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Towards personalized computer simulation of breast cancer treatment: a multi-scale pharmacokinetic and pharmacodynamic model informed by multi-type patient data.

Lai X, Geier OM, Fleischer T, Garred Ø, Borgen E, Funke SW, Kumar S, Rognes ME, Seierstad T, Børressen-Dale AL, Kristensen VN, Engebråten O, Köhn-Luque A, Frigessi A.

Cancer Res. 2019 May 22. pii: canres.1804.2018. doi: 10.1158/0008-5472.CAN-18-1804. [Epub ahead of print]


A Bayesian Two-Way Latent Structure Model for Genomic Data Integration Reveals Few Pan-Genomic Cluster Subtypes in a Breast Cancer Cohort.

Swanson DM, Lien T, Bergholtz H, Sørlie T, Frigessi A.

Bioinformatics. 2019 May 11. pii: btz381. doi: 10.1093/bioinformatics/btz381. [Epub ahead of print]


A theoretical single-parameter model for urbanisation to study infectious disease spread and interventions.

Engebretsen S, Engø-Monsen K, Frigessi A, Freiesleben de Blasio B.

PLoS Comput Biol. 2019 Mar 7;15(3):e1006879. doi: 10.1371/journal.pcbi.1006879. eCollection 2019 Mar.


A three minutes supine position test reveals higher risk of spinal anesthesia induced hypotension during cesarean delivery. An observational study.

Erango M, Frigessi A, Rosseland LA.

F1000Res. 2018 Jul 9;7:1028. doi: 10.12688/f1000research.15142.1. eCollection 2018.


A correction for sample overlap in genome-wide association studies in a polygenic pleiotropy-informed framework.

LeBlanc M, Zuber V, Thompson WK, Andreassen OA; Schizophrenia and Bipolar Disorder Working Groups of the Psychiatric Genomics Consortium, Frigessi A, Andreassen BK.

BMC Genomics. 2018 Jun 25;19(1):494. doi: 10.1186/s12864-018-4859-7.


The peer effect on pain tolerance.

Engebretsen S, Frigessi A, Engø-Monsen K, Furberg AS, Stubhaug A, de Blasio BF, Nielsen CS.

Scand J Pain. 2018 Jul 26;18(3):467-477. doi: 10.1515/sjpain-2018-0060.


DNA methylation at enhancers identifies distinct breast cancer lineages.

Fleischer T, Tekpli X, Mathelier A, Wang S, Nebdal D, Dhakal HP, Sahlberg KK, Schlichting E; Oslo Breast Cancer Research Consortium (OSBREAC), Børresen-Dale AL, Borgen E, Naume B, Eskeland R, Frigessi A, Tost J, Hurtado A, Kristensen VN.

Nat Commun. 2017 Nov 9;8(1):1379. doi: 10.1038/s41467-017-00510-x.


Simulating the life course of psoriasis patients: the interplay between therapy intervention and marital status.

Linder MD, Frigessi A, Piaserico S, Keilman N.

J Eur Acad Dermatol Venereol. 2018 Jan;32(1):62-67. doi: 10.1111/jdv.14567. Epub 2017 Sep 26.


Joint Bayesian modeling of time to malaria and mosquito abundance in Ethiopia.

Belay DB, Kifle YG, Goshu AT, Gran JM, Yewhalaw D, Duchateau L, Frigessi A.

BMC Infect Dis. 2017 Jun 12;17(1):415. doi: 10.1186/s12879-017-2496-4.


Integrative clustering reveals a novel split in the luminal A subtype of breast cancer with impact on outcome.

Aure MR, Vitelli V, Jernström S, Kumar S, Krohn M, Due EU, Haukaas TH, Leivonen SK, Vollan HK, Lüders T, Rødland E, Vaske CJ, Zhao W, Møller EK, Nord S, Giskeødegård GF, Bathen TF, Caldas C, Tramm T, Alsner J, Overgaard J, Geisler J, Bukholm IR, Naume B, Schlichting E, Sauer T, Mills GB, Kåresen R, Mælandsmo GM, Lingjærde OC, Frigessi A, Kristensen VN, Børresen-Dale AL, Sahlberg KK; OSBREAC.

Breast Cancer Res. 2017 Mar 29;19(1):44. doi: 10.1186/s13058-017-0812-y.


Tilting the lasso by knowledge-based post-processing.

Tharmaratnam K, Sperrin M, Jaki T, Reppe S, Frigessi A.

BMC Bioinformatics. 2016 Sep 2;17(1):344. doi: 10.1186/s12859-016-1210-7.


Gene expression analysis supports tumor threshold over 2.0 cm for T-category breast cancer.

Solvang HK, Frigessi A, Kaveh F, Riis ML, Lüders T, Bukholm IR, Kristensen VN, Andreassen BK.

EURASIP J Bioinform Syst Biol. 2016 Feb 8;2016(1):6. eCollection 2016 Dec.


Alcohol and Emotional Contagion: An Examination of the Spreading of Smiles in Male and Female Drinking Groups.

Fairbairn CE, Sayette MA, Aalen OO, Frigessi A.

Clin Psychol Sci. 2015 Sep;3(5):686-701. Epub 2014 Sep 26.


Identifying Novel Gene Variants in Coronary Artery Disease and Shared Genes With Several Cardiovascular Risk Factors.

LeBlanc M, Zuber V, Andreassen BK, Witoelar A, Zeng L, Bettella F, Wang Y, McEvoy LK, Thompson WK, Schork AJ, Reppe S, Barrett-Connor E, Ligthart S, Dehghan A, Gautvik KM, Nelson CP, Schunkert H, Samani NJ; CARDIoGRAM Consortium, Ridker PM, Chasman DI, Aukrust P, Djurovic S, Frigessi A, Desikan RS, Dale AM, Andreassen OA.

Circ Res. 2016 Jan 8;118(1):83-94. doi: 10.1161/CIRCRESAHA.115.306629. Epub 2015 Oct 20.


Development and validation of a gene profile predicting benefit of postmastectomy radiotherapy in patients with high-risk breast cancer: a study of gene expression in the DBCG82bc cohort.

Tramm T, Mohammed H, Myhre S, Kyndi M, Alsner J, Børresen-Dale AL, Sørlie T, Frigessi A, Overgaard J.

Clin Cancer Res. 2014 Oct 15;20(20):5272-80. doi: 10.1158/1078-0432.CCR-14-0458. Epub 2014 Aug 22.


Genome-wide DNA methylation profiles in progression to in situ and invasive carcinoma of the breast with impact on gene transcription and prognosis.

Fleischer T, Frigessi A, Johnson KC, Edvardsen H, Touleimat N, Klajic J, Riis ML, Haakensen VD, Wärnberg F, Naume B, Helland A, Børresen-Dale AL, Tost J, Christensen BC, Kristensen VN.

Genome Biol. 2014;15(8):435. doi: 10.1186/PREACCEPT-2333349012841587. Epub 2014 Aug 22.


Principles and methods of integrative genomic analyses in cancer.

Kristensen VN, Lingjærde OC, Russnes HG, Vollan HK, Frigessi A, Børresen-Dale AL.

Nat Rev Cancer. 2014 May;14(5):299-313. doi: 10.1038/nrc3721. Review.


The Genomic HyperBrowser: an analysis web server for genome-scale data.

Sandve GK, Gundersen S, Johansen M, Glad IK, Gunathasan K, Holden L, Holden M, Liestøl K, Nygård S, Nygaard V, Paulsen J, Rydbeck H, Trengereid K, Clancy T, Drabløs F, Ferkingstad E, Kalas M, Lien T, Rye MB, Frigessi A, Hovig E.

Nucleic Acids Res. 2013 Jul;41(Web Server issue):W133-41. doi: 10.1093/nar/gkt342. Epub 2013 Apr 30.


A Bayesian hierarchical model with spatial variable selection: the effect of weather on insurance claims.

Scheel I, Ferkingstad E, Frigessi A, Haug O, Hinnerichsen M, Meze-Hausken E.

J R Stat Soc Ser C Appl Stat. 2013 Jan;62(1):85-100.


Antibiotic resistance in hospitals: a ward-specific random effect model in a low antibiotic consumption environment.

Aldrin M, Raastad R, Tvete IF, Berild D, Frigessi A, Leegaard T, Monnet DL, Walberg M, Müller F.

Stat Med. 2013 Apr 15;32(8):1407-18. doi: 10.1002/sim.5636. Epub 2012 Oct 1.


Genetic variants affecting the neural processing of human facial expressions: evidence using a genome-wide functional imaging approach.

Brown AA, Jensen J, Nikolova YS, Djurovic S, Agartz I, Server A, Ferrell RE, Manuck SB, Mattingsdal M, Melle I, Hariri AR, Frigessi A, Andreassen OA.

Transl Psychiatry. 2012 Jul 24;2:e143. doi: 10.1038/tp.2012.67.


A characterization of internet dating network structures among nordic men who have sex with men.

Villani A, Frigessi A, Liljeros F, Nordvik MK, de Blasio BF.

PLoS One. 2012;7(7):e39717. doi: 10.1371/journal.pone.0039717. Epub 2012 Jul 13.


Overrepresentation of transcription factor families in the genesets underlying breast cancer subtypes.

Joshi H, Nord SH, Frigessi A, Børresen-Dale AL, Kristensen VN.

BMC Genomics. 2012 May 22;13:199. doi: 10.1186/1471-2164-13-199.


Identifying elemental genomic track types and representing them uniformly.

Gundersen S, Kalaš M, Abul O, Frigessi A, Hovig E, Sandve GK.

BMC Bioinformatics. 2011 Dec 30;12:494. doi: 10.1186/1471-2105-12-494.


Estimated comparative integration hotspots identify different behaviors of retroviral gene transfer vectors.

Ambrosi A, Glad IK, Pellin D, Cattoglio C, Mavilio F, Di Serio C, Frigessi A.

PLoS Comput Biol. 2011 Dec;7(12):e1002292. doi: 10.1371/journal.pcbi.1002292. Epub 2011 Dec 1.


Genome-wide study identifies PTPRO and WDR72 and FOXQ1-SUMO1P1 interaction associated with neurocognitive function.

LeBlanc M, Kulle B, Sundet K, Agartz I, Melle I, Djurovic S, Frigessi A, Andreassen OA.

J Psychiatr Res. 2012 Feb;46(2):271-8. doi: 10.1016/j.jpsychires.2011.11.001. Epub 2011 Nov 29.


The differential disease regulome.

Sandve GK, Gundersen S, Rydbeck H, Glad IK, Holden L, Holden M, Liestøl K, Clancy T, Drabløs F, Ferkingstad E, Johansen M, Nygaard V, Tøstesen E, Frigessi A, Hovig E.

BMC Genomics. 2011 Jul 7;12:353. doi: 10.1186/1471-2164-12-353.


Linear and non-linear dependencies between copy number aberrations and mRNA expression reveal distinct molecular pathways in breast cancer.

Solvang HK, Lingjærde OC, Frigessi A, Børresen-Dale AL, Kristensen VN.

BMC Bioinformatics. 2011 May 24;12:197. doi: 10.1186/1471-2105-12-197.


Molecular disease map of bone characterizing the postmenopausal osteoporosis phenotype.

Jemtland R, Holden M, Reppe S, Olstad OK, Reinholt FP, Gautvik VT, Refvem H, Frigessi A, Houston B, Gautvik KM.

J Bone Miner Res. 2011 Aug;26(8):1793-801. doi: 10.1002/jbmr.396.


Combining gene signatures improves prediction of breast cancer survival.

Zhao X, Rødland EA, Sørlie T, Naume B, Langerød A, Frigessi A, Kristensen VN, Børresen-Dale AL, Lingjærde OC.

PLoS One. 2011 Mar 10;6(3):e17845. doi: 10.1371/journal.pone.0017845.


The Genomic HyperBrowser: inferential genomics at the sequence level.

Sandve GK, Gundersen S, Rydbeck H, Glad IK, Holden L, Holden M, Liestøl K, Clancy T, Ferkingstad E, Johansen M, Nygaard V, Tøstesen E, Frigessi A, Hovig E.

Genome Biol. 2010;11(12):R121. doi: 10.1186/gb-2010-11-12-r121. Epub 2010 Dec 23.


In silico ascription of gene expression differences to tumor and stromal cells in a model to study impact on breast cancer outcome.

Myhre S, Mohammed H, Tramm T, Alsner J, Finak G, Park M, Overgaard J, Børresen-Dale AL, Frigessi A, Sørlie T.

PLoS One. 2010 Nov 19;5(11):e14002. doi: 10.1371/journal.pone.0014002.


Eight genes are highly associated with BMD variation in postmenopausal Caucasian women.

Reppe S, Refvem H, Gautvik VT, Olstad OK, Høvring PI, Reinholt FP, Holden M, Frigessi A, Jemtland R, Gautvik KM.

Bone. 2010 Mar;46(3):604-12. doi: 10.1016/j.bone.2009.11.007. Epub 2009 Nov 14.


A stochastic model for the assessment of the transmission pathways of heart and skeleton muscle inflammation, pancreas disease and infectious salmon anaemia in marine fish farms in Norway.

Aldrin M, Storvik B, Frigessi A, Viljugrein H, Jansen PA.

Prev Vet Med. 2010 Jan 1;93(1):51-61. doi: 10.1016/j.prevetmed.2009.09.010. Epub 2009 Oct 6.


Investigating possible subtypes of schizophrenia patients and controls based on brain cortical thickness.

Lawyer G, Nesvåg R, Varnäs K, Frigessi A, Agartz I.

Psychiatry Res. 2008 Dec 30;164(3):254-64. doi: 10.1016/j.pscychresns.2007.12.017. Erratum in: Psychiatry Res. 2009 Mar 31;171(3):258.


Cytokine expression profiling of the myocardium reveals a role for CX3CL1 (fractalkine) in heart failure.

Husberg C, Nygård S, Finsen AV, Damås JK, Frigessi A, Oie E, Waehre A, Gullestad L, Aukrust P, Yndestad A, Christensen G.

J Mol Cell Cardiol. 2008 Aug;45(2):261-9. doi: 10.1016/j.yjmcc.2008.05.009. Epub 2008 May 28.


Validation of oligoarrays for quantitative exploration of the transcriptome.

Nygaard V, Liu F, Holden M, Kuo WP, Trimarchi J, Ohno-Machado L, Cepko CL, Frigessi A, Glad IK, Wiel MA, Hovig E, Lyng H.

BMC Genomics. 2008 May 30;9:258. doi: 10.1186/1471-2164-9-258.


Indirect genomic effects on survival from gene expression data.

Ferkingstad E, Frigessi A, Lyng H.

Genome Biol. 2008;9(3):R58. doi: 10.1186/gb-2008-9-3-r58. Epub 2008 Mar 22.


Accounting for haplotype phase uncertainty in linkage disequilibrium estimation.

Kulle B, Frigessi A, Edvardsen H, Kristensen V, Wojnowski L.

Genet Epidemiol. 2008 Feb;32(2):168-78. Erratum in: Genet Epidemiol. 2008 Sep;32(6):586-7.


Regional thinning of the cerebral cortex in schizophrenia: effects of diagnosis, age and antipsychotic medication.

Nesvåg R, Lawyer G, Varnäs K, Fjell AM, Walhovd KB, Frigessi A, Jönsson EG, Agartz I.

Schizophr Res. 2008 Jan;98(1-3):16-28. Epub 2007 Oct 22.


Predicting survival from microarray data--a comparative study.

Bøvelstad HM, Nygård S, Størvold HL, Aldrin M, Borgan Ø, Frigessi A, Lingjaerde OC.

Bioinformatics. 2007 Aug 15;23(16):2080-7. Epub 2007 Jun 6.


Climatically driven synchrony of gerbil populations allows large-scale plague outbreaks.

Kausrud KL, Viljugrein H, Frigessi A, Begon M, Davis S, Leirs H, Dubyanskiy V, Stenseth NC.

Proc Biol Sci. 2007 Aug 22;274(1621):1963-9.


A stochastic model for infectious salmon anemia (ISA) in Atlantic salmon farming.

Scheel I, Aldrin M, Frigessi A, Jansen PA.

J R Soc Interface. 2007 Aug 22;4(15):699-706.


Effects of alcohol consumption and antipsychotic medication on brain morphology in schizophrenia.

Nesvåg R, Frigessi A, Jönsson EG, Agartz I.

Schizophr Res. 2007 Feb;90(1-3):52-61. Epub 2007 Jan 10.


Incidence and clinical presentation of IBD in children: comparison between prospective and retrospective data in a selected Norwegian population.

Perminow G, Frigessi A, Rydning A, Nakstad B, Vatn MH.

Scand J Gastroenterol. 2006 Dec;41(12):1433-9.


BDNF gene variants and brain morphology in schizophrenia.

Agartz I, Sedvall GC, Terenius L, Kulle B, Frigessi A, Hall H, Jönsson EG.

Am J Med Genet B Neuropsychiatr Genet. 2006 Jul 5;141B(5):513-23.


Brain-derived neurotrophic factor gene (BDNF) variants and schizophrenia: an association study.

Jönsson EG, Edman-Ahlbom B, Sillén A, Gunnar A, Kulle B, Frigessi A, Vares M, Ekholm B, Wode-Helgodt B, Schumacher J, Cichon S, Agartz I, Sedvall GC, Hall H, Terenius L.

Prog Neuropsychopharmacol Biol Psychiatry. 2006 Jul;30(5):924-33. Epub 2006 Apr 3.


The influence of missing value imputation on detection of differentially expressed genes from microarray data.

Scheel I, Aldrin M, Glad IK, Sørum R, Lyng H, Frigessi A.

Bioinformatics. 2005 Dec 1;21(23):4272-9. Epub 2005 Oct 10.


Genome-wide estimation of transcript concentrations from spotted cDNA microarray data.

Frigessi A, van de Wiel MA, Holden M, Svendsrud DH, Glad IK, Lyng H.

Nucleic Acids Res. 2005 Oct 4;33(17):e143.


Effects of anastrozole on the intratumoral gene expression in locally advanced breast cancer.

Kristensen VN, Sørlie T, Geisler J, Yoshimura N, Linegjaerde OC, Glad I, Frigessi A, Harada N, Lønning PE, Børresen-Dale AL.

J Steroid Biochem Mol Biol. 2005 May;95(1-5):105-11.


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