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Mitochondrial Lon protease - depleted HeLa cells exhibit proteome modifications related to protein quality control, stress response and energy metabolism.

Hamon MP, Gergondey R, L'honoré A, Friguet B.

Free Radic Biol Med. 2020 Feb 20;148:83-95. doi: 10.1016/j.freeradbiomed.2019.12.039. Epub 2020 Jan 3.


Proteome Oxidative Modifications and Impairment of Specific Metabolic Pathways During Cellular Senescence and Aging.

Hamon MP, Ahmed EK, Baraibar MA, Friguet B.

Proteomics. 2019 Sep 10:e1800421. doi: 10.1002/pmic.201800421. [Epub ahead of print] Review.


Effects of the selective inhibition of proteasome caspase-like activity by CLi a derivative of nor-cerpegin in dystrophic mdx mice.

Hovhannisyan Y, Melikyan G, Mougenot N, Gao-Li J, Friguet B, Paulin D, Li Z, Ferry A, Agbulut O.

PLoS One. 2019 Apr 23;14(4):e0215821. doi: 10.1371/journal.pone.0215821. eCollection 2019.


Impairment of glyoxalase-1, an advanced glycation end-product detoxifying enzyme, induced by inflammation in age-related osteoarthritis.

Trellu S, Courties A, Jaisson S, Gorisse L, Gillery P, Kerdine-Römer S, Vaamonde-Garcia C, Houard X, Ekhirch FP, Sautet A, Friguet B, Jacques C, Berenbaum F, Sellam J.

Arthritis Res Ther. 2019 Jan 11;21(1):18. doi: 10.1186/s13075-018-1801-y.


The Oxidized Protein Repair Enzymes Methionine Sulfoxide Reductases and Their Roles in Protecting against Oxidative Stress, in Ageing and in Regulating Protein Function.

Lourenço Dos Santos S, Petropoulos I, Friguet B.

Antioxidants (Basel). 2018 Dec 12;7(12). pii: E191. doi: 10.3390/antiox7120191. Review.


Improvement of Dystrophic Muscle Fragility by Short-Term Voluntary Exercise through Activation of Calcineurin Pathway in mdx Mice.

Delacroix C, Hyzewicz J, Lemaitre M, Friguet B, Li Z, Klein A, Furling D, Agbulut O, Ferry A.

Am J Pathol. 2018 Nov;188(11):2662-2673. doi: 10.1016/j.ajpath.2018.07.015. Epub 2018 Aug 22.


The role of Pitx2 and Pitx3 in muscle stem cells gives new insights into P38α MAP kinase and redox regulation of muscle regeneration.

L'honoré A, Commère PH, Negroni E, Pallafacchina G, Friguet B, Drouin J, Buckingham M, Montarras D.

Elife. 2018 Aug 14;7. pii: e32991. doi: 10.7554/eLife.32991.


The Oxygen Paradox, the French Paradox, and age-related diseases.

Davies JMS, Cillard J, Friguet B, Cadenas E, Cadet J, Cayce R, Fishmann A, Liao D, Bulteau AL, Derbré F, Rébillard A, Burstein S, Hirsch E, Kloner RA, Jakowec M, Petzinger G, Sauce D, Sennlaub F, Limon I, Ursini F, Maiorino M, Economides C, Pike CJ, Cohen P, Salvayre AN, Halliday MR, Lundquist AJ, Jakowec NA, Mechta-Grigoriou F, Mericskay M, Mariani J, Li Z, Huang D, Grant E, Forman HJ, Finch CE, Sun PY, Pomatto LCD, Agbulut O, Warburton D, Neri C, Rouis M, Cillard P, Capeau J, Rosenbaum J, Davies KJA.

Geroscience. 2017 Dec;39(5-6):499-550. doi: 10.1007/s11357-017-0002-y. Epub 2017 Dec 21. Review.


Proteome oxidative carbonylation during oxidative stress-induced premature senescence of WI-38 human fibroblasts.

Le Boulch M, Ahmed EK, Rogowska-Wrzesinska A, Baraibar MA, Friguet B.

Mech Ageing Dev. 2018 Mar;170:59-71. doi: 10.1016/j.mad.2017.07.005. Epub 2017 Jul 27.


Impaired energy metabolism of senescent muscle satellite cells is associated with oxidative modifications of glycolytic enzymes.

Baraibar MA, Hyzewicz J, Rogowska-Wrzesinska A, Bulteau AL, Prip-Buus C, Butler-Browne G, Friguet B.

Aging (Albany NY). 2016 Dec 4;8(12):3375-3389. doi: 10.18632/aging.101126.


Circadian modulation of proteasome activity and accumulation of oxidized protein in human embryonic kidney HEK 293 cells and primary dermal fibroblasts.

Desvergne A, Ugarte N, Radjei S, Gareil M, Petropoulos I, Friguet B.

Free Radic Biol Med. 2016 May;94:195-207. doi: 10.1016/j.freeradbiomed.2016.02.037. Epub 2016 Mar 2.


The glyoxalase enzymes are differentially localized in epidermis and regulated during ageing and photoageing.

Radjei S, Gareil M, Moreau M, Leblanc E, Schnebert S, Friguet B, Nizard C, Petropoulos I.

Exp Dermatol. 2016 Jun;25(6):492-4. doi: 10.1111/exd.12995. Epub 2016 May 12. No abstract available.


Response to Letter Regarding Article, "Anti-inflammatory and Antiatherogenic Effects of the Inflammasome NLRP3 Inhibitor Arglabin in ApoE2.Ki Mice Fed a High-Fat Diet".

Abderrazak A, Couchie D, Darweesh Mahmood DF, Elhage R, Vindis C, Laffargue M, Matéo V, Büchele B, Ayala MR, Gaafary ME, Syrovets T, Slimane MN, Friguet B, Fulop T, Simmet T, Hadri KE, Rouis M.

Circulation. 2015 Nov 24;132(21):e250-1. doi: 10.1161/CIRCULATIONAHA.115.017739. No abstract available.


Hepatocellular carcinoma protein carbonylation in virus C and metabolic syndrome patients.

Martin FA, Mebarki M, Paradis V, Friguet B, Radman M.

Free Radic Biol Med. 2014 Oct;75 Suppl 1:S40. doi: 10.1016/j.freeradbiomed.2014.10.789. Epub 2014 Dec 10.


Role of Oxidized Protein Repair in Human Skeletal Muscle.

Lourenço S, Trollet C, Gillian SB, Friguet B, Petropoulos I.

Free Radic Biol Med. 2014 Oct;75 Suppl 1:S39. doi: 10.1016/j.freeradbiomed.2014.10.787. Epub 2014 Dec 10.


Effects of Lon protease down-regulation on the mitochondrial function and proteome.

Hamon MP, Bayot A, Gareil M, Chavatte L, Lombès A, Friguet B, Bulteau AL.

Free Radic Biol Med. 2014 Oct;75 Suppl 1:S32-3. doi: 10.1016/j.freeradbiomed.2014.10.767. Epub 2014 Dec 10.


Oxi-DIGE: A novel proteomic approach for detecting and quantifying carbonylated proteins.

Baraibar M, Ladouce R, Friguet B.

Free Radic Biol Med. 2014 Oct;75 Suppl 1:S23. doi: 10.1016/j.freeradbiomed.2014.10.739. Epub 2014 Dec 10.


Impaired metabolism of senescent muscle satellite cells is associated with oxidative modifications of glycolytic enzymes.

Baraibar M, Hyzewicz J, Rogowska-Wrzesinska A, Bulteau AL, Prip-Buus C, Butler-Browne G, Friguet B.

Free Radic Biol Med. 2014 Oct;75 Suppl 1:S23. doi: 10.1016/j.freeradbiomed.2014.10.738. Epub 2014 Dec 10.


Circadian modulation of proteasome activities and removal of carbonylated proteins.

Desvergne A, Ugarte N, Petropoulos I, Friguet B.

Free Radic Biol Med. 2014 Oct;75 Suppl 1:S18. doi: 10.1016/j.freeradbiomed.2014.10.631. Epub 2014 Dec 10.


CD4(+) T cell surface alpha enolase is lower in older adults.

Bennett SJ, Augustyniak EM, Dunston CR, Brown RA, Shantsila E, Lip GY, Torrao RD, Pararasa C, Remtulla AH, Ladouce R, Friguet B, Griffiths HR.

Mech Ageing Dev. 2015 Dec;152:56-62. doi: 10.1016/j.mad.2015.09.005. Epub 2015 Oct 1.


AMPK Signaling Involvement for the Repression of the IL-1β-Induced Group IIA Secretory Phospholipase A2 Expression in VSMCs.

El Hadri K, Denoyelle C, Ravaux L, Viollet B, Foretz M, Friguet B, Rouis M, Raymondjean M.

PLoS One. 2015 Jul 10;10(7):e0132498. doi: 10.1371/journal.pone.0132498. eCollection 2015.


Oxidative proteome alterations during skeletal muscle ageing.

Lourenço Dos Santos S, Baraibar MA, Lundberg S, Eeg-Olofsson O, Larsson L, Friguet B.

Redox Biol. 2015 Aug;5:267-274. doi: 10.1016/j.redox.2015.05.006. Epub 2015 Jun 3.


Protein modification and maintenance systems as biomarkers of ageing.

Vanhooren V, Navarrete Santos A, Voutetakis K, Petropoulos I, Libert C, Simm A, Gonos ES, Friguet B.

Mech Ageing Dev. 2015 Nov;151:71-84. doi: 10.1016/j.mad.2015.03.009. Epub 2015 Apr 3. Review.


The transcription factor E4F1 coordinates CHK1-dependent checkpoint and mitochondrial functions.

Rodier G, Kirsh O, Baraibar M, Houlès T, Lacroix M, Delpech H, Hatchi E, Arnould S, Severac D, Dubois E, Caramel J, Julien E, Friguet B, Le Cam L, Sardet C.

Cell Rep. 2015 Apr 14;11(2):220-33. doi: 10.1016/j.celrep.2015.03.024. Epub 2015 Apr 2.


MARK-AGE biomarkers of ageing.

Bürkle A, Moreno-Villanueva M, Bernhard J, Blasco M, Zondag G, Hoeijmakers JH, Toussaint O, Grubeck-Loebenstein B, Mocchegiani E, Collino S, Gonos ES, Sikora E, Gradinaru D, Dollé M, Salmon M, Kristensen P, Griffiths HR, Libert C, Grune T, Breusing N, Simm A, Franceschi C, Capri M, Talbot D, Caiafa P, Friguet B, Slagboom PE, Hervonen A, Hurme M, Aspinall R.

Mech Ageing Dev. 2015 Nov;151:2-12. doi: 10.1016/j.mad.2015.03.006. Epub 2015 Mar 24. Review.


Photosensitizing Activity of Endogenous Eye Lens Chromophores: An Attempt to Unravel Their Contributions to Photo-Aging and Cataract Disease.

Avila F, Friguet B, Silva E.

Photochem Photobiol. 2015 Jul-Aug;91(4):767-79. doi: 10.1111/php.12443. Epub 2015 Mar 28. Review.


Proteasomes, Sir2, and Hxk2 form an interconnected aging network that impinges on the AMPK/Snf1-regulated transcriptional repressor Mig1.

Yao Y, Tsuchiyama S, Yang C, Bulteau AL, He C, Robison B, Tsuchiya M, Miller D, Briones V, Tar K, Potrero A, Friguet B, Kennedy BK, Schmidt M.

PLoS Genet. 2015 Jan 28;11(1):e1004968. doi: 10.1371/journal.pgen.1004968. eCollection 2015 Jan.


NLRP3 inflammasome: from a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases.

Abderrazak A, Syrovets T, Couchie D, El Hadri K, Friguet B, Simmet T, Rouis M.

Redox Biol. 2015;4:296-307. doi: 10.1016/j.redox.2015.01.008. Epub 2015 Jan 14. Review.


Anti-inflammatory and antiatherogenic effects of the NLRP3 inflammasome inhibitor arglabin in ApoE2.Ki mice fed a high-fat diet.

Abderrazak A, Couchie D, Mahmood DF, Elhage R, Vindis C, Laffargue M, Matéo V, Büchele B, Ayala MR, El Gaafary M, Syrovets T, Slimane MN, Friguet B, Fulop T, Simmet T, El Hadri K, Rouis M.

Circulation. 2015 Mar 24;131(12):1061-70. doi: 10.1161/CIRCULATIONAHA.114.013730. Epub 2015 Jan 22.


Mitochondrial proteases and protein quality control in ageing and longevity.

Hamon MP, Bulteau AL, Friguet B.

Ageing Res Rev. 2015 Sep;23(Pt A):56-66. doi: 10.1016/j.arr.2014.12.010. Epub 2015 Jan 8. Review.


Proteomics of muscle chronological ageing in post-menopausal women.

Gueugneau M, Coudy-Gandilhon C, Gourbeyre O, Chambon C, Combaret L, Polge C, Taillandier D, Attaix D, Friguet B, Maier AB, Butler-Browne G, Béchet D.

BMC Genomics. 2014 Dec 23;15:1165. doi: 10.1186/1471-2164-15-1165.


Autophagy impairment in muscle induces neuromuscular junction degeneration and precocious aging.

Carnio S, LoVerso F, Baraibar MA, Longa E, Khan MM, Maffei M, Reischl M, Canepari M, Loefler S, Kern H, Blaauw B, Friguet B, Bottinelli R, Rudolf R, Sandri M.

Cell Rep. 2014 Sep 11;8(5):1509-21. doi: 10.1016/j.celrep.2014.07.061. Epub 2014 Aug 28.


Prevention of dicarbonyl-mediated advanced glycation by glyoxalases: implication in skin aging.

Radjei S, Friguet B, Nizard C, Petropoulos I.

Biochem Soc Trans. 2014 Apr;42(2):518-22. doi: 10.1042/BST20140017. Review.


Annonacin, a natural lipophilic mitochondrial complex I inhibitor, increases phosphorylation of tau in the brain of FTDP-17 transgenic mice.

Yamada ES, Respondek G, Müssner S, de Andrade A, Höllerhage M, Depienne C, Rastetter A, Tarze A, Friguet B, Salama M, Champy P, Oertel WH, Höglinger GU.

Exp Neurol. 2014 Mar;253:113-25. doi: 10.1016/j.expneurol.2013.12.017. Epub 2014 Jan 3.


Effect of Lon protease knockdown on mitochondrial function in HeLa cells.

Bayot A, Gareil M, Chavatte L, Hamon MP, L'Hermitte-Stead C, Beaumatin F, Priault M, Rustin P, Lombès A, Friguet B, Bulteau AL.

Biochimie. 2014 May;100:38-47. doi: 10.1016/j.biochi.2013.12.005. Epub 2013 Dec 17.


Proteome modulation in H9c2 cardiac cells by microRNAs miR-378 and miR-378.

Mallat Y, Tritsch E, Ladouce R, Winter DL, Friguet B, Li Z, Mericskay M.

Mol Cell Proteomics. 2014 Jan;13(1):18-29. doi: 10.1074/mcp.M113.030569. Epub 2013 Sep 25.


Proteome alteration in oxidative stress-sensitive methionine sulfoxide reductase-silenced HEK293 cells.

Ugarte N, Ladouce R, Radjei S, Gareil M, Friguet B, Petropoulos I.

Free Radic Biol Med. 2013 Dec;65:1023-1036. doi: 10.1016/j.freeradbiomed.2013.08.008. Epub 2013 Aug 27.


Differential expression and glycative damage affect specific mitochondrial proteins with aging in rat liver.

Bakala H, Ladouce R, Baraibar MA, Friguet B.

Biochim Biophys Acta. 2013 Dec;1832(12):2057-67. doi: 10.1016/j.bbadis.2013.07.015. Epub 2013 Jul 30.


Proteomic quantification and identification of carbonylated proteins upon oxidative stress and during cellular aging.

Baraibar MA, Ladouce R, Friguet B.

J Proteomics. 2013 Oct 30;92:63-70. doi: 10.1016/j.jprot.2013.05.008. Epub 2013 May 18. Review.


Expression and modification proteomics during skeletal muscle ageing.

Baraibar MA, Gueugneau M, Duguez S, Butler-Browne G, Bechet D, Friguet B.

Biogerontology. 2013 Jun;14(3):339-52. doi: 10.1007/s10522-013-9426-7. Epub 2013 Apr 28.


Deletion of the mitochondrial Pim1/Lon protease in yeast results in accelerated aging and impairment of the proteasome.

Erjavec N, Bayot A, Gareil M, Camougrand N, Nystrom T, Friguet B, Bulteau AL.

Free Radic Biol Med. 2013 Mar;56:9-16. doi: 10.1016/j.freeradbiomed.2012.11.019. Epub 2012 Dec 5.


Oxidative proteome modifications target specific cellular pathways during oxidative stress, cellular senescence and aging.

Baraibar MA, Friguet B.

Exp Gerontol. 2013 Jul;48(7):620-5. doi: 10.1016/j.exger.2012.10.007. Epub 2012 Nov 2. Review.


Protein oxidative damage at the crossroads of cellular senescence, aging, and age-related diseases.

Baraibar MA, Liu L, Ahmed EK, Friguet B.

Oxid Med Cell Longev. 2012;2012:919832. doi: 10.1155/2012/919832. Epub 2012 Oct 17.


Protein damage, repair and proteolysis.

Chondrogianni N, Petropoulos I, Grimm S, Georgila K, Catalgol B, Friguet B, Grune T, Gonos ES.

Mol Aspects Med. 2014 Feb;35:1-71. doi: 10.1016/j.mam.2012.09.001. Epub 2012 Oct 26. Review.


Clearance of genetic variants of amyloid β peptide by neuronal and non-neuronal cells.

Panchal M, El Abida B, Lazar N, Fahy C, Dubost L, Friguet B, Rholam M.

Protein Pept Lett. 2013 May;20(5):550-61.


Changes of the proteasomal system during the aging process.

Baraibar MA, Friguet B.

Prog Mol Biol Transl Sci. 2012;109:249-75. doi: 10.1016/B978-0-12-397863-9.00007-9. Review.


Aging of the dopaminergic system and motor behavior in mice intoxicated with the parkinsonian toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

Schumm S, Sebban C, Cohen-Salmon C, Callebert J, Launay JM, Golmard JL, Boussicault L, Petropoulos I, Hild A, Rousselet E, Prigent A, Friguet B, Mariani J, Hirsch EC.

J Neurochem. 2012 Sep;122(5):1032-46. doi: 10.1111/j.1471-4159.2012.07837.x. Epub 2012 Jul 11.


Catalase, a target of glycation damage in rat liver mitochondria with aging.

Bakala H, Hamelin M, Mary J, Borot-Laloi C, Friguet B.

Biochim Biophys Acta. 2012 Oct;1822(10):1527-34. doi: 10.1016/j.bbadis.2012.05.016. Epub 2012 Jun 7.


The second international conference "genetics of aging and longevity".

Anisimov VN, Bartke A, Barzilai N, Batin MA, Blagosklonny MV, Brown-Borg H, Budovskaya Y, Campisi J, Friguet B, Fraifeld V, Franceschi C, Gems D, Gladyshev V, Gorbunova V, Gudkov AV, Kennedy B, Konovalenko M, Kraemer B, Moskalev A, Petropoulos I, Pasyukova E, Rattan S, Rogina B, Seluanov A, Shaposhnikov M, Shmookler Reis R, Tavernarakis N, Vijg J, Yashin A, Zimniak P.

Aging (Albany NY). 2012 May;4(5):305-17. No abstract available.


Photosensitized reactions mediated by the major chromophore arising from glucose decomposition, result in oxidation and cross-linking of lens proteins and activation of the proteasome.

Avila F, Trejo S, Baraibar MA, Friguet B, Silva E.

Biochim Biophys Acta. 2012 Apr;1822(4):564-72. doi: 10.1016/j.bbadis.2011.11.018. Epub 2011 Dec 7.

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