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Paul Kelly, PhD (1943-2018).

Goffin V, Zingg HH, Sumida C, Touraine P, Friesen HG.

Pituitary. 2019 Feb;22(1):1-3. doi: 10.1007/s11102-018-0929-8. No abstract available.


"I am a part of all that I have met".

Friesen HG.

Clin Invest Med. 2018 Nov 3;41:5-8. doi: 10.25011/cim.v41i2.31407.


Building Sustainable Partnerships to Strengthen Pediatric Capacity at a Government Hospital in Malawi.

Eckerle M, Crouse HL, Chiume M, Phiri A, Kazembe PN, Friesen H, Mvalo T, Rus MC, Fitzgerald EF, McKenney A, Hoffman IF, Coe M, Mkandawire BM, Schubert C.

Front Public Health. 2017 Jul 27;5:183. doi: 10.3389/fpubh.2017.00183. eCollection 2017.


Ubiquitin orchestrates proteasome dynamics between proliferation and quiescence in yeast.

Gu ZC, Wu E, Sailer C, Jando J, Styles E, Eisenkolb I, Kuschel M, Bitschar K, Wang X, Huang L, Vissa A, Yip CM, Yedidi RS, Friesen H, Enenkel C.

Mol Biol Cell. 2017 Sep 15;28(19):2479-2491. doi: 10.1091/mbc.E17-03-0162. Epub 2017 Aug 2.


Functional Analysis of Kinases and Transcription Factors in Saccharomyces cerevisiae Using an Integrated Overexpression Library.

Youn JY, Friesen H, Nguyen Ba AN, Liang W, Messier V, Cox MJ, Moses AM, Andrews B.

G3 (Bethesda). 2017 Mar 10;7(3):911-921. doi: 10.1534/g3.116.038471.


Exploring genetic suppression interactions on a global scale.

van Leeuwen J, Pons C, Mellor JC, Yamaguchi TN, Friesen H, Koschwanez J, Ušaj MM, Pechlaner M, Takar M, Ušaj M, VanderSluis B, Andrusiak K, Bansal P, Baryshnikova A, Boone CE, Cao J, Cote A, Gebbia M, Horecka G, Horecka I, Kuzmin E, Legro N, Liang W, van Lieshout N, McNee M, San Luis BJ, Shaeri F, Shuteriqi E, Sun S, Yang L, Youn JY, Yuen M, Costanzo M, Gingras AC, Aloy P, Oostenbrink C, Murray A, Graham TR, Myers CL, Andrews BJ, Roth FP, Boone C.

Science. 2016 Nov 4;354(6312). pii: aag0839.


High-Content Screening for Quantitative Cell Biology.

Mattiazzi Usaj M, Styles EB, Verster AJ, Friesen H, Boone C, Andrews BJ.

Trends Cell Biol. 2016 Aug;26(8):598-611. doi: 10.1016/j.tcb.2016.03.008. Epub 2016 Apr 22. Review.


High-Throughput Microscopy-Based Screening in Saccharomyces cerevisiae.

Styles EB, Friesen H, Boone C, Andrews BJ.

Cold Spring Harb Protoc. 2016 Apr 1;2016(4):pdb.top087593. doi: 10.1101/pdb.top087593.


Task sharing within a managed clinical network to improve child health in Malawi.

O'Hare B, Phiri A, Lang HJ, Friesen H, Kennedy N, Kawaza K, Jana CE, Chirambo G, Mulwafu W, Heikens GT, Mipando M.

Hum Resour Health. 2015 Jul 21;13:60. doi: 10.1186/s12960-015-0053-z.


CYCLoPs: A Comprehensive Database Constructed from Automated Analysis of Protein Abundance and Subcellular Localization Patterns in Saccharomyces cerevisiae.

Koh JL, Chong YT, Friesen H, Moses A, Boone C, Andrews BJ, Moffat J.

G3 (Bethesda). 2015 Apr 15;5(6):1223-32. doi: 10.1534/g3.115.017830.


Yeast Proteome Dynamics from Single Cell Imaging and Automated Analysis.

Chong YT, Koh JL, Friesen H, Duffy SK, Cox MJ, Moses A, Moffat J, Boone C, Andrews BJ.

Cell. 2015 Jun 4;161(6):1413-24. doi: 10.1016/j.cell.2015.04.051. Erratum in: Cell. 2015 Jul 2;162(1):221. Duffy, Kaluarachchi [corrected to Duffy, Supipi Kaluarachchi].


Cell cycle-regulated oscillator coordinates core histone gene transcription through histone acetylation.

Kurat CF, Lambert JP, Petschnigg J, Friesen H, Pawson T, Rosebrock A, Gingras AC, Fillingham J, Andrews B.

Proc Natl Acad Sci U S A. 2014 Sep 30;111(39):14124-9. doi: 10.1073/pnas.1414024111. Epub 2014 Sep 16.


Bck2 acts through the MADS box protein Mcm1 to activate cell-cycle-regulated genes in budding yeast.

Bastajian N, Friesen H, Andrews BJ.

PLoS Genet. 2013 May;9(5):e1003507. doi: 10.1371/journal.pgen.1003507. Epub 2013 May 9.


Kirkpatrick-Baez microscope for hard X-ray imaging of fast ignition experiments.

Friesen H, Tiedje HF, Hey DS, Mo MZ, Beaudry A, Fedosejevs R, Tsui YY, Mackinnon A, McLean HS, Patel PK.

Rev Sci Instrum. 2013 Feb;84(2):023704. doi: 10.1063/1.4776670.


Exploring the yeast acetylome using functional genomics.

Kaluarachchi Duffy S, Friesen H, Baryshnikova A, Lambert JP, Chong YT, Figeys D, Andrews B.

Cell. 2012 May 11;149(4):936-48. doi: 10.1016/j.cell.2012.02.064.


Functional wiring of the yeast kinome revealed by global analysis of genetic network motifs.

Sharifpoor S, van Dyk D, Costanzo M, Baryshnikova A, Friesen H, Douglas AC, Youn JY, VanderSluis B, Myers CL, Papp B, Boone C, Andrews BJ.

Genome Res. 2012 Apr;22(4):791-801. doi: 10.1101/gr.129213.111. Epub 2012 Jan 26.


Restriction of histone gene transcription to S phase by phosphorylation of a chromatin boundary protein.

Kurat CF, Lambert JP, van Dyk D, Tsui K, van Bakel H, Kaluarachchi S, Friesen H, Kainth P, Nislow C, Figeys D, Fillingham J, Andrews BJ.

Genes Dev. 2011 Dec 1;25(23):2489-501. doi: 10.1101/gad.173427.111.


Clathrin light chain directs endocytosis by influencing the binding of the yeast Hip1R homologue, Sla2, to F-actin.

Boettner DR, Friesen H, Andrews B, Lemmon SK.

Mol Biol Cell. 2011 Oct;22(19):3699-714. doi: 10.1091/mbc.E11-07-0628. Epub 2011 Aug 17.


A quantitative literature-curated gold standard for kinase-substrate pairs.

Sharifpoor S, Nguyen Ba AN, Youn JY, van Dyk D, Friesen H, Douglas AC, Kurat CF, Chong YT, Founk K, Moses AM, Andrews BJ.

Genome Biol. 2011;12(4):R39. doi: 10.1186/gb-2011-12-4-r39. Epub 2011 Apr 14. Erratum in: Genome Biol. 2012;13(5):417. Young, Ji-Young [corrected to Youn, Ji-Young].


Dissecting BAR domain function in the yeast Amphiphysins Rvs161 and Rvs167 during endocytosis.

Youn JY, Friesen H, Kishimoto T, Henne WM, Kurat CF, Ye W, Ceccarelli DF, Sicheri F, Kohlwein SD, McMahon HT, Andrews BJ.

Mol Biol Cell. 2010 Sep 1;21(17):3054-69. doi: 10.1091/mbc.E10-03-0181. Epub 2010 Jul 7.


Dual functions of Mdt1 in genome maintenance and cell integrity pathways in Saccharomyces cerevisiae.

Traven A, Lo TL, Pike BL, Friesen H, Guzzo J, Andrews B, Heierhorst J.

Yeast. 2010 Jan;27(1):41-52. doi: 10.1002/yea.1730.


Dual regulation by pairs of cyclin-dependent protein kinases and histone deacetylases controls G1 transcription in budding yeast.

Huang D, Kaluarachchi S, van Dyk D, Friesen H, Sopko R, Ye W, Bastajian N, Moffat J, Sassi H, Costanzo M, Andrews BJ.

PLoS Biol. 2009 Sep;7(9):e1000188. doi: 10.1371/journal.pbio.1000188. Epub 2009 Sep 8.


Regulation of cell polarity through phosphorylation of Bni4 by Pho85 G1 cyclin-dependent kinases in Saccharomyces cerevisiae.

Zou J, Friesen H, Larson J, Huang D, Cox M, Tatchell K, Andrews B.

Mol Biol Cell. 2009 Jul;20(14):3239-50. doi: 10.1091/mbc.E08-12-1255. Epub 2009 May 20.


Pho85, a multifunctional cyclin-dependent protein kinase in budding yeast.

Huang D, Friesen H, Andrews B.

Mol Microbiol. 2007 Oct;66(2):303-14. Epub 2007 Sep 10. Review.


Comprehensive curation and analysis of global interaction networks in Saccharomyces cerevisiae.

Reguly T, Breitkreutz A, Boucher L, Breitkreutz BJ, Hon GC, Myers CL, Parsons A, Friesen H, Oughtred R, Tong A, Stark C, Ho Y, Botstein D, Andrews B, Boone C, Troyanskya OG, Ideker T, Dolinski K, Batada NN, Tyers M.

J Biol. 2006;5(4):11. doi: 10.1186/jbiol36. Epub 2006 Jun 8.


Characterization of the yeast amphiphysins Rvs161p and Rvs167p reveals roles for the Rvs heterodimer in vivo.

Friesen H, Humphries C, Ho Y, Schub O, Colwill K, Andrews B.

Mol Biol Cell. 2006 Mar;17(3):1306-21. Epub 2006 Jan 4.


Interaction of the Saccharomyces cerevisiae cortical actin patch protein Rvs167p with proteins involved in ER to Golgi vesicle trafficking.

Friesen H, Colwill K, Robertson K, Schub O, Andrews B.

Genetics. 2005 Jun;170(2):555-68. Epub 2005 Mar 31. Erratum in: Genetics. 2009 Aug;182(4):1399.


Global mapping of the yeast genetic interaction network.

Tong AH, Lesage G, Bader GD, Ding H, Xu H, Xin X, Young J, Berriz GF, Brost RL, Chang M, Chen Y, Cheng X, Chua G, Friesen H, Goldberg DS, Haynes J, Humphries C, He G, Hussein S, Ke L, Krogan N, Li Z, Levinson JN, Lu H, Ménard P, Munyana C, Parsons AB, Ryan O, Tonikian R, Roberts T, Sdicu AM, Shapiro J, Sheikh B, Suter B, Wong SL, Zhang LV, Zhu H, Burd CG, Munro S, Sander C, Rine J, Greenblatt J, Peter M, Bretscher A, Bell G, Roth FP, Brown GW, Andrews B, Bussey H, Boone C.

Science. 2004 Feb 6;303(5659):808-13.


Yeast functional genomics and cell biology: no longer in the dark.

Friesen H, Millman JS, Andrews BJ.

Genome Biol. 2003;4(12):352. Epub 2003 Nov 24.


Fewer students select family medicine.

Friesen H.

Can Fam Physician. 2003 Jul;49:864. No abstract available.


Regulation of the yeast amphiphysin homologue Rvs167p by phosphorylation.

Friesen H, Murphy K, Breitkreutz A, Tyers M, Andrews B.

Mol Biol Cell. 2003 Jul;14(7):3027-40. Epub 2003 Apr 4.


Perinatal asphyxia at Port Moresby General Hospital: a study of incidence, risk factors and outcome.

Oswyn G, Vince JD, Friesen H.

P N G Med J. 2000 Mar-Jun;43(1-2):110-20.


Low birthweight at a Papua New Guinea highlands hospital.

Peters HR, Vince JD, Friesen H.

J Trop Pediatr. 2001 Feb;47(1):17-23. doi: 10.1093/tropej/47.1.17.


Reshaping health research in Canada: an initiative whose time has come.

Friesen HG.

Clin Invest Med. 1999 Jun;22(3):119-20. No abstract available.


Protection of breastfeeding in Papua New Guinea.

Friesen H, Vince J, Boas P, Danaya R.

Bull World Health Organ. 1999;77(3):271-4.


Infant feeding practices in Papua New Guinea.

Friesen H, Vince J, Boas P, Danaya R, Mokela D, Ogle G, Asuo P, Kemiki A, Lagani W, Rongap T, Varughese M, Saweri W.

Ann Trop Paediatr. 1998 Sep;18(3):209-15.


The Medical Research Council of Canada: integrating research to Canada's health care system.

Friesen HG.

Nat Med. 1998 Dec;4(12):1353-5. No abstract available.


Development of an anti-bleeding agent for recombinant hirudin induced skin bleeding in the pig.

Dickneite G, Nicolay U, Friesen HJ, Reers M.

Thromb Haemost. 1998 Jul;80(1):192-8.


Equal opportunities in Canada.

Friesen HG.

Nature. 1998 Jan 22;391(6665):326. No abstract available.


Fibroblast growth factor-like autoantibodies in plasma from patients with multiple endocrine neoplasia type 1 and prolactinoma.

Zimering MB, Katsumata N, Friesen HG, Eng J, Riley DJ, Thakker-Varia S, Marx SJ, Ezzat S.

Ann N Y Acad Sci. 1997 Apr 5;815:520-3. No abstract available.


Curriculum package.

Friesen H.

J Psychosoc Nurs Ment Health Serv. 1997 Feb;35(2):4. No abstract available.


Assessment of HIV/AIDS knowledge, attitudes and behaviour of high school students in Papua New Guinea.

Friesen H, Danaya R, Doonar P, Kemiki A, Lagani W, Mataio G, Rongap T, Vince J.

P N G Med J. 1996 Sep;39(3):208-13.


Paediatric HIV infection.

Friesen H.

P N G Med J. 1996 Sep;39(3):183-9. Review.


Predicting career success.

O'Brecht M, Friesen H.

Science. 1996 Aug 30;273(5279):1156-7. No abstract available.


Recombinant hirudin as a periprocedural antithrombotic in coronary angioplasty for unstable angina pectoris.

Hafner G, Rupprecht HJ, Luz M, Terres W, Schindel F, Friesen HJ, Heinrichs H, Jessel A, Meyer J, Prellwitz W.

Eur Heart J. 1996 Aug;17(8):1207-15.


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