Frischauf I, Litviňuková M, Schober R, Zayats V, Svobodová B, Bonhenry D, Lunz V, Cappello S, Tociu L, Reha D, Stallinger A, Hochreiter A, Pammer T, Butorac C, Muik M, Groschner K, Bogeski I, Ettrich RH, Romanin C, Schindl R.

Sci Signal. 2017 Nov 28;10(507). pii: eaao0358. doi: 10.1126/scisignal.aao0358.

8.

Live-cell imaging of ER-PM contact architecture by a novel TIRFM approach reveals extension of junctions in response to store-operated Ca2+-entry.

Poteser M, Leitinger G, Pritz E, Platzer D, Frischauf I, Romanin C, Groschner K.

Sci Rep. 2016 Oct 19;6:35656. doi: 10.1038/srep35656.

9.

The STIM1: Orai Interaction.

Frischauf I, Fahrner M, Jardín I, Romanin C.

Adv Exp Med Biol. 2016;898:25-46. doi: 10.1007/978-3-319-26974-0_2. Review.

PMID:
27161223
10.

A calcium-accumulating region, CAR, in the channel Orai1 enhances Ca(2+) permeation and SOCE-induced gene transcription.

Frischauf I, Zayats V, Deix M, Hochreiter A, Jardin I, Muik M, Lackner B, Svobodová B, Pammer T, Litviňuková M, Sridhar AA, Derler I, Bogeski I, Romanin C, Ettrich RH, Schindl R.

Sci Signal. 2015 Dec 22;8(408):ra131. doi: 10.1126/scisignal.aab1901.

11.

The polybasic lysine-rich domain of plasma membrane-resident STIM1 is essential for the modulation of store-operated divalent cation entry by extracellular calcium.

Jardin I, Dionisio N, Frischauf I, Berna-Erro A, Woodard GE, López JJ, Salido GM, Rosado JA.

Cell Signal. 2013 May;25(5):1328-37. doi: 10.1016/j.cellsig.2013.01.025. Epub 2013 Feb 8.

PMID:
23395841
12.

Canonical transient receptor potential (TRPC) 1 acts as a negative regulator for vanilloid TRPV6-mediated Ca2+ influx.

Schindl R, Fritsch R, Jardin I, Frischauf I, Kahr H, Muik M, Riedl MC, Groschner K, Romanin C.

J Biol Chem. 2012 Oct 12;287(42):35612-20. doi: 10.1074/jbc.M112.400952. Epub 2012 Aug 29.

13.

Novel pyrazole compounds for pharmacological discrimination between receptor-operated and store-operated Ca(2+) entry pathways.

Schleifer H, Doleschal B, Lichtenegger M, Oppenrieder R, Derler I, Frischauf I, Glasnov TN, Kappe CO, Romanin C, Groschner K.

Br J Pharmacol. 2012 Dec;167(8):1712-22. doi: 10.1111/j.1476-5381.2012.02126.x.

14.

Molecular determinants within N terminus of Orai3 protein that control channel activation and gating.

Bergsmann J, Derler I, Muik M, Frischauf I, Fahrner M, Pollheimer P, Schwarzinger C, Gruber HJ, Groschner K, Romanin C.

J Biol Chem. 2011 Sep 9;286(36):31565-75. doi: 10.1074/jbc.M111.227546. Epub 2011 Jul 1.

15.

STIM1 couples to ORAI1 via an intramolecular transition into an extended conformation.

Muik M, Fahrner M, Schindl R, Stathopulos P, Frischauf I, Derler I, Plenk P, Lackner B, Groschner K, Ikura M, Romanin C.

EMBO J. 2011 May 4;30(9):1678-89. doi: 10.1038/emboj.2011.79. Epub 2011 Mar 22.

16.

Cooperativeness of Orai cytosolic domains tunes subtype-specific gating.

Frischauf I, Schindl R, Bergsmann J, Derler I, Fahrner M, Muik M, Fritsch R, Lackner B, Groschner K, Romanin C.

J Biol Chem. 2011 Mar 11;286(10):8577-84. doi: 10.1074/jbc.M110.187179. Epub 2011 Jan 10.

17.

Resting state Orai1 diffuses as homotetramer in the plasma membrane of live mammalian cells.

Madl J, Weghuber J, Fritsch R, Derler I, Fahrner M, Frischauf I, Lackner B, Romanin C, Schütz GJ.

J Biol Chem. 2010 Dec 24;285(52):41135-42. doi: 10.1074/jbc.M110.177881. Epub 2010 Oct 20.

18.

Plasticity in Ca2+ selectivity of Orai1/Orai3 heteromeric channel.

Schindl R, Frischauf I, Bergsmann J, Muik M, Derler I, Lackner B, Groschner K, Romanin C.

Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19623-8. doi: 10.1073/pnas.0907714106. Epub 2009 Nov 3.

19.

Mechanistic view on domains mediating STIM1-Orai coupling.

Fahrner M, Muik M, Derler I, Schindl R, Fritsch R, Frischauf I, Romanin C.

Immunol Rev. 2009 Sep;231(1):99-112. doi: 10.1111/j.1600-065X.2009.00815.x. Review.

PMID:
19754892
20.

Molecular determinants of the coupling between STIM1 and Orai channels: differential activation of Orai1-3 channels by a STIM1 coiled-coil mutant.

Frischauf I, Muik M, Derler I, Bergsmann J, Fahrner M, Schindl R, Groschner K, Romanin C.

J Biol Chem. 2009 Aug 7;284(32):21696-706. doi: 10.1074/jbc.M109.018408. Epub 2009 Jun 8.

21.

Increased hydrophobicity at the N terminus/membrane interface impairs gating of the severe combined immunodeficiency-related ORAI1 mutant.

Derler I, Fahrner M, Carugo O, Muik M, Bergsmann J, Schindl R, Frischauf I, Eshaghi S, Romanin C.

J Biol Chem. 2009 Jun 5;284(23):15903-15. doi: 10.1074/jbc.M808312200. Epub 2009 Apr 14.

22.

A Cytosolic Homomerization and a Modulatory Domain within STIM1 C Terminus Determine Coupling to ORAI1 Channels.

Muik M, Fahrner M, Derler I, Schindl R, Bergsmann J, Frischauf I, Groschner K, Romanin C.

J Biol Chem. 2009 Mar 27;284(13):8421-6. doi: 10.1074/jbc.C800229200. Epub 2009 Feb 3.

23.

The STIM/Orai coupling machinery.

Frischauf I, Schindl R, Derler I, Bergsmann J, Fahrner M, Romanin C.

Channels (Austin). 2008 Jul-Aug;2(4):261-8. Epub 2008 Jul 21. Review.

PMID:
18769136
24.

2-aminoethoxydiphenyl borate alters selectivity of Orai3 channels by increasing their pore size.

Schindl R, Bergsmann J, Frischauf I, Derler I, Fahrner M, Muik M, Fritsch R, Groschner K, Romanin C.

J Biol Chem. 2008 Jul 18;283(29):20261-7. doi: 10.1074/jbc.M803101200. Epub 2008 May 21.

25.

Proliferation of aligned mammalian cells on laser-nanostructured polystyrene.

Rebollar E, Frischauf I, Olbrich M, Peterbauer T, Hering S, Preiner J, Hinterdorfer P, Romanin C, Heitz J.

Biomaterials. 2008 Apr;29(12):1796-806. doi: 10.1016/j.biomaterials.2007.12.039. Epub 2008 Jan 31.

PMID:
18237776
26.

Dynamic coupling of the putative coiled-coil domain of ORAI1 with STIM1 mediates ORAI1 channel activation.

Muik M, Frischauf I, Derler I, Fahrner M, Bergsmann J, Eder P, Schindl R, Hesch C, Polzinger B, Fritsch R, Kahr H, Madl J, Gruber H, Groschner K, Romanin C.

J Biol Chem. 2008 Mar 21;283(12):8014-22. doi: 10.1074/jbc.M708898200. Epub 2008 Jan 10.

27.

The first ankyrin-like repeat is the minimum indispensable key structure for functional assembly of homo- and heteromeric TRPC4/TRPC5 channels.

Schindl R, Frischauf I, Kahr H, Fritsch R, Krenn M, Derndl A, Vales E, Muik M, Derler I, Groschner K, Romanin C.

Cell Calcium. 2008 Mar;43(3):260-9. Epub 2007 Jul 12.

PMID:
17624425
28.

UV surface modification of a new nanocomposite polymer to improve cytocompatibility.

Olbrich M, Punshon G, Frischauf I, Salacinski HJ, Rebollar E, Romanin C, Seifalian AM, Heitz J.

J Biomater Sci Polym Ed. 2007;18(4):453-68.

PMID:
17540119

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